JP2000026290A - Maintenance of muscular strength with branched chain amino acid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To maintain the starting and persistent muscular strength at the time of motion by orally ingesting branched chain amino acids. SOLUTION: Branched chain amino acids containing (A) leucine, (B) isoleucine and (C) valine as active ingredients are included so as to preferably provide 1:2:1 formulation ratio of the ingredients A:B:C and orally ingested. When the branched chain amino acids are orally ingested, the daily dose thereof for an adult is about 500-2,000 mg expressed in terms of the active ingredients and ingested in divided one to several portions to thereby provide desired effects without adverse effects. The breakdown of muscles is suppressed by ingesting a branched chain amino acid formulated preparation before motion to improve the deterioration in muscular strength, muscular fatigue, central fatigue, etc. The branched chain amino acids are directly degraded and oxidized in peripheral muscular tissues to provide an energy source. Since the muscular metabolism is promoted and hydrolysis of myoproteins is suppressed, the consumption of muscles can be prevented to restore the muscles in a short time.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[Technical field to which the invention pertains] Exercise can cause severe damage to muscles, causing muscle fatigue and weakness. This damage causes muscle pain and muscle tension,
It leads to a decrease in athletic ability. If you keep this condition, you will be injured, you will be liable to lose your muscles, your hips, neck / shoulder / arm syndrome, and swelling will be difficult to continue sports. Intense athletes strengthen skeletal muscles to improve athletic performance and prevent injuries, but it is difficult to increase them simply by eating and generally consumes a large amount of protein for body building It is recommended that you However, although athletes require more protein than ordinary people, it is desirable to avoid ingesting a large amount of protein because the processing of ammonia nitrogen puts a burden on the kidneys and the like. During exercise, there is a pathway that degrades muscle proteins, converts leucine and the like to alanine, releases it into the blood, and makes it a substrate for gluconeogenesis in the liver (glucose-alanine cycle). If you exercise for a long time, the amount of muscle protein that is degraded by this pathway will become a non-negligible level, and the muscle protein you have made will be destroyed. Despite the fact that increasing muscle protein is not easy, skeletal muscle breakdown occurs easily to perform exercise. Degraded muscles undergo re-synthesis of muscle proteins as needed, but scrapping and building the same muscles is a waste of energy and is an athlete who competes at a high level. Can not maintain muscle strength. To avoid this situation, before starting exercise, use branched-chain amino acids (BC
Ingesting AA) and increasing the concentration of these amino acids in the blood significantly reduces muscle protein degradation. In the present invention, as a means of preventing the breakdown of muscle proteins, oral intake of branched-chain amino acids (BCAA) reduces muscular weakness, muscle fatigue, and central fatigue.

[0002]

2. Description of the Related Art Muscles are overworked during intense sports. Muscles are originally made up of very thin bundles of muscle fibers, and when you exercise hard, hundreds or thousands of muscle fibers can break. The broken muscle fiber is connected in about 2 hours, but at this time, amino acids that are the raw materials of muscle are needed. In particular, the essential amino acids called branched-chain amino acids (leucine, isoleucine, valine) hold an important key. The connected muscle fibers are then less likely to break, and the repetition strengthens the entire muscle. However, if the body lacks amino acids, which are the raw materials of muscles, the use of red blood cells causes a shortage of iron, causing anemia and other factors, making muscle repair impossible. An important issue in muscle fiber repair is how to deliver the necessary raw materials to muscles as quickly as possible. Current,
Many muscle supplements are sold as a sports supplement for exercise and post-exercise muscle fatigue, but there is no product that affects muscle synthesis / decomposition control, not as a material for muscle synthesis.

