JP2000143487A - Cosmetic, liquid cosmetic and external preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic useful for a healthy skin or the skin suffered from allergic dermatitis including atopic dermatitis. SOLUTION: A cosmetic which is useful for wide range of the skin covering an ordinary skin, allergic skin and atopic skin is obtained by constituting it so that it is composed of eucalyptus oil, cysteine, an antiinflammatory agent, a liquid property-contrlling agent, an emulsifier and purified water.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to cosmetics and external preparations which can be applied to sensitive skin showing symptoms such as allergic dermatitis including atopic dermatitis.

[0002]

2. Description of the Related Art In recent years, many people have visited various hospitals complaining of various allergic symptoms. Such allergies are described in the Biochemistry Dictionary (Tokyo Kagaku Doujinshi) as "a state in which a living body sensitized to an antigen shows a strong reaction when the antigen is re-entered". Each person has different symptoms.

[0003] There are cases where a living body that did not cause any special symptoms when first contacted with the substance becomes more responsive when contacted with the same substance repeatedly.
A condition that is more reactive to the same substance than initially is an allergy.

[0004] Various antigens have been identified as antigens that cause such allergic symptoms. For example, there are a wide variety of types such as plant pollen, animal hair, mites, and the like, which have become a topic in recent years, and volatile chemical substances emitted from exhaust gas components, synthetic interior materials, and the like.

[0005] Allergies include immediate allergic reactions involving antibodies and delayed allergic reactions mediated by sensitized lymphocytes without the involvement of antibodies.

[0006] Among them, an antigen that causes an immediate allergic reaction is called an allergen. Normally, a normal person does not provoke an immune response that is hypersensitive to this allergen, but a case showing immediate hypersensitivity to this allergen is called atopy.

[0007] A person who exhibits symptoms of atopic hypersensitivity produces an IgE antibody called reagin against the above allergen, and this IgE antibody has an iron ion receptor of the IgE antibody on the membrane surface and has histamine. Binds to mast cells with the containing granules.

[0008] IgE antibody mast cells bind to antigens and secrete pharmacologically active substances such as histamine, and cause strong biological reactions such as those seen in symptoms such as atopic dermatitis.

[0009] In atopic dermatitis, which is a typical example of atopic diseases, itching is extremely strong at the diseased site. The pruritus is so strong that the skin surface at the site of the disease cannot be scratched until the skin surface is damaged. Many atopic patients have often observed bleeding from scratches on the skin surface.

[0010] Further, even if the symptoms do not reach severe atopic dermatitis as described above, patients with allergic dermatitis in which redness, itching, eczema such as papules, vesicles, oozing, etc., occur on the skin are not There are many.

[0011] How to deal with allergic dermatitis, including atopic dermatitis, is still not well established today, especially in severe atopic dermatitis, relying on folk remedies or having strong side effects. Symptomatic treatment is given using steroid hormones temporarily.

[0012] For those who have allergic dermatitis, it is generally necessary to take care to keep the skin surface clean and to avoid irritation due to chemical substances. For this reason, it is difficult for women, especially, to select cosmetics to be used directly on the skin, and they use trial and error to search for natural cosmetics that are considered to have relatively little skin irritation, using extracts from natural substances such as plants as the main component. There are many examples.

[0013]

When allergic dermatitis is caused as described above, it is difficult to select cosmetics to be used, and even if natural cosmetics are selected incorrectly, allergic dermatitis may occur. Cases have also been reported to worsen.

For many women, cosmetics are used directly on the face and the like on a daily basis. Therefore, especially when the skin itself has already become hypersensitive such as allergic dermatitis, the choice of cosmetics is extremely high. is important.

The present inventor has been treating many allergic patients for many years and has been strengthening the above-mentioned feelings. Even if he has allergic dermatitis including atopic dermatitis, he can use it safely. The development of cosmetics that can be done has been considered urgent.

In the case of a drug, the method of use, the amount used,
Furthermore, by properly setting the period of use and the like, the drug is used so that its medicinal effect is obtained in the best condition and side effects are minimized.

