JP2000026285A - Plaster - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a plaster giving low stimulation and capable of stably keeping a liquid component in a tacky adhesive layer. SOLUTION: This plaster has a tacky adhesive layer formed on one surface of a substrate. The tacky adhesive layer is produced by compounding a tacky adhesive polymer having a weight-average molecular weight of >=2,000,000 with a liquid plasticizer and a solid plasticizer compatible with the polymer. The tacky adhesive polymer having a weight-average molecular weight of >=2,000,000 is preferably a copolymer produced by using an alkyl (meth)acrylate as a main copolymerizing component.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a patch which is applied to a skin surface to protect the skin surface, and is used for continuous administration of a drug through the skin to the body.

[0002]

2. Description of the Related Art Various patches on the skin, such as patches for protecting skin surfaces such as healthy skin and wound skin, and patches for transdermal administration of drugs through the skin into the body, etc. External preparations have been developed. Because these agents are applied on the skin surface, in addition to the ease of handling at the time of application and the ability to follow the movement of the skin surface, in addition to the suppression of irritation due to keratin damage to the skin, that is, low irritation Is required.

[0003] Among them, with respect to handling properties and low irritation to the skin, the composition of the adhesive itself is changed to appropriately reduce the skin adhesive force, or a liquid component such as water or an oil component is added to the adhesive layer. There may be mentioned a method in which a water-containing gel or oily gel is added to give a soft feeling to the pressure-sensitive adhesive layer. Further, in this method, it is known that a pressure-sensitive adhesive is cross-linked by using a cross-linking agent to give a cohesive force, and a liquid component is retained in the pressure-sensitive adhesive layer. The cross-linking agent reacts with a functional group of the pressure-sensitive adhesive, for example, a carboxyl group, a hydroxyl group, or an amino group at a plurality of locations, and as a result, the pressure-sensitive adhesive layer has a network structure to hold the liquid component. In this reaction, when the liquid component, additive, drug, etc. have a functional group capable of reacting with the cross-linking agent, the cross-linking agent has a lower molecular weight than the adhesive due to the difference in diffusivity. It is common to react with some of these, and in many cases it is. As a result, since the pressure-sensitive adhesive is not cross-linked by the cross-linking agent, there is a problem that the liquid component is not retained in the pressure-sensitive adhesive, and in addition, the original effects of the liquid component, additives, drugs, and the like are not exhibited.

[0004]

SUMMARY OF THE INVENTION The present invention is to solve the above-mentioned problems, and an object of the present invention is to provide a patch having a low-irritating property, which satisfactorily holds a liquid component in an adhesive layer. Is to do.

[0005]

Means for Solving the Problems In order to solve the above problems, the present inventors have studied a method for retaining a liquid component without using a cross-linking agent. As a result, the weight average molecular weight of the pressure-sensitive adhesive was 2,000,000. By using the above adhesive polymer,
The inventors have found that the above problems can be solved, and have completed the present invention.

That is, the present invention has the following features. (1) a patch comprising a pressure-sensitive adhesive layer formed on one surface of a support, wherein the pressure-sensitive adhesive layer is a pressure-sensitive polymer having a weight average molecular weight of 2,000,000 or more, and a liquid plasticizer compatible with the polymer and An adhesive patch comprising a solid plasticizer. (2) The adhesive polymer is a copolymer obtained by copolymerizing an alkyl (meth) acrylate as a main component (1).
Patch. (3) The amount of the liquid plasticizer is 10 to 100 parts by weight based on 100 parts by weight of the adhesive polymer (1) or
The patch of (2). (4) The liquid plasticizer is a fatty acid ester composed of a higher fatty acid having 12 to 16 carbon atoms and a lower monohydric alcohol having 1 to 4 carbon atoms, or the fatty acid ester, a fatty acid having 8 to 10 carbon atoms and Glycerin (1) to above
The patch of any one of (3). (5) The patch according to any one of the above (1) to (4), wherein the amount of the solid plasticizer is 10 parts by weight or less based on 100 parts by weight of the adhesive polymer. (6) The patch according to any one of the above (1) to (5), wherein the solid plasticizer is a monoglyceride comprising a fatty acid having 8 to 10 carbon atoms and glycerin. (7) The pressure-sensitive adhesive layer further contains a transdermally absorbable drug
The patch according to any one of (1) to (6).

