JOP20170175B1 - Process for the preparation of androgen receptor antagonists and intermediates thereof - Google Patents

Process for the preparation of androgen receptor antagonists and intermediates thereof

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Publication number
JOP20170175B1
JOP20170175B1 JOP/2017/0175A JOP20170175A JOP20170175B1 JO P20170175 B1 JOP20170175 B1 JO P20170175B1 JO P20170175 A JOP20170175 A JO P20170175A JO P20170175 B1 JOP20170175 B1 JO P20170175B1
Authority
JO
Jordan
Prior art keywords
preparation
androgen receptor
intermediates
receptor antagonists
antagonists
Prior art date
Application number
JOP/2017/0175A
Other languages
Arabic (ar)
Inventor
Ilpo Laitinen
Oskari Karjalainen
Original Assignee
Orion Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Corp filed Critical Orion Corp
Priority to JOP/2017/0175A priority Critical patent/JOP20170175B1/en
Publication of JOP20170175A1 publication Critical patent/JOP20170175A1/en
Application granted granted Critical
Publication of JOP20170175B1 publication Critical patent/JOP20170175B1/en

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Abstract

The present invention relates to an improved process for the preparation of carboxamide structured androgen receptor (AR) antagonists such as N-((S)-1-(3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl)-propan-2-yl)-5-(1-hydroxyandnot;ethyl)-1H-pyrazole-3-carboxamide (1A) and key intermediates thereof such as 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile (V). AR antagonists are useful in the treatment of cancer, particularly prostate cancer and other diseases where AR antagonism is desired.
JOP/2017/0175A 2017-10-10 2017-10-10 Process for the preparation of androgen receptor antagonists and intermediates thereof JOP20170175B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JOP/2017/0175A JOP20170175B1 (en) 2017-10-10 2017-10-10 Process for the preparation of androgen receptor antagonists and intermediates thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JOP/2017/0175A JOP20170175B1 (en) 2017-10-10 2017-10-10 Process for the preparation of androgen receptor antagonists and intermediates thereof

Publications (2)

Publication Number Publication Date
JOP20170175A1 JOP20170175A1 (en) 2019-04-10
JOP20170175B1 true JOP20170175B1 (en) 2021-08-17

Family

ID=75469100

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2017/0175A JOP20170175B1 (en) 2017-10-10 2017-10-10 Process for the preparation of androgen receptor antagonists and intermediates thereof

Country Status (1)

Country Link
JO (1) JOP20170175B1 (en)

Also Published As

Publication number Publication date
JOP20170175A1 (en) 2019-04-10

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