[0017] On the other hand, cosmetics, unlike pharmaceuticals, are used daily and on a daily basis. Therefore, from the viewpoint different from pharmaceuticals, there is a risk that, for example, skin and other obstacles may occur even when used continuously for many years. Consideration from a viewpoint different from that of the drug is particularly required, for example, it does not occur.

Furthermore, it is more important to prevent the quality from being changed even in a normal ordinary handling environment for a long period of time as compared with the medicine.

As described above, in cosmetics, it is desirable that the cosmetics can be picked up daily, usually and as conceived, gentle on the skin, and used with peace of mind.

Cosmetics are roughly classified into basic cosmetics and finished cosmetics. Generally, makeup is performed using a plurality of types of cosmetics belonging to any of these. The present inventor has developed a broad range of basic cosmetics that are likely to be in direct contact with the skin, and among them, lots of base cosmetics that can be used as lotion and liquid cosmetics such as emulsion. I thought it was necessary.

The present inventor has been studying the side effects of steroid hormones for many years and has witnessed the horror of the side effects.

The side effects of steroid hormones include:
For example, induction of infections, gastric ulcers, liver damage, plasma sclerosis, skin abnormalities (skin becomes thin, hard, dry, or darkened due to pigmentation,
Such as reduced or destroyed immune function in skin tissue), cataracts,
Various cases such as adrenal insufficiency, diabetes, purpura, and mental illness have been reported.

For atopic diseases, when this steroid hormone agent is initially used, a strong pruritus is relieved, and the eczema state of the affected area is also improved. for that reason,
It is a general trend that both atopic patients and physicians continue to use steroid hormones while being ignorant of the frightening side effects.

However, if the steroid hormone agent is continuously applied to the affected area as an external preparation such as a steroid ointment, the skin gradually becomes dark and keratinized and hard. Normally, skin with a healthy skin surface has some degree of moistness and is in a soft state, but its skin surface is
Continued use of steroid hormones changes the skin into dry, hard skin.

The skin keratinized in this way by using a steroid hormone agent is more likely to be attracted to mites, bacteria, and mold, and in many cases, atopic dermatitis is harder to cure and worsens.

On the other hand, when the use of the steroid hormone agent which has been used for a long time is stopped, the skin symptoms may return to the original state, but often worsen than before. Many atopic patients have anorexia, vomiting, diarrhea, and complain of headache and anxiety. In many cases, the symptoms of atopic dermatitis worsen to the degree that they can be clearly seen from the outside, and the treatment does not proceed slowly. Such strong mental stress can adversely affect sensitive skin, causing the skin to become more gritty and darker.

By examining the use of steroid hormones, it is recommended to use them every other day even if they are used in large amounts, or to use small amounts continuously, even if they are used in large amounts. Various methods of use have been reported in the literature.

However, in any case, since atopic diseases cannot be completely cured in a short period of time, steroid hormones tend to be used for a long period of time even if the use method is devised, and the occurrence of side effects occurs. At present, it is used in excess of a certain amount, which is said to be reduced.

[0029] Since the use of steroid hormones has led to darkening of the skin due to the above-mentioned circumstances, a large number of patients have visited the present inventor, and in particular, many women suffer from the symptoms of atopic dermatitis. In order to avoid being noticed from the outside, she always comes to the hospital using cosmetics with strong concealing power to hide the symptoms.

However, most of the conventional cosmetics cannot be used for atopic patients who have reached such a state. Some cosmetics indicate that they cannot be used in the case of atopic dermatitis.

In a situation in which cosmetics that can be used safely by an atopic patient are not sufficiently prepared, using cosmetics without stopping even when going out causes atopic dermatitis to worsen. Therefore, among cosmetics, it is desired that a cosmetic base, such as a lotion that is used on a daily basis to directly touch the skin, can be used without exacerbating atopic dermatitis.