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The patch of the present invention is obtained by forming a pressure-sensitive adhesive layer on one surface of a support. The support used in the present invention is not particularly limited, but includes a liquid plasticizer, a solid plasticizer, and a drug whose content does not decrease due to loss of the drug from the back surface through the support, that is, these components. Are preferred. Specifically, polyester, nylon, polyvinyl chloride, polyethylene, polypropylene, ethylene-vinyl acetate copolymer,
Examples include a film made of polytetrafluoroethylene, an ionomer resin and the like, a metal foil, and a laminate film of these. Among these, in order to improve the adhesiveness (anchoring force) between the support and the pressure-sensitive adhesive layer, the support is a laminate film of a non-porous film and a porous film made of the above material, and the porous film side It is preferable to form a pressure-sensitive adhesive layer.

The porous film is not particularly limited as long as the anchoring property of the pressure-sensitive adhesive layer is good, and examples thereof include paper, woven fabric, non-woven fabric, and mechanically perforated sheet. Cloths and non-woven fabrics are preferred. The thickness of the porous film is from 10 to 500 μm in consideration of improvement of anchoring force and flexibility of the patch, and about 10 to 200 μm for a thin patch such as a plaster type or an adhesive tape type. In the case of a woven or non-woven fabric, the basis weight is 5
To 30 g / m ^2, preferably preferably in terms of that improvement of anchoring force to 8 to 20 g / m ^2.

The pressure-sensitive adhesive layer formed on one side of the support comprises an adhesive polymer and a liquid plasticizer and a solid plasticizer compatible with the polymer. The adhesive polymer has a weight average molecular weight of 2,000,000 or more, preferably 2.5,000,000 or more. When such a high-molecular-weight adhesive polymer is used as an adhesive, the cohesive force of the adhesive polymer holds the liquid plasticizer and the solid plasticizer in the adhesive layer. When the polymerization average molecular weight is less than 2,000,000, the cohesive force of the adhesive polymer is inferior, so that the liquid plasticizer and the solid plasticizer are not retained in the adhesive layer, and the adhesive is formed by blooming on the surface of the adhesive layer. Getting worse. Also,
The upper limit of the weight average molecular weight of the polymer is about 10,000,000.

[0010] Emulsion polymerization, bulk polymerization and suspension polymerization are employed for the production of such a polymer having a weight average molecular weight of 2,000,000 or more. However, since the adjustment of the weight average molecular weight is relatively easy, the emulsification polymerization is carried out. Polymerization is preferably employed.

The weight-average molecular weight referred to in the present invention is a value obtained by dissolving a polymer in a measuring solvent such as tetrahydrofuran or dimethylsulfoxide, and detecting the polymer by gel permeation chromatography (GPC) using a differential refraction system. .

The adhesive polymer is not particularly limited as long as it has a weight average molecular weight of 2,000,000 or more and can be compatible with a liquid plasticizer and a solid plasticizer described later, but is preferably (meth) acrylic acid. It is a copolymer obtained by copolymerizing an alkyl ester as a main component. As the alkyl (meth) acrylate, specifically, the alkyl group is a linear alkyl group having 4 or more carbon atoms such as butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl or the like. Examples thereof include alkyl (meth) acrylates which are branched alkyl groups, and these are used alone or in combination of two or more.

