JP2000233021A - Right or wrong judging device for hypodermic injection and needleless syringe with its function - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a needleless syringe free from the failure in injection, capable of executing the hypodermic injection by judging the right or wrong on injection on the basis of a thickness of subcutaneous fat and a special quality of skin, and adjusting the injection pressure. SOLUTION: This needleless syringe can set the optimum injection pressure by screwing a compression adjustment nut 39 obtained by integrating a detent block 38 with a piston rod 23 for demounting a nozzle 22 and moving the compression adjustment nut 39, the injection pressure is adjusted on the basis of the judgement of right or wrong determined by a right or wrong judging device for hypodermic injection in advance and the display of the thickness of the subcutaneous fat, and the liquid medicine is sucked and injected, whereby the injection can be executed with the injection pressure optimum to the injection part of a patient, which prevents the failure in injection.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a needleless syringe for performing a subcutaneous injection by jetting a predetermined amount of a chemical solution inhaled from a nozzle orifice of a nozzle, and in particular, to measure the thickness of subcutaneous fat and the characteristics of skin at an injection site. The present invention relates to a subcutaneous injection availability determination device capable of setting an optimum injection pressure and a needleless syringe.

[0002]

2. Description of the Related Art A needleless syringe is a syringe that injects a predetermined amount of a drug solution through a nozzle orifice of a nozzle at the tip of the needle and then jets the drug solution from the nozzle orifice into a patient's subcutaneous area. In other words, injection with a needleless syringe is a needleless injection that does not use a needle at the time of subcutaneous injection. It is also used for self-injection.

Conventionally, in such a needleless syringe,
As shown in FIG. 9, a method in which a piston in a nozzle is moved at a high speed by using a compression spring to jet a chemical solution is often used. The needleless syringe 61 has a front cylinder 64 into which a nozzle 62 having an injection hole 62a at the distal end is inserted and fixed, and a rear cylinder 65 internally provided with a latch mechanism 72 for latching and releasing the piston rod 63. Screw part 6
9 and screw the piston rod 6
3 are arranged. A barbed piston 68 is connected to the tip of the piston rod 63.
A compression spring is wound around the center of the
A compression section 67 is provided to apply a biasing force to the distal end side by moving 3 backward. This needleless syringe 61
When a chemical vial (not shown) is applied to the tip of the nozzle 62 and the rear cylinder 65 is rotated and retracted, the piston 68 retreats in conjunction with the piston rod 63 and the Hollow space (chemical chamber)
Is created, and the drug solution is sucked into it. Then, after inhaling the necessary amount of the drug solution, when the tip of the nozzle is applied to the injection site and the latch release button 72a is pressed, the latch ball 71 jumps out of the recess 70, the piston rod 63 is released from the latch mechanism 72, and the compression unit The piston 68 is advanced at a high speed by the urging force of the distal end at 67, and the drug solution is injected into the injection site. A gas-pressure needleless syringe is also used in which a small gas cylinder containing a compressed gas is attached to the front cylinder 64, the compressed gas is released into the compression section 67, and the piston is advanced at that pressure.

[0004]

The conventional needleless syringe is constructed as described above, but the condition of the patient's own subcutaneous fat, such as the thickness of the subcutaneous fat and the hardness of the skin, is determined by age, sex, physique, injection site, etc. In contrast, conventional needleless syringes inhale and inject only the required amount of the drug solution, and the injection pressure is fixed, so that injection takes place. There is a problem that it is injected into the fast muscular layer and causes a dangerous condition due to hypoglycemia. In addition, if the skin is hard or thick, smooth injection cannot be performed, causing pain at the time of injection and a problem that a predetermined amount of the drug solution cannot be injected.

[0005] The present invention has been made in view of such circumstances, and a subcutaneous injection feasibility determination device capable of determining the injection feasibility by measuring the thickness of the subcutaneous fat and the skin characteristics of the patient himself. It is another object of the present invention to provide a needleless syringe having a function of setting an optimum injection pressure based on the determination result and performing injection.