Further, it goes without saying that allergic dermatitis can be used with confidence, as described above, and that it is required to be able to use even healthy skin. Not only does it have no adverse effects when used on healthy skin, but when it is used on healthy skin, it can also have the cosmetic effect inherent in cosmetics that can make the skin more fresh and beautiful. is necessary.

That is, the inventor of the present invention is useful for beautiful skin effects such as skin care even when used by a person with healthy skin, and helps to reduce the symptoms when used by a person with allergic dermatitis.
Furthermore, we thought that it was necessary to develop cosmetics that would allow even those with atopic dermatitis to use the cosmetics, especially those who are frank.

An object of the present invention is to provide a cosmetic product which can be used for healthy skin and allergic dermatitis skin including atopic dermatitis.

[0035]

The present invention is a cosmetic having an antiallergic composition, wherein the antiallergic composition comprises eucalyptus oil and an amino acid.

The amino acid is a sulfur-containing amino acid.

The amino acid is characterized in that cysteine is used.

[0038] In the cosmetic of any one of the above constitutions, the cosmetic contains an anti-inflammatory substance derived from a crude drug.

The anti-inflammatory substance is characterized in that glycyrrhizinate is used.

The present invention is a liquid cosmetic comprising eucalyptus oil, an amino acid, an anti-inflammatory agent, a liquidity regulator, an emulsifier, and purified water.

It is characterized in that cysteine is used as the amino acid and glycyrrhizinate is used as the anti-inflammatory agent.

The external preparation of the present invention is characterized by having eucalyptus oil, an amino acid, an anti-inflammatory agent, a liquidity regulator, and an emulsifier.

It is characterized in that cysteine is used as the amino acid and glycyrrhizinate is used as the anti-inflammatory agent.

By combining eucalyptus oil and amino acids, a cosmetic ingredient that can be used with confidence in allergic dermatitis, even in atopic dermatitis in which the symptoms have progressed further, and in normal healthy skin Could be obtained. As the amino acid, a sulfur-containing amino acid is preferably used, and cysteine is more preferably used.

Also, by using eucalyptus oil,
Due to its fragrance component, a moderate scent can also be obtained. In the case of allergic dermatitis, it often reacts sensitively even to a small amount of fragrance contained in cosmetics.However, the use of eucalyptus oil as well as its inherent antibacterial effect makes it a cosmetic product without using other synthetic fragrances. The required aromaticity can be obtained.

Although the present inventor has witnessed the strong side effects of steroid hormones, they seriously accept that steroid hormones have strong side effects, but also have undeniable therapeutic effects. It has the same therapeutic effect as the steroid hormone agent, does not show strong side effects, and is effective for alleviation, improvement, and treatment of allergic symptoms by using a safely usable substance in combination with the antiallergic composition. I thought.

As such a substance, glycyrrhizinate (same as glycyrrhizinate) conventionally used as an anti-inflammatory agent was found to be effective. It is more preferred to use a salt of glycyrrhizic acid obtained from licorice, for example dipotassium glycyrrhizinate (same as dipotassium glycyrrhizinate).

In particular, when dipotassium glycyrrhizinate is used, it is highly effective in dermatitis of type I allergy in which the IgE antibody is involved among the four types of allergic reactions.

[0049] However, although it is considerably less effective than the above-mentioned dipotassium glycyrrhizinate for type I allergy, it is conceivable to use, for example, indomethacin or sodium cromoglycate instead.

On the other hand, various forms of cosmetics such as basic cosmetics and finish cosmetics are conceivable. In particular, liquid cosmetics such as lotions, which are applied directly to the skin and are used in a relatively large amount, are used in the present invention. The inventor thought.

[0051] Atopic dermatitis is mainly liable to appear on indirect parts such as the face, neck, arms and the back of the knee, and such a part is also a part where sweat and the like are relatively easy to be wiped and also a part which is easily tacky with sweat. Therefore, a fresh feeling after use of cosmetics is particularly required.

The liquid cosmetic of the present invention having the above-mentioned constitution is uniformly mixed so that oil does not float when it is put on the skin, and it is also quickly absorbed from the skin, and becomes smooth after use, and The skin is also smooth and smooth.

