JP2000093511A - Medicinal solution quantity adjustment aid of pre-filled syringe - Google Patents

Abstract

PROBLEM TO BE SOLVED: To easily adjust the quantity of a medicinal solution in a pre-filled syringe to an appropriate dosage. SOLUTION: A pre-filled syringe 10 has a cylinder 12 storing both a medicinal solution 38 and a plunger 24 and a nozzle 17 for attaching a needle is formed at one end of the cylinder while a rod passage opening 16 through which a plunger rod 26 is passed is formed at the other end. The end face of the plunger or the like that indicates the chemical itself or the boundary of the chemical enables the quantity of the chemical to be visually checked via the cylinder wall that is at least partially transparent. A chemical quantity adjustment aid 170 includes a main body 72 having a retaining groove 74 in which the cylinder 12 of the syringe 10 can be removably retained and graduations 86 provided on the main body to enable the quantity of the chemical in the cylinder to be measured. At least a portion of the cylinder near the nozzle along the longitudinal direction can be retained and fixed in the retaining groove 74 so that the quantity of the chemical in the cylinder can be visually checked and so that the plunger 24 in the cylinder can be moved by the plunger rod. The graduations 86 are arranged on the outer surface of the main body adjacent to the retaining groove along the longitudinal direction of the retaining groove.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an aid for adjusting the amount of a drug solution in a prefilled syringe. More specifically, the present invention relates to a method for adjusting the amount of a drug solution for one adult housed in a pre-filled syringe and adjusting the amount of the drug solution to be used for administration to a child or a patient with a small weight. About the tool.

[0002]

2. Description of the Related Art A prefilled syringe is filled with a drug solution, a solid drug such as a lyophilized product is filled, and a drug solution is prepared in a prefilled syringe at the time of use using a dissolving or suspending solution. Further, both a solid drug such as a lyophilized product and a solvent are filled in a prefilled syringe, and there are three types that are dissolved or suspended at the time of use in the syringe. Regardless of the type, the prefilled syringe is manufactured aseptically for the purpose of simplifying the operation required for preparing the drug solution at the time of administration and avoiding microbial contamination,
And it is designed to be sterile until the time of administration.

[0003] In general, a drug solution filled in a prefilled syringe or a drug solution dissolved or suspended at the time of administration in a syringe is regarded as a single dose for an adult patient. Is used as a single-use disposable syringe to administer (JP-A-4-322662). From such usage,
The prefilled syringe is not graduated.

However, in a prefilled syringe filled with an active ingredient such as luteinizing hormone or insulin, it is desired to administer an appropriate dose in terms of body weight, for example, to a pediatric patient instead of the whole amount of the drug solution filled in the syringe. In some cases, it is difficult to adjust the appropriate dose. In addition, a complicated operation is required even when it is necessary to discharge a surplus drug solution until the drug solution filled in the prefilled syringe reaches the calculated dose after calculating the weight-converted dose.

Therefore, it is desired to develop a drug solution adjusting aid for a prefilled syringe which enables the administration of an appropriate amount of a drug solution or the like filled in a prefilled syringe and which can adjust a target dose without calculating a body weight. Was rare. As a conventional liquid medicine adjusting aid for a syringe, an auxiliary tool attached to a plunger of a syringe for dispensing the same amount of liquid medicine every time is described in Japanese Utility Model Application Publication No. 60-63352. Japanese Patent Application Laid-Open No. 9-164202 discloses an auxiliary device for inhaling a drug solution in an ampoule into a syringe. However, it has been difficult to easily adjust the amount of the drug solution filled in the prefilled syringe using the assisting device described in each of these publications.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to provide a drug solution adjusting aid provided with a scale capable of easily adjusting a drug solution in a prefilled syringe to an appropriate dose.
Another object of the present invention is to provide a combination of such a prefilled syringe and a drug solution adjusting aid. Another object of the invention is
It is an object of the present invention to provide a drug solution adjusting aid which allows a drug solution to be administered in a syringe to be adjusted by a drug solution adjusting aid having a scale without providing a scale on a disposable prefilled syringe. Yet another object of the present invention is to adjust the amount of liquid in the prefilled syringe with reference to a scale indicating that the cylinder of the prefilled syringe is easily inserted and positioned in the correct position of the holding groove and the amount of liquid to be administered. It is an object of the present invention to provide a chemical solution adjusting aid that enables the above-mentioned operation. Still another object of the present invention is to provide an auxiliary device for adjusting the liquid amount of a prefilled syringe with excellent operability which minimizes the possibility of erroneous administration by omitting a weight conversion process. Other objects and advantages of the present invention will become apparent in the following description and embodiments of the present invention with reference to the drawings.

