JP2000001412A - Antimicrobial apatite and its production - Google Patents
Antimicrobial apatite and its productionInfo
- Publication number
- JP2000001412A JP2000001412A JP10163907A JP16390798A JP2000001412A JP 2000001412 A JP2000001412 A JP 2000001412A JP 10163907 A JP10163907 A JP 10163907A JP 16390798 A JP16390798 A JP 16390798A JP 2000001412 A JP2000001412 A JP 2000001412A
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- JP
- Japan
- Prior art keywords
- antibacterial
- apatite
- hydroxyapatite
- calcium
- phase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
【０００１】[0001]
【発明の属する技術分野】本発明は、抗菌性を有するア
パタイトに関するものであり、特に安価かつ容易に製造
できる白色の抗菌性アパタイト及びその製造方法に関す
る。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an apatite having an antibacterial property, and more particularly to a white antibacterial apatite which can be easily produced at low cost and a method for producing the same.
【０００２】[0002]
【従来の技術】ハイドロキシアパタイト（Ｃａ10（ＰＯ
4）6（ＯＨ）2）は生体の骨の構成成分として知られ、
生体組織との親和性及び結合性に富んでいるので、これ
を担体として種々な生体機能性を付与する試みが行われ
ている。例えば特開平３−２７１２０９号公報には、ハ
イドロキシアパタイトに銀と亜鉛及び／又は銅の抗菌性
金属イオンを担持させた抗菌性アパタイトが記載されて
いる。また特開平３−９０００７号公報には、ハイドロ
キシアパタイトのＣａイオンを銀、銅、亜鉛等の抗菌性
金属イオンとイオン交換して担持させた抗菌剤が記載さ
れている。2. Description of the Related Art Hydroxyapatite (Ca 10 (PO
4 ) 6 (OH) 2 ) is known as a constituent of bone in living organisms,
Because of its high affinity and binding properties with living tissue, attempts have been made to use it as a carrier to impart various biological functions. For example, JP-A-3-271209 describes an antibacterial apatite in which hydroxyapatite carries antibacterial metal ions of silver, zinc and / or copper. JP-A-3-9007 describes an antibacterial agent in which Ca ions of hydroxyapatite are ion-exchanged with antibacterial metal ions such as silver, copper and zinc to be carried.
【０００３】[0003]
【発明が解決しようとする課題】しかし、前記のように
銀、銅、亜鉛等の異種金属をハイドロキシアパタイトに
担持させ、又はイオン交換すると、期待する抗菌力が得
られなかったり、ハイドロキシアパタイト本来の生体親
和性が損なわれたり、使用する抗菌性金属が銀である場
合は高価であるばかりでなく担持処理も煩雑で製造コス
トが嵩み、しかも製剤の色が黒く商品価値が低い等、十
分な実用性が得られなかった。本発明は、上記の課題を
解決するためになされたものであって、従ってその目的
は、ハイドロキシアパタイト本来の生体親和性を損なわ
ず、高価な異種金属を用いず、製造も容易でコストがか
からず、製剤の色が白色でしかも高い抗菌性を有する抗
菌性アパタイト及びその製造方法を提供することにあ
る。However, when different metals such as silver, copper, and zinc are supported on hydroxyapatite or ion-exchanged as described above, the expected antibacterial activity cannot be obtained, or the original hydroxyapatite cannot be obtained. If the biocompatibility is impaired or the antibacterial metal used is silver, it is not only expensive but also complicated to carry out the supporting process, the production cost increases, and the color of the preparation is black and the commercial value is low. Practicality was not obtained. The present invention has been made in order to solve the above-mentioned problems, and therefore, has as its object the advantage of not impairing the original biocompatibility of hydroxyapatite, using no expensive dissimilar metals, and being easy to manufacture and cost-effective. In view of the above, an object of the present invention is to provide an antibacterial apatite having a white formulation and a high antibacterial property, and a method for producing the same.