In the above description, cosmetics, especially a lotion, have been described. However, as long as the antiallergic composition described above is contained and its action is obtained, for example, an emulsion other than the above-mentioned lotion may be used. It may be configured as a liquid cosmetic as described above.

Further, cosmetics other than liquid cosmetics may be constituted. For example, even in the form of pharmaceuticals,
In particular, it can be provided in the form of an external preparation that can be applied to the skin.

Further, as liquid cosmetics, in addition to the above-mentioned anti-inflammatory agents such as eucalyptus oil, amino acids and dipotassium glycyrrhizinate, a liquid conditioner, an emulsifier and purified water may be blended as other components.

Although the detailed mechanism of action has not been elucidated, the combined use of an amino acid and eucalyptus oil allows
Antiallergic properties that could not be obtained when used alone (for example, alleviation of allergic symptoms)
Is obtained, and it is speculated that some synergistic action of both components may be exerted.

Further, by using dipotassium glycyrrhizinate as an anti-inflammatory agent in combination with the above-mentioned amino acids and eucalyptus oil, although the detailed mechanism of action is not clear,
When each of these is used alone, or any two
To the extent that it was not obtained when using a combination of people, alleviation of allergic symptoms etc. was obtained,
It is presumed that the three components exert some kind of synergistic action.

[0058]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Embodiments of the present invention will be described below based on examples.

The cosmetic of the present invention contains an antiallergic composition containing eucalyptus oil and amino acids. As amino acids, there are various amino acids, and among them, it is preferable to use sulfur-containing amino acids, particularly cysteine.

The cysteine may be used as a raw material from the production stage, or may be produced at the production stage using other sulfur-containing amino acids other than cysteine so that the final product contains cysteine in a predetermined amount. No problem.

Since sulfur-containing amino acids may generate hydrogen sulfide and the like during decomposition, it is necessary to prevent the generation of this unpleasant odor.

In the antiallergic composition contained in the cosmetic of the present invention, it is essential that the composition has an amino acid such as cysteine and eucalyptus oil.
The configuration must not lack any of them.

It is preferable that the cosmetic of the present invention be used in combination with an anti-inflammatory agent which exhibits almost the same pharmacologic effect as the steroid hormone agent and does not show significant side effects such as the steroid hormone agent. A salt of glycyrrhizic acid, which is an active ingredient obtained from the herbal medicine licorice, may be used. More preferably, for example, dipotassium glycyrrhizinate may be used.

The anti-allergic composition having the above-mentioned composition was adjusted for pH (pH) using a liquid property adjuster conventionally used in cosmetics and the like. By performing such a liquid property adjustment, emulsification conditions using an emulsifier at the time of uniformly mixing cysteine with eucalyptus oil can be adjusted.

At the same time, it can be adjusted to a liquid property so that it can be used not only for normal skin but also for skin with symptoms of allergic dermatitis.

(Embodiment) In this embodiment, a case where the present invention is applied to a liquid cosmetic will be described. Such liquid cosmetics include:
An antiallergic composition containing cysteine and eucalyptus oil, a liquid property adjuster, an emulsifier, and an antiinflammatory agent are mixed and prepared at a predetermined ratio.

A weak alkali was prepared using disodium citrate and sodium bicarbonate as a liquid property modifier. The overall liquidity was kept within the range of 8 ≦ pH ≦ 9.

The above pH range was set as a range that satisfies both conditions applicable to sensitive skin and conditions for ensuring uniform mixing of cysteine.

Originally, it is generally said that the pH of the skin is weakly acidic due to various secretions to the skin surface, and the self-purifying action is maintained in this pH range. It is considered that the range of the liquid property that is easy to use even for sensitive skin as described above is from weakly acidic to neutral and weakly alkaline.

However, the use of cysteine and eucalyptus oil, which constitute the antiallergic composition, which is an essential component of the present invention, requires uniform mixing of these components. The above was found to be preferable.

