JP2000214149A5 - - Google Patents
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- JP2000214149A5 JP2000214149A5 JP1999019594A JP1959499A JP2000214149A5 JP 2000214149 A5 JP2000214149 A5 JP 2000214149A5 JP 1999019594 A JP1999019594 A JP 1999019594A JP 1959499 A JP1959499 A JP 1959499A JP 2000214149 A5 JP2000214149 A5 JP 2000214149A5
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- JP
- Japan
- Prior art keywords
- mass spectrometer
- liquid chromatograph
- inlet opening
- spraying
- central axis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000007788 liquid Substances 0.000 claims description 17
- 238000005507 spraying Methods 0.000 claims description 8
- 230000005684 electric field Effects 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 239000002184 metal Substances 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 description 13
- 238000010586 diagram Methods 0.000 description 6
- 238000000889 atomisation Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
Description
【０００８】
【課題を解決するための手段】
上記課題を解決するために成された本発明は、液体クロマトグラフ部から与えられる液体試料をイオン化して質量分析部に導入するためのＬＣ／ＭＳインタフェイスを具備する液体クロマトグラフ質量分析装置において、該ＬＣ／ＭＳインタフェイスは、
a)液体試料を大気圧下で噴霧する噴霧手段と、
b)該噴霧手段と真空室との間に設けられ、該噴霧手段により噴霧された液滴を導入するための入口開口と、該入口開口の中心軸と直交又は斜交した中心軸を有する出口開口とを備える分離室と、
c)前記入口開口から出路開口に至る湾曲形状のイオン通過路を形成すべく分離室内に配設された電界形成手段であって、イオン通過路の延伸方向に互いに分離された複数の金属板電極により１本の仮想ロッド電極が形成され、該イオン通過路を取り囲んで周方向に互いに分離され且つイオン通過路の延伸方向に沿って延伸する偶数本の仮想ロッド電極から成る電界形成手段と、
を備えることを特徴としている。
0008
[Means for solving problems]
The present invention made to solve the above problems is in a liquid chromatograph mass spectrometer provided with an LC / MS interface for ionizing a liquid sample given from the liquid chromatograph unit and introducing it into the mass spectrometer. , The LC / MS interface
a) A spraying means for spraying a liquid sample under atmospheric pressure,
b) An outlet provided between the spraying means and the vacuum chamber and having an inlet opening for introducing droplets sprayed by the spraying means and a central axis orthogonal to or oblique to the central axis of the inlet opening. A separation room with an opening and
c) A plurality of metal plate electrodes separated from each other in the extending direction of the ion passage path, which are electric field forming means arranged in the separation chamber to form a curved ion passage path from the inlet opening to the exit passage opening. A single virtual rod electrode is formed by the above means, and an electric field forming means including an even number of virtual rod electrodes that surround the ion passage path, are separated from each other in the circumferential direction, and extend along the extension direction of the ion passage path.
It is characterized by having.
【００１０】
【発明の実施の形態】
本発明に係る液体クロマトグラフ質量分析装置では、例えば、１本の仮想的ロッド電極を構成する複数の金属板電極には、イオン通過路の延伸方向に階段状に相違する直流電圧と共通の高周波電圧とが重畳された電圧がそれぞれ印加される。また、イオン通過路の周囲において隣接する仮想的ロッド電極に対しては、高周波電圧の位相は互いに反転したものとされる。
0010
BEST MODE FOR CARRYING OUT THE INVENTION
In the liquid chromatograph mass spectrometer according to the present invention, for example, a plurality of metal plate electrodes constituting one virtual rod electrode have a high frequency common to a DC voltage that differs stepwise in the extending direction of the ion passage path. The voltage on which the voltage is superimposed is applied. Further, it is assumed that the phases of the high frequency voltage are reversed with respect to the virtual rod electrodes adjacent to each other around the ion passage path.
【００１２】
【発明の効果】
本発明に係る液体クロマトグラフ質量分析装置によれば、ＬＣ／ＭＳインタフェイスにおいて、大きな液滴を排除して比較的粒径の揃った微小液滴及びイオンのみを選別して後段へ送ることができる。そのため、分析時の背景雑音を減少させることができる。
0012
【Effect of the invention】
According to the liquid chromatograph mass spectrometer according to the present invention, in the LC / MS interface, it is possible to exclude large droplets and select only minute droplets and ions having a relatively uniform particle size and send them to the subsequent stage. it can. Therefore, the background noise at the time of analysis can be reduced.
【００１３】
【実施例】
まず、上記従来の装置とは異なる液体クロマトグラフ質量分析装置の一実施例を図面を参照して説明する。図１は本実施例による液体クロマトグラフ質量分析装置の要部の構成図である。図６に示した従来の質量分析装置と異なるのは、霧化室１０内において、ノズル１１と壁部１３との間にサイクロンチャンバ３０が設けられていることである。
0013
【Example】
First, an embodiment of a liquid chromatograph mass spectrometer different from the conventional device will be described with reference to the drawings. FIG. 1 is a block diagram of a main part of the liquid chromatograph mass spectrometer according to the present embodiment. The difference from the conventional mass spectrometer shown in FIG. 6 is that the cyclone chamber 30 is provided between the nozzle 11 and the wall portion 13 in the atomization chamber 10.
