JO2677B1 - Improved process for the preparation of the clevudine compound as an anti-HBV agent - Google Patents

Improved process for the preparation of the clevudine compound as an anti-HBV agent

Info

Publication number
JO2677B1
JO2677B1 JO2007521A JOP20070521A JO2677B1 JO 2677 B1 JO2677 B1 JO 2677B1 JO 2007521 A JO2007521 A JO 2007521A JO P20070521 A JOP20070521 A JO P20070521A JO 2677 B1 JO2677 B1 JO 2677B1
Authority
JO
Jordan
Prior art keywords
clevudine
preparation
improved process
arabinofuranosyl
thymine
Prior art date
Application number
JO2007521A
Other languages
Arabic (ar)
English (en)
Inventor
سوج،كوانج-هو
بارك،هي-كوانج
هان،تاي-هي
كو،تشانج-هوي
سونج-جو وو،
Original Assignee
باكوانج فارم كو.،ال تي دي
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by باكوانج فارم كو.،ال تي دي filed Critical باكوانج فارم كو.،ال تي دي
Application granted granted Critical
Publication of JO2677B1 publication Critical patent/JO2677B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JO2007521A 2006-12-08 2007-12-06 Improved process for the preparation of the clevudine compound as an anti-HBV agent JO2677B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020060124497A KR100839322B1 (ko) 2006-12-08 2006-12-08 Ｂ형 간염 치료제 클레부딘의 개선된 제조방법

Publications (1)

Publication Number Publication Date
JO2677B1 true JO2677B1 (en) 2013-03-03

Family

ID=39492283

Family Applications (1)

Application Number Title Priority Date Filing Date
JO2007521A JO2677B1 (en) 2006-12-08 2007-12-06 Improved process for the preparation of the clevudine compound as an anti-HBV agent

Country Status (3)

Country Link
KR (1) KR100839322B1 (ko)
JO (1) JO2677B1 (ko)
WO (1) WO2008069451A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105943547B (zh) * 2016-05-23 2018-01-19 北京慧宝源生物技术股份有限公司 抗hbv的药物组合物及其应用
CN106831901A (zh) * 2016-12-14 2017-06-13 安徽省诚联医药科技有限公司 2‑脱氧‑2‑氟‑1,3,5‑三苯甲酰基‑α‑D‑阿拉伯呋喃糖的制备方法
CN109467583A (zh) * 2018-11-17 2019-03-15 扬州工业职业技术学院 一种克拉夫定的绿色合成工艺

Also Published As

Publication number Publication date
KR20080052827A (ko) 2008-06-12
KR100839322B1 (ko) 2008-06-17
WO2008069451A1 (en) 2008-06-12

Similar Documents

Publication Publication Date Title
EP2609923A3 (en) Nucleoside Phosphoramidates
CL2011001906A1 (es) Compuestos derivados de ribosidos de tieno[3,4-d]pirimidin-7-ilo, y fosfatos de ribosidos; compuestos intermediarios; metodos de preparacion; metodo de tratamiento; composicion farmaceutica; y su uso para tratar una infeccion viral causada por un virus hepatitis c o un virus flaviridae.
SG137868A1 (en) Heterocyclic antiviral compounds
UA91721C2 (ru) Азеотропная композиция, способ получения е-1,3,3,3-тетрафторпропена, способ его отделения и очищения
NZ598000A (en) Composition for treating hbv infection
HK1108100A1 (en) Method of heating materials in order to produce objects and device for implementing said method
JP2010525944A5 (ko)
TW200745151A (en) Antiviral nucleosides
WO2002044400A3 (en) Compositions and methods for extracting a nucleic acid
UA92607C2 (ru) СПОСОБ УДАЛЕНИЯ МЕТАЛЛИЧЕСКОГО ОТЛОЖения, содержащего соединения металлов, С ПОВЕРХНОСТИ
MX2007006610A (es) Metodo para simplificar acidos nucleicos microbianos por modificacion quimica de citosinas.
JO2677B1 (en) Improved process for the preparation of the clevudine compound as an anti-HBV agent
EP1679386A4 (en) HIGH RESISTANCE MAGNETIC STEEL SHEET AND WORKPIECE MANUFACTURED FROM SUCH SHEET, AND PROCESS FOR PRODUCING THE SAME
MY154878A (en) Process for purifying staurosporine
EP1999673A4 (en) ADDRESS MANIPULATION FOR PROVIDING NETWORK TOOLS, EVEN IF TRANSACTION ACCELERATION IS USED ON A NETWORK
DE50311003D1 (de) Verbundkeramikkörper sowie verfahren zum herstellen eines solchen
MXPA03000612A (es) Metodos y procesos mejorados para desinfeccion con yodo.
ATE418405T1 (de) Hochkinetische energie zur bearbeitung von material einsetzendes verfahren
ZA200802936B (en) Vero cell line which is adapted to grow in suspension,method of obtaining same and viral vaccines
IL198801A0 (en) Process for preparing 3,5-di-omicron-acyl-2-fluoro-2-c-methyl-d-ribono-gamma-lactone
TW200800942A (en) Chemical compounds
DE60101321D1 (de) Verfahren zur reinigung wässriger pufferlösungen
MXPA02008460A (es) Proceso catalizado con metal de transicion para la adicion de aminas a enlaces dobles carbono-carbono.
JP2007523063A5 (ko)
WO2007032005A3 (en) Novel amine-borane compounds and uses thereof