【０００４】[0004]
【課題を解決するための手段】前記の課題を解決するた
めに本発明は、Ｃａ／Ｐのモル比が１．８〜５．０の範
囲内であるカルシウム過剰型ハイドロキシアパタイトが
焼成されてなる抗菌性アパタイトを提供する。本発明の
抗菌性アパタイトは、水中で水酸化カルシウムとリン酸
とをＣａ／Ｐのモル比が１．８〜５．０の範囲内となる
ように反応させ、生成したカルシウム過剰型ハイドロキ
シアパタイトを７００℃〜１２００℃の範囲内で焼成す
ることにより製造することができる。According to the present invention, there is provided a calcium-rich hydroxyapatite having a Ca / P molar ratio in the range of 1.8 to 5.0. Provides antibacterial apatite. The antibacterial apatite of the present invention is obtained by reacting calcium hydroxide and phosphoric acid in water such that the molar ratio of Ca / P is in the range of 1.8 to 5.0. It can be manufactured by firing in the range of 700 ° C to 1200 ° C.
【０００５】[0005]
【発明の実施の形態】以下、本発明を好ましい実施の形
態により詳しく説明する。本発明は、Ｃａ／Ｐのモル比
が１．８〜５．０の範囲内であるカルシウム過剰型ハイ
ドロキシアパタイトを焼成して得られた生成物が、優れ
た抗菌性と生体親和性とを併せ持つことを見いだしたこ
とにより達成された。この生成物（本発明の抗菌性アパ
タイト）は、水中で水酸化カルシウムとリン酸とをＣａ
／Ｐのモル比が１．８〜５．０の範囲内となるように反
応させ、生成した沈澱物を分取して７００℃〜１２００
℃の範囲内で焼成することにより容易に製造することが
できる。DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in more detail with reference to preferred embodiments. According to the present invention, a product obtained by calcining a calcium-rich hydroxyapatite having a Ca / P molar ratio in the range of 1.8 to 5.0 has excellent antibacterial properties and biocompatibility. Achieved by finding out. This product (the antibacterial apatite of the present invention) converts calcium hydroxide and phosphoric acid into Ca in water.
The reaction was carried out so that the molar ratio of / P was within the range of 1.8 to 5.0, and the resulting precipitate was separated and collected at 700 ° C to 1200 ° C.
It can be easily manufactured by firing within the range of ° C.
【０００６】通常のハイドロキシアパタイト（Ｃａ
10（ＰＯ4）6（ＯＨ）2）におけるＣａ／Ｐのモル比は
１．６７であるから、このモル比が１．８〜５．０の範
囲内である本発明の抗菌性アパタイトは、ハイドロキシ
アパタイトの骨格を有しながら明らかにカルシウム過剰
型となっている。そして、単に反応液から分離して乾燥
したカルシウム過剰型ハイドロキシアパタイトではな
く、これを７００℃〜１２００℃の範囲内で焼成したと
き特に優れた抗菌力が発現することがわかった。この抗
菌力は、通常のハイドロキシアパタイトと水酸化カルシ
ウム又は酸化カルシウムのそれぞれ単独又は単なる混合
物では得ることができないものである。[0006] Ordinary hydroxyapatite (Ca
Since the molar ratio of Ca / P in 10 (PO 4 ) 6 (OH) 2 ) is 1.67, the antibacterial apatite of the present invention having a molar ratio in the range of 1.8 to 5.0 is: It is clearly calcium-rich while having a hydroxyapatite skeleton. Then, it was found that particularly excellent calcium-free hydroxyapatite, which was separated from the reaction solution and dried, exhibited particularly excellent antibacterial activity when calcined in the range of 700 ° C to 1200 ° C. This antibacterial activity cannot be obtained by ordinary hydroxyapatite and calcium hydroxide or calcium oxide alone or in a simple mixture.