[0007]

The prefilled syringe according to the present invention has a cylinder for accommodating a medicinal solution and a plunger, and a nozzle for mounting a needle at one end of the cylinder. A rod passage opening is formed at the other end to allow the plunger rod to pass therethrough, and the medicinal solution is accommodated in a cylinder between the nozzle and the plunger, and the amount of the medicinal solution is a plunger end face indicating a boundary of the medicinal solution itself or the medicinal solution. Thereby, the liquid medicine amount adjusting aid is visible at least partially through the transparent cylinder wall, and the liquid medicine amount adjusting auxiliary tool has a holding groove capable of detachably holding the cylinder of the prefilled syringe, and the cylinder provided to the main body. It has a scale that enables measurement of the amount of the chemical solution in the inside. The body includes an engagement portion that engages the outer shoulder of the syringe to provide axial positioning of the syringe with respect to the scale. The holding groove can accommodate and fix at least a part of the cylinder in the longitudinal direction near the nozzle so that the amount of the chemical solution in the cylinder can be visually recognized and the plunger in the cylinder can be moved by the plunger rod. The scale is arranged on the outer surface of the main body adjacent to the holding groove in the longitudinal direction of the holding groove.

[0008] The chemical solution adjusting aid of the present invention can preferably have the following configuration. That is, (a) the holding groove has a depth dimension capable of accommodating half or more of the circular cross section of the cylinder, a peripheral surface engaging portion to be engaged with the outer peripheral surface of the cylinder, and an inlet narrow portion. (B) The circumferential surface engaging portion of the holding groove generates a resistance force against passage when the largest dimension portion of the outer circumferential surface passes into the holding groove. (C) The main body is made of a flexible material. (D) The holding groove has irregularities corresponding to the shape of the outer peripheral surface of the prefilled syringe. (E) The scale is a scale corresponding to the weight of the patient to which the drug solution is to be administered.

(F) The prefilled syringe has a stopper which divides the inside of the cylinder into a front chamber adjacent to the nozzle and a rear chamber on the side of the rod passage, and allows the front chamber and the rear chamber to communicate when the stopper is moved to a predetermined position. A bypass, and having a convex portion formed on the outer peripheral surface of the cylinder outside the bypass, a drug substance dried in the front chamber, a solvent in the rear chamber, when administering a drug solution to the patient, The plunger is pushed toward the nozzle, the stopper is moved to a predetermined position together with the solvent, the solvent flows into the anterior chamber via the bypass, and mixes with the drug substance in the anterior chamber to produce a drug solution for one adult patient. (G) The scale is for reducing the amount of drug solution in the cylinder to one child.
(H) The dimensions of the inlet constriction of the retaining groove are smaller than the cylinder diameter of the prefilled syringe.

