JP2000016933A - Alleviation for symptoms of allergic diseases - Google Patents

Abstract

PROBLEM TO BE SOLVED: To alleviate the symptoms of allergic diseases, for example, rhinitis or pollinosis, by applying a formulated aqueous solution containing a specific amount of hinokitiol to the affected parts of the allergic diseases regularly and repetitively. SOLUTION: The symptoms of allergic diseases are alleviated by repetitively applying a formulated aqueous solution containing 3-15% of hinokitiol to the affected parts regularly and/or by inhaling the vapor of the aqueous solution. The formulated aqueous solution is prepared by dissolving powdery hinokitiol in water, by emulsifying the powder particles of hinokitiol or including the hinokitiol powder in sustained release capsules.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a method for alleviating the symptoms of allergic diseases such as nasal inflammation, hay fever, dry skin accompanied by itching in the elderly, and itch in the limbs caused by food allergy.

[0002]

2. Description of the Related Art For example, allergic rhinitis causes symptoms such as runny nose, sneezing and nasal congestion due to house dust (dust, mites, mold, etc.) and changes in temperature. Nasal drops are used. In addition, hay fever, pollen such as cedar and cypress becomes an allergen, causing symptoms such as itchy eyes, runny nose, and sneezing.
Nasal drops are used.

[0003]

The number of people with allergic diseases such as nasal inflammation and hay fever is increasing year by year, despite being said to be a complex factor such as environmental pollution and ingestion of various food additives. It is the fact that we are bothered. For example, hay fever suffers from a decrease in concentration, malaise, low-grade fever, and the like resulting from the symptoms, in addition to the symptoms themselves caused by various pollens flying around from February to May every year. It is the fact that people with such allergic diseases are eager to fix the symptoms as soon as possible.

The present invention has been made in view of such circumstances, and has as its object to provide a novel method for alleviating symptoms of allergic diseases such as nasal inflammation and hay fever.

[0005]

Means for Solving the Problems In order to solve the above problems, the present inventors have conducted intensive studies, and as a result, they have been used in hair restorations, dentifrices, cosmetics, etc. for antibacterial purposes. Experiments have confirmed that hinokitiol, a substance permitted to be used in foods as an existing additive (preservative), is effective in alleviating symptoms of allergic diseases such as nasal inflammation and hay fever, and completed the present invention. That is the reason.

In other words, the method for alleviating the symptoms of allergic diseases according to claim 1 of the present invention is to repeatedly apply a preparation water containing 3 to 15% of hinokitiol to affected areas of allergic diseases, and / or It is characterized by alleviating the symptoms of the disease by inhaling the volatilization of water. In this symptom alleviation method, prepared water containing 3 to 15% of hinokitiol is used. Specifically, prepared water obtained by dissolving hinokitiol powder in water or emulsifying hinokitiol powder in water is used. Things,
It is encapsulated in a capsule for sustained release.

[0007]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to embodiments. First, hinokitiol used in the method of the present invention will be outlined. Hinokitiol is a non-benzene-based organic compound having a seven-membered ring called tropolone, has a composition of molecular formula C ₁₀ H ₁₂ O ₂ , is a solid having a melting point of 51 ° C. and a boiling point of 178 ° C., and shows weak acidity. The chemical formula of hinokitiol is as shown in FIG. Hinokitiol is inherently water-insoluble, and its use as it is for medical use has its limits. However, the brand names “Hiba Extract” and “Hiba Capsule” developed by Mutsumi Shoji Co., Ltd. with the technical cooperation of Kisei Tech are products obtained by dissolving hinokitiol in water without using a surfactant or the like. In the present invention, the “Hiba Extract” and the “Hiba Capsule” are used as the preparation water.

"Hiba Extract" and "Hiba Capsule"
As the name implies, among the cypress wood,
It contains hinokitiol contained in Hiba oil extracted from Aomori Hiba, which has the highest antibacterial properties. "Hiba extract" is obtained by dissolving the hinokitiol powder in water, and "Hiba capsule" is obtained by emulsifying hinokitiol powder in water and encapsulated in a capsule so as to release it gradually. Each component is as follows.