On the other hand, if the pH exceeds 9, even if it is preferable from the viewpoint of uniform mixing, on the other hand, in the case of allergic dermatitis in which alkalinity is strongly sensitive, or in the case of more severe atopic dermatitis, irritation may occur. May be so strong that the symptoms may worsen.

Further, a person with allergic dermatitis feels discomfort during use, such as a burning sensation during use of cosmetics and an increased pruritus. Therefore, the above-mentioned pH range was set as a range where the above-mentioned conditions are satisfied.

The composition ratios of the above-mentioned various components in the liquid cosmetics of this example were shown as relative ratios to cysteine used as an amino acid as follows. The components in the following proportions are uniformly mixed in a liquid state.

[0074]

[Table 1]

Each component may be prepared so that the total of each component is 100% by weight in the above composition range.

Further, in addition to the above components, for example, a preservative and fungicide, a bactericide and the like may be appropriately added as necessary. It can be adjusted within.

The cosmetic of the present embodiment, which has the composition of the above-mentioned component ratio and is formed into a uniform liquid, can be used by the palm by rubbing against the skin surface such as the face. The skin surface feels smooth and the sticky touch on the skin surface does not last forever. After penetration, the skin surface has a smooth smooth feeling. There is no glare on the skin part used, and a smooth feeling of use is obtained.

Further, the use of ordinary cosmetics for patients with atopic dermatitis is refrained from the use of atopic dermatitis in order to exacerbate atopic dermatitis. It has been found that it can be used for patients.

Further, it was found that the effect of improving the skin condition before and after use can be obtained for patients with normal skin that has not deteriorated as much as atopic dermatitis.

This situation is shown in the graphs of FIGS.
In the graphs of FIGS. 1 and 2, the liquid cosmetics of the present example having the above-mentioned component composition were recorded every day after use for 7 days after use, and this was displayed in a graph.

In each of the graphs of FIGS. 1 and 2, the state after use is divided into five stages of “very good”, “good”, “normal”, “not good”, and “bad” in the horizontal axis direction. Evaluation sections are provided, and the number of days of use for 7 days is further shown in the horizontal axis direction for each evaluation section on the horizontal axis. The vertical axis indicates the cumulative frequency of the number of responses for each number of days in each evaluation category.

In the positive direction of the horizontal axis, positive evaluations of “normal”, “good”, and “very good” are provided, and in the negative direction, negative evaluations of “not good” and “bad” are provided.

FIG. 1 shows an example of the result of using the cosmetics of this example on eight patients with normal skin showing symptoms of allergic dermatitis. In FIG. 1, eight different marks are displayed for each subject so that the evaluation responses of the eight subjects over seven days can be tracked.

From FIG. 1, it can be seen from FIG. 1 that the overall distribution of the cumulative frequency related to the evaluation after use is biased rightward from the vertical axis in the directions of “normal”, “good”, and “very good”. It is clear that the evaluation is concentrated on the “good” evaluation category.

In the leftward direction from the vertical axis, a distribution of “not very good” is observed, and it is recognized that the cosmetics of this example are generally effective in improving allergic symptoms on normal skin.

On the other hand, FIG. 2 shows an example of the result of using the cosmetics of this example on five patients with skin having atopic dermatitis. In this test, the progress after use is normal, such as those who switch between "normal" and "good", those who change from "normal" to "good", those who change from "normal" to "not very good", etc. Different from the above-mentioned use evaluation performed on skin patients, various results appeared.

Thus, in a patient with atopic dermatitis, it can be said that the atopic symptoms are greatly related to the previous symptom history, treatment history, and the like, and represent difficulties in coping uniformly.

However, the results shown in FIG. 2 indicate that the cosmetic of this example can be used for patients with atopic dermatitis. That is, although the ratio is smaller than that of patients with normal skin, the cumulative frequency distribution in the right direction from the vertical axis indicating the evaluation results of “normal” and “good” is larger than the left side from the vertical axis.