[0010] The present invention also provides a combination of a prefilled syringe provided with a cylinder for accommodating a medicinal solution and a plunger and a medicinal solution amount adjusting aid. In this combination,
The pre-filled syringe has a nozzle for mounting a needle at one end of an at least partially transparent cylinder,
At the other end, there is formed a rod passage opening through which the plunger rod passes, and the medicinal solution is stored in the cylinder between the nozzle and the plunger, and the amount of the medicinal solution is visually recognized by itself or the plunger end surface indicating the boundary of the medicinal solution. It is made possible and comprises a shoulder including a plane substantially perpendicular to the cylinder axis direction. The chemical solution adjustment aid includes a main body having a holding groove capable of detachably housing and fixing the cylinder of the prefilled syringe, and a scale provided on the main body to measure a chemical solution amount in the cylinder. An engaging portion that engages with the shoulder of the syringe and positions the cylinder at a predetermined position in the axial direction with respect to the scale is provided. The holding groove allows the amount of the chemical solution in the cylinder to be visually recognized and the plunger in the cylinder to be moved by the plunger rod. As possible, at least a part of the cylinder in the longitudinal direction near the nozzle can be accommodated, and the scale is arranged on the outer surface of the main body adjacent to the retaining groove along the longitudinal direction of the retaining groove.

The combination of the present invention can preferably have the following configuration. That is, (h) the prefilled syringe is a stopper that divides the inside of the cylinder into a front chamber adjacent to the nozzle and a rear chamber on the rod passage opening side, and a bypass that can communicate the front chamber and the rear chamber when the stopper is moved to a predetermined position. , And a convex portion formed outside the bypass on the outer peripheral surface of the cylinder. (I) The holding groove of the chemical solution adjusting aid has a concave portion for accommodating a convex portion on the outer peripheral surface of the prefilled syringe. (J)
The pre-filled syringe includes a finger grip extending radially outward from near the rod passage of the cylinder,
When the step formed near the nozzle is engaged with the shoulder of the holding groove and the cylinder is accommodated in the holding groove, a predetermined gap in the longitudinal direction of the cylinder is generated between the finger grip and the outer surface of the adjacent main body.

An auxiliary device for adjusting the amount of a drug solution for a prefilled syringe according to one embodiment of the present invention includes a holding groove having a substantially semicircular cross section which is opened on the upper surface of the main body, and the dose of the drug solution is provided near the holding groove on the upper surface of the main body. It has a scale of. It is preferable that the medicinal-fluid-volume adjusting aid is shorter than the length from the tip of the nozzle for attaching the injection needle of the prefilled syringe to the finger grip.
It is preferable that the holding groove has irregularities corresponding to the shape of the outer peripheral surface of the cylinder of the prefilled syringe, and is formed of a flexible material.

In the present invention, the scale attached to the chemical solution adjusting aid is attached so that, for example, the upper end (nozzle side) of the medical solution in the prefilled syringe from which air has been vented becomes zero. The unit of the scale is m according to the purpose of administration.
1, kg indicating the weight-converted dose of a pediatric patient, or an international unit used for insulin or the like. The cross-sectional shape of the holding groove is substantially semicircular, and has irregularities corresponding to the shape of the outer peripheral surface of the prefilled syringe.

The holding groove may have a concave portion corresponding to the shape of a convex portion (bypass) extending in the axial direction of the outer surface of the cylinder. In this case, by forming the recess corresponding to the bypass on the inner peripheral surface of the holding groove, the prefilled syringe can be stably held regardless of where the bypass of the prefilled syringe is located in the recess of the holding groove. Also,
The cross-sectional shape of the holding groove can be, for example, a substantially semicircle having a circumference slightly larger than a semicircle obtained by dividing the cross section of the cylinder of the prefilled syringe into half.

[0015] The aid for adjusting the amount of a drug solution for a prefilled syringe of the present invention is made of a material having strength that can be used repeatedly rather than disposable. The material is preferably a material that does not easily change its scale due to the environmental temperature and that does not easily peel off the scale even if it is used a plurality of times. As one of the preferable materials of the drug solution adjusting aid for the prefilled syringe of the present invention, a flexible synthetic resin is preferable in order to improve the operability when attaching the prefilled syringe. Examples of such synthetic resins include polypropylene, polyethylene, polycarbonate, polyvinyl chloride, polyester, polystyrene, ethylene-vinyl acetate, ionomer,
Acrylic, polyurethane, ABS, polyacetal, acrylic butadiene styrene, acrylic styrene and the like can be mentioned.

