JP2000086231A - Aluminum oxide.magnesium silicate aluminate composite, its production, acid controlling agent and its use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a composite material by easy producing method which shows good reactivity with acid, no ageing process, high stability and high resistance against abuse by compounding Al2O3 hydrate with an analogue component of magnesium silicate aluminate. SOLUTION: A soluble aluminum compd. is reacted with a compd. which supplies alkali and/or carbonate ion under the conditions of 7 to 12 pH at 20 to 90 deg.C. To the obtd. gel, a soluble aluminum compd., soluble magnesium compd. and silicate compd. are added under condition of 7 to 12 pH. The obtd. reaction product is filtered, cleaned and dried to obtain an aluminum oxide.magnesium silicate aluminate composite material expressed by the formula of (Al2O3).[Al2 O3.MgO.(SiO2)y].mH2O wherein m is 2<=m<=70; x is 0.5<=x<9 and y is 0.5<=y<=2 which is a powder showing a noncrystalline diffraction pattern by powder X-ray analysis.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel aluminum oxide / magnesium silicate composite, a method for producing the same, and an antacid. More specifically, the composite and a method for producing the same, in which a high antacid aluminum hydroxide gel is combined with a similar component such as magnesium aluminate silicate,
In addition, the acid reactivity and neutralizing ability of the composite as an active ingredient are high, and the antacidity is high.Furthermore, the composite has no aging phenomenon which is a drawback of the conventional aluminum hydroxide, and has more stability. The present invention relates to an antacid which is high, more resistant to abuse, and has good preservability and workability. Further, the present invention relates to an excipient and an adsorbent utilizing the physical properties of the present compound.

[0002]

2. Description of the Related Art Dried aluminum hydroxide gel is in the form of an amorphous powder and is more frequently used as an antacid than before. However, commercially available dried aluminum hydroxide gel has a problem that it has a slow reaction to stomach acid and is inferior in immediate effect, and when stored for a long period of time, crystallization progresses and the acid neutralizing ability decreases. In order to solve this problem, a method in which aluminum hydroxide gel is used as an antacid in a slurry state without drying, or an improvement of a conventional method of binding carbonate ions, has been attempted.
Patent Literature 1 discloses a method for suppressing the hydrolysis by substituting the alkali of the aluminum hydroxide gel with a divalent ion such as Ca to identify and bind the divalent carbonate ion, and Disclosed chemical formula (M ₂ O) _x Al ₂ O
₃ (CO ₂ ) _y R _z · mH ₂ O, wherein M is a monovalent alkali metal, R is a divalent or higher organic acid, and X is 0 <x <0.
2, y is 0.01 ≦ y <1, z is 0.01 ≦ z <1, m
Represents a number of 2 ≦ m <10, and a dry aluminum hydroxide gel represented by 0.1 ≦ y + z <1 (JP-A-8-410)
No. 76) is known. However, in the method of using the slurry as it is, it is not possible to use it by freezing under low-temperature drying, and there is a problem that bacteria grow and rot at normal temperature or higher, which is not preferable from the viewpoint of preservability and workability. Was. In addition, the latter method of specifying and binding divalent carbonate ions has a drawback that aging actually progresses and the acid neutralizing ability decreases. Furthermore, in the conventional method of binding carbonate ions, the stability increases as the amount of carbonate ions increases, but the content of Al ₂ O ₃ decreases accordingly, and the acid neutralizing ability decreases significantly. There was an essential problem of doing so. The dried aluminum hydroxide gel containing a divalent or higher valent organic acid disclosed by the inventors of the present invention is improved in both acid reactivity and acid neutralization ability as compared with conventional products, and is easy to manufacture. However, further improvement was required. Also,
The amorphous powder represented as magnesium aluminate silicate has a composition ratio of Al ₂ O ₃ : MgO: SiO ₂ = 1:
1: 0.5 to 2, for example magnesium aluminate metasilicate, can be obtained as a homogeneous composition,
To crystallize Al ₂ O ₃ hydrate Some even simply by increasing the Al ₂ O ₃ component in a similar procedure, could not be amorphous and composition to obtain a uniform powder.