[0006]

In order to achieve the above object, a subcutaneous injection availability determination apparatus according to the first aspect of the present invention comprises:
It is characterized by comprising measuring means for measuring the thickness of subcutaneous fat at an injection site, and judgment display means for judging whether subcutaneous injection is possible based on the measurement result and displaying the result. The apparatus for determining whether or not subcutaneous injection according to the second aspect of the present invention is a measuring means for measuring characteristics of skin at an injection site, determines whether or not subcutaneous injection is possible based on the measurement result, and displays the result. A determination display means for performing the determination. In the needleless syringe according to the third aspect of the present invention, the initial position of the compression spring that applies a biasing force in the forward direction to the rod connected to the piston to move the piston at high speed in the nozzle to eject the chemical solution. And a setting function for setting an optimum injection pressure. Next, in the needleless syringe according to the fourth aspect of the present invention, in order to move the piston at high speed in the nozzle to eject the chemical solution, the initial stage of the compression spring which applies a biasing force to the rod connected to the piston in the forward direction is provided. It is characterized by having a setting function of changing the position and setting an optimal injection pressure and a function of displaying the set pressure. The needleless syringe according to the fifth aspect of the present invention is a measuring device for measuring the thickness of subcutaneous fat at an injection site, and determines whether subcutaneous injection is possible based on the measurement result,
It is characterized by including a judgment display means for displaying the result. Furthermore, the needleless syringe according to the invention of claim 6 is
Measuring means for measuring the properties of the skin at the injection site, and determine whether subcutaneous injection is possible based on the measurement results,
It is characterized by including a judgment display means for displaying the result.

The apparatus for judging the possibility of subcutaneous injection and the needleless syringe of the present invention are configured as described above, and measure the thickness of the subcutaneous fat of the patient and the state of the hardness of the skin to determine whether injection is possible. Injection can be performed by setting the liquid injection pressure, so that dangerous injection and injection failure can be eliminated.

[0008]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described specifically with reference to examples. FIG. 1 is a schematic configuration diagram showing an embodiment of a subcutaneous injection availability determination device of the present invention. The present apparatus includes an oscillator 2a for transmitting an ultrasonic pulse signal in close contact with an injection site of a skin B1 of a patient, and an ultrasonic signal that repeats reflection between the skin B1 and a boundary surface between the subcutaneous fat B2 and the muscle B3. A probe 2 composed of a receiving transducer 2b for receiving the signal, a matching material 2c for reducing reflection of the transmitted ultrasonic signal on the skin B1, and an electric pulse signal for driving the transmitting transducer 2a. A pulse generator 3 to be generated, a receiving unit 4 for amplifying a pulse signal from the pulse generator 3 and a multiplex echo signal received by the receiving transducer 2b, and a pulse interval of the multiplex echo signal are measured. A fat thickness measuring unit 5 for converting into subcutaneous fat thickness data, comparing the subcutaneous fat thickness data with pre-stored injectable limit subcutaneous fat thickness data, and outputting an injection possibility determination symbol Part 6 and leather And a display unit 7 for displaying the fat thickness data and determined symbols.

In the above configuration, both transducers are disposed at a fixed angle with respect to the horizontal plane, and when an ultrasonic pulse is transmitted in the direction of arrow A from the transmitting transducer 2a of the probe 2,
The ultrasonic pulse repeatedly reflects between the skin B1 and the boundary surface between the subcutaneous fat B2 and the muscle B3, and a multiple echo signal as shown in FIG. 2 is transmitted from the receiving transducer 2b to the receiving unit 4. A known time width measurement circuit is used for the fat thickness measurement unit 5, and the pulse interval of the multiplex echo signal has a time width τ (se
After being converted to c), the speed of sound in subcutaneous fat is c (mm / s)
As ec), a calculation of (τ × c) / 2 (mm) is performed to obtain fat thickness data.

