JP2000186032A - Easily disintegrating solid substance and its production - Google Patents

Abstract

PROBLEM TO BE SOLVED: To attain simple and inexpensive production of an easily disintegrating solid substance in spite that this solid substance has a high porosity and is readily disintegrated by saliva or the like in oral cavity. SOLUTION: Liquid components are mixed with solid components including an excipient to prepare a liquid mixture (9). This liquid mixture (9) is irradiated with microwaves (21) to heat the liquid mixture from the inside to vaporize the liquid components to form the granules of high porosity.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to easily disintegrable solids such as pharmaceutical preparations which disintegrate easily in the oral cavity. The present invention also relates to an easily disintegrable solid that can be easily and inexpensively manufactured, and a method for manufacturing the same.

[0002]

BACKGROUND OF THE INVENTION Various oral dosage forms are known as pharmaceuticals, but generally used tablets and capsules have a problem that they are not easy to take for elderly and children with weak swallowing power. . On the other hand, in the case of oral dosage forms such as powders and granules, there is a problem that it is not easy to handle by spilling a part of the packaging bag or chopping it when taking it, and it is not easy to take a predetermined amount, In addition, there is also a problem that a part is likely to remain in the oral cavity and discomfort remains. Furthermore, all of these oral dosage forms require drinking water at the time of ingestion, and there is also a problem that bedridden patients easily drink this drinking water from their mouth and cannot take medicine easily. Therefore, various pharmaceutical dosage forms comprising easily disintegrable solids that are easily dissolvable in the mouth while being in a solid state that is easy to handle during storage, and can be quickly dissolved and swallowed in a small amount of water such as saliva have been proposed. ing.

[0003]

2. Description of the Related Art As a conventional easily disintegrable solid, there is, for example, a pharmaceutical preparation having a high porosity disclosed in Japanese Patent Publication No. Sho 62-50445. This easily disintegrable solid is prepared by freeze-drying an open matrix network of a pharmaceutically acceptable water-soluble or water-dispersible polymer carrier substance, and loading the drug substance on the open matrix network. ,
The density was adjusted to 10 to 200 mg / ml.

[0004]

In the above prior art, although the solid material has a high porosity and collapses rapidly in the oral cavity,
Since the voids are formed by sublimation of the frozen solvent, in order to obtain a dosage form having a high porosity, it is necessary to freeze a large amount of solvent, for example, 80% or more, and then sublimate the frozen solvent under high vacuum. Therefore, it takes a long time to manufacture and cannot be implemented inexpensively. The present invention solves the above problems, and provides an easily disintegrable solid that can be easily and inexpensively produced while having a high porosity and easily disintegrating in the oral cavity due to saliva and the like, and a technique for producing the same. Subject.

[0005]

Means for Solving the Problems The present invention has the following structure to solve the above-mentioned problems. That is, the present invention 1 provides a liquid mixture (9) by mixing a liquid component with a solid component containing an excipient, and irradiating the liquid mixture (9) with a microwave (21) to produce a liquid mixture ( An easily disintegratable solid material characterized in that the liquid component is vaporized by heating from the inside of 9) to form a granular material (6) having a high porosity.

The present invention 2 is the invention according to the above-mentioned invention 1, wherein the surface layer of the granular material (6) has a surface layer (6a) having a higher density than the inside thereof.
Is formed.

The present invention 3 also provides a liquid mixture (9) by mixing a liquid component with a solid component containing an excipient, and dispensing the liquid mixture (9) into a container (5) of a container (2). )
Then, the liquid mixture (9) is irradiated with a microwave (21) in the container (5) and heated from the inside of the liquid mixture (9) to remove the liquid component. This is a method for producing a conductive solid.

The easily disintegrable solid of the present invention refers to a solid which disintegrates quickly and easily due to a small amount of water in the oral cavity and the like, and is used outside foods such as food for easy nutrition supplementation and breath fresheners. Although it can be applied to products, it is particularly useful as a pharmaceutical dosage form. The granular material forming the easily disintegrable solid refers to a solid having a certain range of size suitable for ingestion and the like, and is limited to a specific shape such as a tablet shape, a granular shape, a fine granular shape, and an irregular mass. However, it is more preferable to make the tablets into a tablet shape or a lump, because handling at the time of taking out from the package is easy and the like.