<Hiba Extract>-Ingredient-Content water-75-80% Hinokitiol-3-15% Active ingredient other than Hinokitiol-17-5% (β-Drabrin , Carvacrol, etc.) <Ingredients> Content: Water 50% Hinokitiol 3% Active ingredient other than Hinokitiol 27% (β-Drabrin, Carvacrol, etc.) ) Others 20% The results of analysis tests by the Japan Food Research Laboratories on the safety of the above "Hiba Extract" and "Hiba Capsule" are as follows.

Analytical test items Result Detection limit Analysis method Arsenic (as As) Not detected 0.1 ppm DDTC-Ag Spectrophotometry Lead Not detected 0.05 ppm Atomic absorption spectrometry Cadmium Not detected 0.01 ppm Atomic absorption photometry Total mercury detection Without 0.01 ppm Reduction vaporization atomic absorption spectrometry Copper Not detected 0.05 ppm Atomic absorption spectrometry Total chromium Not detected 0.5 ppm Diphenylcarbazide Spectrophotometry Cyan Not detected 0.1 ppm Pyridinepyrazolone Spectrophotometry Surfactant ionic thin Layer chromatographic method Anionic surfactant Not detected * Note Nonionic surfactant Not detected Cationic surfactant Not detected Soap Not detected * Note) Safety of sulfonate or sulfate and hinokitiol itself Reports on the teratogenicity of the natural additive hinokitiol at the Japan Society for Food Sciences, Tokyo Metropolitan Institute of Public Health. According to an experiment by oral administration to mice on pregnancy 9 days, "ED value (1% teratogenicity) was 19
It is relatively large at 0 mg / kg, and the regression equation has a steep straight line. Considering the results of its use in foods and the speed of excretion, teratogenicity is almost negligible when used as an additive. It seems that there is no problem. "

By the way, when the ED value is converted to a person weighing 40 kg, the weight is 7.6 g, and the amount of Hiba extract squeezed out with a cotton swab is 20 mg when weighed, and the amount of hinokitiol is low (3%). 0.6 mg,
Since the concentration is 3 mg even at a high concentration (15%), it is considered that there is almost no problem. However, these numerical values are measured under the following conditions.

Weight of cotton swab 0.33 g Weight of cotton swab impregnated with formula water 0.45 g Weight of cotton swab after squeezing 0.43 g Weight of formula water sucked into the swab 0.12 g Weight of formula water squeezed out 0.02 g Next, each experiment is specifically described. However, in the above “Hiba extract”, low-concentration water prepared by mixing hinokitiol to a content of about 3%, and hinokitiol by 15%
Two types of high-concentration mixed water prepared to a content of about% were used. --- Effect on allergic rhinitis --- <Experiment 1> Subject A: 20-year-old woman Since she was small, she showed allergic symptoms due to house dust and changes in temperature, and used nasal drops such as Nabel (Chugai Pharmaceutical). are doing. In the experiment, the use of nasal drops was stopped.

Experimental method: The lifestyle was changed every week, and the number of times the nose was blown each day, the time during which the nose was unwell, and the state of the nose were recorded over a total of 9 weeks. The way of living each week is as follows. Week 1: Stop using nasal drops and get sick. Week 2: Spent house dust without cleaning the room (the first floor of the apartment).

Week 3: Clean the room frequently. Week 4: Clean the room and spray low-concentration water on the desk and floor. Week 5: Same as week 4. Week 6: Skiing and stopping (change in environment). Week 7: Return to the countryside and suspend (environmental change).

Week 8: Clean the room, sleep over your nose and mouth with a towel sprayed with low-concentration formula water. Week 9: Same as week 8. In the above-mentioned nine-week life, the average number of times of nose biting per day is described for each week as follows.

Week 1 Week 2 Week 3 Week 4 Week 5 Week 6 Week 7 Week 8 Week 9 Week 17.6 18.1 10.2 14.1 9.4 7.7 6.1 5.4 4.1 The first and second weeks are affected by temperature changes and the like, and there are about five days in two weeks when the runny nose does not stop, and the symptoms become more severe later.

In the third week, the temperature drops only for one day, and when the heating is turned on, the nose is rinsed with the dust. On this day, the number of times of nose biting is about 20 times, and on other days, it is 10 times or less, and relieving symptoms by cleaning is remarkable. After the fourth week, use low-concentration water for cleaning. In the latter half of the day, he gets sick, gets sick, and the number of nose blows is as high as 20 times, which lasts 3-4 days.