[0003]

DISCLOSURE OF THE INVENTION The present invention relates to a novel aluminum oxide / magnesium aluminate silicate having a completely amorphous and uniform composition in which an Al ₂ O ₃ component is uniformly dispersed, a method for producing the same, and a method for producing the same. An object of the present invention is to provide an antacid, excipient and adsorbent comprising a composite. More specifically, the present invention can be obtained by complexing Al ₂ O ₃ hydrate, which is easily crystallized as an antacid, and whose acid neutralization ability tends to be reduced, with a similar component such as magnesium aluminate silicate. To provide a more stable, abuse-resistant aluminum oxide-magnesium aluminate composite, a simple method for producing the composite, and use as a stable and highly antacid antacid using the composite. Aim.

[0004]

Means for Solving the Problems The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that the formula (I) (Al ₂ O ₃ ) _x. [Al ₂ O ₃ .MgO. (SiO ₂ ) _y ] · mH ₂ O (I) (where m is a number in the range of 2 ≦ m ≦ 70, and x is 0.5
≦ x <9, preferably a number in the range of 1 ≦ x ≦ 6, and y indicates a number in the range of 1 ≦ y ≦ 2. The present inventors have found that an aluminum oxide-magnesium silicate aluminate composite (hereinafter, referred to as a composite) can solve the above-mentioned problem.

[0005] The composite of the present invention has good reactivity with an acid, and can be used as an antacid of the present invention by containing the composite as an active ingredient. In addition, since the composite of the present invention has good reactivity with an acid, it can be effectively used in a cation exchanger, an acid adsorbent, a soil neutralizer, and other fields. Furthermore, it can be used as an excipient by utilizing the amorphous powder.

The composite of the present invention has an amorphous powder whose diffraction pattern in powder X-ray diffraction.

The composite of the present invention can be synthesized by the following production method.

The production methods are roughly classified into a method of reacting magnesium aluminate with aluminum oxide before the reaction of aluminum oxide (method A) and a method of reacting aluminum oxide with a reaction product of magnesium aluminate silicate (method B). . Specifically, (Method A) is to react a soluble aluminum compound, an alkali and / or a carbonate ion-supplying compound under conditions of pH 7 to 12, preferably pH 8 to 10, and obtain a soluble aluminum compound in the obtained gel; The soluble magnesium compound and the silicate compound are adjusted to pH 7 to 12, preferably p
A method for producing an aluminum oxide / magnesium aluminate silicate composite, comprising adding the reaction mixture under conditions of H8 to 10, filtering the obtained reaction product, washing and drying. The order in which the soluble aluminum compound, the soluble magnesium compound and the silicate compound are added to the gel obtained above is not particularly limited. Then, a silicate compound may be added.

[0009] Alternatively, in the (Method B), a silicate compound is added to a soluble aluminum compound, and then a soluble magnesium compound is added. The obtained gel is mixed with a soluble aluminum compound and an alkali and / or carbonate ion supplying compound. A method for producing an aluminum oxide / magnesium aluminate silicate composite, wherein the reaction is carried out under conditions of pH 7 to 12, preferably pH 8 to 10.

The reaction temperature is not particularly limited, but is usually 2
The temperature is 0 to 90 ° C, preferably 20 to 60 ° C.

The soluble aluminum compound used herein includes, for example, aluminates such as sodium aluminate and potassium aluminate, aluminum chloride, aluminum nitrate, aluminum sulfate, potassium aluminum sulfate, aluminum bromide, sodium aluminum sulfate, and sulfuric acid. Aluminum ammonium or the like is used.

As the alkali, sodium hydroxide, potassium hydroxide or an aluminate such as sodium aluminate or potassium aluminate is used.

As the carbonate ion supplying compound, carbonates such as sodium carbonate, potassium carbonate and lithium carbonate, bicarbonates such as potassium bicarbonate and sodium bicarbonate, and carbon dioxide are used.

As the soluble magnesium compound, magnesium chloride, magnesium sulfate, magnesium nitrate and the like are used.

Examples of the silicate compound include sodium silicate No. 3 and sodium silicate (Na ₂ O / SiO _2).
= 0.25 to 0.5) or an alkali silicate such as potassium silicate.

