JP2000065817A - Testing reagent base material and manufacture thereof - Google Patents

Abstract

PROBLEM TO BE SOLVED: To automatically manufacture a testing reagent base material generating no chlorine gas or nitrogen oxide in a burning process by sticking a reagent adhesive on the upper face of a synthetic paper supporting material made of polypropylene resin mainly and sticking separate paper on the upper face of the reagent adhesive. SOLUTION: A testing reagent base material 1 is constructed of a synthetic paper supporting material 2 mainly formed of polypropylene resin, an reagent adhesive 3 stuck onto the upper face of the supporting material 2, and separate paper 4 stuck to the reagent adhesive 3. The synthetic paper supporting material 2 with a thickness of about 150-500 μm is used. The reagent adhesive 3 is an acrylic adhesive with a thickness of about 100-150 μm, and its upper and lower faces are clamped by means of the separate paper 4 like a double-sided adhesive tape. The separate paper 4 stuck on the upper face side of the reagent adhesive 3 is divided into a plurality of pieces by means of a plurality of slits 4a formed in its longitudinal direction, so that the respective divided separate paper pieces can be peeled off separately.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a substrate for a test reagent and a method for producing the same.

[0002]

2. Description of the Related Art In general, samples derived from living organisms such as blood, saliva, sweat, semen, vaginal secretions, urine, feces, and foodstuffs,
In the analysis of water quality, air, soil, and the like, the presence or absence and the amount of various parameters contained therein are inspected. For example, in a medical setting,
Rapid and simple examination of the presence or absence of human hemoglobin in feces is indispensable for early detection of colorectal cancer and the like. At the time of such an inspection, an inspection reagent in which a reagent layer for sample inspection is provided on a support material is employed.

[0003] Specifically, a plastic test reagent case having one or a plurality of recesses capable of accommodating a test reagent is prepared, and the test reagent is placed in the test reagent case. The test sample is applied by dropping, and the presence or absence of each main component contained in the test sample and its amount are determined based on the presence or absence of lines, the number, color tone, color change, etc. that appear in the reagent layer after a certain period of time. Things.

[0004]

In a medical site such as a hospital or a laboratory, a test reagent used for a test is contaminated with a biological sample applied dropwise. The contaminated test reagent is collected by a designated trader as specially managed general waste specified by the Waste Management Law, and then incinerated or directly incinerated at a hospital or the like. However, since the support material of the test reagent is formed of plastic or paper, when incinerated, chlorine-based gas or nitrogen oxide may be generated depending on the type of plastic.

The present invention has been made in view of the above problems, and an object of the present invention is to provide a base material for a test reagent which does not generate a chlorine-based gas or a nitrogen oxide when incinerated.

Further, the present invention relates to a method of manufacturing a test reagent base capable of automatically manufacturing a test reagent base that does not generate chlorine-based gas or nitrogen oxides when incinerated. To provide.

[0007]

Means for Solving the Problems The invention according to claim 1 of the present invention provides a synthetic paper support material mainly composed of a polypropylene resin, a medicinal adhesive adhered to the upper surface of the support material,
And release paper adhered to the upper surface of the medicinal adhesive.

According to this invention, since the synthetic paper mainly composed of a polypropylene resin composed of carbon and hydrogen is employed as the support material constituting the base material for the test reagent, the incineration treatment is performed after the test is completed. However, it becomes carbon dioxide gas and water, and does not generate chlorine-based gas or nitrogen oxides.

According to the first aspect of the present invention, the release paper is
When one or more slits are formed, the release paper can be divided into a plurality of pieces, and the desired reagent is applied only to the medicated adhesive that has been peeled off and released from the required release paper. A reagent layer can be formed. As a result,
It is possible to form a target reagent layer for each set range of the support material. At this time, the area other than the area where the reagent is applied is masked by the release paper that has not been peeled off, or by the previously applied reagent, so that the target reagent layer can be reliably formed within the set range. .

Further, according to the present invention, one release paper of a medicinal adhesive whose both surfaces are covered with release paper is peeled off and exposed on the upper surface of a synthetic paper support material made mainly of polypropylene resin. After attaching the medicated adhesive, the release paper, the medicinal adhesive and the support material laminated in order from the top are punched into a set shape, and the laminated release paper, the medicinal adhesive and the support material are integrally formed. When the roll is pulled out and wound up, the release paper, the medicinal adhesive and the support material punched and laminated in a set shape are separated as a base material for a test reagent.

According to the present invention, it is possible to automatically produce a base material for a test reagent which does not generate chlorine-based gas or nitrogen oxides when incinerated.