【０００７】前記温度範囲内で焼成されたカルシウム過
剰型ハイドロキシアパタイト、すなわち本発明の抗菌性
アパタイトは、Ｘ線回折並びに電子顕微鏡写真等により
微細構造を検査すると、明らかにハイドロキシアパタイ
ト相を有し、その表面もしくは相間に酸化カルシウム又
は水酸化カルシウムの微細結晶相が均一に析出し固着し
ている構造が認められる。この微細構造によって抗菌性
が発現する理由は明確でないが、ハイドロキシアパタイ
トの基相がその生体親和性によって細菌やウイルス等の
微生物を強く吸着し、比表面積の拡大された酸化カルシ
ウム相又は水酸化カルシウム相が、その塩基性によって
微生物タンパク質を破壊することによると考えられる。[0007] The calcium-rich hydroxyapatite calcined in the above-mentioned temperature range, that is, the antibacterial apatite of the present invention, when examined for its microstructure by X-ray diffraction and electron micrographs, clearly has a hydroxyapatite phase. A structure in which a fine crystalline phase of calcium oxide or calcium hydroxide is uniformly precipitated and fixed on the surface or between the phases is observed. It is not clear why the antimicrobial properties are exhibited by this microstructure, but the base phase of hydroxyapatite strongly adsorbs microorganisms such as bacteria and viruses due to its biocompatibility, and the calcium oxide phase or calcium hydroxide with an increased specific surface area It is believed that the phase is due to its basicity destroying microbial proteins.
【０００８】本発明において、Ｃａ／Ｐのモル比は１．
８〜５．０の範囲内とされる。この比が１．８未満で
は、ハイドロキシアパタイト相に対する酸化カルシウム
相又は水酸化カルシウム相の割合が５重量％未満とな
り、十分な抗菌力が発現しない。またＣａ／Ｐモル比が
５．０を越えると、ハイドロキシアパタイト相に対する
酸化カルシウム相又は水酸化カルシウム相の割合が５０
重量％を越えることになり、ハイドロキシアパタイト相
が酸化カルシウム相又は水酸化カルシウム相に隠ぺいさ
れて生体親和性が発現しなくなる。In the present invention, the molar ratio of Ca / P is 1.
It is in the range of 8-5.0. If this ratio is less than 1.8, the ratio of the calcium oxide phase or calcium hydroxide phase to the hydroxyapatite phase will be less than 5% by weight, and sufficient antibacterial activity will not be exhibited. When the Ca / P molar ratio exceeds 5.0, the ratio of the calcium oxide phase or calcium hydroxide phase to the hydroxyapatite phase becomes 50%.
If it exceeds 10% by weight, the hydroxyapatite phase is hidden by the calcium oxide phase or the calcium hydroxide phase, and biocompatibility is not exhibited.
【０００９】本発明においては、水溶液から合成したカ
ルシウム過剰型ハイドロキシアパタイトを７００℃〜１
２００℃の範囲内で焼成することが必要である。焼成温
度が７００℃未満ではカルシウム過剰型ハイドロキシア
パタイトがハイドロキシアパタイト相と酸化カルシウム
相又は水酸化カルシウム相とに明確に相転換せず、抗菌
力が発現されない。また焼成温度が１２００℃を越える
と、酸素アパタイト相が生成し、抗菌力が低下する。In the present invention, calcium-rich hydroxyapatite synthesized from an aqueous solution is treated at 700 ° C to 1 ° C.
It is necessary to bake within the range of 200 ° C. If the calcination temperature is less than 700 ° C., the calcium-excess type hydroxyapatite does not clearly convert into a hydroxyapatite phase and a calcium oxide phase or a calcium hydroxide phase, and no antibacterial activity is exhibited. When the firing temperature exceeds 1200 ° C., an oxygen apatite phase is formed, and the antibacterial activity is reduced.
【００１０】本発明の抗菌性アパタイトは、抗菌剤とし
て使用するに際して、通常許容されている各種の製剤用
助剤や本発明の抗菌性アパタイト以外の抗菌剤その他の
活性成分、各種バインダー、着色剤等と混合して使用す
ることができる。また本発明の抗菌性アパタイトには、
ハイドロキシアパタイト相の水酸基の一部がＣｌ- 、Ｆ
- 、ＣＯ3 2- 又はＮＯ3 2-等で置換されたものが含まれ
ていてもよい。When the antibacterial apatite of the present invention is used as an antibacterial agent, it is usually used for various preparation auxiliaries, antibacterial agents other than the antibacterial apatite of the present invention, other active ingredients, various binders and coloring agents. And the like. In addition, the antibacterial apatite of the present invention,
Some of the hydroxyl groups of the hydroxyapatite phase Cl -, F
- it may include those substituted with CO 3 2- or NO 3 2-like.