The composite obtained by the production method of the present invention can be obtained as a white amorphous powder by filtering, washing and drying the reaction product according to a conventional method. If desired, this composite may be further pulverized and sieved with a suitable mesh sieve. Alternatively, the reaction product is filtered,
After washing, a slurry is obtained, and the slurry is subjected to a conventional method.
By spray drying, an amorphous powder can be obtained. When mixing the slurry, a stirring treatment and a colloid mill treatment may be performed for better mixing. The slurry concentration is not particularly limited as long as it can be spray-dried, and is usually preferably about 10 to 30%.
Although there is no particular limitation on the drying method, a method capable of instantaneous drying such as spray drying is desirable from the viewpoint of stability.

The composite of the present invention is useful as an antacid.

The composite of the present invention has a high reactivity and a neutralizing ability, a high stability against aging, a high abuse resistance, a high antacid power of at least 200 or more, and a good preservability and workability. is there. The stability of the antacid of the present invention containing this composite as an active ingredient can be understood from the fact that the acid of this composite acid after leaving it for 1 hour under saturated steam at 100 ° C. is 70 or more before leaving it.

A feature of the composite of the present invention is that the composite of the present invention is an amorphous powder, as shown in the X-ray diffraction spectrum described later. That is, since the system of the aluminum hydroxide gel and the magnesium aluminate silicate is uniformly dispersed, the hydrolysis and crystallization of the Al ₂ O ₃ component over time is prevented, thereby contributing to stabilization, and It is assumed that the neutralization reaction does not delay.

The antacid of the present invention contains the composite of the present invention as an active ingredient. With such an antacid, the pH of the stomach acid can be quickly neutralized to about 3, and even in a severe aging test, a stable value of 200 ml / g or more, which sufficiently functions as an antacid, can be obtained. Good thing.

The antacid can be appropriately selected from various dosage forms, for example, powders, granules, fine granules, tablets, suspensions, syrups, etc. according to the purpose of use. In addition, if necessary, general compounding components of pharmaceuticals such as diluents, excipients, disintegrants, and lubricants, other active ingredients, and other antacids can be added. The composite of the present invention itself can be used as a pharmaceutical excipient or additive. Moreover,
Utilizing the property of being stable and amorphous, it can also be used as various adsorbents.

The present invention is described in more detail in the following examples.

[0023]

EXAMPLE 1 Aluminum sulfate solution (Al ₂ O ₃ : 7.1%) 236.7
g to water to make a total volume of 250 mL, and add this to (1-A)
Liquid. Sodium carbonate 1 containing 99.5% by weight
7.5 g of a 50% by weight sodium hydroxide solution 10
g and water to make a total volume of 100 mL, which is referred to as solution (1-B). Magnesium chloride hexahydrate (Mg
O: 19.8%) and 16.8 g, aluminum sulfate solution (Al ₂ O _3: a 100mL by adding water to a mixture of 7.1%) 29.6 g, to do this with the (1-C) solution . 33.5 g of sodium aluminate (Al ₂ O ₃ : 18.8%)
Was added to water to make 100 mL, and this was used as solution (1-D). No. 3 sodium silicate (SiO ₂ : 29.0%) 1
Water was added to 7.1 g to make 100 mL, and this was added to (1-
E) The solution is used.

100 mL of water was placed in a 1 L reaction vessel,
° C, and the solution (1-A) was added at 25 mL /
And (1-B) solution were added simultaneously at a rate of 10 mL / min. At the time of addition, 4 m
The pH was adjusted with a sodium hydroxide solution having an ol / L concentration. 10 mL / min of (1-C) solution was added to the obtained gel, and (1-D)
The solution was added simultaneously at a rate of 10 mL / min.
The pH was adjusted with a 4 mol / L sodium hydroxide solution so that H maintained 8 to 10. Next, E liquid was added for 10m.
It was added at a rate of L / min.

The reaction solution obtained by the above reaction was filtered by Nutsche and washed. After drying at 90 ° C. for 20 hours, the mixture was pulverized in a mortar and sieved with a 100 mesh sieve. When the obtained white powder was analyzed using a powder X-ray diffractometer, it was confirmed that the powder was an amorphous powder. In addition, chemical analysis showed that (Al ₂ O ₃ ) _2.00 · [Al ₂ O ₃ · MgO · (SiO ₂ )
_0.96 ] · 11.3H ₂ O.