The subcutaneous fat thickness data is compared with the pre-stored comparative subcutaneous fat thickness data in the injectability judging section 6 and the results are "1", "2",
The data is displayed on the display unit 17 together with the subcutaneous fat thickness data, distinguished by the symbols “3” and “N”. This symbol is
Refers to the injection pressure level to be applied, for example,
The injection pressure corresponding to “1”, “2” and “3” was increased to 14M
By setting the subcutaneous fat thickness range that can be injected with this injection pressure at Pa, 16 MPa, and 18 MPa, it is possible to determine which injection pressure level the measured subcutaneous fat thickness data corresponds to. The symbol “N” indicates that injection is impossible. The subcutaneous injection thickness limit is determined in advance, and the “N” symbol is displayed when the measured subcutaneous fat thickness data falls below the subcutaneous injection thickness limit. . By using the subcutaneous injection availability determination device 1, the patient can know whether or not the injection is possible and the injection pressure level before the injection. In the case where the injection is possible, the injection is performed by setting the injection pressure of the needleless syringe to the optimum pressure. Can eliminate dangerous injections and injection failures.

FIG. 3 is a schematic structural view showing another embodiment of the apparatus for determining whether or not subcutaneous injection is possible according to the present invention. This device is formed on both sides of a probe 12 having a transmitting oscillator 12a for transmitting an ultrasonic continuous wave in close contact with an injection site of a patient's skin B1, and on both surfaces of the transmitting oscillator 12a. Thin film electrode 12
b, and an AC sweep signal generator for inputting an AC signal (for example, a sine wave signal) whose frequency is swept to the power amplifier 13 14, an AC for detecting a current supplied to the oscillator for transmission 12a and converting the current to a DC current
A / DC converter 15, a peak detector 18 for detecting a peak point from its output characteristics and inputting a sweep stop signal to the AC sweep signal generator 14, a frequency at that time, that is, a natural frequency, It comprises an injection possible / impossible determining section 16 that compares the pre-stored injectable limit frequency, determines whether injection is possible, and outputs a determination symbol, and a determination display section 17 that displays the natural frequency and the determination symbol.

In the above configuration, the AC sweep signal generated by the AC sweep signal generator 14 is
3 and is applied between both electrodes 12b of the oscillator for transmission 12a. The transmitting oscillator 12a vibrates while being in close contact with the skin B1, but a resonance state occurs at a natural frequency determined by the characteristics of the skin B1, and the AC shown in FIG.
A peak waveform appears on the output characteristics of the / DC converter 15.
The peak point is detected by the peak detection unit 18, at which point a sweep stop signal is sent to the AC sweep signal generator 14 to stop the sweep.

The natural frequency varies depending on the hardness or lumps of the skin, etc. The natural frequency at which injection is not possible is stored in advance in the injection feasibility determining section 16, and compared with this, if the injection is possible, " If the injection is not possible, it is converted into the symbol "N" and displayed on the display unit 17 together with the natural frequency. This indication allows the patient to avoid forcing injections due to the characteristics of the skin.

FIGS. 5 (a) and 5 (b) are a sectional view and an AA sectional view of an embodiment of the needleless syringe of the present invention, and FIG. 6 is a plan view thereof. As shown in FIG. 5 (a), the present needleless syringe 21 has a cylindrical body 26 formed by screwing a front cylindrical body 24 and a rear cylindrical body 25 having both open end surfaces. The front side cylindrical body 24 is provided with a nozzle 22 at its distal end by a screw portion 3.
6 is screwed. Further, a piston rod 23 that can reciprocate in the axial direction of the cylinder 26 is provided. A flange ring 29 is integrally attached to the distal end side of the piston rod 23, and a compression force adjusting nut 39 to which a pair of rotation stopping blocks 38 is fixed is screwed at a screw portion 37 behind the flange ring 29.
Is screwed. As shown in FIG. 5B, the rotation stopping block 38 moves along the groove 24a provided in the front cylinder 24. At the rear end of the piston rod 23, a latch groove 34 is provided on the periphery and the guide pipe 30
Are fitted in the axial direction. Further, a stopper plate 40 having an insertion hole for the piston rod 23 is fixed to the inner surface of the front end of the front cylinder 24. A strong compression spring 32 passed through the piston rod 23 is interposed between the compression force adjusting nut 39 and the guide pipe 30. The compression spring 32 constantly urges the piston rod 23 in the forward direction. Structure.