Incidentally, FIGS. 1 and 2 show that the cosmetic of the present embodiment was used for “Normal”,
Those who showed a positive evaluation of the availability of "good" and "very good" are found to be close to about 90% of the whole.

In particular, since alcohol is not used in this embodiment, even when used for allergic dermatitis or atopic dermatitis, the irritating feeling after use on such sensitive skin is hardly generated.

In this embodiment, the case where the liquid cosmetic is constituted is described.
Alternatively, it may be constituted as an external preparation of a drug in which an antiallergic composition in which the relative ratio of eucalyptus oil and cysteine is set to the above ratio in a cream or an ointment base is blended.

[0092] Even when the composition is used as a cosmetic or a drug such as an external preparation other than this example, it is necessary to include an antiallergic composition containing eucalyptus oil and an amino acid (for example, cysteine). . Preferably, the weight ratio to cysteine is preferably controlled within the range of 60 to 62 parts by weight of eucalyptus oil with respect to 1 part by weight of cysteine.

Further, dipotassium glycyrrhizinate was used as an anti-inflammatory agent, but its mixing ratio may be relatively wide with respect to 1 part by weight of cysteine. In addition, although there are components in the above composition in which the upper limit of blending is determined in Japan, in this case, a product having a component ratio corresponding to the upper limit may be used.

Further, in this embodiment, the case where dipotassium glycyrrhizinate is contained is shown, but a configuration not containing dipotassium glycyrrhizinate may be employed.

In the present embodiment, disodium citrate and sodium hydrogen carbonate were used as the liquid property adjusting agent, but other substances may be used.

The other ingredients may be constituted by using materials conventionally used in cosmetics quality standards and the Japanese Pharmacopoeia. To the extent that atopic dermatitis is not exacerbated, for example, an antiseptic and fungicide and a bactericide may be appropriately added as needed.

[0097]

The cosmetics of the present invention can be used widely for healthy skin, allergic skin and atopic skin.

Those who show allergic dermatitis with normal skin show improvement in allergic dermatitis.

[0099] Even on atopic skin, it can be used without causing extreme deterioration.

[0100] Even on atopic skin, the improvement effect is seen.

[Brief description of the drawings]

FIG. 1 is a graph showing the situation before and after use when the cosmetic of the present invention is applied to a person with normal skin.

FIG. 2 is a graph showing conditions before and after use when the cosmetic of the present invention is applied to a person with atopic skin.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 25/04 A61K 31/00 626 37/08 637E A61K 31/19 31/19 31/198 31/195 603 F term (reference) 4C083 AA121 AA122 AB312 AC302 AC442 AC581 AC582 AD531 AD532 BB01 BB44 BB51 CC04 DD01 DD23 EE06 EE10 EE13 4C206 DA14 MA02 MA03 MA05 MA83 NA06 NA14 ZA89 ZB11 ZB13

Claims (9)

[Claims] 1. A cosmetic having an antiallergic composition, wherein the antiallergic composition comprises eucalyptus oil and an amino acid. 2. The cosmetic according to claim 1, wherein the amino acid is a sulfur-containing amino acid. 3. The cosmetic according to claim 1, wherein cysteine is used as the amino acid. 4. The cosmetic product according to claim 1, wherein said cosmetic product contains an anti-inflammatory substance derived from a crude drug. 5. The cosmetic according to claim 4, wherein glycyrrhizinate is used as the anti-inflammatory substance. 6. A liquid cosmetic comprising eucalyptus oil, an amino acid, an anti-inflammatory agent, a liquid property adjuster, an emulsifier, and purified water. 7. The liquid cosmetic according to claim 6, wherein cysteine is used as the amino acid and glycyrrhizinate is used as the anti-inflammatory agent. 8. An external preparation comprising an amino acid, an anti-inflammatory agent, a liquid property modifier, an emulsifier, and eucalyptus oil. 9. The external preparation according to claim 8, wherein cysteine is used as the amino acid, and glycyrrhizinate is used as the anti-inflammatory agent.