Example 2 Sodium aluminate (Al ₂ O ₃ : 18.8%)
Water was added to 5 g to make 200 mL, and this was used as solution (2-A). No. 3 sodium silicate (SiO ₂ : 29.0)
%) 25.7 g of water was added to make 100 mL, and this was designated as solution (2-B). Magnesium chloride hexahydrate (Mg
(O: 19.8%) Water was added to 16.8 g to make 100 mL, and this was used as solution (2-C). Water was added to 266.3 g of an aluminum sulfate solution (Al ₂ O ₃ : 7.1%) to obtain 30
0 mL, and use this as solution (2-D). Water is added to a mixture of 20.0 g of sodium carbonate containing 99.5% by weight and 11 g of a sodium hydroxide solution having a concentration of 50% by weight to make the total volume 100 mL, and this is referred to as a solution (2-E).

Solution A was placed in a 1 L reaction vessel, heated to 40 ° C., and with stirring, solution B was added at a rate of 10 mL / min, and then solution C was added at a rate of 10 mL / min. Solution D and solution E were simultaneously added to the obtained gel at a rate of 30 mL / min and a solution E at a rate of 10 mL / min. At the time of addition, the pH was adjusted with a 4 mol / L sodium hydroxide solution so that the reaction pH was maintained at 8 to 10. It was adjusted.

The reaction solution obtained by the above reaction was filtered by Nutsche and washed. After drying at 90 ° C. for 20 hours, the mixture was pulverized in a mortar and sieved with a 100 mesh sieve. When the obtained white powder was analyzed using a powder X-ray diffractometer, it was confirmed that the powder was an amorphous powder. Chemical analysis showed that (Al ₂ O ₃ ) _1.96. [Al ₂ O ₃ .MgO. (SiO ₂ )
_1.48 ] .12.5 H ₂ O.

Example 3 Aluminum sulfate solution (Al ₂ O ₃ : 7.1%) 473.4
g to water to make a total volume of 500 mL.
Liquid. Sodium carbonate 3 containing 99.5% by weight
5.0 g of a 50% by weight sodium hydroxide solution 20
g and water to make a total volume of 200 mL, which is referred to as solution (3-B). Magnesium chloride hexahydrate (Mg
Water is added to a mixture of 16.8 g of O (19.8%) and 29.6 g of aluminum sulfate liquid (Al ₂ O ₃ : 7.1%) to make 100 mL, which is referred to as liquid (3-C). . 33.5 g of sodium aluminate (Al ₂ O ₃ : 18.8%)
To 100 mL by adding water thereto, and use this as solution (3-D). No. 3 sodium silicate (SiO ₂ : 29.0%)
Water was added to 8.6 g to make 50 mL, and this was added to (3-E)
Liquid.

400 mL of water was placed in a 2 L reaction vessel,
° C, and with stirring, the solution (3-A) was added at 25 mL /
And the solution (3-B) were added simultaneously at a rate of 10 mL / min. At the time of addition, 4 m
The pH was adjusted with a sodium hydroxide solution having an ol / L concentration. 10 mL / min of (3-C) solution was added to the obtained gel, and (3-D)
The solution was added simultaneously at a rate of 10 mL / min and the solution E at a rate of 5 mL / min.
The pH was adjusted with a sodium hydroxide solution having an ol / L concentration.

The reaction solution obtained by the above reaction was filtered by Nutsche and washed. After drying at 90 ° C. for 20 hours, the mixture was pulverized in a mortar and sieved with a 100 mesh sieve. When the obtained white powder was subjected to chemical analysis, it was found that (Al ₂ O ₃ ) _4.05 · [Al ₂ O ₃ · MgO · (SiO ₂ )
_0.51 ] · 17.4H ₂ O. Further, when the powder was analyzed using a powder X-ray diffractometer, the powder was amorphous as in Examples 1 and 2.

Example 4 Sodium aluminate (A
(l ₂ O ₃ : 18.8%)
L and this is designated as solution A. No. 3 sodium silicate (S
(IO ₂ : 29.0%) water was added to 25.7 g and 100 m
L and this is B liquid. Water was added to 16.8 g of magnesium chloride hexahydrate (MgO: 19.8%) and 100
mL, and use this as solution C. Aluminum sulfate liquid (A
(1 ₂ O ₃ : 7.1%)
And this is designated as solution D. Water was added to a mixture of 50.0 g of sodium carbonate containing 99.5% by weight and 29.5 g of sodium hydroxide solution having a concentration of 50% by weight, and water was added to make a total amount of 25%.
Make 0 mL, and use this as solution E.