【００１１】本発明の抗菌性アパタイトは、従来知られ
ている抗菌性アパタイトのように銀、銅、亜鉛等の抗菌
性金属イオンを含まず、ハイドロキシアパタイトの構成
元素のみで構成されているので安全性が高く、簡単かつ
安価に製造でき、しかも白色であるから、広範な分野に
適用が可能である。本発明の抗菌性アパタイトの適用分
野としては、例えば医療用器具、医薬、家庭・病院・公
共用器具備品、食器・調理器具・食品容器、食品、衣服
・衣料品、履き物、玩具、事務用機器等を挙げることが
できる。The antibacterial apatite of the present invention does not contain antibacterial metal ions such as silver, copper, zinc and the like, unlike the conventionally known antibacterial apatite, and is composed of only the constituent elements of hydroxyapatite. Since it is highly resistant, can be manufactured easily and inexpensively, and is white, it can be applied to a wide range of fields. The application fields of the antibacterial apatite of the present invention include, for example, medical utensils, medicines, home and hospital / public equipment, tableware / cooking utensils / food containers, food, clothing / clothing, footwear, toys, office equipment And the like.
【００１２】[0012]
【実施例】（実施例１）蒸留水１Ｌに水酸化カルシウム
８５．２８ｇを攪拌混合した。次に８５重量％のリン酸
６９．１８ｇを徐々に加え、燐酸カルシウム質の沈澱物
を生成した。この沈澱物を濾過し、電気炉にて９００℃
に１時間焼成し、白色粉末として実施例１の抗菌性アパ
タイトを得た。EXAMPLES (Example 1) 85.28 g of calcium hydroxide was mixed with stirring in 1 L of distilled water. Next, 69.18 g of 85% by weight phosphoric acid was slowly added to form a calcium phosphate precipitate. The precipitate was filtered, and 900 ° C in an electric furnace.
The antibacterial apatite of Example 1 was obtained as a white powder.
【００１３】得られた白色粉末をＸ線回折分析した結
果、図１に示すように、ハイドロキシアパタイト相（Ｈ
Ａｐ）に起因するピーク（図１中○で示す）と酸化カル
シウム相（ＣａＯ）に起因するピーク（図１中△で示
す）とが認められ、Ｃａ／Ｐのモル比は１．９であっ
た。このモル比から、ハイドロキシアパタイト相に対す
る酸化カルシウム相の割合は１０重量％であることがわ
かった。また走査型電子顕微鏡による観察では、図２に
示すように、ハイドロキシアパタイト相の表面もしくは
相間に酸化カルシウムの微細結晶が均一に析出し固着し
ている構造が認められた。As a result of X-ray diffraction analysis of the obtained white powder, as shown in FIG. 1, the hydroxyapatite phase (H
Ap) (peak in FIG. 1) and a peak due to calcium oxide phase (CaO) (indicated by Δ in FIG. 1), and the molar ratio of Ca / P was 1.9. Was. From this molar ratio, it was found that the ratio of the calcium oxide phase to the hydroxyapatite phase was 10% by weight. In addition, observation by a scanning electron microscope revealed a structure in which fine crystals of calcium oxide were uniformly precipitated and fixed on the surface of the hydroxyapatite phase or between the phases, as shown in FIG.
