JO1320B1 - phenethnolamine derivatives - Google Patents
phenethnolamine derivativesInfo
- Publication number
- JO1320B1 JO1320B1 JO19841320A JOP19841320A JO1320B1 JO 1320 B1 JO1320 B1 JO 1320B1 JO 19841320 A JO19841320 A JO 19841320A JO P19841320 A JOP19841320 A JO P19841320A JO 1320 B1 JO1320 B1 JO 1320B1
- Authority
- JO
- Jordan
- Prior art keywords
- compounds
- hydrogen
- physiologically acceptable
- protecting group
- alkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000006239 protecting group Chemical group 0.000 abstract 2
- 102100039705 Beta-2 adrenergic receptor Human genes 0.000 abstract 1
- 101710152983 Beta-2 adrenergic receptor Proteins 0.000 abstract 1
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 206010062109 Reversible airways obstruction Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical class NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Phenethanolamine derivatives are disclosed of formula wherein m is 2 to 8; n is 1 to 7 provided that m+n is 4 to 12; Ar is phenyl or phenyl substituted by one or two halogen atoms, alkyl or alkoxy groups or by an alkylenedioxy group; R1 and R2 are hydrogen or alkyl provided that the sum total of carbon atoms in R1 and R2 is not more than 4; and the physiologically acceptable salts and solvates thereof. The compounds have a selective stimulant action at beta 2-adrenoreceptors and may be used inter alia in the treatment of diseases associated with reversible airways obstructions such as asthma and chronic bronchitis. The compounds may be formulated in conventional manner as pharmaceutical compositions with physiologically acceptable carriers or excipients. The compounds may be prepared, for example by alkylation of an amine: where R3, R5 and R6 is hydrogen or a protecting group, followed by removal of any protecting group.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838317087A GB8317087D0 (en) | 1983-06-23 | 1983-06-23 | Chemical compounds |
| GB838329568A GB8329568D0 (en) | 1983-11-04 | 1983-11-04 | Chemical compounds |
| GB848401889A GB8401889D0 (en) | 1984-01-25 | 1984-01-25 | Chemical compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO1320B1 true JO1320B1 (en) | 1986-11-30 |
Family
ID=48087287
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JO19841320A JO1320B1 (en) | 1983-06-23 | 1984-05-02 | phenethnolamine derivatives |
Country Status (1)
| Country | Link |
|---|---|
| JO (1) | JO1320B1 (en) |
-
1984
- 1984-05-02 JO JO19841320A patent/JO1320B1/en active
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