The monomer copolymerizable with the above-mentioned alkyl (meth) acrylate includes, for example, (meth)
Monomers having a carboxyl group such as acrylic acid, itaconic acid, maleic acid, and maleic anhydride; styrenesulfonic acid, allylsulfonic acid, sulfopropyl (meth) acrylate, (meth) acryloyloxynaphthalenesulfonic acid, acrylamidomethylpropanesulfonic acid, etc. A monomer having a sulfonic acid group; a monomer having a hydroxyl group such as hydroxyethyl (meth) acrylate and hydroxypropyl (meth) acrylate; (meth) acrylamide, dimethyl (meth) acrylamide, N-butyl (meth) (Meth) acrylic acid derivatives having an amide group such as acrylamide and N-methylol (meth) acrylamide; (meth) acrylic acid aminoethyl ester, (meth) acrylic acid dimethylaminoethyl ester, ( Data) (meth) acrylic acid aminoalkyl esters of acrylic acid t- butyl aminoethyl ester; (meth) acrylic acid methoxyethyl ester,
(Meth) acrylic acid ethoxyethyl ester, (meth)
(Meth) acrylic acid alkoxyalkyl esters such as tetrahydrofurfuryl acrylate; (meth)
(Meth) acrylic acid alkoxyalkylene glycol esters such as methacrylic acid methoxyethylene glycol ester, (meth) acrylic acid methoxydiethylene glycol ester, (meth) acrylic acid methoxypolyethylene glycol ester, and (meth) acrylic acid methoxypolypropylene glycol ester; Acrylonitrile; vinyl acetate, vinyl propionate, N-vinyl-2-pyrrolidone, methylvinylpyrrolidone, vinylpyridine, vinylpiperidone, vinylpyrimidine, vinylpiperazine, vinylpyrazine, vinylpyrrole, vinylimidazole, vinylcaprolactam, vinyloxazole, vinylmorpholine, etc. And the like. These compounds are used alone or in combination of two or more. The copolymerization amount of these monomers is appropriately set according to the weight average molecular weight of the obtained copolymer.

The adhesive polymer is a rubber polymer other than the above-mentioned acrylate polymer, such as a silicone polymer, a polyisobutylene polymer, a styrene / butadiene polymer, and a styrene / isoprene / styrene polymer. Even if it is used, it can be used as long as the compatibility with the liquid plasticizer and the solid plasticizer and the solubility and release of the drug are sufficient.

The liquid plasticizer and the solid plasticizer compounded in the pressure-sensitive adhesive layer plasticize the pressure-sensitive adhesive layer to give a soft feeling, thereby reducing skin irritation.

The liquid plasticizer used in the present invention includes:
As long as it is liquid at room temperature itself and exhibits a plasticizing action and is compatible with the above-mentioned adhesive polymer, it is not particularly limited, but it can improve the transdermal absorbability of the drug and the storage stability. preferable. Specifically, carbon number 12-16
A fatty acid ester comprising a higher fatty acid and a lower monohydric alcohol having 1 to 4 carbon atoms; a fatty acid having 8 to 10 carbon atoms; glycols such as ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, and polypropylene glycol;
Fats and oils such as olive oil, castor oil, squalene, and lanolin; ethyl acetate, ethyl alcohol, dimethyldecylsulfoxide, methyloctylsulfoxide, dimethylsulfoxide, dimethylformamide, dimethylacetamide, dimethyllauramide, dodecylpyrrolidone,
Organic solvents such as isosorbitol; liquid surfactants; conventionally known plasticizers such as diisopropyl adipate, phthalic acid ester and diethyl sebacate; hydrocarbons such as liquid paraffin; other ethoxylated stearyl alcohol, glycerin ester ( Liquid at room temperature), isopropyl myristate, isotridecyl myristate,
Ethyl laurate, N-methylpyrrolidone, ethyl oleate, oleic acid, diisopropyl adipate, diisopropyl palmitate, octyl palmitate, 1,
Examples thereof include 3-propanediol and glycerin. Of course, those which are liquid at room temperature are used. These may be used alone or in combination of two or more.