In the fifth week, I was in a dusty place for two days at a bargain part-time job, so my condition was bad. Excluding these days, the nose biting frequency was slightly lower than in the week of just cleaning. During the sixth week, no symptoms appear during skiing exercises, but nasal congestion and runny nose during breaks.

[0019] In the seventh week, a better situation continues at the homecoming home.
In the eighth and ninth weeks, sleep with a mask impregnated with a low concentration of compounding water. The nose-blowing time after waking in the morning remains, but in the afternoon there is apparent relief of symptoms. Summarizing the results of Experiment 1 above, allergic rhinitis
Although it is caused by house dust and mold in the room, it is presumed that an aqueous solution of hinokitiol, which originally has a high antibacterial property, has a considerable effect on controlling house dust and mold.
From the week onwards, it is considered that the patient became more effective because he wore a mask impregnated with low-concentration water at bedtime. That is, since the hinokitiol volatilized from the mask is continuously inhaled during bedtime, it is considered that the antibacterial effect of hinokitiol is effective. Also, from this, when hinokitiol comes closer to the affected area called the mucous membrane in the nose,
The guesswork holds that it may work better. In any case, the use of hinokitiol-containing preparation water has remarkably improved rhinitis symptoms for 20 years. --- Effect on hay fever --- Experiment 2 Subject B: 54-year-old female Symptoms began in the 20s, but the symptoms became full-fledged in the 30s and lasted for about 20 years, and last year ( Until (1997), he was taking the medicine ordered by the doctor twice a day.

Experimental method: "Hiba extract" was used in the following manner. However, the method of use was left to the discretion of the individual, and the start and suspension of use were left to the user's own judgment. The same applies to Experiments 3 to 10 described later. Impregnated into the mask attached to gargle ear to dilute the eye source is attached to the nasal swab attached to wear a cotton swab in eye drops water 1998 February 27, is a state in which there is no etc. stop the terrible sneezing and a runny nose, to this day Initially, applying "Hiba Extract" to the tip of the nose by the above method improved the symptoms a little. After that, when the method was performed, the symptoms disappeared in about 30 minutes.
He had a runny nose and sneezing the next day, but he performed the procedure twice and went to bed. I did nothing for about three days from the next morning, but no symptoms appeared. Symptoms appeared on the fourth day, but when the method was performed, the symptoms were alleviated and eventually disappeared. Over time, the symptoms gradually became less likely to occur. <Experiment 3> Subject C: 65-year-old woman Eyes itch due to hay fever from about 60 years old. This year (Heisei 10), the eyes have been itching anyway for just one month.
I hate the medicine and put up with it without using it.

Experimental method: The method was carried out twice on March 20 and 21, 1998. Immediately after the first application, the itch disappeared, and thereafter the symptoms of hay fever disappeared without the use of "Hiba Extract". <Experiment 4> Test subject D: 39-year-old woman Symptoms of hay fever appear from about 20 years old. Symptoms appear approximately every year from February to May. At that time, he used Alcyon every day. When I stopped the medicine, she sneezed and runny nose. In the experiment, the drug was stopped.

Experimental method: The method was carried out in the morning, noon and night on March 21, 1998, but there was no effect on that day. However, the next morning, the symptoms disappeared. Thereafter, the method was performed every morning and evening for two weeks.
During that time, the symptoms disappeared even after the use of "Hiba Extract" was stopped. However, during that time, when she was once exposed to cleaning dust at the workplace, she had symptoms, but opened the window and the symptoms subsided. <Experiment 5> Subject E: 48-year-old woman suffered from hay fever for 10 years. Until last year (1997), he had been using adrenal cortical hormones for his eyes. This year, she stopped using it and dilute eucalyptus oil by putting it on her nose.

Experimental method: The method was carried out every morning, noon and evening for 5 days from April 5, 1998, but the use was stopped because there was no noticeable effect. <Experiment 6> Subject F: a 47-year-old man had been taking medication to relieve symptoms, but recently switched to spraying.

Experimental method: Method on April 7, 1998,
Was done. After that, he went to drink and stayed up late at night, and became ill. Itching seems to have disappeared, but no noticeable effect is known. <Experiment 7> Subject G: 20-year-old woman Usually OK, but symptoms appear when going out.
Experimental method: When the eyes were itchy, the "Hiba Extract" was diluted with water and washed, and the itch disappeared. However, the duration of the effect appeared short. <Experiment 8> Subject H: a 42-year-old man had more hay fever than childhood, and often caught a cold when he was small. Responds to Kamogaya and usually has symptoms from February to July. My eyes, ears, and throat itch all the time and my nose is blocked.