The total length in the longitudinal direction of the chemical solution adjusting aid of the present invention is determined by taking into consideration the operability when mounting the prefilled syringe on the chemical solution adjusting aid and the operability of pushing the plunger, etc. Is preferably shorter than the length from the distal end to the finger grip of the prefilled syringe. The shoulder of the syringe for axially positioning the cylinder with respect to the scale is formed in a nozzle fitting for connecting a nozzle to the cylinder or a fitting for connecting a finger grip to the cylinder. An engagement portion provided on the adjustment aid for positioning the cylinder in the axial direction with respect to the scale is formed by a radial step portion in the holding groove or an outer surface of the main body near an end of the holding groove. The force for fixing the cylinder in the holding groove is selected such that the cylinder does not move by the operation of adjusting the amount of the chemical solution, but can move for positioning the cylinder in the axial direction with respect to the scale.

[0017]

In order to adjust the amount of the drug solution in the cylinder using the aid for adjusting the amount of the drug solution for the prefilled syringe of the present invention, first, the injection needle is attached to the nozzle of the prefilled syringe together with the injection needle cap, and then the prefilled syringe is attached. Push the cylinder of the syringe into the holding groove of the chemical solution adjustment aid. At this time, the shoulder of the syringe and the engaging portion of the assisting tool are brought into abutment to position the cylinder in a predetermined relationship with the scale. The prefilled syringe is housed and fixed in a holding groove having a substantially semicircular cross section, and is held to such an extent that the prefilled syringe and the drug solution adjusting aid do not come off easily when adjusting the drug solution amount.

Next, after lifting up the chemical solution adjusting aid and the prefilled syringe together and exhausting the gas in the cylinder, according to the scale of the chemical solution adjusting aid, the prefilled syringe plan is adjusted to a scale position indicating an appropriate dose. Push in the jar to adjust the dose. If the scale displayed on the solution adjustment aid is in kg, indicating the weight-converted dose of a pediatric patient, the front of the stopper should be aligned with the scale indicating the patient's weight without converting the weight. Just push in the jar to get the appropriate dose.

When the prefilled syringe is mounted on the assisting device by making the cross section of the holding groove approximately semicircular, the size of the narrow portion of the inlet of the holding groove is smaller than the cylinder diameter of the prefilled syringe, so that the cylinder is inserted. Sometimes it reaches its final position shortly after passing through some resistance.
Therefore, it is easily perceived by the resistance change that the cylinder of the syringe has reached the final position, and the cylinder can be reliably housed in the correct position.

[0020]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, an embodiment of the present invention will be described with reference to FIGS. FIG. 1 is a schematic side view including a partial cross section before use of a typical double-chamber type prefilled syringe 10 which can be adjusted by the liquid amount adjusting aid of the present invention. In the prefilled syringe 10 of FIG. 1, a nozzle 17 for mounting a needle is formed at one end of the cylinder 12, and a rod passage port 1 through which a plunger rod 26 connected to a plunger 24 is passed at the other end.
6 are formed. 1. Pre-filled syringe 1 before use in FIG.
Nozzle 17 is a nozzle cap 4 made of rubber or the like.
2 is covered. Attachment portions 18 and 151 for connecting the nozzle 17 to the cylinder and attachment portions 150 for connecting the finger grip 15 to the cylinder are formed with shoulder portions 19 and 151 including planes substantially perpendicular to the axial direction. FIG. 2 shows that the injection needle 44 is attached to the nozzle 17 of the syringe 10 and the solvent 36 is mixed with the dry medicine 33 to administer the medicine with the prefilled syringe of FIG.
FIG. 4 is a schematic side view showing a state in which is formed by a partial cross section. The injection needle 44 includes a mounting portion 45 and a needle tube 46, and the needle tube 46 is covered with a removable transparent needle cap 47.