The above-mentioned solid component refers to a component remaining in a granular material due to the vaporization of a liquid component. When the liquid component is mixed, the solid component has any shape such as solid, fine, powder, crystal, oil, and solution. It may be. When the easily disintegratable solid is in the form of a pharmaceutical preparation, various pharmaceutical components can be used as the solid component. Specifically, for example, nourishing tonic health drugs, antipyretic analgesics and anti-inflammatory drugs, psychotropic drugs, anxiolytic drugs, antidepressants, hypnotic sedatives, antispasmodics, central nervous system drugs, brain metabolism improvers, antiepileptic drugs, sympathetic drugs Nerve stimulants, gastrointestinal drugs, antacids,
Antiulcer, antitussive expectorant, antiemetic, respiratory stimulant, bronchodilator, allergic drug, oral medicine, antihistamine, cardiotonic, arrhythmic, diuretic, antihypertensive, vasoconstrictor, coronary vasodilator Drugs, peripheral vasodilators, agents for hyperlipidemia,
Bile drugs, antibiotics, chemotherapeutics, drugs for diabetes, drugs for osteoporosis, skeletal muscle relaxants, analgesics, hormones, alkaloid drugs, sulfa drugs, gout drugs, anticoagulants, anti-malignant One or more components selected from tumor agents and the like are included.

[0010] As a nourishing tonic health medicine, for example, vitamin A, vitamin D, vitamin E (d-α-tocopherol acetate, etc.), vitamin B ₁ (dibenzoylthiamine, fursultiamine hydrochloride, etc.), vitamin B ₂ (butyric acid, etc.) riboflavin, etc.), vitamin B ₆ (pyridoxine hydrochloride), vitamin C (ascorbic acid, sodium L- ascorbate), vitamin vitamin B ₁₂ (such as acetic hydroxocobalamin); protein; calcium, magnesium, minerals such as iron Examples include amino acids, oligosaccharides, and crude drugs. As antipyretic analgesic and anti-inflammatory drugs,
For example, aspirin, acetaminophen, etensamide, ibuprofen, diphenhydramine hydrochloride, dl-chlorpheniramine maleate, dihydrocodeine phosphate, noscabine, methylephedrine hydrochloride, phenylpropanolamine hydrochloride, caffeine, anhydrous caffeine,
Serrapeptase, lysozyme chloride, tolfenamic acid, mefenamic acid, diclofenac sodium, flufenamic acid, salicylamide, aminopyrine, ketoprofen,
Indomethacin, bucolol, pentazocine and the like can be mentioned. Psychotropic drugs include, for example, chlorpromazine, reserpine and the like. As anxiolytics,
For example, alprazolam, chlordiazepoxide, diazepam and the like can be mentioned. Antidepressants include, for example, imipramine, maprotiline, amphetamine and the like.

Examples of the sedative-hypnotic include estazolam, nitrazepam, diazepam, perlapine, phenobarbital sodium and the like. Examples of antispasmodics include scopolamine hydrobromide, diphenhydramine hydrochloride, papaverine hydrochloride and the like. Examples of central nervous system drugs include citicoline, rothyrenine and the like. Examples of cerebral metabolism improving agents include idebenone,
And meclofenixate hydrochloride. Antiepileptic agents include, for example, phenytoin, carbamazepine and the like. Sympathetic stimulants include, for example, isoproterenol hydrochloride and the like. Examples of the gastrointestinal drug include gastric digestive agents such as diastase, sugar-containing pepsin, funnel extract, cellulase AP3, lipase AP, and calyx oil; intestinal agents such as perperin hydrochloride, resistant lactic acid bacteria, and bifidobacteria. Examples of the antacid include magnesium carbonate, sodium bicarbonate, magnesium aluminate metasilicate, synthetic hydrotalcite, precipitated calcium carbonate, magnesium oxide and the like. Examples of the anti-ulcer agent include lansoprazole, omeprazole, rabeprazole, pantoprazole, famotidine, cimetidine, ranitidine hydrochloride and the like.