Experimental method: According to the method, 2-3
For a time, the itching of the eyes stopped, but then it became itchy again. Even with the method, the nose was not eliminated. <Experiment 9> Subject I: a 42-year-old male used a drug to relieve symptoms.

Experimental method: The method was carried out on the night of April 17, 1998. When I got up the next morning, my nose became stuffy and sneezing, and my nose remained heavy. At 8:30 in the morning, the method subsided, but the symptoms subsided for a while, but then became the worst all day. If the method is performed that night, the symptoms subside for a while, but the nose is congested and the nose continues to be heavy at night. When the method was performed at 9:00 in the morning on the third day, the symptoms subsided after a while, and the condition was good all day, but became ill at 8:00 pm. At 9 o'clock the method went. 4
From day one, sneezing and runny nose occur in the morning and night, but the situation has improved. <Experiment 10> Subject J: 24-year-old female Symptoms appear every year from February to June from the age of 5th to 6th grade in elementary school, and symptoms may appear for a certain period of time even outside this period.
When I was in the second year of junior high school, I noticed the reaction of house dust,
For the first time in high school, she reacts with a cat at a friend's house. He had been using antihistamines until 3 years ago, but he was only drowsy and had no effect. . Last year I took it about twice a day.

Experimental method: From February 27, 1998, the following treatments were performed at each of the six periods. a) When the low-concentration water was stopped by applying it to the nose and eyes (2)
/ 27 ~ 3/9) b) Stop applying low-concentration compounding water to the nose and eyes, and at the same time, use a commercially available eyewash to wash eyes and wear a mask impregnated with low-concentration compounding water (3). / 10-3 / 3/20) c) When the concentrated water was stopped by applying it to the nose and eyes (3
/ 21-3 / 30) d) When low-concentration compounded water was applied to the nose and eyes every morning and evening (3
/ 31-4 / 30) e) Low-concentration mixed water was applied to the nose and eyes every day in the morning and evening.
(5/1 to 5/22) f) Time when use of the preparation water was stopped (5
/ 22 or later) The physical condition of the day in each season is "good for physical condition", "good for physical condition change", "bad for physical condition", "slight rhinitis due to cold but no problem". Briefly, the daily state of each period is represented as follows. a) △△△ △△ △△ × b) △△ △△ △△ △△ × △△ △△ c) ○ △△△ △△△ x △ △ d) ○ ○ ○ ○ ×× ○○○○○○○ × ○○
○○○ ×× △ □ e) □ and ○ f) □ and ○ Each period is summarized as follows. Period of a) When the method using low-concentration water is performed only once, the symptoms stop after about 1 to 2 days of elaboration. When a large amount of pollen is bathed when going out, it is not effective to perform the method using low-concentration water once. If the symptoms are disturbed by going out, etc., it takes 3 to 4 days to recover with the method using low-concentration water. Period b) Washing eyes and washing the nose slightly alleviates the symptoms. Even if the eyes are washed, the nose is washed, and the method using low-concentration mixed water is used, it takes 2-3 days to recover the pollen when going out. Period c) Symptoms stop after about 3 days with the method using a high concentration of mixed water. High-concentration mixed water method, 1
Even if you go about twice, it is ineffective for dust allergy. Even after dusting, if the method using concentrated water with high concentration is applied, it will recover in 1-2 days. Period of d) By performing the method using low-concentration water in the morning and evening, symptoms can be alleviated quite stably. All three times the symptoms worsened during this period were due to dust. Even if the method using low-concentration water is used in the morning and evening, it is ineffective for dust. When the method using low-concentration water is carried out in the morning and evening, it takes 1-2 days to recover the symptoms with dust. The symptoms of dust can be recovered by intensively using the immediately high-concentration mixed water method about three times. If the treatment for dust is delayed, it takes about two days to recover even if the method using high-concentration water is used. e, f) Allergies due to cold or cold may be caused by a little. In this case, the eyes are not itchy. For allergy caused by cold or cold, it is considered useful to warm the neck with a muffler or the like.