Further, according to the present invention, one release paper of a medicinal adhesive whose both surfaces are coated with release paper is peeled off and exposed on the upper surface of a synthetic paper support material mainly made of polypropylene resin. After adhering the medicated pressure-sensitive adhesive, one or more slits are formed in the release paper, and the release paper, the medicinal pressure-sensitive adhesive and the support material laminated in order from the top are punched into a set shape. When pulling out and winding the laminated release paper, medicated adhesive and the support material together, it is necessary to separate the release paper, medicated adhesive and the support material that have been punched out into a set shape as a test reagent base material. It is a feature.

According to the present invention, a substrate for a test reagent which can form a plurality of reagent layers without generating chlorine-based gas or nitrogen oxides when incinerated is automatically manufactured. be able to.

[0014]

Embodiments of the present invention will be described below with reference to the drawings.

FIG. 1 shows an embodiment of the test reagent substrate 1 of the present invention. The test reagent substrate 1 includes a synthetic paper support 2 mainly composed of a polypropylene resin,
The medical adhesive 3 is adhered to the upper surface of the support material 2, and the release paper 4 is adhered to the medical adhesive 3. In this embodiment, length 300 mm × width 1
Although the case where it is formed in a rectangular shape of 00 mm is illustrated, the shape is not limited to a square, and it can be formed in an arbitrary shape such as a circular shape.

The base material 2 is a synthetic paper mainly made of a polypropylene resin and has a thickness of 150 to 500 μm. This synthetic paper is formed by adding an additive to a polypropylene resin, granulating the pellet into a pellet shape by a granulator, feeding the polypropylene resin pellet to an extruder, extruding through a die from the extruder, and forming a sheet shape. After laminating a surface layer on each of the upper and lower surfaces of the base layer stretched in the longitudinal direction, the base layer and the surface layer are stretched in the horizontal direction.

This synthetic paper has excellent water resistance,
Its tear resistance to tension, bending, impact, etc. greatly exceeds the level of paper, and is resistant to acids, alkalis, organic solvents, oils, etc., and has a very smooth surface with a very uniform surface. are doing.

The medical adhesive 3 has a thickness of 100 to 150 μm.
And is provided in a state where upper and lower surfaces are sandwiched by release papers 4 and 4 like a double-sided tape. The medicated adhesive 3 is commercially available, for example, from Adhesive Research Co. under the trade name AS-110.

A plurality of slits 4a are formed in the release paper 4 stuck on the upper surface side of the medicated adhesive 3, and the release paper 4 is divided into a plurality of slits by the slits 4a. Then, the release paper 4 can be separated for each divided release paper 4. That is, although not shown in detail, by peeling off any divided release paper 4, only the medicated adhesive 3 in a range corresponding to the released release paper 4 can be exposed. A reagent layer can be formed by applying a target reagent to the medicated adhesive 3.
The number of slits 4a formed in the release paper 4 and their intervals are arbitrarily set according to the purpose of the test reagent.

Next, an apparatus 10 for producing the test reagent substrate 1 will be described with reference to FIG. This manufacturing apparatus 10
Are a reel 11 of a roll-shaped support material 2, a reel 12 of a roll-shaped medicinal adhesive 2 having release papers 4 and 4 adhered to both sides, and a release paper 4 on the lower surface side of the medicinal adhesive 4. A take-up reel 13, a release paper 4, a pressure-sensitive adhesive 3, and a support material 2, which are sequentially stacked from the top, a knife cutter 14 for forming the slit 4 a in the release paper 4, and a release paper 4 , Adhesive 3 and support 2
Device 15 that punches the release paper 4, adhesive 3 and support material 2 that have been stacked, and pulls out the laminate, release paper 4, adhesive 3 and support material 2 that have been punched and have the set shape That is, the feeding device 16 is configured to separate the test reagent base material 1 and the winding device 17 that winds the release paper 4, the adhesive 3, and the support material 2 of the punched trace having the set shape punched out. I have.

The knife cutter 14 has a plurality of disc-shaped cutters 141 provided on a rotating shaft, and is driven by a motor (not shown) connected to the rotating shaft.
The slit 41 is formed in the release paper 4 by rotating the 41. Although not shown in detail, the knife cutter 14 can be vertically moved up and down so as to adjust the cutting depth with respect to the release paper 4, and can be appropriately attached to the rotating shaft corresponding to the position where the slit 4 a is formed with respect to the release paper 4. An arbitrary number of disk-shaped cutters 14 can be positioned and correspond to the number of slits 4a with respect to the release paper 4.
1 can be mounted on a rotating shaft.

The punching device 15 is provided with a processing die 151.
And a crank device 152 for raising and lowering the processing die 151
The release paper 4, the adhesive 3 and the support material 2 laminated by the height of the blade formed on the processing die 151 and the elevating stroke of the crank device 152 are punched into a set shape.