【００１４】この抗菌性アパタイトを乳鉢で粉砕し粉末
にした後、Brain Heart Infusion液体培地４０ｍｌ中に
０．１重量％〜１．０重量％添加した。次いでこの液体
培地に大腸菌を１０6 ｃｆｕ／ｍｌの濃度で播種し、３
７℃で３日間培養し、抗菌性を調べた。その結果、実施
例１の抗菌性アパタイトを０．５重量％以上添加した液
体培地では、培養６時間以降で大腸菌がすべて死滅し、
優れた抗菌性が確認された。The antibacterial apatite was pulverized in a mortar into powder, and then added in an amount of 0.1% by weight to 1.0% by weight in 40 ml of a Brain Heart Infusion liquid medium. Next, Escherichia coli was inoculated on this liquid medium at a concentration of 10 6 cfu / ml,
The cells were cultured at 7 ° C. for 3 days and examined for antibacterial properties. As a result, in the liquid medium to which the antibacterial apatite of Example 1 was added in an amount of 0.5% by weight or more, all the E. coli were killed after 6 hours of culture,
Excellent antibacterial properties were confirmed.
【００１５】（実施例２）蒸留水１Ｌにクエン酸５７．
４６ｇを溶解した。この水溶液に炭酸カルシウム１５．
０２ｇを攪伴混合した。次に、８５重量％のリン酸３．
４６ｇを徐々に加え、燐酸カルシウム質の沈澱物を生成
した。この沈澱物を濾過し、電気炉にて９００℃に１時
間焼成し、白色粉末として実施例２の抗菌性アパタイト
を得た。Example 2 Citric acid was added to 1 L of distilled water.
46 g were dissolved. Calcium carbonate 15.
02 g was stirred and mixed. Next, 85% by weight of phosphoric acid.
46 g was slowly added to form a calcium phosphate precipitate. The precipitate was filtered and calcined at 900 ° C. for 1 hour in an electric furnace to obtain the antibacterial apatite of Example 2 as a white powder.
【００１６】得られた白色粉末をＸ線回折分析した結
果、ハイドロキシアパタイト相に起因するピークと酸化
カルシウム相に起因するピークとが認められ、Ｃａ／Ｐ
のモル比は４．５であった。このモル比から、ハイドロ
キシアパタイト相に対する酸化カルシウム相の割合は４
５重量％であることがわかった。また走査型電子顕微鏡
による観察で、ハイドロキシアパタイト相の表面もしく
は相間に酸化カルシウムの微細結晶が均一に析出し固着
している構造が認められた。As a result of X-ray diffraction analysis of the obtained white powder, a peak attributable to the hydroxyapatite phase and a peak attributable to the calcium oxide phase were observed.
Was 4.5. From this molar ratio, the ratio of the calcium oxide phase to the hydroxyapatite phase was 4%.
It was found to be 5% by weight. Observation with a scanning electron microscope revealed a structure in which fine crystals of calcium oxide were uniformly precipitated and fixed on the surface of the hydroxyapatite phase or between the phases.
【００１７】この抗菌性アパタイトを乳鉢で粉砕し粉末
にした後、Brain Heart Infusion液体培地４０ｍｌ中に
０．１重量％〜１．０重量％添加した。次いでこの液体
培地に大腸菌を１０6 ｃｆｕ／ｍｌの濃度で播種し、３
７℃で３日間培養し、抗菌性を調べた。その結果、実施
例２の抗菌性アパタイトを０．５重量％以上添加した液
体培地では、培養６時間以降で大腸菌がすべて死滅し、
優れた抗菌性が確認された。The antibacterial apatite was pulverized in a mortar into powder, and then added in an amount of 0.1% by weight to 1.0% by weight in 40 ml of a Brain Heart Infusion liquid medium. Next, Escherichia coli was inoculated on this liquid medium at a concentration of 10 6 cfu / ml,
The cells were cultured at 7 ° C. for 3 days and examined for antibacterial properties. As a result, in the liquid medium to which the antibacterial apatite of Example 2 was added in an amount of 0.5% by weight or more, all Escherichia coli was killed after 6 hours of culture,
Excellent antibacterial properties were confirmed.