次に、本発明に係る液体クロマトグラフ質量分析装置の一実施例を図面により説明する。図３はこの実施例による液体クロマトグラフ質量分析装置の要部の構成図である。この質量分析装置では、サンプリングコーン１５の中心軸とスキマー１７の中心軸とは平行ではなくほぼ直交しており、第１中間室１４内には、イオン（及び液滴）をスキマー１７のオリフェスに導くための湾曲したイオン通過路を形成するイオンレンズ４０が設けられている。
Next, an embodiment of the liquid chromatograph mass spectrometer according to the present invention will be described with reference to the drawings. FIG. 3 is a block diagram of a main part of the liquid chromatograph mass spectrometer according to this embodiment. In this mass spectrometer, the central axis of the sampling cone 15 and the central axis of the skimmer 17 are not parallel but substantially orthogonal to each other, and ions (and droplets) are converted into the orifes of the skimmer 17 in the first intermediate chamber 14. An ion lens 40 is provided to form a curved ion passage path for guiding.
【図面の簡単な説明】
【図１】 液体クロマトグラフ質量分析装置の一実施例の要部の構成図。
【図２】 図１の実施例におけるサイクロンチャンバの外観を示す上面図（ａ）及び側面図（ｂ）。
【図３】 本発明に係る液体クロマトグラフ質量分析装置の一実施例の要部の構成図。
【図４】 イオンレンズをイオン入射側から見た平面図。
【図５】 イオンレンズを中心とする要部の構成図。
【図６】 ＥＳＰを利用した従来のＬＣ／ＭＳインタフェイスを備える質量分析装置の構成図。
[Simple explanation of drawings]
FIG. 1 is a block diagram of a main part of an embodiment of a liquid chromatograph mass spectrometer.
2 is a top view (a) and a side view (b) showing the appearance of the cyclone chamber in the embodiment of FIG. 1. FIG.
FIG. 3 is a block diagram of a main part of an embodiment of a liquid chromatograph mass spectrometer according to the present invention.
FIG. 4 is a plan view of an ion lens as viewed from the ion incident side.
FIG. 5 is a block diagram of a main part centered on an ion lens.
FIG. 6 is a block diagram of a mass spectrometer including a conventional LC / MS interface using ESP.
Claims (1)
a)液体試料を大気圧下で噴霧する噴霧手段と、
b)該噴霧手段と真空室との間に設けられ、該噴霧手段により噴霧された液滴を導入するための入口開口と、該入口開口の中心軸と直交又は斜交した中心軸を有する出口開口とを備える分離室と、
c)前記入口開口から出路開口に至る湾曲形状のイオン通過路を形成すべく分離室内に配設された電界形成手段であって、イオン通過路の延伸方向に互いに分離された複数の金属板電極により１本の仮想ロッド電極が形成され、該イオン通過路を取り囲んで周方向に互いに分離され且つイオン通過路の延伸方向に沿って延伸する偶数本の仮想ロッド電極から成る電界形成手段と、
を備えたことを特徴とする液体クロマトグラフ質量分析装置。In a liquid chromatograph mass spectrometer equipped with an LC / MS interface for ionizing and introducing a liquid sample given from the liquid chromatograph unit into the mass spectrometer, the LC / MS interface comprises:
a) a spraying means for spraying a liquid sample under atmospheric pressure;
b) An inlet opening provided between the spraying means and the vacuum chamber for introducing droplets sprayed by the spraying means, and an outlet having a central axis orthogonal or oblique to the central axis of the inlet opening A separation chamber comprising an opening;
c) Electric field forming means disposed in the separation chamber to form a curved ion passage from the inlet opening to the outlet opening, and a plurality of metal plate electrodes separated from each other in the extending direction of the ion passage An electric field forming means comprising an even number of virtual rod electrodes which are formed by the above, are separated from each other in the circumferential direction and extend along the extending direction of the ion passing path,
A liquid chromatograph mass spectrometer comprising:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11019594A JP2000214149A (en) | 1999-01-28 | 1999-01-28 | Liquid chromatograph mass analyser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11019594A JP2000214149A (en) | 1999-01-28 | 1999-01-28 | Liquid chromatograph mass analyser |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000214149A JP2000214149A (en) | 2000-08-04 |
| JP2000214149A5 true JP2000214149A5 (en) | 2005-10-13 |
Family
ID=12003581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP11019594A Withdrawn JP2000214149A (en) | 1999-01-28 | 1999-01-28 | Liquid chromatograph mass analyser |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2000214149A (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8410435B2 (en) | 2009-06-10 | 2013-04-02 | Msi. Tokyo, Inc. | Cyclone separator type mass analyzing system |
| JP2013007639A (en) | 2011-06-24 | 2013-01-10 | Hitachi High-Technologies Corp | Liquid chromatography mass spectrometer device |
| WO2014087746A1 (en) * | 2012-12-03 | 2014-06-12 | 富士電機株式会社 | Particle beam forming device |
| CN112858452B (en) * | 2021-01-19 | 2023-10-03 | 岛津企业管理（中国）有限公司 | Living body analysis system combining probe electrospray ionization and mass spectrum |
| KR102614315B1 (en) * | 2021-12-02 | 2023-12-19 | 영인에이스 주식회사 | Mass spectrometer |
-
1999
- 1999-01-28 JP JP11019594A patent/JP2000214149A/en not_active Withdrawn
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