JP2000154143A - Hyperlipemia-ameliorating agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a hyperlipemia-ameliorating agent not causing side effect, capable of propagating Lactobacillus bifidus, capable of lowering the values of serum potassium and serum phosphorus, capable of settling headache and shoulder stiffness and helpful for patients with renal failure or the like by including dietary microfilaments (and oligosaccharides). SOLUTION: This hyperlipemia-ameliorating agent includes (A) dietary microfilaments such as purified, finely divided cellulose including >=95 wt.% α-cellulose, having 5-50 μm maximum particle diameter, and substantially not including electrolytes, (e.g. K, Na, Mg, P or the like) and caloric ingredients such as digestible carbohydrates, or (B) the ingredient A and oligosaccharides such as fructo-oligosaccharide. The weight contents of the ingredient A and the oligosaccharides preferably are respectively 5-100 wt.% and 0-60 wt.%. both based on the weight of the agent. The agent is preferably administered before and after every meal in a quantity of 0.5-6.0 g/meal in terms of the ingredient A.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to improvement of hyperkalemia and hyperphosphatemia containing fine dietary fiber or fine dietary fiber and oligosaccharide as main components; improvement of hyperlipidemia; improvement of headache and shoulder stiffness; The present invention relates to an agent for improving dermatosis; increasing blood vitamins;

[0002]

[0006] Patients with renal failure, dialysis patients, dental diseases, dentures, people with weak digestive systems, and people who eat out a lot have a low fiber intake from food.

[0003] Dietary fiber intake is high in less developed countries and low in developed countries. At present, our country is the country with the lowest dietary fiber intake, westernized diet, preference for soft foods,
Due to the increase in processed foods and ready-to-eat foods, as well as the taste-centered meals and the frequent use of easily prepared meals, the general population has become deficient in the intake of dietary fiber. The present invention is based on the finding that the above-mentioned diseases, which are often found in patients with renal insufficiency, dialysis patients, diet-restricted patients, malformed persons, etc., are mainly caused by insufficient intake of dietary fiber, or the proliferation of dietary fiber and bifidobacteria and lactobacilli It aims to find out that it is caused by a deficiency of factors and to prevent or treat these diseases.

[0004]

DISCLOSURE OF THE INVENTION The present invention is directed to improving hyperkalemia, improving hyperphosphatemia, improving hyperlipidemia, improving hyperlipidemia, which contains fine dietary fiber or fine dietary fiber and oligosaccharides as main components. Pharmaceuticals and foods used for improving and eliminating headache, shoulder stiffness, acne, folliculitis, pigmentation, dandruff, skin dryness and other skin diseases, increasing blood vitamins, and improving various hemorrhoids.

[0005] As fine dietary fiber, fine cellulose,
Fine hemicellulose, fine lignin, fine pectin and the like can be used. Particularly fine cellulose is suitable, natural pulp, linters, hydrolyzing raw materials such as bagasse with mineral acid, and further mechanically pulverized if necessary,
This is washed with water and dried to obtain a powder. 90% or more as α-cellulose content, preferably 9%
5% or more, hydrolysis yield is 85% or more, preferably 95% or more.
% Or more, and the maximum particle diameter is 200 μm or less, preferably 10 μm or less.
A purified powder having a particle size of 0 μm or less, more preferably 5 to 50 μm, and substantially free of electrolytes such as potassium, sodium, magnesium and phosphorus and caloric components such as digestible carbohydrates is used.

[0006] As oligosaccharides used in the present invention, fructooligosaccharides, galacto-oligosaccharides and the like can be used. Fructooligosaccharides are particularly suitable, and are obtained by allowing fructosyltransferase to act on sucrose. The specific production method is disclosed in JP-B-59-5383.
No. 4 publication. Oligosaccharides have the function of increasing bifidobacteria and lactobacilli in the intestine, and have been found to have an effect of improving intestinal flora.

[0007] In the present invention, a formulation containing fine dietary fiber and an oligosaccharide is preferred. By blending both, it is very easy to manufacture molded products such as granules and fine granules,
And it becomes easy. In addition, oligosaccharides impart high-quality sweetness, have the effect of improving the texture, make it possible to drink only saliva without the aid of water, and have a long-term resistance to continuous use. Is also eliminated.

The mixing ratio of the fine dietary fiber and the oligosaccharide can be arbitrarily determined, but the content of the fine dietary fiber in the preparation is in the range of 5% to 100%, and the content of the oligosaccharide is 0% to 60%. % Are preferred.

The preparation of the present invention can be formed into a form that is easy to ingest, and for example, can be prepared into powders, granules, fine granules, capsules and tablets commonly used in medicines and foods. Also, if necessary, taste components, coloring agents,
Fragrances, binding liquids, and the like can be added, and can also be coated and formulated.

The dosage of the preparation of the present invention depends on the content of the diet to be ingested, and is usually 0.5 times before and after each meal in terms of fine dietary fiber.
Take ~ 6.0 g / meal.

[0011]

The following diseases are improved by taking the preparation of the present invention. 1. Serum potassium levels decrease. Serum phosphorus levels decrease. 2. Hyperlipidemia is improved and serum lipids are reduced. 3. Headache and shoulder stiffness are resolved. 4. Acne, folliculitis and urticaria are eliminated or improved. Pigmentation is eliminated or improved. Dandruff, skin dryness is improved or eliminated. 5. Blood Vitamin (folic acid, vitamin B _12, etc.) is increased. 6. Various hemorrhoids are improved.