Solution A was placed in a 2 L reaction vessel, heated to 40 ° C., and with stirring, solution B was added at a rate of 10 mL / min, and then solution C was added at a rate of 10 mL / min. Solution D and solution E were simultaneously added to the obtained gel at a rate of 56 mL / min and a solution E at a rate of 20 mL / min. At the time of addition, the pH was adjusted with a 4 mol / L sodium hydroxide solution so that the reaction pH was maintained at 8 to 10. It was adjusted.

The reaction solution obtained by the above reaction was filtered by Nutsche and washed. After drying at 90 ° C. for 20 hours, the mixture was pulverized in a mortar and sieved with a 100 mesh sieve. When the obtained white powder was subjected to chemical analysis, (Al ₂ O ₃ ) _5.37 · [Al ₂ O ₃ · MgO · (SiO ₂ )
_1.50 ] · 28.0 H ₂ O. Further, the powder was analyzed using a powder X-ray diffractometer, and was found to be amorphous as in Examples 1 and 2.

Comparative Example 1 46.2 g of aluminum hydroxide (Al ₂ O ₃ : 65%)
Magnesium hydroxide (MgO: 69.1%) 14.5g
And 10 g of silica gel (SiO ₂ : 99.9%) (Al ₂
The molar ratio of O ₃ , MgO and SiO ₂ = 3: 1: 1) was powder mixed using a ball mill for 30 minutes. When the obtained white powder was analyzed using a powder X-ray diffractometer, peaks of aluminum hydroxide and magnesium hydroxide were confirmed.

Comparative Example 2 46.2 g of aluminum hydroxide (Al ₂ O ₃ : 65%)
Magnesium hydroxide (MgO: 69.1%) 14.5g
And 10 g of silica gel (SiO ₂ : 99.9%) (Al ₂
Water was added to the molar ratio of O ₃ , MgO and SiO ₂ = 3: 1: 1) to make a total volume of 1 L, which was placed in a 1 L autoclave,
Hydrothermal reaction was performed at 120 ° C. for 3 hours. The reaction solution obtained by the above reaction was filtered through Nutsche and washed. 2 at 90 ° C
After drying for 0 hour, the mixture was pulverized in a mortar and sieved with a 100 mesh sieve. From the powder X-ray diffraction spectrum of the obtained white powder, peaks of aluminum hydroxide and magnesium hydroxide were confirmed. In addition, the chemical analysis showed that (Al
₂ O ₃ ) _3.07・ MgO ・ (SiO ₂ ) _1.01・ 11.1H ₂ O
The composition was as follows.

Comparative Example 3 Magnesium aluminate silicate (Al_TwoO_Three: 26.3
%, MgO: 10.3%, SiO_Two: 27.2%) 1
0.0g and dried aluminum hydroxide gel (Al_TwoO _Three:
52.0%) 10.0 g (Al_TwoO_Three, MgO and SiO
_TwoOf 3: 1: 1.77) into a plastic bag.
The powder was mixed by the method for 3 minutes. The obtained white mixture was powder X
When analyzed using a line diffraction device, it was found to be an amorphous powder.
It was confirmed that. In addition, this mixture is X
X-ray analysis confirmed a pseudo-boehmite peak.

Antacidity test: Using the powders obtained in Examples 1 to 4 and Comparative Examples 1 to 3, the antacidity was measured in accordance with the antacidity test method of the Japanese Pharmacopoeia. Further, the sample was allowed to stand at 100 ° C. under a saturated steam pressure for 1 hour, and its antacidity was also measured. Table 1 shows the results of the antacid testing of the examples and comparative examples.

(1) Acid neutralization ability test 0.2 g of each sample was precisely weighed and placed in a stoppered flask.
Add exactly 100 mL of 0.1N hydrochloric acid, stopper tightly,
After shaking at 2 ° C. for 1 hour, the mixture is filtered. Accurately measure 50 mL of the filtrate, and titrate the excess hydrochloric acid with a 0.1 N sodium hydroxide solution while stirring well until the pH becomes 3.5. The amount of 0.1N hydrochloric acid consumed in the sample is determined from the titer of the 0.1N sodium hydroxide solution. The amount of 0.1N hydrochloric acid consumed per gram of the sample is defined as the acid neutralizing ability.