Examples of antitussive expectorants include cloperastine hydrochloride, dextromeltophan hydrobromide, theophylline, potassium guaiacol sulfonate, guaifenesin, codeine phosphate and the like. Examples of the antiemetic include difenidol hydrochloride, metoclopramide and the like. Examples of the respiratory enhancer include levallorphan tartrate. As a bronchodilator,
Examples include theophylline and salbutanol sulfate. Allergic drugs include, for example, amlexanox, seratrodast and the like. Examples of the oral medicine include oxytetracycline, triamcinolone acetonide, chlorhexidine hydrochloride, lidocaine and the like. Examples of the antihistamine include diphenhydramine hydrochloride, promethazine, isotipendyl hydrochloride, dl-chlorpheniramine maleate, and the like. Examples of cardiotonic agents include caffeine, digoxin and the like. Examples of the agent for arrhythmia include procainamide hydrochloride, propranolol hydrochloride, pindolol and the like. Diuretics include, for example, isosorbide, furosemide and the like. Examples of the antihypertensive include delapril hydrochloride, manidipine hydrochloride, candesartan cilexetil, methyldopa and the like.

Examples of the vasoconstrictor include phenylephrine hydrochloride. Examples of coronary vasodilators include carbochromene hydrochloride, molsidomine, perapamil hydrochloride and the like. Peripheral vasodilators include, for example, cinnarizine and the like. As agents for hyperlipidemia,
For example, cerivastatin sodium, simvastatin,
Pravastatin and the like. As a bolus,
For example, dehydrocholic acid, trepiptone and the like can be mentioned. As antibiotics, for example, cephemex antibiotics such as cephalexin, amoxicillin, pipmecillinam hydrochloride, cefotiam hydrochloride, cefozopran hydrochloride, cefmenoxime hydrochloride, cefsulodin sodium; ampicillin,
Synthetic antibacterial agents such as cyclacin, sulbenicillin sodium, nalidixic acid, and enoxacin; monobactam antibiotics such as carmonam sodium; penem antibiotics and carpapenem antibiotics. Examples of the chemotherapeutic agent include sulfamethizole hydrochloride, thiazosulfone and the like. As antidiabetic agents, for example, tolbutamide, voglibose, pioglitazone hydrochloride,
Troglitazone and the like. Examples of the agent for osteoporosis include ipriflavone and the like. Examples of the skeletal muscle relaxant include metocarpamol and the like. Examples of the antitussive include meclizine hydrochloride, cimenhydrinate and the like.

Examples of hormonal agents include liotinin sodium, dexamethasone sodium phosphate, prednisolone, oxendrone, leuprorelin acetate and the like. Examples of the alkaloid narcotics include opium, morphine hydrochloride, tocon, oxycodone hydrochloride, opium alkaloid hydrochloride, cocaine hydrochloride and the like. Examples of the sulfa drug include sulfamine, sulfamethizole and the like. Examples of gout remedies include allopurinol, colchicine and the like. Examples of the anticoagulant include dicoumarol.
Examples of antineoplastic agents include 5-fluorouracil,
Uracil, mitomycin and the like.

The above-mentioned pharmaceutical ingredient is used in an amount of 0.01 to 70 parts by weight, preferably 0.02 to 50 parts by weight, more preferably 0.1 to 30 parts by weight, based on 100 parts by weight of the solid. Among the above-mentioned pharmaceutical ingredients, nourishing tonic health drugs, antipyretic analgesics and anti-inflammatory drugs, hypnotics and sedatives, central nervous system drugs, gastrointestinal drugs, anti-ulcer drugs, antitussive expectorants, allergy drugs, arrhythmias, diuretics, blood pressure lowering Agents, vasoconstrictors, coronary vasodilators, agents for hyperlipidemia, agents for diabetes, agents for osteoporosis, skeletal muscle relaxants, depressants and the like are preferably used.

The excipient contained in the solid component may be any excipient that can maintain the shape of the solid from which the liquid component has been removed, and specifically includes, for example, sorbitol, mannitol, maltitol, reduced starch saccharification And sugar alcohols such as xylitol, reduced palatinose and erythritol. However, the present invention is not limited to these, and two or more of them may be mixed and used at an appropriate ratio. This excipient is 5 to 90 parts per 100 parts by weight of solids.
Parts by weight, preferably 10 to 80 parts by weight.

Specific examples of the liquid component include distilled water and alcohol. However, the liquid component is not limited to a specific component, but may be any solvent or dispersion medium that dissolves or disperses the solid component. Good. The liquid component dissolves or disperses the solid component. Therefore, the liquid mixture may be a solution in which the solid component is completely dissolved, and a part or all of the solid component may be dissolved. It may be dispersed without performing. When the liquid solid is prepared in a state where the fine solid components are dispersed, an easily disintegrable solid having a structure in which the fine granules are aggregated can be obtained. Therefore, in this case, for example, by coating a bitter pharmaceutical component with a sweet component or the like to form each fine granule, the medicinal component can be taken without causing the recipient to feel bitter even when disintegrated in the oral cavity. Can be.