From the viewpoint of use, the effect is obtained within 5 minutes when "Hiba Extract" is used for instillation and gargle for itching of eyes and throat, but it takes about 30 minutes for nasal drops. In many cases, it takes time for the effect to be obtained. "Hiba extract" impregnated in the mask seems to work even more slowly. In the case of "wasted" eyes or nose clogging, it often does not work immediately. If the amount of "Hiba Extract" is insufficient in use, it seems to temporarily worsen the symptoms.

Experiments 2 to 10 described above were conducted on nine subjects with pollen symptoms. The results of each experiment were summarized as follows.
The following three points. I: "Hiba extract" has a function of remarkably eliminating the symptoms accompanied by itching.

It is effective for 7 out of 9 people, one is unknown,
It didn't work for one. Subjects B, C, D who were effective
After three years of continuous use, "Hiba Extract"
Even without using, the symptoms recovered to a level that almost disappeared for a long time. For a certain period of time after the disappearance of the symptoms, the treatment is continued in the morning and evening. II: When it is considered that the amount of pollen and dust is large, it is necessary to increase the absolute amount of hinokitiol to eliminate itching. Small amounts of hinokitiol seem to rather temporarily increase symptoms. The experiences of the subjects D, G, H, I and J are helpful. III: When hay fever is enhanced, the direct effect of “Hiba extract” is hardly seen.

Subjects E and F did not show any remarkable effect. In this case, it is unclear whether it is not effective simply because the amount of hinokitiol is small, or whether it is not effective because the conditions are changed due to the increase. As described above, as a general review of the effects of "Hiba Extract" on hay fever, "Hiba Extract" has a remarkable effect not on specific individuals but on many unspecified people. However, hay fever has the problem of individual differences, and it can be seen that the same person has a different effect and recovery process depending on the amount of antigen. In other words, when going out when the amount of antigen is considered to be large, especially when there is a large amount of dust and the like, more absolute amount of hinokitiol is required to alleviate the symptoms. If treatment is delayed, recovery takes about 1 to 3 days. Furthermore, if the allergy is more enhanced, it may be difficult or ineffective in some cases. The cause may be that the amount of hinokitiol is simply insufficient, or whether it is not effective because of the increased condition.
It is unknown what is clear. In any case, "Hiba Extract" seems to work immediately (about 5 minutes) on the eyes and throat when it works, and on the nose a little later.

In terms of age, it has been found that when it is effective for a generation of aged people whose metabolism is weakened, it works in a few attempts and recovers easily. For the middle-aged and highly aggressive generations, there were cases in which it gradually worked and cases in which it did not work. In addition, in the case of young people, the metabolism is generally high, so that it works well when the degree of symptoms is low, but does not work when the symptoms are severe. Even if it doesn't work, it seems that it works better after 2-3 days. In addition, no particular reports have been received from the subjects on side effects. --- Effects on senile itch--Experiment 11 Subject K: 82-year-old man Over the past 10 years, his feet and back have itchy seasonally.

Experimental method: When hinokitiol in “Hiba capsule” was applied to the feet after bathing, the itch disappeared immediately, and the skin fell off when the affected area was rubbed. On the next day, the same effect was obtained when the back was similarly applied after bathing. After that, it is stable without any symptoms. <Experiment 12> Subject L: 73-year-old female Urticaria tends to appear from 7 years old. He has been taking medicine since he was about 20 years old. It seems to be the cause of the food, but I checked it but didn't know. Drying of limbs occurs about six years ago. 2
I feel a little better than drinking Chinese medicine turmeric more than a year ago. Itching is on the calves, inside the thighs, near the navel, etc.

Experimental method: On May 31, 1998, the upper part of the calf was itchy and inevitable, so "Hiba capsule" was applied to the affected area. It was crisp for a while, but soon itchy. When the affected area was rubbed, the skin seemed to come off. The first one was black, and the second was white. After removal, the skin became slightly moist and moist. From the next day on, there has been no problem for more than one week.

As a summary of Experiments 11 and 12, the fact that the intention of the itch disappears easily and the symptoms become difficult to appear thereafter seems to be very similar to the effect on the elderly hay fever. --- Effect on food allergy --- <Experiment 13> Subject M: 36-year-old woman Originally, there is some rhinitis in constitution. One or two days after eating the manuka bonito, a red and rashy rash develops on both feet and hands, accompanied by large itching.