Among the above liquid plasticizers, a higher fatty acid having 12 to 16 carbon atoms and a higher fatty acid having 1 carbon atom in terms of compatibility with the tacky polymer, appropriate skin adhesion, and no volatilization in the heating step are used. It is preferably a fatty acid ester composed of lower monohydric alcohols of 4 to 4. Examples of the higher fatty acid having 12 to 16 carbon atoms include lauric acid, myristic acid, and palmitic acid. Examples of the lower monohydric alcohol having 1 to 4 carbon atoms include methyl alcohol, ethyl alcohol, and propyl alcohol. And isopropyl alcohol. Particularly preferred is isopropyl myristate.

Furthermore, in consideration of the improvement in transdermal absorption of the drug, a fatty acid having 8 to 10 carbon atoms and glycerin may be used in addition to the above fatty acid ester. 8 carbon atoms
Examples of the ten fatty acids include caprylic acid (octanoic acid, C ₈ ), pelargonic acid (nonanoic acid, C ₉ ), and capric acid (decanoic acid, C ₁₀ ).

The compounding amount of the liquid plasticizer is preferably 10 to 100 parts by weight, more preferably 60 to 100 parts by weight, based on 100 parts by weight of the above-mentioned adhesive polymer. When the amount is less than 10 parts by weight, the plasticization of the pressure-sensitive adhesive layer may be insufficient and skin irritation may not be reduced. On the contrary, when the amount exceeds 100 parts by weight, the adhesive polymer has The liquid plasticizer and the solid plasticizer may not be able to be held in the pressure-sensitive adhesive layer due to the cohesive force, and the adhesive may be inferior due to blooming on the surface of the pressure-sensitive adhesive layer.

The solid plasticizer used in the present invention is not particularly limited as long as it is solid at room temperature itself, exhibits a plasticizing action and is compatible with the above-mentioned adhesive polymer. It is preferable to improve percutaneous absorbability and storage stability of the product. Specifically, the number of carbon atoms is 8 to
Stabilizers (antioxidants) such as monoglycerides comprising 10 fatty acids and glycerin, acrylate copolymers and other polymers, ascorbic acid, L-ascorbic acid, stearic acid esters, L- or DL-alanine, etc. And higher fatty acids having 11 or more carbon atoms, such as lauric acid, myristic acid, and palmitic acid, and fatty acid esters of glycerin which are solid (wax-like) at normal temperature. These can be used alone or in combination of two or more. Of course, solid materials at room temperature are used among these. In the pressure-sensitive adhesive layer, the solid-state plasticizer is compatible with the above-described pressure-sensitive adhesive polymer and liquid plasticizer, and is present in a state where the solid state of the solid-state plasticizer is not maintained.

Among the above-mentioned solid plasticizers, those having 8 to 10 carbon atoms in terms of compatibility with the tacky polymer, appropriate skin adhesion, no volatilization in the heating step, and percutaneous absorption of the drug. Monoglycerides comprising fatty acids and glycerin are preferred. As the fatty acid having 8 to 10 carbon atoms, for example, caprylic acid (octanoic acid, C ₈ ), pelargonic acid (nonanoic acid,
C ₉ ), capric acid (decanoic acid, C ₁₀ ) and the like.

The amount of the solid plasticizer is preferably 10 parts by weight or less, more preferably 5 parts by weight or less, based on 100 parts by weight of the above-mentioned adhesive polymer. When the compounding amount exceeds 10 parts by weight, the liquid plasticizer and the solid plasticizer cannot be held in the pressure-sensitive adhesive layer even by the cohesive force of the pressure-sensitive adhesive polymer, and the pressure-sensitive adhesive layer blooms and adheres. May be inferior. The lower limit of the compounding amount is sufficient as long as the plasticizing action of the pressure-sensitive adhesive layer can be exerted,
It is about 0.01 part by weight.

