JOP20180097B1 - 1,8-naphthyridine gluosamine derivatives,their use in the treatment of microbial infections,and amethod for preparation - Google Patents

1,8-naphthyridine gluosamine derivatives,their use in the treatment of microbial infections,and amethod for preparation

Info

Publication number
JOP20180097B1
JOP20180097B1 JOP/2018/0097A JOP20180097A JOP20180097B1 JO P20180097 B1 JOP20180097 B1 JO P20180097B1 JO P20180097 A JOP20180097 A JO P20180097A JO P20180097 B1 JOP20180097 B1 JO P20180097B1
Authority
JO
Jordan
Prior art keywords
alkyl
hydroxy groups
gluosamine
amethod
naphthyridine
Prior art date
Application number
JOP/2018/0097A
Other languages
Arabic (ar)
Inventor
Aya Ahmed Mohammed Mohammed Miss
Ghadeer Abdul Rahman Yousef Suaifan Prof
Mayadah Bashir Ag Shehadeh Dr
Original Assignee
Univ Of Jordan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Of Jordan filed Critical Univ Of Jordan
Priority to JOP/2018/0097A priority Critical patent/JOP20180097B1/en
Priority to PCT/JO2019/050010 priority patent/WO2020084648A1/en
Publication of JOP20180097A1 publication Critical patent/JOP20180097A1/en
Application granted granted Critical
Publication of JOP20180097B1 publication Critical patent/JOP20180097B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

The present disclosure provides a compound of Formula (I) or any pharmaceutically acceptable salt thereof for use in treating a microbial infection in a subject, a method for preparing the same, and a pharmaceutical composition thereof: Formula (I) wherein R1 may include hydrogen; alkyl; cycloalkyl; alkenyl; cycloalkenyl; alkynyl; aryl; or heteroaryl; R2, R3, R4 may independently include hydrogen; alkyl; cycloalkyl; alkoxy; aryloxy; heteroaryloxy; halogen; hydroxyl; cyano; or heteroaryl; R5, R6, R7, R8 may include free hydroxy groups; fully acylated hydroxy groups; or partially acylated hydroxy groups having the group R9-(C=O)-; and wherein R9 may include alkyl; substituted or unsubstituted aryl; or arylalkyl.
JOP/2018/0097A 2018-10-22 2018-10-22 1,8-naphthyridine gluosamine derivatives,their use in the treatment of microbial infections,and amethod for preparation JOP20180097B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JOP/2018/0097A JOP20180097B1 (en) 2018-10-22 2018-10-22 1,8-naphthyridine gluosamine derivatives,their use in the treatment of microbial infections,and amethod for preparation
PCT/JO2019/050010 WO2020084648A1 (en) 2018-10-22 2019-01-30 1,8-naphthyridine glucosamine derivatives, their use in the treatment of microbial infections, and a method for preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JOP/2018/0097A JOP20180097B1 (en) 2018-10-22 2018-10-22 1,8-naphthyridine gluosamine derivatives,their use in the treatment of microbial infections,and amethod for preparation

Publications (2)

Publication Number Publication Date
JOP20180097A1 JOP20180097A1 (en) 2020-04-22
JOP20180097B1 true JOP20180097B1 (en) 2023-03-28

Family

ID=70330951

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2018/0097A JOP20180097B1 (en) 2018-10-22 2018-10-22 1,8-naphthyridine gluosamine derivatives,their use in the treatment of microbial infections,and amethod for preparation

Country Status (2)

Country Link
JO (1) JOP20180097B1 (en)
WO (1) WO2020084648A1 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
WO2003079980A2 (en) * 2002-03-19 2003-10-02 A & D Bioscience, Inc. Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
WO2005091857A2 (en) * 2004-03-12 2005-10-06 Bayer Pharmaceuticals Corporation 1,6-naphthyridine and 1,8-naphthyridine derivatives and their use to treat diabetes and related disorders

Also Published As

Publication number Publication date
JOP20180097A1 (en) 2020-04-22
WO2020084648A1 (en) 2020-04-30

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