Experimental method: On the night of the day when the rash occurred, “Hiba Capsule” was applied to one leg before going to bed, and immediately became feverish, and the itching was removed immediately. The next morning, the itch on the other foot, which had not been painted, had been removed. However, there was itching in the hand next to the knee kid next to it. When I applied "Hiba capsule" to the itch, the itch was removed immediately. The next night, I applied "Hiba capsule" to the itch. Itching seems to last for about half a day to one day. However, after that, the rash began to appear on the face and the like, and the use of "HIBA capsule" was stopped. The doctor gave me a hormonal medicine and Alcion, but the worst conditions continued for a few days. After that, it took about a month to recover almost by trying Chinese medicine.

As a summary of this experiment 13, although it is certain that "Hiba capsule" stops allergic itch at one time, it seems that there are still many problems to be completely cured. --- Summary from Experiments 1 to 13--It is known how natural "Hiba extract" and "Hiba capsule" containing hinokitiol are effective for allergic diseases such as nasal inflammation and hay fever. When inferring with reference to the general process of allergy enhancement, the following three possibilities are possible. No. 1: Hinokitiol originally has a high antibacterial property, and is directly useful for controlling various germs such as mites and molds related to inflammation. Second: Since hinokitiol is weakly acidic, it relieves lipid peroxides, which are often found in people with allergies as antioxidants, and suppresses excessive action of active oxygen released from granules. Third: The structure of hinokitiol with hydroxyl and oxygen has the effect of stimulating the sympathetic nerve (borrowed from future immunology), and corrects the excessively parasympathetic state found in the early symptoms of allergy to the sympathetic nerve. It is also effective in suppressing the secretion of substances that make nerves irritable.

In general, in a state where hay fever is chronic and exacerbated, it is considered that the nervous system is prone to sympathetic nervous system, and it is considered that “Hiba extract” and “Hiba capsule” are hardly effective. In the case of a method for treating hay fever by sympathetic nerve block using an anesthetic, it does not work for a person with mild hay fever, which is said to be more effective for a person with severe symptoms. However, it is needless to say that these are analogies to the extent of being tired and must be made by expert research.

The results of Experiment 1 to Experiment 13 revealed that one person had rhinitis, 7 out of 9 hay fever, and 2 senile itch.
Symptoms of people with a wide variety of allergic diseases, 11 out of 13 people, one person allergic to food, were alleviated or almost eliminated. In particular, hinokitiol was used to prevent itching caused by allergic diseases. It is the fact that the included "Hiba Extract" and "Hiba Capsule" are effective. Also, no problems have been found with regard to safety, particularly at this stage.

[0040]

As described above, according to the method for alleviating the symptoms of allergic diseases according to the present invention, hinokitiol can be used in an amount of 3%.
By repeatedly applying the preparation water containing up to 15% to the affected part of the allergic disease regularly and / or by inhaling the volatilization of the preparation water, the symptoms of the disease are alleviated, so that nasal inflammation and hay fever etc. For a person with an allergic disease, treatment for symptoms can be performed without worrying about side effects. Moreover, hinokitiol is naturally occurring and is gentle not only on the human body but also on the environment.

[Brief description of the drawings]

FIG. 1 is a chemical formula of hinokitiol contained in the preparation water used in the symptom alleviation method of the present invention.

Continued on front page F term (reference) 4C076 AA12 AA53 AA55 AA93 BB21 BB31 CC03 CC04 DD21E DD37 DD40 FF68 GG08 GG11 GG46 4C206 AA01 AA02 CB15 MA02 MA05 MA37 MA57 MA76 MA83 NA10 NA14 ZA34 ZA89 ZB11 ZB13

Claims (3)

[Claims] (1) by repeatedly applying a preparation water containing 3 to 15% of hinokitiol to an affected area of an allergic disease, and / or by inhaling the volatilization of the preparation water.
A method for alleviating the symptoms of an allergic disease, which comprises alleviating the symptoms of the disease. 2. The method for alleviating symptoms of an allergic disease according to claim 1, wherein said preparation water is obtained by dissolving hinokitiol powder in water. 3. The method for alleviating symptoms of an allergic disease according to claim 1, wherein the preparation water is obtained by emulsifying hinokitiol powder in water and encapsulating the mixture in a capsule so as to release it gradually. .