JP2000026301A - Therapeutic agent for dermatosis - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject therapeutic agent capable of checking pruritus, moderating the keratinizing tendency of a horny layer, suppressing the propagation of bacteria and fungi and manifesting effects on atopic dermatitis without any adverse effects by including several ingredients having pharmacodynamic effects and converting the resultant agent into an ointment. SOLUTION: This therapeutic agent for dermatosis is obtained by including (A) acetylcholine chloride, (B) caffeine and sodium benzoate, (C) oxytetracycline hydrochloride and (D) trichomycin and converting the resultant agent into an ointment. The amounts of the formulated respective ingredients are preferably 25 g of the ingredient A, 25 g of the ingredient B, 1,000 mg of the ingredient C and 500,000 units of the ingredient D. Furthermore, (E) 250 mg of chloramphenicol is preferred. The ingredient A is capable of removing pruritus of skin and the ingredient B is capable of softening a horny layer of the skin and facilitating the peeling of the horny layer. The ingredient C is effective against staphylococci, streptococci, Escherichia coli, or the like, and the ingredient D is effective against fungi. The ingredient E is effective against the staphylococci, Escherichia coli, or the like. Atopic dermatitis is effectively treated by pharmacodynamic effects of the formulated respective ingredients.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a therapeutic agent for skin diseases,
In particular, the present invention relates to a drug for treating a skin disease which is applied to a portion having a skin disease such as atopic dermatitis and is effective against bacteria and fungi, the horny layer of an affected part is easily peeled off, and the drug is easily infiltrated.

[0002]

2. Description of the Related Art In recent years, in particular, the number of children having an atopic constitution has been increasing, and at the same time, even after puberty, it is often difficult to heal. It is said that, although they were not so early in their childhood, they have become atopic since puberty and are more likely to cause atopic dermatitis. Steroids are commonly used in the treatment of atopic dermatitis, and these steroids are currently the most effective for atopic dermatitis and can reduce itching and inflammation. There is a disadvantage that side effects are large. Therefore, there is a need for a topical drug that does not have such side effects.

[0003]

According to Yasuaki Tokuda, a professor at Tokyo Medical University, the first feature of the atopic constitution is that the skin secretes less fat. Normal skin is protected and moisturized by the double fat film.However, in the case of atopic constitution, since the secretion of fat is small, the skin is not moistened, the protective function is reduced, the skin is easily damaged, Foreign matter is easily invaded from the surface. The second feature of atopic constitution is the tendency of the outermost stratum corneum of the skin to keratinize. For this reason, the surface and pores of the skin protrude and become rough, which makes the skin more easily damaged. The third characteristic of atopic constitution is that sweat does not go well out of the skin because the stratum corneum absorbs the sweat that has come out. The stratum corneum that originally makes up the stratum corneum has the property of absorbing water very well, but usually because of the moderate amount of fat,
Has gone out of the skin without absorbing sweat. But,
In atopic constitutions that have less fat and tend to be keratinized, the stratum corneum absorbs sweat, so that the stratum corneum swells and crushes the sweat tube. Even if there is more sweat, there is no way to get out of the sweat, so sweat can easily form there. When sweat is formed, the skin becomes blistered or itchy, causing skin injuries and foreign substances invading there. Thus, in atopic constitution,
Low secretion of fat, keratinization of the stratum corneum, and difficulty in secreting sweat create a situation in which the skin is easily damaged and foreign substances easily enter the inside of the skin from the outside. As a result, the chances of causing an allergic reaction to airborne substances such as mites and pollen are greatly increased. Therefore, the present invention supplements the lack of secretion of fat from the outside, moisturizes the skin, stops itching, and reduces the keratinization tendency of the stratum corneum. An object of the present invention is to provide a remedy for a skin disease which is effective for atopic dermatitis, while preventing a state that is easily invaded, suppressing the growth of bacteria and fungi, and causing no side effects.

[0004]

DISCLOSURE OF THE INVENTION The present invention is a remedy for skin diseases comprising an ointment containing acetylcholine chloride, sodium benzoate oxytetracycline, and tricomycin.