[0040]

[Table 1]

The "abuse test" in the above table is based on the antacidity (0.1N HClm
L / g).

The antacid retention ability (%) in the formula was determined by the following formula. Antacid retention ability (%) = (antacidity after standing at 100 ° C./saturated steam pressure / acidity) × 100

Test Examples 1-2 An X-ray diffraction spectrum after an abuse test using the aluminum oxide-magnesium silicate composite obtained by the production method of Examples 1 and 2 is shown in FIG.

Test Example 3 X after the abuse test using the powder obtained by the production method of Comparative Example 3
The line diffraction spectrum is shown in FIG.

From the results shown in Table 1 above, Examples 1 to 5 of the present invention are shown.
The aluminum oxide of the present invention obtained by the production method of Example 4
The magnesium silicate aluminate composite has, for example, much better antacidity than the powders of Comparative Examples 1 and 2. In addition, the abuse test, for example, the antacidity (0.1 N-HCl mL / g) after standing at 100 ° C. saturated steam pressure is remarkably excellent. Further, from the results of Comparative Example 3, it can be seen that the mere mixture does not provide the stability as in the composite of the present invention. Specifically, the antacidity of the powder obtained in Comparative Example 3 is the same as that of the magnesium aluminate silicate composite of the present invention, but the antacidity (0.1 N-HCl mL / G), and the antacid power are remarkably reduced, and it can be seen that the mere mixture does not provide the stability as in the composite of the present invention.

[0046]

According to the present invention, a novel aluminum oxide
The present invention provides a magnesium silicate magnesium aluminate composite, a method for producing the same, and an antacid. More specifically, according to the present invention, A
A composite in which l ₂ O ₃ hydrate is complexed with a similar component such as magnesium aluminate, a method for producing the same, and an acid-reactive and neutralizing agent containing the composite as an active ingredient, which has high acidity and antacid. Provides antacids that are more stable, more stable, more abusive, and have better storage and workability without the aging phenomena that are the disadvantages of conventional aluminum hydroxide due to their compounding. We were able to.

[Brief description of the drawings]

FIG. 1 is an X-ray diffraction spectrum of an aluminum oxide / magnesium aluminate silicate composite obtained by the production method of Examples 1 and 2, and a powder obtained by the production method of Comparative Examples 1 to 3.

FIG. 2 is an X-ray diffraction spectrum diagram after an abuse test using the aluminum oxide / magnesium aluminate silicate composite obtained by the production method of Examples 1 and 2 in Test Examples 1 and 2, and Test Example 3 is FIG. 9 is an X-ray diffraction spectrum after an abuse test using the powder obtained by the production method of Comparative Example 3.

Claims (8)

[Claims] 1. Formula (I) (Al ₂ O ₃ ) _x. [Al ₂ O ₃ .MgO. (SiO ₂ ) _y ] .mH ₂ O (I) (where m is 2 ≦ m ≦ 70) A number in the range, x is 0.5
X represents a number in the range of x <9, and y represents a number in the range of 0.5 ≦ y ≦ 2. The aluminum oxide / magnesium silicate aluminate composite represented by). 2. The composite according to claim 1, wherein the diffraction pattern in the powder X-ray diffraction is an amorphous powder. 3. The method according to claim 1, wherein the initial antacid degree is 200 or more,
The composite according to claim 1 or 2, wherein the antacid strength after leaving for 1 hour under saturated steam of 00C is 70% or more of that before leaving. 4. A soluble aluminum compound, a soluble magnesium compound and a silicate compound are reacted with a soluble aluminum compound, an alkali and / or a carbonate ion-supplying compound under conditions of pH 7 to 12 to obtain a gel.
The reaction product obtained under the conditions of H7 to H12 is obtained, and the obtained reaction product is filtered, washed and dried.
A method for producing a composite according to any one of claims 1 to 3. 5. A silicate compound is added to a soluble aluminum compound, and then a soluble magnesium compound is added. The resulting gel is mixed with a soluble aluminum compound and an alkali and / or carbonate ion-supplying compound at a pH of 7 to 12. 4. The method according to claim 1, wherein the reaction product is filtered, washed, and dried. 6. An antacid containing the compound according to claim 1 as an active ingredient. 7. An excipient containing the composite according to claim 1 as an active ingredient. 8. An adsorbent containing the composite according to claim 1 as an active ingredient.