The above liquid mixture may contain various additives used for general pharmaceutical dosage forms, foods and the like. Such additives include, but are not limited to, for example, binders, acidulants, foaming agents, artificial sweeteners, flavors, colorants, stabilizers, and the like. As the binder, for example, hydroxypropylcellulose, hydroxypropylmethylcellulose, crystalline cellulose,
Examples include pregelatinized starch, polyvinylpyrrolidone, gum arabic powder, gelatin, and pullulan. Examples of the sour agent include citric acid, tartaric acid, malic acid and the like. Examples of the foaming agent include baking soda.
As artificial sweeteners, for example, saccharin sodium, dipotassium glycyrrhizinate, aspartame, stevia,
Thaumatin and the like. Examples of the flavor include lemon, lemon lime, orange, and menthol. Examples of the coloring agent include food colors such as Food Yellow No. 5, Food Red No. 2, Food Blue No. 2, etc .; Examples of the stabilizer include a basic substance in the case of a basic pharmaceutical ingredient, and an acidic substance in the case of an acidic pharmaceutical ingredient.

The heating of the liquid mixture is carried out under reduced pressure under reduced pressure so that the liquid component is easily vaporized at a low temperature of, for example, 70 ° C. or less, preferably 50 ° C. or less in order to prevent deterioration of solid components such as medicines. It is preferable to irradiate the wave or use a liquid component having a low boiling point such as ethyl alcohol.

[0020]

According to the first aspect of the present invention, the mixture is uniformly heated not only from the surface but also from the inside by the irradiation of the microwave, the liquid component contained in the liquid mixture is quickly vaporized and removed from the entire mixture, and the solid component remains. . At this time, since the solid component contains an excipient, a portion from which the liquid component has been removed remains as a space, and a granular material having a large number of voids is formed. The void may be formed in a space created by removing the liquid component, or a large number of voids may be formed by generating bubbles by vaporizing the liquid component. Further, a foaming agent that generates a gas such as carbon dioxide gas by heating can be mixed in the liquid mixture.
However, when the particles are rapidly expanded due to the generation of bubbles, the voids formed inside the granules tend to be non-uniform, and it is preferable to avoid excessive expansion.

It is more preferable that the air is ventilated with dry air or the like in conjunction with the irradiation of the microfiber, since the vaporized liquid component can be efficiently removed from the granular material. Further, for the vaporization of the liquid component by the heating, other heating means may be used in combination.For example, most of the liquid component is removed by heating a microwave to form a granular material having a high porosity. The remaining liquid components remaining on the body may be removed by ventilation drying or the like.

According to the second aspect of the present invention, since a high-density skin layer is formed on the surface of the granular material, the skin layer imparts appropriate hardness to the dry easily collapsible solid.

According to the third aspect of the present invention, a solid having a high porosity is formed in the housing portion of the container by irradiation with the microwave. At this time, by making the container made of a thin synthetic resin or the like, the influence of the microwave can be hardly affected, whereby the liquid mixture is uniformly heated without being partially heated. Then, the container in which the solids are formed in the storage section is sealed as it is with an opening portion using a seal sheet or the like, or is transferred to another package and packed, thereby completing the production of the easily collapsible solids. .

[0024]

Embodiments of the present invention will be described below with reference to the drawings. 1 to 4 show an embodiment in which the easily disintegratable solid of the present invention is applied to an orally disintegrating pharmaceutical dosage form. FIG. 1 is a longitudinal sectional view of the orally disintegrating pharmaceutical dosage form packaged in a blister. 2 is a schematic configuration diagram of the above-mentioned pharmaceutical dosage form manufacturing apparatus, and FIG.
Is a partially enlarged view of a liquid mixture dispensing step, and FIG. 4 is a partially enlarged view of a microwave irradiation step.

As shown in FIG. 1, the orally disintegrating pharmaceutical dosage form (1) of this embodiment contains a package comprising a blister film (2) and a seal sheet (3), that is, a blister package (4). It is housed tightly in the recess (5), and is formed into a tablet-like granular material (6) having a high porosity containing a pharmaceutical ingredient, an excipient and other additives. In the blister package (4), the receiving recess formed in the blister film (2) is provided.
A perforation line (7) is inserted around (5).
By breaking along (7), each accommodating concave portion (5) can be separated from each other while being sealed with a seal sheet (3).