[0005]

The present invention is a remedy for skin diseases comprising an ointment containing 25 g of acetylcholine chloride, 25 g of sodium benzoate, 1000 mg of oxytetracycline hydrochloride, 500,000 units of tricomycin and 250 mg of chloramphenicol. However, acetylcholine chloride has the effect of removing the itch of the skin, and sodium benzoate benzoate softens the stratum corneum and makes it easier to peel off. Oxytetracycline hydrochloride is the main component of terramycin (Pfizer Pharmaceutical Co., Ltd.) injection and is effective against staphylococci, streptococci, Escherichia coli and the like. Tricomycin and chloramphenicol are antibiotics contained in Tricomycin K tablets (Fujisawa Pharmaceutical Co., Ltd.). Tricomycin is effective against fungi such as Tricomonas and Candida. Against growth. Thus, when an ointment containing these medicinal ingredients is applied to the affected area of atopic dermatitis, the ointment protects the skin epidermis and moisturizes it. Acetylcholine chloride works for itching, and itchy skin.
At the same time, sodium caffeine benzoate softens the stratum corneum, making it easier to peel off, and works to penetrate the drug and increase its effectiveness. On the other hand, this atopic dermatitis is easy for bacteria to multiply and may cause suppuration. The cause is Staphylococcus aureus, where chloramphenicol kills it. The affected area is also in a state where fungi can easily proliferate. Tricomycin acts on the affected area to sterilize it. By repeatedly applying this ointment to the affected area, the therapeutic effect of atopic dermatitis can be improved.

[0006]

Example 1 The present invention relates to a method for preparing 25 g of acetylcholine chloride,
A skin disease therapeutic agent comprising an ointment containing 25 g of sodacaffeine benzoate, 1000 mg of oxytetracycline hydrochloride, 500,000 units of tricomycin and 250 mg of chloramphenicol, wherein 25 g of acetylcholine chloride and 25 g of sodium benzoate are added. 25g and Teramycin (Pfizer Pharmaceutical Co., Ltd.) Injection 20ml
(Containing 1000 mg of oxytetracycline hydrochloride),
Tricomycin K tablets (Fujisawa Pharmaceutical Co., Ltd.) are mixed with 10 tablets (containing 500,000 units of tricomycin and 250 mg of chloramphenicol) and mixed with white petrolatum to form an ointment. In this case, the base is not limited to white petrolatum. Although the amount of the drug component shown here is not limited to this value, as a result of the experiment, the ointment having this value showed the best effect.

[0007]

The present invention is a remedy for skin diseases comprising an ointment containing 25 g of acetylcholine chloride, 25 g of sodium benzoate, 1000 mg of oxytetracycline hydrochloride, 500,000 units of tricomycin and 250 mg of chloramphenicol. Because of the medicinal properties of each of the ingredients in it, the lack of secretion of fat in the affected area is compensated from the outside, the skin is moisturized, itching is stopped, and the keratinization of the stratum corneum is eased. It prevents wounds and foreign substances from easily entering the inside of the skin from the outside, suppresses the growth of bacteria and fungi, and is very effective in atopic dermatitis. Furthermore, there is an effect that there is no side effect seen in steroid drugs.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 31/65 A61K 31/65 F-term (Reference) 4C076 AA08 BB31 CC18 CC32 DD34 DD60 FF67 4C086 AA01 CA03 CB07 DA29 MA03 MA04 MA28 MA63 ZA89 ZB13 ZB35 4C206 AA01 EA02 FA42 MA03 MA04 MA48 MA83 ZA89 ZB13 ZB35

Claims (2)

[Claims] 1. A remedy for skin diseases comprising an ointment containing acetylcholine chloride, sodium caffeine benzoate, oxytetracycline hydrochloride, and tricomycin. 2. The treatment of skin diseases according to claim 1, comprising an ointment containing 25 g of acetylcholine chloride, 25 g of sodium benzoate, 1000 mg of oxytetracycline hydrochloride, 500,000 units of tricomycin and 250 mg of chloramphenicol. medicine.