On the other hand, a fixing ring 42 is fixed to the inner surface of the rear cylinder 25 with a screw portion 50 behind the projection 43. A latch release button 44 is inserted behind the fixing ring 42 so as to be movable in the axial direction. The latch release button 44 is restricted from protruding rearward by a presser 45 fixed to the rear cylinder 25 with a screw 46. The movable small piece 4 is provided on the rear end side of the fixed ring 42.
7 is fitted so as to be movable in the axial direction. A compression spring 47a is interposed between the movable small piece 47 and the rear end surface of the latch release button 44, and the latch release button 44 is constantly urged in the backward direction by the compression spring 47a.

A plurality of small holes 48 penetrating in the circumferential direction are formed in the rear end paragraph portion of the fixing ring 42, and a latch ball 49 is fitted in each hole. When the inner surface of the front end of the latch release button 44 advances beyond the latch ball 49, the latch release button 44 is locked with the latch ball 49 by the urging force of the compression spring 47a, so that the front cylinder 24 is moved to the rear cylinder 25. , The components from the fixing ring 42 to the latch ball 49 move forward together with the rear cylinder 25.

On the other hand, as shown in FIG. 6, on the peripheral surface of the thin portion on the rear end side of the front cylindrical body 24, a chemical injection amount scale SA indicating the amount of the chemical injected by one injection is displayed. . A reading window 41 using a transparent member is provided at a position where the movement of the rotation stop block 38 can be read on the front end side of the front cylinder 24, and the injection pressure setting scale SB is displayed on the reading window 41. .

As shown in FIG. 5 (a), the middle part of the rear cylinder 25 has a double cylindrical shape over a certain distance in the axial direction. Rear cylinder 2
5 is screwed into the front cylinder 2 between the outer cylinder and the inner cylinder.
4 has a structure in which the thin portion on the rear end side enters, so that the chemical solution injection scale SA can be read at the leading edge of the outer cylinder.

Using the needleless syringe 21 and the subcutaneous injection availability determination device 1, needleless injection is performed in the following procedure. 1. The subcutaneous fat thickness at the injection site is measured using the subcutaneous injection availability determination device 1 of FIG. 1, and the availability of the injection and the injection pressure level are read from the display unit 7. The display is “1”,
If it is either “2” or “3”, proceed to the following item 2,
When "N", no injection is performed. 2. The nozzle 22 at the tip of the needleless syringe is turned to remove it from the front cylinder 24, and the piston 28 is pulled out from the piston rod 23. 3. By inserting a rod portion having a square cross section on the tip side of the piston rod 23 into a tool with a square hole, and turning it around,
Detent block 3 screwed into piston rod 23
8 is moved in the axial direction. Then, the index 41a of the rotation stop block 38 is adjusted to the set scale of the reading window 41 which is the same as the previously measured subcutaneous fat level. 4. After inserting the piston 28 into the piston rod 23, the nozzle 22 is attached to the front cylinder 24.

[5] When the rear cylinder 25 is rotated with the other hand while holding the front cylinder 24 with one hand, and the rear cylinder 25 is screwed into the front cylinder 24 and advanced, the movable small piece 47 The distal end is fitted into the recess in the rear end surface of the piston rod 23, and the latch release button 44 is moved rearward by the compression spring 47a to be reset. Then, the latch ball 49
Is partially dropped into the latch groove 34, and at the same time, the compression spring 47
As a result, the latch release button 44 urged in the backward direction at a, keeps holding the latch ball 49 from the side. As a result, the state where the piston rod 23 is locked to the fixing ring 42 by the latch ball 49 is maintained without the latch ball 49 protruding from the latch groove 34. In this state, the leading edge of the outer cylinder of the rear cylinder 25 is set to be located on the zero line of the chemical solution injection amount scale SA.

6. As shown in FIG.
The adapter 27a into which the suction needle 27b is inserted
Of the drug solution vial into the needleless syringe 2
Bind to 1. While holding the front cylinder 24 with one hand, rotate the rear cylinder 25 in the reverse direction with the other hand,
The piston rod 23 and the piston 28 locked to the rear cylinder 2 are also retracted while being pulled.
Eject 5. Since the retreat distance of the piston rod 23, that is, the retreat distance of the rear cylinder 25, corresponds to the amount of the chemical solution to be injected in one injection, the front edge of the outer cylinder of the rear cylinder 25 is moved once. Is set to the scale line of the chemical solution injection amount scale SA indicating the required amount of the chemical solution.

