JO1810B1 - Therapeutic agent - Google Patents

Abstract

Compounds of formula I And pharmaceutically acceptable salts thereof in which one of A or B represents N and the other represents N or C-R3 , R1 represents hydrogen, halo, alkyl, hydroxyl, carboxyalkenyl, alkoxycarbonylalkenyl, hydroxyalkyl, carboxyalkyl, alkoxycarbonylalkyl, alkoxy, halogenated alkyl, carboxy, alkoxycarbonyl, alkanoylamino or carbamoylalkenyl, R2 represents hydrogen, halo, alkoxy, hydroxyl, alkanoyloxy, or phenoxy, R3 represents hydrogen, or alkyl, R4 represnts hydrogen , halo alkoxycarbonyl, cyano, benzyloxycarbonyl, alkanoyl, benzoyl, alkyl, carboxy, alkylthio, or carbanoyl , R5 represents hydrogen or alkyl, R9 represents hydrogen or alkyl, R10 represents phenyl, pyridyl, or pyrimidinyl substituted by OR6 and optionally further substituted wherein R6 represents hydrogen, alkyl, alkoxycarbonyl or carbamoyl, alicyclic hydrocarbon , phenyl,. Cycloalkyl-alkyl, arylalkyl, or pyridyl, or when R10 represents phenyl, OR6 represents a monosaccharide group or a disaccharide group, which are antirheumatic agents, Compositions containing these compounds and processes to prepare them are also disclosed.