JP2000186092A5 - - Google Patents
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- Publication number
- JP2000186092A5 JP2000186092A5 JP1998364369A JP36436998A JP2000186092A5 JP 2000186092 A5 JP2000186092 A5 JP 2000186092A5 JP 1998364369 A JP1998364369 A JP 1998364369A JP 36436998 A JP36436998 A JP 36436998A JP 2000186092 A5 JP2000186092 A5 JP 2000186092A5
- Authority
- JP
- Japan
- Prior art keywords
- production method
- ucn
- less
- solution containing
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- PBCZSGKMGDDXIJ-HQCWYSJUSA-N 7-hydroxystaurosporine Chemical compound N([C@H](O)C1=C2C3=CC=CC=C3N3C2=C24)C(=O)C1=C2C1=CC=CC=C1N4[C@H]1C[C@@H](NC)[C@@H](OC)[C@]3(C)O1 PBCZSGKMGDDXIJ-HQCWYSJUSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- PBCZSGKMGDDXIJ-UHFFFAOYSA-N 7beta-hydroxystaurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3C(O)NC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 PBCZSGKMGDDXIJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003929 acidic solution Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10364369A JP2000186092A (ja) | 1998-12-22 | 1998-12-22 | Ｕｃｎ−０１の製造法 |
| CA002293023A CA2293023A1 (en) | 1998-12-22 | 1999-12-17 | Process for producing ucn-01 |
| US09/466,903 US6197955B1 (en) | 1998-12-22 | 1999-12-20 | Production of staurosporine derivative using acid isomerization |
| DE69908288T DE69908288T2 (de) | 1998-12-22 | 1999-12-21 | Verfahren zur Herstellung von UCN-01 |
| AT99125341T ATE241630T1 (de) | 1998-12-22 | 1999-12-21 | Verfahren zur herstellung von ucn-01 |
| EP99125341A EP1020471B1 (en) | 1998-12-22 | 1999-12-21 | Process for producing UCN-01 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10364369A JP2000186092A (ja) | 1998-12-22 | 1998-12-22 | Ｕｃｎ−０１の製造法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2000186092A JP2000186092A (ja) | 2000-07-04 |
| JP2000186092A5 true JP2000186092A5 (enExample) | 2005-07-28 |
Family
ID=18481646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10364369A Abandoned JP2000186092A (ja) | 1998-12-22 | 1998-12-22 | Ｕｃｎ−０１の製造法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US6197955B1 (enExample) |
| EP (1) | EP1020471B1 (enExample) |
| JP (1) | JP2000186092A (enExample) |
| AT (1) | ATE241630T1 (enExample) |
| CA (1) | CA2293023A1 (enExample) |
| DE (1) | DE69908288T2 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6887864B2 (en) | 2002-03-12 | 2005-05-03 | Hoffmann-La Roche Inc. | Azepane derivatives |
| NZ544756A (en) | 2003-07-22 | 2009-09-25 | Astex Therapeutics Ltd | 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| JP5475235B2 (ja) * | 2005-01-21 | 2014-04-16 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62220196A (ja) | 1986-03-20 | 1987-09-28 | Kyowa Hakko Kogyo Co Ltd | 新規物質ｕｃｎ―０１ |
| WO1989007105A1 (fr) | 1988-02-04 | 1989-08-10 | Kyowa Hakko Kogyo Co., Ltd. | Derives de staurosporine |
| EP0575955B1 (en) * | 1992-06-22 | 1999-09-15 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing staurosporine derivatives |
-
1998
- 1998-12-22 JP JP10364369A patent/JP2000186092A/ja not_active Abandoned
-
1999
- 1999-12-17 CA CA002293023A patent/CA2293023A1/en not_active Abandoned
- 1999-12-20 US US09/466,903 patent/US6197955B1/en not_active Expired - Fee Related
- 1999-12-21 AT AT99125341T patent/ATE241630T1/de not_active IP Right Cessation
- 1999-12-21 DE DE69908288T patent/DE69908288T2/de not_active Expired - Fee Related
- 1999-12-21 EP EP99125341A patent/EP1020471B1/en not_active Expired - Lifetime
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