Further, each of the winding devices 13, 17 and the feeding device 16 has a motor (not shown), and operates in synchronization with each other. That is, the above-described punching device 15 operates to operate the processing die 15.
When 1 is lowered, the winding devices 13, 17 and the feed device 16 are stopped, while when the processing die 151 is raised,
The feeder 16 is operated to pull out the laminated release paper 4, the medicated adhesive 3, and the support material 2 by a set length, and the winding devices 13, 17 are also operated, respectively, so that the release paper 4 on the lower surface side and the set shape are changed. The release paper 4, the medicated adhesive 3, and the support material 2 of the punched traces are wound up by the same length.

The feeding device 16 includes a belt conveyor made up of a belt 162 wound between a pair of rotating rollers 161 and 161, the release paper 4 laminated almost in contact with the belt 162 of the belt conveyor, The belt 162 is formed with a number of small holes (not shown). A suction unit 164 is provided between the pair of rotating rollers 161 and 161 and connected to a vacuum source (not shown) such as a blower. Therefore, when the suction unit 164 is suctioned by a vacuum source (not shown), a negative pressure is applied to the release paper 4, the medicinal adhesive 3, and the support material 2 stacked through the small holes formed in the belt 162, and the suction is applied to the belt 162. Can be done.

Next, the manufacturing apparatus 10 configured as described above
The process of manufacturing the test reagent base material 1 using will be described.

First, the support material 2 and both sides are release papers 4, 4
After the rolls of the medicated pressure-sensitive adhesive 3 sandwiched between the reels 11 and 12 are respectively mounted on the reels 11 and 12, the release paper 4 on the lower surface side is peeled off and the leading end thereof is fixed to the take-up reel 13. Further, the leading end of the supporting member 2 is pulled out and positioned on the center line, and the deviation in the left-right direction with respect to the feeding direction is regulated by a regulating roller (not shown). Then, the medicated pressure-sensitive adhesive 3 stuck to the upper-side release paper 4 is placed on the support material 2 and stuck to each other, and then passed through the punch device 15 to the feeding device 16 and sandwiched. As described above, the release paper 4, the medicinal adhesive 3, and the support material 2 are attached and integrated from the top in this order, and then the feed device 16 is operated to pull out the same length. Then, when the release paper 4, the medical adhesive 3, and the support material 2 adhered together are pulled out by the feeding device 16, the release paper 4, the medical adhesive 3, and the support material 2 having the set shape punched out are removed. The end is fixed to the winding device 17 and wound.

Here, when the knife cutter 14 is operated, a slit 4a is formed in the release paper 4 by the disk-shaped knife 141 along the longitudinal direction thereof. Further, when the punching device 15 is operated, the processing die 151 moves up and down by the stroke through the crank device 152, and punches the release paper 4, the medical adhesive 3, and the support material 2 adhered together into a set shape. . When the punching operation by the punching device 15 is completed, the release paper 4, the medicated adhesive 3, and the support material 2 that have been stacked via the feeding device 16 are pulled out, and the winding device 17 is used.
Rewind through. At this time, in the feeder 16, the release paper 4, the medicated adhesive 3, and the support 2, that is, the test reagent substrate 1, which have been punched out and have a set shape, are stamped.
Negative pressure is applied through the suction portion 164 and the small holes of the belt 162, and the suction portion 164 is attracted to and separated from the belt 162.
On the other hand, the release paper 4, the medicated adhesive 3, and the support material 2, on which the set shape has been punched out, are stacked on the winding device 1.
7

On the other hand, the release paper 4, the medical adhesive 3, and the support 2, which are separated in the set shape, are separated by the suction section 164.
, The negative pressure is no longer applied, so that the substrate is released as the test reagent substrate 1.

The substrate 1 for a test reagent produced in this way
Is supplied to the test reagent maker,
The divided release papers 4 are sequentially peeled off, and a target reagent is sequentially applied to the exposed medical adhesive 3 to form a reagent layer. In this case, when the separated release paper 4 is peeled off to expose the corresponding medicinal adhesive 3 and a target reagent is applied, except for the exposed medicinal adhesive 3, the release paper 4 stuck except for the exposed medicinal adhesive 3, The mask is masked by the previously applied reagent. Therefore, the target reagent can be applied only to the medicated adhesive 3 exposed by peeling off the divided release paper 4.

When the test reagent is manufactured, the tape-shaped test reagent having a plurality of target reagent layers can be formed by cutting at predetermined intervals in the longitudinal direction.