The mixing ratio of the liquid plasticizer and the solid plasticizer is as follows:
The weight ratio is preferably from 1: 0.02 to 1: 0.20, more preferably from 1: 0.04 to 1: 0.18, and the total amount of the liquid plasticizer and the solid plasticizer is: It is preferably 20 to 1 with respect to 100 parts by weight of the above adhesive polymer.
00 parts by weight, more preferably 40 to 90 parts by weight.

The pressure-sensitive adhesive layer may further contain a transdermally absorbable drug. The percutaneously absorbable drug used in the present invention is appropriately selected depending on the purpose of treatment. Examples thereof include corticosteroids, analgesics and anti-inflammatory agents, hypnotic sedatives, tranquilizers, antihypertensives, and antihypertensive diuretics. Drugs, antibiotics, anesthetics, antibacterial agents, antifungal agents, vitamins, coronary vasodilators, antihistamines, antitussives, sex hormones, antidepressants, cerebral circulation improvers, antiemetic agents, antitumor agents, biopharmaceuticals, etc. And transdermally absorbable drugs. These drugs are used in combination of two or more as necessary. Among them, it is preferable to use a hydrophobic drug (dissolution amount of 0.4 g or less in 100 g of water) from the viewpoint of uniform dispersibility in the pressure-sensitive adhesive layer and transdermal absorption.

The content of these drugs is appropriately set according to the kind of the transdermally absorbable drug and the purpose of administration, but is preferably 1 to 40% by weight, more preferably 3 to 40% by weight in the pressure-sensitive adhesive layer.
30% by weight. When this content is less than 1% by weight,
If the release of a therapeutically effective amount of the drug cannot be expected, and if it exceeds 40% by weight, the therapeutic effect is limited and economically disadvantageous.

The thickness of the pressure-sensitive adhesive layer is preferably from 10 to 200 μm, more preferably from 30 to 100 μm, in consideration of the adhesiveness and the necessary amount of the drug and its utilization when the drug contains a transdermally absorbable drug. It is.

The patch of the present invention has a weight average molecular weight of 20.
More than 100,000 polymer, liquid plasticizer and solid plasticizer (percutaneously absorbable drug for prevention and treatment of various diseases) are mixed with a solvent if necessary, and this solution is mixed. The thickness after drying is preferably 10 to 20 on the separator.
It is formed by applying and drying to form a pressure-sensitive adhesive layer so as to have a thickness of 0 μm, more preferably 30 to 100 μm, and transferring this pressure-sensitive adhesive layer to one surface of a support.

When the patch of the present invention contains a transdermally absorbable drug in a patch for coating used for protecting the skin surface, for example, a plaster, a dressing, etc., for example, prevention and treatment of various diseases It can be suitably used as a patch for performing the following.

The patch of the present invention contains a liquid plasticizer and a solid plasticizer in a polymer having good adhesiveness.
The adhesiveness of the pressure-sensitive adhesive layer is appropriately reduced, and the pressure-sensitive adhesive layer is plasticized to give a soft feeling to achieve low irritation. In the present invention, a high-molecular weight adhesive polymer having a weight average molecular weight of 2,000,000 or more is used as the adhesive, but since this adhesive polymer has a high cohesive force, it is not necessary to perform a conventional crosslinking treatment of the adhesive. In both cases, the liquid plasticizer and the solid plasticizer can be held in the pressure-sensitive adhesive layer only by the cohesive force of the pressure-sensitive adhesive polymer. Therefore, the patch of the present invention simultaneously satisfies the skin adhesiveness and the low irritation, which is an opposite property. Also, liquid plasticizer, solid plasticizer, even if the drug has any functional group,
The original effect can be exhibited.

[0030]

EXAMPLES The present invention will be described in detail with reference to the following examples, but the present invention is not limited to these examples. In the following text, all parts mean parts by weight.

(Preparation of Acrylic Copolymer A) 75 parts of 2-ethylhexyl acrylate, isobutyl acrylate 2
0 parts, acrylic acid 5 parts, 1-dodecanethiol 0.06
And 0.2 part of ammonium peroxodisulfate were emulsion-polymerized in an aqueous solution to prepare a solution of acrylic acid copolymer A (weight average molecular weight: 2,000,000).