In the prefilled syringe 10 of FIGS. 1 and 2, the cylinder 12 containing the drug solution 38 and the plunger 24 is at least partially transparent. Cylinder 1
The chemical solution (amount) 38 in 2 is made visible through the transparent portion of the cylinder, for example, by seeing through the chemical solution itself or the end of the plunger adjacent to the chemical solution. The prefilled syringe 10 of FIG. 1 is of a double chamber type, in which a stopper 34 for dividing the inside of the cylinder into a front chamber 31 adjacent to the nozzle 17 and a rear chamber 32 on the rod passage opening 16 side is moved to a predetermined position. The bypass chamber 14 communicates the front chamber 31 and the rear chamber 32, and the convex portion 11 formed on the outer peripheral surface 13 of the cylinder radially outward of the bypass 14. N ₂ gas or the like) accommodates the solvent 36 and some of the gas 35 into the rear chamber 32.

The stopper 34 disposed in the cylinder 12 is fitted tightly to the inner peripheral surface of the cylinder so that the solvent 36 does not leak into the front chamber 31 and wet the dry medicine 33 before use. The front chamber side of the rear chamber 32 is sealed by a stopper 34, and the rod passage opening side of the rear chamber 32 is sealed by a plunger 24.
The plunger 24 is fixed to an end of the plunger rod 26 and is movable toward the nozzle 17 in the cylinder 12 by being pressed by the plunger rod 26. The plunger rod 26 has a male screw 28, and an inner peripheral surface of the rod passage 16 is provided with a female screw (not shown) that is threadedly engaged with the male screw 28.

FIG. 3 is a schematic plan view of the chemical solution adjusting aid of the first embodiment of the present invention, and FIG. 4 is a schematic sectional view of the chemical solution adjusting aid of FIG. 3 taken along line AA. FIG. 5 is a schematic cross-sectional view of the chemical liquid amount adjusting aid of FIG. 3 taken along line BB, and is a schematic cross-sectional view shown in combination with a cylinder cross-sectional portion having a bypass. 3 to 5 includes a main body 72 having a holding groove 74 and a scale 86. The main body 72 is made of a synthetic resin having a slight elasticity. The scale 86 is disposed on the outer surface of the main body 72 adjacent to the holding groove 74 in the axial direction of the holding groove 74. The scale is a scale corresponding to the weight of the patient to which the medicinal solution is to be administered, and is provided to reduce the amount of the medicinal solution in the cylinder to one child.

The holding groove 74 has such a dimension that the cylinder 12 of the prefilled syringe shown in FIG. 2 can be removably received and fixed. The holding groove 74 is, as shown in FIG.
In the top view, the cylinder outer peripheral surface 13 of the syringe (FIG. 5)
, A concave portion 76 wider than the peripheral surface engaging portion 75, a step portion 78 composed of an annular plane perpendicular to the axial direction of the holding groove, and a narrow groove portion 82 narrower than the peripheral surface engaging portion 75. Having. The engaging portion 78 formed by the step of the holding groove engages with the shoulder portion 19 formed near the nozzle 17 of the cylinder to position the cylinder 12 with respect to the scale 86 in the axial direction. The concave portion 76 is formed in an annular shape inside the holding groove 74.

The depth dimension H of the peripheral surface engaging portion 75 of the holding groove 74
In FIG. 4, the radius R of the cylinder and the additional dimension α (α> 0) are set so as to accommodate at least half of the circular cross section of the cylinder 12 of the syringe. The circumferential surface engaging portion 75 includes an opening of the holding groove and a narrow portion 88 having a width smaller than 2R by a minute dimension in a portion from the opening to the additional dimension α. Narrow part 88
Generates a resistance force when the maximum dimension portion (2R) of the outer peripheral surface of the cylinder passes through the opening of the holding groove and into the holding groove. The body 72 of the aid is so small that the constriction 88 is slightly expanded by a small dimension when the largest part of the cylinder passes.
Is made of a flexible synthetic resin material. The holding groove 74 has irregularities corresponding to the shape of the outer peripheral surface of the prefilled syringe.