In this embodiment, the test reagent substrate 1 for producing a test reagent having a plurality of reagent layers has been described. Then, the substrate 4 may be peeled off, and the slit 4a, that is, the knife cutter 14 becomes unnecessary.

Further, in the above-described embodiment, the case where the rectangular test reagent base material 1 is manufactured corresponding to the manufacture of the tape-shaped test reagent has been described. In the case of manufacturing the base material 1 for use, it may be punched into a circular shape or various shapes. When manufacturing such a base material 1 for a test reagent, a processing die having a blade for punching into a circular shape or various shapes may be prepared. In the case where a plurality of reagent layers are formed in producing the test reagent substrate 1 having a circular shape or various shapes, one or more concentric slits or one or more concentric slits may be formed. A book slit may be formed. In this case, the knife cutter 14 is not required, and the release paper 4 has a blade capable of forming a concentric slit or a slit similar to various shapes, and has a blade for punching into a circular shape or various shapes. Prepare a processing die or prepare another processing die with a blade that can form concentric slits or slits similar to various shapes, and a blade for punching into a circular shape or various shapes. It is sufficient to prepare a processing die having the same, form a concentric slit or a slit similar to various shapes by using two punching devices, and punch a circular or various shape.

By the way, the test reagent manufactured by the test reagent maker is delivered to a hospital or a testing institution and used for various tests. Here, the test reagent that has been tested at a hospital or the like is contaminated with a biological sample,
Collected as specially managed municipal waste by designated contractors and then incinerated or directly incinerated in hospitals. At this time, the support material 2 constituting the test reagent base material 1 is
Since it is made of synthetic paper mainly composed of a polypropylene resin composed of carbon and hydrogen, it becomes carbon dioxide and water when incinerated, and does not generate chlorine-based gas or nitrogen oxide.

[0034]

As described above, according to the first aspect of the present invention, the support material constituting the base material for the test reagent is formed of synthetic paper mainly composed of a polypropylene resin composed of carbon and hydrogen. Thus, even if the incineration treatment is performed after the inspection is completed, carbon dioxide and water are formed, and no chlorine-based gas or nitrogen oxide is generated.

According to the third or fourth aspect of the present invention, it is possible to automatically manufacture a base material for a test reagent which does not generate chlorine-based gas or nitrogen oxide when incinerated. it can.

[Brief description of the drawings]

FIG. 1 is an exploded perspective view showing one embodiment of a test reagent base material of the present invention.

FIG. 2 is an explanatory view showing an outline of an apparatus for producing a substrate for a test reagent in FIG. 1;

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Test reagent base material 2 Synthetic paper support material 3 Medical adhesive 4 Release paper 4a Slit 10 Manufacturing device 11,12 Feeding reel 14 Knife cutter 15 Punch device 13,17 Winding device 16 Feeding device

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 2G042 AA01 CA01 CA10 CB01 CB03 DA08 FB07 FC01 FC08 2G045 AA13 AA16 CA25 CB03 FB11 FB15 FB17 GC12 HA10 HA14 HA20 JA07 4F100 AK07A BA02 CA12B CB05B DG10A E912

Claims (4)

[Claims] 1. A synthetic paper support material mainly composed of a polypropylene resin, a medicinal adhesive adhered to an upper surface of the support material, and a release paper adhered to an upper surface of the medicinal adhesive. A base material for test reagents, characterized in that: 2. The test reagent substrate according to claim 1, wherein one or more slits are formed in the release paper. 3. A medicated pressure-sensitive adhesive, which is obtained by peeling one of the release papers of a medical pressure-sensitive adhesive whose both surfaces are covered with release paper, is adhered to the upper surface of a synthetic paper support material mainly composed of a polypropylene resin. After that, the release paper, the medicinal adhesive and the support material laminated in order from the top are punched into a set shape, and when the laminated release paper, the medicinal adhesive and the support material are integrally pulled out and wound, the set shape is obtained. A method for producing a base material for test reagents, comprising separating a release paper, a medicinal adhesive and a support material, which have been punched out and laminated, into a base material for test reagents. 4. A medicated pressure-sensitive adhesive whose one surface is exfoliated by exfoliating one release paper of a medicated pressure-sensitive adhesive whose both surfaces are covered with release paper, is adhered to an upper surface of a synthetic paper support material mainly composed of a polypropylene resin. After that, one or more slits are formed in the release paper, and the release paper, the medicinal adhesive and the support material laminated in order from the top are punched into a set shape, and the laminated release paper and the medicinal adhesive are laminated. A base material for a test reagent, wherein a release paper, a medicinal adhesive and a support material punched out and laminated in a set shape are separated as a base material for a test reagent when the agent and the support material are integrally pulled out and wound up Manufacturing method.