(Preparation of Acrylic Copolymer B) Under an inert gas atmosphere, 75 parts of 2-ethylhexyl acrylate, 5 parts of acrylic acid and 0.2 parts of azobisisobutyronitrile were used.
The solution was polymerized in ethyl acetate to prepare a solution of acrylic acid copolymer B (weight average molecular weight 1.5 million).

Examples 1 to 4 and Comparative Examples 1 to 8 According to the composition shown in Table 1, a solution for forming an adhesive layer was prepared, and this solution was applied on a polyester separator so that the thickness after drying was 60 μm. Then, it was dried at 100 ° C. for 5 minutes to form an adhesive layer. This adhesive layer was transferred to the nonwoven fabric surface of a polyester nonwoven fabric (8 g / m ² ) / polyester film (2 μm thick) laminate to obtain a patch.

[0034]

[Table 1]

Experimental Examples The following tests were carried out using the patches obtained in Examples 1 to 4 and Comparative Examples 1 to 8 (for those containing coronate HL, after storage at 70 ° C. for 2 days). Was.

1. Skin Adhesion Each sample 10 obtained in Examples 1-4 and Comparative Examples 1-8
cm ² was applied to the inner side of the upper arm of six volunteers, and skin adhesion after 24 hours was visually determined. The one that adhered best (good adhesion) was evaluated as 5, and the one that peeled remarkably was evaluated as 1. Table 2 shows the results.

According to Table 2, Examples 1-4 and Comparative Example 3,
Patches 6 and 8 had good skin adhesion. However, in the adhesive patches of Comparative Examples 1, 2, 4, and 5, the cohesive force of the adhesive polymer was poor, so that isopropyl myristate was not retained by the adhesive layer and bloomed at the separator interface. Did not. Comparative Example 7
In the adhesive patch, metoprolol as a drug and coronate HL as a cross-linking agent reacted preferentially, so that isopropyl myristate was not retained in the pressure-sensitive adhesive layer, and blooming occurred at the separator interface. Did not.

2. Exfoliation amount 50mm 12mm width inside the upper arm of 6 volunteers
Each sample cut to length was affixed for 6 hours and then peeled off. The sample was immersed in a staining solution having the following composition for 24 hours, washed with distilled water and stained for the exfoliated keratinocytes. However, since the dyeing solution used in this test soaked into the nonwoven fabric constituting the support, a patch using a 12 μm-thick polyester film as the support was prepared and used for this test. For the patches of Examples 3 and 4 and Comparative Examples 4 to 8 containing metoprolol as a drug for percutaneous absorption, exactly the same placebo preparation was prepared except that no metoprolol was added, and this was tested. . Each stained sample was cut into a size of 12 mm × 5 mm, and these samples were immersed in 5 ml of a 1% sodium dodecyl sulfate aqueous solution for 24 hours to extract a dye from the adherent keratinocytes, and absorbance of the extract ( 595 nm)
Was measured with a spectrophotometer. As a control sample, a sample not attached to the skin surface was used, and the same extraction operation was performed to measure the absorbance. The difference in absorbance between the sample and the control sample was defined as the amount of exfoliated keratinocytes. Table 2 shows the results. The greater the amount of exfoliated keratinocytes, the higher the absorbance.
This absorbance is preferably 1.0 or less, particularly preferably 0.5 or less. A good correlation was observed between the number of exfoliated keratinocytes counted with a stereomicroscope and the absorbance. <Staining solution composition> Gentian Violet 1.0% Brillian Green 0.5% Distilled water 98.5%

3. Pain degree Each sample cut to a size of 10 cm ² was attached to the inner side of the upper arm of six volunteers, and the pain at the time of peeling one hour later was measured. The average of the pain was evaluated based on the following criteria. Table 2 shows the results. 1: Painless 2: Painful 3: Slightly painful 4: Painful 5: Extremely painful

According to Table 2, the patches of Examples 1 to 4 showed a small amount of exfoliation and little pain at the time of exfoliation. However, the patches of Comparative Examples 3 and 6 had a large amount of exfoliation, and felt pain when exfoliated. The patches of Comparative Examples 1, 2, 4, 5, and 7 could not be measured because blooming occurred at the separator interface.