FIG. 6A is a schematic plan view showing a combination of the chemical solution adjusting aid 170 and the prefilled syringe 10 according to the second embodiment of the present invention, and FIG. 6B is a schematic elevation view of FIG. 6A. . In the combination of the prefilled syringe 10 and the assisting device 170 shown in FIGS.
No. 0 has a nozzle 17 for mounting a needle at one end of the cylinder 12 and a plunger rod 26 at the other end.
Is formed, a chemical solution 38 is accommodated in the cylinder, and the amount of the chemical solution can be seen through the wall of the cylinder 12. Auxiliary tool 170
A main body 72 having a holding groove in which the cylinder 12 of the syringe 10 can be detachably housed and fixed, and a scale 8 provided on the main body so that the amount of the chemical solution 38 in the cylinder can be measured.
6, the holding groove is used to visually check the amount of the chemical solution 86 (plunger position) in the cylinder and to check the plunger 24 in the cylinder.
Is movable by the plunger rod 26,
At least a part of the cylinder in the longitudinal direction near the nozzle 17 can be accommodated. The scale 86 of the auxiliary tool is disposed on the outer surface of the main body adjacent to the holding groove along the longitudinal direction of the holding groove.

In the combination of the embodiment of FIGS. 6A and 6B, the mounting portion 15 of the finger grip 15 of the syringe 10 is provided.
0 has a shoulder 151 at the end opposite the finger grip 15 that includes a plane substantially perpendicular to the cylinder axis. On the other hand, the holding groove 74 of the auxiliary tool 170 is provided with a peripheral surface engaging portion 75 that engages with the cylinder outer peripheral surface 13 (FIG. 5) of the syringe, and the holding groove 7.
4 has an engagement portion 173 having an end surface perpendicular to the axial direction at one end. In the embodiment of FIGS. 6A and 6B, the axial positioning of the cylinder 12 of the syringe is performed by abutting the shoulder 151 of the syringe with the engaging portion 173 of the assisting device. The embodiment of FIGS. 6A and 6B
The engaging portion 78 comprising the step of the holding groove in the embodiment of FIGS.
Is not provided. The embodiment of FIGS. 6A and 6B has the same structure as the embodiment of FIGS. 1 to 5 except for the structure for positioning, and the same structures are denoted by the same reference numerals, and duplicate description will be omitted. Is omitted.

The procedure for administering a drug solution to a patient using the prefilled syringe 10 shown in FIGS. 1 to 6B is as follows.
The nozzle cap 42 is removed from the nozzle 17, and the mounting portion 45 of the injection needle 44 with the needle cap 47 attached is attached to the nozzle 1.
7 is fitted. Next, cylinder 1 of the prefilled syringe
2 is pushed into the holding groove 74 of the assisting tool through the entrance narrow portion 88, and the shoulder 19 and the engaging portion 78 (FIGS. 1 to 5) or the shoulder 151 and the engaging portion 173 (FIGS. 6A and 6B) are connected. The cylinder 12 is positioned with respect to the scale 86 by abutment. Next, the rod end 29 of the end of the plunger rod 26 is rotated around the axis of the rod 26,
A male screw 28 formed on the outer periphery of the rod is engaged with a female screw (not shown) provided on the inner peripheral surface of the rod passage port 16 and rotated, thereby moving the rod 26 in the axial direction and pushing the plunger 24 toward the nozzle. Then, the solvent and the stopper 33 are moved toward the nozzle. When the stopper 33 moves to a predetermined position that opens both ends of the bypass 14, the solvent 32 flows into the front chamber 31 via the bypass 14, and the dry medicine 3 in the front chamber 31.
3 is dissolved or suspended, and a drug solution for one adult patient is generated in the anterior chamber 31. After the plunger 24 is pushed in and the gas in the cylinder is exhausted, the plunger is pushed in according to the scale 86 of the auxiliary tool, and the plunger is moved until a dosage suitable for the patient is reached. After the amount of medicinal solution in the cylinder has reached a dose suitable for the patient, the syringe is removed from the aid, the needle cap is removed, and the syringe is applied.