7. When the latch release button 44 is pressed while the injection hole 22a is pressed against the injection site of the patient, the compression spring 47a is pressed and contracted and the latch release button 4 is pressed.
4 advances and the latch ball 49 jumps out of the latch hole 34 in the radial direction, so that the engagement between the piston rod 23 and the fixing ring 42 is released. When the engagement between the piston rod 23 and the fixing ring 42 is released, the piston rod 23 momentarily advances to a position where the flange ring 29 hits the stopper plate 40 by the urging force of the strong compression spring 32,
A predetermined chemical liquid injection is performed. As described above, the present needleless syringe can be used for subcutaneous injection with the optimal injection pressure set.

FIG. 8 is a schematic structural view of a needleless syringe according to another embodiment. In this syringe, a transmitting oscillator 52a and a receiving oscillator 52b obtained by miniaturizing the transmitting oscillator 2a and the receiving oscillator 2b used in the subcutaneous injection availability determination device shown in FIG. At the same time, the motor 53 is incorporated into the compression force adjusting ring 55 so as to move on the screw portion 37 of the piston rod 23. As the motor 53, for example, an ultrasonic motor having a rotor 53a that can be screwed with the screw portion 37 and a stator 53b that can be fixed to the compression force adjusting ring 55 can be used. The transmitting oscillator 5 provided in the nozzle 52
A supply line for supplying the driving power to 2a and a signal extraction line from the receiving oscillator 52b and an electric wiring to the motor 53 are extracted to the outside through a connection terminal 54 provided on the front cylinder 24, and the connection terminal is provided. The drive circuit of the motor 53 is connected to the main body 1a of the needleless syringe shown in FIG.

The thickness of the subcutaneous fat is measured by this needleless syringe, and an index 41 is set on the setting scale of the reading window (41 in FIG. 6) which is the same as the symbol shown on the display unit 7 of the main body 1a (FIG. 1).
The motor 53 is driven so that a coincides with each other, and the optimal injection pressure is set. By using this needleless syringe, a series of operations from determination display to injection can be performed in a short time without moving the injection site. The injection procedure is performed in the same manner as the needleless syringe 21 in FIG. In addition, by using the compression force adjustment nut (39 in FIG. 5A) instead of the compression force adjustment ring 55 and the motor 53, the nozzle 52 is removed, and the compression force adjustment nut 39 is manually moved to perform injection. The pressure can also be adjusted. Further, in the above embodiment, the determination result is displayed on the display unit of the subcutaneous injection availability determination device, but the display unit may be provided on the needleless syringe itself. The above description is directed to a syringe that determines an injection pressure by a compression spring, but by closing the front from the projection 43 of the rear cylinder 25 and forming a cylinder container having the piston rod 23 as a cylinder axis, Even in a gas pressure needleless syringe that introduces compressed gas and moves the piston rod at high speed with the gas pressure to perform injection, the compressed gas is set to generate an injection pressure corresponding to the determination result of the subcutaneous injection availability determination device. By doing so, the present invention can be applied.

[0025]

The needleless syringe of the present invention is constructed as described above, and is provided with a means for measuring the thickness of subcutaneous fat and displaying the result. Since the pressure level can be known before the injection, dangerous injections and injection failures can be eliminated. In addition, a subcutaneous injection availability determination device provided with a means for measuring skin characteristics and displaying the result can avoid excessive injection. Furthermore, by using a needleless syringe with a subcutaneous injection availability determination function equipped with a setting means capable of setting an optimal injection pressure, dangerous injection into muscle can be avoided and injection can be performed at an injection pressure suitable for subcutaneous fat thickness. it can. Then, the thickness of the subcutaneous fat is measured, and a means for displaying the result and a needleless syringe equipped with a setting means for setting an optimal injection pressure are used to perform a series of steps from determination display to injection without moving the injection site. The operation can be performed in a short time.

[Brief description of the drawings]

FIG. 1 is a schematic configuration diagram showing an embodiment of a subcutaneous injection availability determination device of the present invention.

FIG. 2 is a pulse response diagram showing a multiple echo signal in the subcutaneous injection availability determination device of the present invention.