When taking the orally disintegrating pharmaceutical dosage form (1), the accommodation recess (5) is opened by peeling off the sealing sheet (3), and the contained pharmaceutical dosage form (1) is removed. Although it may be taken out, in this embodiment, a granular layer is formed by forming a skin layer (6a) having a higher density on the surface of the pharmaceutical dosage form (1) than the inside thereof.
The so-called press-through pack (PTP) type packaging in which the strength of (6) is increased and the seal sheet (3) is broken by the pharmaceutical dosage form (1) itself by pushing up from below the blister film (2) in FIG. It is.

The pharmaceutical dosage form (1) removed from the blister package (4) is put into the oral cavity as it is. This pharmaceutical dosage form
A large number of open-cell-like voids (8) are formed in (1), and are easily dissolved and swallowed by saliva or the like in the oral cavity. In this case, the pharmaceutical dosage form (1) may be crushed by pressing with a tooth or a tongue in the oral cavity to dissolve it more quickly.

Next, a method for producing the orally disintegrating pharmaceutical dosage form (1) using the production apparatus (10) shown in FIG. 2 will be described. As shown in FIG. 2, the manufacturing apparatus (10) for the pharmaceutical dosage form (1) comprises a film supply roll (11),
(22), dispensing device (12) for liquid mixture (9), microwave irradiation device (13), sheet supply roll (14), concave sealing roll (15), cutting roll (16), winding roll (17) ) And a discharge device (18) for the blister package (4).

The blister film (2) sent out from the film supply roll (11) is fed to a storage recess forming device (22).
After the receiving recess (5) is formed in the above, after passing sequentially below the dispensing device (12), in the microwave irradiation device (13), and between the recess sealing roll (15), the cutting roll (16) surrounds it. And the blister package (4) in which the pharmaceutical dosage form (1) is hermetically packaged is cut off. And this unnecessary part
(19) is taken up by a take-up roll (17), while the blister package (4) is carried out to a next step such as a packing step by a carry-out device (18).

The tank (20) of the dispensing device (12) contains a liquid mixture (9) obtained by mixing a predetermined solid component and a liquid component. The blister film (2) sent out from the film supply roll (11) and passed through the housing recess forming device (22) has the upper opening (5a) of the housing recess (5) as shown in FIG. When reaching the lower position of the device (12), a predetermined amount of the liquid mixture (9) is injected from the dispensing device (12) into the receiving recess (5). Therefore, in this embodiment, the blister film (2) constitutes a container for the liquid mixture (9).

The blister film (2) containing the liquid mixture (9) then reaches the inside of the microwave irradiation device (13), as shown in FIG.
Irradiated. Thereby, the liquid mixture (9) is uniformly heated from the inside, the liquid component is vaporized, and the granular material (6) having a large number of voids is formed. At this time, the thin blister film (2) formed of a PVC film or the like is hardly affected by the microwave (21) and does not substantially generate heat. Never overheat. Dry air is passed through the microwave irradiation device (13) so that the vaporized liquid component is quickly discharged to the outside.

After the liquid component is removed by the above heating, a sheet supply roll is placed on the upper surface of the blister film (2).
The seal sheet (3) from (14) is supplied and bonded by the concave sealing roll (15), and the pharmaceutical dosage form (1) is placed in the storage concave part.
(5) Sealed inside. Then, the unnecessary part (19) is cut off by the cutting roll (16) as described above,
(4) is carried out to the next process by the carry-out device (18).

In the present embodiment, the liquid component is vaporized using hot air as well. However, the liquid component may be vaporized only by irradiating microwaves, or another drying means may be used together. In addition, a foaming agent may be added to the liquid mixture, and the mixture may be foamed by slightly increasing the temperature to expand the mixture. In this case, foaming at a relatively low temperature of about 50 ° C. is preferable from the viewpoint of preventing thermal effects on the pharmaceutical ingredients.

In this embodiment, the case where the liquid mixture is continuously treated by the microwave irradiation apparatus has been described. However, in the present invention, the liquid mixture may be treated in a batch system. Irradiating a microwave under reduced pressure can vaporize a liquid component at a low temperature, and is suitable for a pharmaceutical component that is easily degraded by heating.