[0029]

According to the present invention, the liquid medicine adjusting aid for a prefilled syringe is attached to the prefilled syringe, and the plunger of the prefilled syringe is pushed in according to the scale displayed on the upper surface of the liquid medicine adjusting aid to handle the patient. The appropriate dosage can be easily adjusted. By setting the scale of the assisting device in terms of the weight, an appropriate dose corresponding to the patient can be easily obtained. Further, the cylinder accommodating the syringe in the holding groove is securely held by covering the narrow portion in the longitudinal direction of the syringe holding groove slightly smaller in size than the maximum diameter portion.

Further, in the chemical solution adjusting aid for a prefilled syringe according to the present invention, preferably, a convex portion corresponding to a shoulder between a nozzle mounting portion of the prefilled syringe and the nozzle is formed at a front portion of the holding groove. However, the contact between the shoulder of the prefilled syringe and the convex portion can prevent the movement of the prefilled syringe in the holding groove toward the injection needle. Due to the uneven shape formed in the syringe holding groove in this way, when the prefilled syringe is mounted on the chemical solution adjusting aid of the present invention, the cylinder portion of the prefilled syringe is accurately mounted at the scale position on the upper surface of the chemical solution adjusting aid. The position of the scale and the cylinder is not displaced by the chemical liquid adjustment operation, and accurate chemical liquid adjustment can be performed.

[Brief description of the drawings]

FIG. 1 is a schematic side view including a partial cross section before use of a typical prefilled syringe that can be adjusted by the liquid amount adjusting aid of the present invention.

FIG. 2 is a schematic side view including a partial cross section of the prefilled syringe of FIG. 1 in a state in which an injection needle is attached to administer a drug solution and a solvent is mixed with a dry drug to form a drug solution.

FIG. 3 is a schematic plan view of a chemical solution adjusting aid according to the first embodiment of the present invention.

FIG. 4 is a schematic cross-sectional view of the chemical solution adjustment aid of FIG. 3 along the line AA.

5 is a schematic cross-sectional view of the chemical liquid amount adjusting auxiliary tool taken along line BB of FIG. 3, which is a schematic cross-sectional view showing a combination of external shapes of a cylinder cross-sectional portion having a bypass portion of a prefilled syringe.

FIG. 6A is a schematic plan view showing a state in which a chemical solution amount adjusting aid and a prefilled syringe according to a second embodiment of the present invention are combined. FIG. 6B is a schematic elevation view of FIG. 6A.

[Explanation of symbols]

10: prefilled syringe, 11: convex, 12: cylinder, 13: cylinder outer peripheral surface, 14: bypass, 15: finger grip, 16: rod passage, 17: nozzle, 18: nozzle support, 19: shoulder, 24: plunger, 26: plunger rod, 28: screw, 29: rod end, 31: front chamber, 32: rear chamber, 33: dry drug, 3
4: stopper, 35: gas, 36: solvent, 38: chemical, 42:
Nozzle cap, 44: injection needle, 45: mounting part, 46:
Needle tube, 47: Needle cap, 70: Chemical solution adjustment aid, 7
2: Main body, 74: holding groove, 75: peripheral engaging portion, 76: concave portion, 78: engaging portion (step portion), 82: narrow groove portion, 86: scale, 88: narrow portion, 150: mounting portion, 151: shoulder, 1
73: engagement portion (end face), R: radius, H: depth.