FIG. 3 is a schematic configuration diagram showing another embodiment of the subcutaneous injection availability determination device of the present invention.

FIG. 4 is an output response diagram showing a change in output of an AC / DC converter.

5 (a) and 5 (a) are sectional views of a needleless syringe according to the present invention.
It is -A sectional drawing.

FIG. 6 is a plan view of a needleless syringe according to the present invention.

FIG. 7 is a combined view of a needleless syringe and a drug solution vial according to the present invention.

FIG. 8 is a schematic structural view showing another embodiment of the needleless syringe according to the present invention.

FIG. 9 is a schematic configuration diagram of a conventional needleless syringe.

[Explanation of symbols]

 1, 11 ... subcutaneous injection availability determination device 2, 12 ... probe 2a, 12a, 52a ... transmitting oscillator 2b, 52b ... receiving oscillator 2c ... matching material 3. ..Pulse generator 4 ・ ・ ・ Receiving unit 5 ・ ・ ・ Fat thickness measuring unit 6, 16 ・ ・ ・ Injection determination unit 7, 17 ・ ・ ・ Display unit 12b ・ ・ ・ Electrode 13 ・ ・ ・ Power amplifying unit 14 ... AC sweep signal generator 15 ... AC / DC converter 18 ... peak detector 21, 51, 61 ... needleless syringe 22, 52, 62 ... nozzle 22a, 62a ... Injection hole 22b ・ ・ ・ Chemical solution chamber 22c, 35, 43, 70 ・ ・ ・ Dent 23, 63 ・ ・ ・ Piston rod 24, 64 ・ ・ ・ Front cylinder 25, 65 ・ ・ ・ Rear cylinder 26, 66 ・..Cylinder 27 ... Chemical vial 28, 68 ... Piston 29 ... Lung ring 30 ・ ・ ・ Guide pipe 31 ・ ・ ・ Flange 32,47a ・ ・ ・ Compression spring 34 ・ ・ ・ Latch groove 36,37,50,69 ・ ・ ・ Screw part 38 ・ ・ ・ Detent block 39 ・ ・ ・Compressive force adjusting nut 40 ・ ・ ・ Stopper plate 41 ・ ・ ・ Reading window 41a ・ ・ ・ Index 42 ・ ・ ・ Fixing ring 43 ・ ・ ・ Protrusion 44, 72a ・ ・ ・ Latch release button 45 ・ ・ ・ Holder 46 ・..Screw 47 ... Movable small piece 48 ... Small hole 49 ... Latch ball 53 ... Motor 53a ... Rotor 53b ... Stator 54 ... Connection terminal 55 ... Compression Force adjusting ring 63a Stopper 67 Compressing part 72 Latch mechanism B1 Skin B2 Subcutaneous fat B3 Muscle SA Drug solution injection scale SB Injection pressure Constant scale

Claims (6)

[Claims] 1. A measuring device for measuring the thickness of subcutaneous fat at an injection site, and a judgment display device for judging whether subcutaneous injection is possible based on the measurement result and displaying the result. Subcutaneous injection availability determination device. 2. The apparatus according to claim 1, further comprising a measuring means for measuring skin characteristics at the injection site, and a judging display means for judging whether subcutaneous injection is possible based on the measurement result and displaying the result. Subcutaneous injection availability determination device. 3. An initial position of a compression spring that applies a biasing force in a forward direction to a rod connected to the piston in order to move a piston at a high speed in a nozzle to eject a chemical solution,
A needleless syringe having a setting function capable of setting an optimum injection pressure. 4. An initial position of a compression spring that applies a biasing force in a forward direction to a rod connected to the piston to move a piston at a high speed in the nozzle to eject a chemical solution,
A needleless syringe having a setting function for setting an optimal injection pressure and a function for displaying the set pressure. 5. A measuring device for measuring the thickness of subcutaneous fat at an injection site, and a judgment display device for judging whether or not subcutaneous injection is possible based on the measurement result and displaying the result. Needleless syringe. 6. A measuring device for measuring characteristics of skin at an injection site, and judgment display means for judging whether subcutaneous injection is possible based on the measurement result and displaying the result. Needleless syringe.