【００１８】（比較例１）通常の湿式法で合成したハイ
ドロキシアパタイトの粉末と水酸化カルシウムの粉末と
を別々に、Brain Heart Infusion液体培地４０ｍｌ中に
それぞれ０．１重量％〜１．０重量％添加した。これら
の液体培地に大腸菌をそれぞれ１０6 ｃｆｕ／ｍｌの濃
度で播種し、３７℃で３日間培養し、抗菌性を調べた。
その結果、ハイドロキシアパタイトを単独で添加した液
体培地では大腸菌がいずれも対数直線的に増殖し、抗菌
性は認められなかった。また、水酸化カルシウムを単独
で０．１重量％〜０．５重量％添加した液体培地でも大
腸菌が対数直線的に増殖し、抗菌性は認められなかっ
た。一方、水酸化カルシウムを１重量％添加した液体培
地では、培養１日以降で大腸菌がすべて死滅し、抗菌性
が確認された。しかしこの水酸化カルシウムの抗菌性
は、実施例１及び実施例２の抗菌性アパタイトの抗菌性
に比較すると弱いものであった。(Comparative Example 1) Hydroxyapatite powder and calcium hydroxide powder synthesized by an ordinary wet method were separately separated in a Brain Heart Infusion liquid medium (40 ml) in an amount of 0.1% by weight to 1.0% by weight. Was added. Escherichia coli was inoculated on each of these liquid culture media at a concentration of 10 6 cfu / ml, and cultured at 37 ° C. for 3 days to examine antibacterial properties.
As a result, in the liquid medium to which hydroxyapatite alone was added, Escherichia coli all grew logarithmically, and no antibacterial activity was observed. Escherichia coli also grew logarithmically in a liquid medium containing 0.1% to 0.5% by weight of calcium hydroxide alone, and no antibacterial activity was observed. On the other hand, in the liquid medium to which 1% by weight of calcium hydroxide was added, all Escherichia coli was killed after one day of culture, and antibacterial activity was confirmed. However, the antibacterial properties of this calcium hydroxide were weaker than those of the antibacterial apatites of Examples 1 and 2.
【００１９】（比較例２）通常の湿式法で合成したハイ
ドロキシアパタイト１００ｇと硝酸銀３ｇとを蒸留水１
Ｌに加え攪拌混合した。その後に沈澱物を濾過し、１２
００℃に１時間焼成し、銀２重量％を含む比較例２の抗
菌性アパタイトを得た。この抗菌性アパタイトの色は暗
灰色であった。Comparative Example 2 100 g of hydroxyapatite and 3 g of silver nitrate synthesized by a usual wet method were mixed with distilled water 1
And mixed with stirring. Then the precipitate was filtered off and 12
It was baked at 00 ° C. for 1 hour to obtain the antibacterial apatite of Comparative Example 2 containing 2% by weight of silver. The color of this antibacterial apatite was dark gray.
【００２０】比較例２の粉末を、Brain Heart Infusion
液体培地４０ｍｌ中に０．１重量％〜１．０重量％添加
した。この液体培地に大腸菌を１０6 ｃｆｕ／ｍｌの濃
度で播種し、３７℃で３日間培養し、抗菌性を調べた。
比較例２の抗菌性アパタイトを０．１重量％〜０．５重
量％添加した液体培地では大腸菌がいずれも対数直線的
に増殖し、抗菌性が認められなかった。一方、比較例２
の抗菌性アパタイトを１重量％添加した液体培地では、
培養１日以降で大腸菌がすべて死滅し、抗菌性が確認さ
れた。しかし比較例２の抗菌性アパタイトによる抗菌性
は、実施例１及び実施例２の抗菌性アパタイトの抗菌性
に比較すると弱いものであった。The powder of Comparative Example 2 was used for Brain Heart Infusion.
0.1% by weight to 1.0% by weight was added to 40 ml of a liquid medium. Escherichia coli was inoculated into this liquid medium at a concentration of 10 6 cfu / ml, cultured at 37 ° C. for 3 days, and examined for antibacterial properties.
In the liquid medium to which 0.1% to 0.5% by weight of the antibacterial apatite of Comparative Example 2 was added, Escherichia coli all grew logarithmically linearly, and no antibacterial property was observed. On the other hand, Comparative Example 2
In a liquid medium containing 1% by weight of antibacterial apatite,
After one day of culture, all the E. coli were killed, and antibacterial properties were confirmed. However, the antibacterial property of the antibacterial apatite of Comparative Example 2 was weaker than that of the antibacterial apatite of Example 1 and Example 2.