Claims (7)

[Claims] 1. A cylinder for accommodating a drug solution and a plunger, a nozzle for attaching a needle is formed at one end of the cylinder, and a rod passage opening for passing a plunger rod is formed at the other end, and the drug solution is formed. A device for adjusting a liquid amount of a prefilled syringe, which is housed in a cylinder between a nozzle and a plunger and whose liquid amount is visible, having a holding groove capable of detachably holding a cylinder of the prefilled syringe. And a scale provided on the main body to enable measurement of the amount of the drug solution in the cylinder, wherein the main body is engaged with an outer shoulder of the syringe to perform axial positioning of the syringe with respect to the scale. The holding groove is provided near the nozzle so that the amount of the chemical solution in the cylinder can be visually recognized and the plunger in the cylinder can be moved by the plunger rod. The scale is arranged along the longitudinal direction of the holding groove on the outer surface of the main body adjacent to the holding groove. Adjustment aid. 2. The holding groove has a depth dimension capable of accommodating half or more of a circular cross section of the cylinder, a peripheral surface engaging portion engaged with an outer peripheral surface of the cylinder, and an inlet narrow portion. 2. The chemical liquid amount adjusting aid according to claim 1, wherein a resistance force against passage is generated when a maximum dimension portion of the outer peripheral surface of the cylinder is passed into the holding groove. 3. The method according to claim 1, wherein the main body is made of a flexible material, and the holding groove has an uneven shape corresponding to a shape of an outer peripheral surface of the prefilled syringe. Utensils. 4. The chemical solution adjusting aid according to claim 1, wherein the scale is a scale corresponding to a weight of a patient to which the medical solution is administered. 5. The pre-filled syringe includes a stopper for dividing the inside of the cylinder into a front chamber adjacent to the nozzle and a rear chamber on the rod passage opening side, and a bypass for communicating the front chamber and the rear chamber when the stopper is moved to a predetermined position. And a convex portion formed outside the bypass on the outer peripheral surface of the cylinder, containing a medicine in the front chamber and a solvent in the rear chamber, and when administering a drug solution to a patient, pushes the plunger to the nozzle side and plugs the same with the solvent. Is moved to a predetermined position, the solvent flows into the anterior chamber via the bypass, and mixes with the medicine in the anterior chamber to generate a chemical solution for one adult, and the scale reduces the amount of the chemical solution in the cylinder to one child. The chemical liquid amount adjusting aid according to any one of claims 1 to 4, wherein the chemical liquid amount adjusting auxiliary tool is used for adjusting a chemical liquid amount. 6. A combination of a prefilled syringe provided with a cylinder for accommodating a drug solution and a plunger and a drug solution adjusting aid, wherein the prefilled syringe has a nozzle for mounting an injection needle at one end of the cylinder, At the other end, a rod passage port for passing the plunger rod is formed, the chemical solution is accommodated in a cylinder between the nozzle and the plunger, and the amount of the chemical solution is made visible. A main body having a holding groove capable of detachably housing and holding a cylinder of a prefilled syringe, and a scale provided on the main body so as to measure a medicinal solution amount in the cylinder, wherein the main body is provided with an outer shoulder of the syringe. An engagement portion that engages with the portion to position the cylinder in the axial direction with respect to the scale. The cylinder can accommodate at least a part of the longitudinal direction of the cylinder near the nozzle so that the plunger can be moved by the plunger rod, and the scale is arranged along the longitudinal direction of the holding groove on the outer surface of the main body adjacent to the holding groove. A combination characterized by being performed. 7. The prefilled syringe includes a stopper for dividing the inside of the cylinder into a front chamber adjacent to the nozzle and a rear chamber on the side of the rod passage, and connects the front chamber and the rear chamber when the stopper is moved to a predetermined position. The bypass has a convex portion formed on the outer peripheral surface of the cylinder outside the bypass, and the holding groove of the chemical solution adjusting aid has a concave portion for accommodating the convex portion on the outer peripheral surface of the prefilled syringe. 7. The combination of claim 6, wherein