[0003]

The amino acids that cannot be synthesized in the body and need to be replenished from outside the body are called essential amino acids,
There are eight types: leucine, isoleucine, valine (above branched-chain amino acids), phenylalanine, tryptophan (above aromatic amino acids), methionine (sulfur-containing amino acids), lysine (basic amino acids), and threonine (amino acids having an OH group). In addition, arginine, a semi-essential amino acid that can be synthesized in the body but is insufficient,
Histidine plus 10 types are called nutritionally essential amino acids. Of these, leucine, isoleucine, and valine all have a branched structure and are therefore collectively referred to as branched-chain amino acids (BCAA). BCAAs are all essential amino acids and are metabolized mainly in muscles. They exhibit unique physiological effects such as energy production and regulation of muscle protein metabolism, so they are different from many other amino acids metabolized in the liver. Therefore, the present invention provides a branched-chain amino acid (B) containing leucine, isoleucine and valine as active ingredients.
Due to the nature of muscle protein turnover by ingesting CAA), it is important to protect the muscle once it is completed during intense exercise and to maintain the athletic ability of athletes Is the challenge.

[0004]

According to the present invention, a branched-chain amino acid containing leucine, isoleucine and valine as active ingredients accounts for about 40% of essential amino acids, and most of the other amino acids ingested are protein in the liver. Focusing on the fact that it is used for synthesis and gluconeogenesis, it has an organ specificity used mainly for muscles and other tissues other than the liver, such as the kidneys, and has been found to be useful for maintaining muscle strength during exercise. . More specifically, skeletal muscle is the largest pool of amino acids, and skeletal muscle contains large amounts of BCAAs. Alanine is produced using the amino group of BCAA of skeletal muscle and is supplied to gluconeogenesis in the liver. In addition, skeletal muscle is a major metabolic site of BCAA, and the metabolism of BCAA is enhanced by enhanced catabolism of skeletal muscle protein. Therefore, the amino group generated by transamination of BCAA binds to pyruvate generated from glucose in the course of glucose metabolism, becomes alanine, a glycogenic amino acid, is transported to the liver, and is used for gluconeogenesis. . This is called a glucose alanine cycle and plays an important role as a gluconeogenesis system by mass exchange between skeletal muscle and liver (muscle live).
r fuel cycle), and also carries the action of carrying ammonia to the liver from muscle tissues without a mechanism of urea synthesis to the liver and detoxifying it. This breakdown of muscle protein can be detected by an increase in the amount of excreted nitrogen in urine and an amount of excreted 3-methylhistidine in urine. On the other hand, the deaminated carbon skeleton of BCAA is also composed of pyruvate, acetyl-CoA, and acetoacetate (TCA).
cid) It is used for gluconeogenesis instead of cycle or a substance constituting the gluconeogenesis system. The fact that the enhancement of body protein degradation is aimed at gluconeogenesis has been proved by the fact that glucose administration suppresses it.
n sparing effectglucose
Called. Since there is almost no transaminase in the liver, it is not metabolized in the liver and undergoes catabolism mainly in peripheral muscle tissue. That is, regardless of the state of liver function, BCAA is consumed in the periphery, the blood concentration decreases, and the uptake into the periphery is promoted. It has been shown that oral intake of BCAA suppresses muscle protein degradation. In particular, leucine promotes muscle protein biosynthesis and, conversely, plays a role in regulating protein degradation. In addition to the protein-saving effect,
Release of glutamine and alanine, release of insulin from pancreas, uptake of amino acids in each tissue, and
It is involved in the metabolism of cholesterol and triglyceride in adipose tissue, and the ratio of leucine to other branched-chain amino acids (isoleucine, valine) is important for efficient protein metabolism. In the transport of neutral amino acids to the brain, BC
AA and AAA (aromatic amino acids) are neutral amino acids, which bind to common carriers and pass through the blood-brain barrier, but the uptake of neutral amino acids into the brain is c
Ompetitive, low levels of BCAA increase AAA uptake. AAA is the original neurotransmitter amine dobamine, norepinephrine,
A precursor of serotonin, this neurot in the brain
Along with a decrease in transmitter (neurotransmitter), an increase in cerebral amines (octopamine, tyramine, phenylethanolamine, phenethylamine) generated from phenylalanine and tyrosine in the brain increases. These are false neurotransmitters
Itter) inhibits the original neurotransmitter amines dopamine and norepinephrine. Such BCAA
And AAA imbalance cause brain amine abnormalities. When exercising vigorously, sufficient intake of branched-chain amino acids (BCAA) should be taken orally when muscle protein synthesis increases after exercise because BCAA and AAA imbalance causes abnormalities in brain amines. But it is important for building muscle.