【００２１】上記の結果から、本発明の抗菌性アパタイ
トは、通常のハイドロキシアパタイト又は水酸化カルシ
ウムの単独では得られない優れた抗菌力を示し、銀を含
むハイドロキシアパタイトに比べても、銀を含まないに
係わらず優れた抗菌力を示し、しかも色が白色であるこ
とから適用範囲が広いことがわかる。From the above results, the antibacterial apatite of the present invention exhibits an excellent antibacterial activity which cannot be obtained by ordinary hydroxyapatite or calcium hydroxide alone, and contains more silver than hydroxyapatite containing silver. It shows excellent antibacterial activity irrespective of whether it is used or not, and its color is white.
【００２２】[0022]
【発明の効果】本発明の抗菌性アパタイトは、Ｃａ／Ｐ
のモル比が１．８〜５．０の範囲内であるカルシウム過
剰型ハイドロキシアパタイトが７００℃〜１２００℃の
範囲内で焼成されてなるものであるので、通常のハイド
ロキシアパタイトの構成元素のみで構成されているにも
係わらず優れた抗菌力を有し、しかも白色で安全性が高
く、簡単かつ安価に製造でき、広範な分野に適用が可能
である。The antibacterial apatite of the present invention has a Ca / P
Is a calcined calcium-rich hydroxyapatite having a molar ratio of 1.8 to 5.0 in the range of 700 ° C to 1200 ° C. Despite the fact that it has excellent antibacterial activity, it is white and highly safe, can be easily and inexpensively manufactured, and can be applied to a wide range of fields.
【図１】 本発明の一実施例を示すＸ線回折グラフFIG. 1 is an X-ray diffraction graph showing one embodiment of the present invention.
【図２】 上記実施例の微細構造を示す走査型電子顕微
鏡写真FIG. 2 is a scanning electron micrograph showing the fine structure of the above example.
Claims (2)
囲内であるカルシウム過剰型ハイドロキシアパタイトが
焼成されてなることを特徴とする抗菌性アパタイト。1. An antibacterial apatite obtained by calcining a calcium-rich hydroxyapatite having a Ca / P molar ratio in the range of 1.8 to 5.0.
ａ／Ｐのモル比が１．８〜５．０の範囲内となるように
反応させ、生成したカルシウム過剰型ハイドロキシアパ
タイトを７００℃〜１２００℃の範囲内で焼成すること
を特徴とする抗菌性アパタイトの製造方法。2. Calcium hydroxide and phosphoric acid are converted to C in water.
An antibacterial property characterized by reacting so that the molar ratio of a / P is in the range of 1.8 to 5.0, and calcining the resulting calcium-rich hydroxyapatite in the range of 700 ° C to 1200 ° C. Apatite manufacturing method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10163907A JP2000001412A (en) | 1998-06-11 | 1998-06-11 | Antimicrobial apatite and its production |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP10163907A JP2000001412A (en) | 1998-06-11 | 1998-06-11 | Antimicrobial apatite and its production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2000001412A true JP2000001412A (en) | 2000-01-07 |
Family
ID=15783101
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP10163907A Withdrawn JP2000001412A (en) | 1998-06-11 | 1998-06-11 | Antimicrobial apatite and its production |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2000001412A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002003320A (en) * | 2000-06-22 | 2002-01-09 | Tomita Pharmaceutical Co Ltd | Bactericidal agent and method for sterilization |
| JP2010184917A (en) * | 2009-02-13 | 2010-08-26 | Mitsubishi Materials Corp | Antibacterial member |
-
1998
- 1998-06-11 JP JP10163907A patent/JP2000001412A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002003320A (en) * | 2000-06-22 | 2002-01-09 | Tomita Pharmaceutical Co Ltd | Bactericidal agent and method for sterilization |
| JP4576026B2 (en) * | 2000-06-22 | 2010-11-04 | 富田製薬株式会社 | Disinfectant and disinfecting method |
| JP2010184917A (en) * | 2009-02-13 | 2010-08-26 | Mitsubishi Materials Corp | Antibacterial member |
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