Since the preparation of the present invention does not substantially contain electrolytes such as potassium, phosphorus, magnesium, and sodium, it can be taken by patients with renal failure, dialysis patients, hyperkalemia, hyperphosphatemia, heart failure and the like. it can. In addition, since this drug does not substantially contain a caloric component, even if taken daily, there is no side effect such as weight gain and the taking can be continued.

[0013]

EXAMPLES Example 1 Ingestion of Fiber Preparation and Serum Electrolyte Purpose The purpose of this study is to clarify the effect of taking a fiber preparation on serum electrolyte concentration in dialysis patients. Method Chronic dialysis patient 1 who has been rehabilitated to dialysis twice a week for 6 hours
0 dietary fiber preparations of the present invention (0.
189 g, containing 0.082 g of fructooligosaccharides, the same applies hereinafter) in a daily dose of 45 tablets, and the serum potassium, sodium, chlor, calcium, and phosphorus values were measured before administration, 1 month after administration, and 2 months after administration. Results As shown in Table 1, serum potassium and phosphorus were reduced by taking the fiber preparation. On the other hand, there was no significant change in sodium, chlor and calcium values.

[0014]

[Table 1]

Example 2 Ingestion of Fiber Preparation and Serum Lipid Purpose The effect of taking a fiber preparation on serum lipids is clarified. Methods For 11 healthy dialysis patients, one healthy person was administered 45 tablets daily, and the serum lipid levels before and 4 months after the administration were measured. Results As shown in Table 2, total cholesterol, neutral fats, phospholipids, free fatty acids, etc. decreased in dialysis patients. 1 and 2 show the total cholesterol level and the phospholipid level of one patient observed over time. The cholesterol level of one healthy individual also dropped from 300 mg / dl to 240 mg / dl. After that, it decreased to 180 mg / dl.

[0016]

[Table 2]

Example 3 Intake of fiber preparation and headache, aim of shoulder The effects of taking a fiber preparation on headache and shoulder stiffness are clarified. METHODS: Sixteen patients with chronic or habitual headache and eight with shoulder stiffness (of which five had both symptoms) were given 45 to 15 tablets of fiber daily, We looked at the effects on the symptoms. Results Headache disappeared in 4 out of 6 cases with headache. In one case with a severe headache such that he could not work, after taking the fiber agent three times, the headache disappeared when the fiber agent was taken, and recurred after a while after discontinuation, and required an analgesic. Six of the eight patients with shoulder stiffness disappeared. Two of them received massage once or twice a week, but became unnecessary.

Example 4 Taking Fiber Preparations and Dermatosis Purpose The effects of taking fiber preparations on dermatosis are clarified. Method A total of 13 healthy persons with abnormal skin findings and 13 dialysis patients were administered 45 to 15 tablets of fibrous preparation a day to observe the effects on dermatosis. Results As shown in Table 3, remarkable disappearance of pigmentation was observed in 9 out of 10 dialysis patients who exhibited unique pigmentation by taking the fiber preparation, and the skin became fair and healthy. The patient was discontinued and the fibrous agent was administered again to the patient who showed brown pigmentation again, and disappeared again. Folliculitis (including acne) disappeared in all cases, and in particular in two cases, the use of anabolic hormones for a long period of time resulted in the disappearance of chronically present hair folliculitis in the hair and neck of the head. In addition, in one patient with urticaria, hives disappeared by taking the fiber preparation. Pruritus, dandruff and dry skin disappeared. In the case where the skin was dry and "gritty", it was observed that the skin became moist.

[0019]

[Table 3]

Example 5 Ingestion of Fiber Preparation and Blood Vitamin Purpose The effect of taking a fiber preparation on the blood vitamin concentration is clarified. METHODS dialysis patients nine, the fiber material was 3-month administration of 45 tablets per day, blood was measured folic acid and vitamin B _12. Six of them re-examined approximately one month later. Results As shown in Table 4, the blood folate concentration was significantly increased in 6 out of 9 cases. Vitamin B ₁₂ was also significantly higher in 2 cases. 6
A re-examination of the cases showed a similar trend.

[0021]

[Table 4]

Example 6 Taking Fiber Preparation and Hemorrhoids Purpose The improvement effect of hemorrhoids by taking a fiber preparation is clarified. Method For 4 patients with hemorrhoidal bleeding and anal prolapse, 45 tablets per day were administered for 3 months to examine the effect of improving hemorrhoids. Results As shown in Table 5, hemorrhoid hemorrhage stopped in all cases, and the hemorrhoid pain disappeared. In three patients with anal prolapse, anal prolapse was difficult, and it was easy and easy to return the anal prolapse part back into the anus without any pain.

[0023]

[Table 5]

[Brief description of the drawings]

FIG. 1 is a graph showing changes in the total cholesterol level of a dialysis patient who has taken the fiber preparation of the present invention.

FIG. 2 is a graph showing changes in phospholipids in a dialysis patient who has taken the fiber preparation of the present invention.

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Claims (1)

[Claims] 1. An agent for improving hyperlipidemia containing fine dietary fiber or fine dietary fiber and oligosaccharide as main components.