[0005]

BEST MODE FOR CARRYING OUT THE INVENTION The instantaneous / endurable muscular strength maintenance agent of the present invention comprises a branched chain amino acid containing leucine / isoleucine / valine as an active ingredient, which is combined with a known food or food ingredient, a pharmaceutical carrier or an excipient. Combined by a method known per se,
It can be used as a food that maintains muscle power and endurance. The food or food ingredient to be used is not particularly limited, and can be appropriately selected by those skilled in the art according to the specific use of the intended muscle strength maintaining agent. Also, the form of the muscle strength maintaining agent is not particularly limited, and can be made into various individuals and shapes depending on the specific use. The instantaneous
In order to exert the effect of the endurance muscular strength maintenance agent, it is particularly important that the mixing ratio of the branched-chain amino acids is most significant when the ratio of isoleucine: leucine: valine is close to 1: 2: 1. It is important to commercialize in consideration of the ratio. The method of ingestion is oral ingestion, and in the case of oral ingestion of a branched-chain amino acid containing leucine, isoleucine, and valine as an active ingredient, for adults,
By taking about 500 mg to 2,000 mg as an active ingredient and ingesting it once or several times a day,
We can show desired effect without side effect.

[0006]

EXAMPLES The instantaneous / endurable muscular strength maintaining agent of the present invention was commercialized by blending 630 mg of a branched-chain amino acid in 5 tablets.
The shape was a tablet tablet. As other food ingredients, arginine, glutamic acid, sodium aspartate,
Lactose and collagen were blended. We asked the 22-year-old tennis player, a cup player, to orally ingest the muscular strength agent commercialized in this way, and ingested about 10 tablets one hour before the game and about 10 tablets immediately after the game. Ingested. I couldn't feel any muscle fatigue during the game, so I was able to fully demonstrate my ability. There was no muscle pain or muscle sting, no weakness or no muscle fatigue in the next day's game. No central fatigue was felt during the game. The result of the match was a single and double win at the European Circuit. He finished second in the Masters and achieved excellent results.

[0007]

According to the present invention, when an athlete performs intense exercise,
Muscle tissue is broken down. Ingesting a muscle-strengthening agent containing branched-chain amino acids before exercise reduces muscle breakdown and resolves problems such as muscle weakness, muscle fatigue, and central fatigue. Muscles can be maintained in the best condition the day after exercise. Branched chain amino acids (leucine, isoleucine, valine) are amino acids used as energy during exercise. Replenishing it before exercise can save carbohydrate consumption and help maintain exercise performance. Muscle fatigue during exercise is caused by a substance called lactic acid, which is produced in the muscles. The three essential amino acids, leucine, isoleucine, and valine, suppress this lactic acid production. Even during prolonged exercise, muscle fatigue and muscle weakness are less likely to occur, and exercise ability for instantaneous power and endurance is maintained. In addition, in the case of central fatigue, oral intake of BCAA increases the blood concentration of BCAA and corrects competition of neutral amino acids at the blood-brain barrier and changes in monoamines in the brain. I do not feel. Branched chain amino acids (BCAAs) are directly decomposed and oxidized in peripheral muscle tissue to become an energy source, which promotes muscle metabolism and suppresses the breakdown of muscle proteins, thus preventing muscle wasting and repairing muscles in a short time. Is possible, and athletic ability is maintained.

Claims (1)

[Claims] (1) An instantaneous and endurable maintenance of muscle strength during exercise by ingesting a branched-chain amino acid orally.