In the above embodiment, the case where the liquid mixture accommodated in the accommodating recess of the blister film is irradiated with microwaves is explained. In the present invention, however, after the granular material is formed in the accommodating portion of another container, the granular material is formed. May be transferred to a blister package or another package for packaging.
In the above embodiment, the case where the present invention is applied to a pharmaceutical dosage form is described. However, the easily disintegratable solid of the present invention can be applied to solids other than the pharmaceutical dosage form such as food, and not only humans but also other animals. It is needless to say that the present invention can be applied to the administration to the human body.

[0036]

EXPERIMENTAL EXAMPLE 15 g of mannitol and 5 g of distilled water were uniformly mixed to obtain a creamy liquid mixture. This was dispensed into five blister films having ten receiving recesses in each sheet, and placed in a batch-type oven. First, 50
Reduce the pressure to Torr and add a microwave of 125 w to 18
Irradiated for minutes. Thereby, the water content of the mixture was 19.
8%. In addition, moisture measurement is by an infrared moisture meter.

Next, the inside of the batch-type oven was returned to normal pressure, and a microwave of 125 w was irradiated for 40 minutes while blowing hot air at 60 ° C. The direction of the air was regulated so that the hot air did not directly hit the liquid mixture. The water content of the obtained solid was 2.1%, and a slightly dense skin layer was formed on the surface. The solid did not disintegrate when pinched with a fingertip, but when absorbed in the mouth, it rapidly absorbed saliva and was easily disintegrated with a slight pressing force that could be touched with the tongue tip.

[0038]

Since the present invention is constructed and operates as described above, it has the following effects.

(A) In the present invention 1, since the liquid mixture is uniformly heated from the inside and the liquid component is quickly vaporized and removed from the whole mixture, a large number of voids can be formed uniformly. The obtained easily disintegrable solid can be easily disintegrated in the oral cavity or the like by saliva or the like. Moreover,
It is only necessary to heat and evaporate the liquid component quickly by irradiating with microwaves, and it is possible to carry out the method in a short time, easily and inexpensively as compared with the above-mentioned freeze-drying method of the prior art.

(B) In the present invention 2, since a high-density skin layer is formed on the surface of the granular material, a moderate hardness can be given to the easily collapsible solid, and it can be obtained in the production process and the distribution process. It is possible to eliminate the risk of breakage and to facilitate the operation of taking out from the package and the handling of solid matter after taking out.

(C) In the present invention 3, since a solid having a high porosity can be formed without partially heating the liquid mixture by irradiation with microwaves, a good easily disintegrable solid can be easily obtained in a short time. Can be manufactured. In addition, since it can be directly manufactured in a package such as a blister package, an easily disintegratable solid that is packaged at a lower cost can be manufactured, and is particularly suitable for a pharmaceutical dosage form.

[Brief description of the drawings]

FIG. 1 is a longitudinal section of an orally disintegrating pharmaceutical dosage form packaged in a blister, illustrating an embodiment of the present invention.

FIG. 2 is a schematic configuration diagram of an apparatus for manufacturing a pharmaceutical dosage form.

FIG. 3 is a partially enlarged view of a liquid mixture dispensing step.

FIG. 4 is a partially enlarged view in a microwave irradiation step.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 ... Easily disintegrable solid (orally disintegrable pharmaceutical dosage form), 2 ... Container (blister film), 3 ... Seal sheet, 5 ... Accommodation part (accommodation concave part), 5a ... Opening part, 6 ... Granular body, 9 ... liquid mixture, 21 ... microwave.

Claims (3)

[Claims] A liquid mixture is prepared by mixing a liquid component with a solid component containing an excipient to prepare a liquid mixture (9).
Irradiate (9) with microwave (21) to obtain liquid mixture (9)
An easily disintegratable solid material, characterized in that the liquid component is vaporized by heating from the inside of the powder to form a granular material (6) having a high porosity. 2. The easily disintegratable solid according to claim 1, wherein a skin layer (6a) having a higher density than the inside is formed on the surface of the granular material (6). 3. A liquid mixture (9) is prepared by mixing a liquid component with a solid component containing an excipient, and this liquid mixture is prepared.
(9) is poured into the receiving part (5) of the container (2), and then the liquid mixture (9) is microwaved (2) into the receiving part (5).
A method for producing an easily disintegrable solid, comprising irradiating 1) and heating the inside of the liquid mixture (9) to remove the liquid component.