4. Skin transfer rate Samples of Examples 3 and 4 and Comparative Examples 4 to 8 (10 cm
² ) is adhered to the inside of the upper arm of a person for 8 hours, peeled off, and metoprolol, a drug, is extracted from the tape using methanol and quantified using HPLC (detector: UV 210 nm). The content of the drug contained in the sample was defined as 100%, and the human skin transfer rate was calculated from the measured value. Table 2 shows the results. This transition rate is 10%
More preferably, it is preferably at least 30%.

From Table 2, it can be seen that the patches of Examples 3 and 4 have a good transfer rate, but the patches of Comparative Examples 6 and 8 have an inferior transfer rate as compared with these examples. Met. In addition, the adhesive patches of Comparative Examples 4, 5, and 7 could not be measured because the adhesive polymer and isopropyl myristate remained at the application site.

[0043]

[Table 2]

[0044]

As is apparent from the above description, according to the present invention, the liquid plasticizer and the solid plasticizer can be favorably held in the pressure-sensitive adhesive layer without performing the crosslinking treatment. It is possible to provide a patch which simultaneously satisfies the skin adhesiveness and the low irritation of the contradictory property. In addition, no matter what functional group the liquid plasticizer, the solid plasticizer, and the drug have, the original effect can be exhibited.

 ──────────────────────────────────────────────────続 き Continuing on the front page (72) Inventor Jin Akimi 1-1-2 Shimohozumi, Ibaraki-shi, Osaka Nitto Denko Corporation (72) Inventor Saburo Otsuka 1-1-1-2 Shimohozumi, Ibaraki-shi, Osaka No. Nitto Denko Corporation (72) Inventor Yuichi Inoue 1-2-1, Shimohozumi, Ibaraki City, Osaka Prefecture Nitto Denko Corporation F-term (reference) DD60G EE07A EE09A EE10A EE11A EE12A EE13A EE14A EE15A EE16A EE23G EE48A EE53G FF31 FF67 4J040 DF041 DF051 HB02 HB09 HB10 HB11 HB12 HB24 HB31 HB32 HDB31 HC11 HC11 HCB

Claims (7)

[Claims] 1. A patch comprising a pressure-sensitive adhesive layer formed on one side of a support, wherein the pressure-sensitive adhesive layer is compatible with a pressure-sensitive adhesive polymer having a weight-average molecular weight of 2,000,000 or more. An adhesive patch comprising an adhesive and a solid plasticizer. 2. The patch according to claim 1, wherein the adhesive polymer is a copolymer obtained by copolymerizing an alkyl (meth) acrylate as a main component. 3. The patch according to claim 1, wherein the amount of the liquid plasticizer is 10 to 100 parts by weight based on 100 parts by weight of the adhesive polymer. 4. The liquid plasticizer is a fatty acid ester composed of a higher fatty acid having 12 to 16 carbon atoms and a lower monohydric alcohol having 1 to 4 carbon atoms, or the fatty acid ester having 8 to 10 carbon atoms. The patch according to any one of claims 1 to 3, wherein the patch is a fatty acid and glycerin. 5. The patch according to claim 1, wherein the amount of the solid plasticizer is 10 parts by weight or less based on 100 parts by weight of the adhesive polymer. 6. The patch according to claim 1, wherein the solid plasticizer is a monoglyceride comprising a fatty acid having 8 to 10 carbon atoms and glycerin. 7. The patch according to claim 1, wherein the pressure-sensitive adhesive layer further contains a transdermally absorbable drug.