ITUB20152371A1 - Procedimento per indurre resistenza alla tossina difterica in cellule umane, relativi prodotti ed usi - Google Patents
Procedimento per indurre resistenza alla tossina difterica in cellule umane, relativi prodotti ed usiInfo
- Publication number
- ITUB20152371A1 ITUB20152371A1 ITUB2015A002371A ITUB20152371A ITUB20152371A1 IT UB20152371 A1 ITUB20152371 A1 IT UB20152371A1 IT UB2015A002371 A ITUB2015A002371 A IT UB2015A002371A IT UB20152371 A ITUB20152371 A IT UB20152371A IT UB20152371 A1 ITUB20152371 A1 IT UB20152371A1
- Authority
- IT
- Italy
- Prior art keywords
- difteric
- toxin
- procedure
- human cells
- related products
- Prior art date
Links
- 210000005260 human cell Anatomy 0.000 title 1
- 230000001939 inductive effect Effects 0.000 title 1
- 239000003053 toxin Substances 0.000 title 1
- 231100000765 toxin Toxicity 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0271—Chimeric animals, e.g. comprising exogenous cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/12—Animals modified by administration of exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0331—Animal model for proliferative diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUB2015A002371A ITUB20152371A1 (it) | 2015-07-21 | 2015-07-21 | Procedimento per indurre resistenza alla tossina difterica in cellule umane, relativi prodotti ed usi |
US15/745,829 US20180216112A1 (en) | 2015-07-21 | 2016-07-19 | Process for inducing resistance to diphtheria toxin in human cells, products and uses thereof |
PCT/IB2016/054293 WO2017013585A1 (en) | 2015-07-21 | 2016-07-19 | Process for inducing resistance to diphtheria toxin in human cells, products and uses thereof |
EP16757079.5A EP3325625B1 (en) | 2015-07-21 | 2016-07-19 | Process for inducing resistance to diphtheria toxin in human cells, products and uses thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUB2015A002371A ITUB20152371A1 (it) | 2015-07-21 | 2015-07-21 | Procedimento per indurre resistenza alla tossina difterica in cellule umane, relativi prodotti ed usi |
Publications (1)
Publication Number | Publication Date |
---|---|
ITUB20152371A1 true ITUB20152371A1 (it) | 2017-01-21 |
Family
ID=54251679
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITUB2015A002371A ITUB20152371A1 (it) | 2015-07-21 | 2015-07-21 | Procedimento per indurre resistenza alla tossina difterica in cellule umane, relativi prodotti ed usi |
Country Status (4)
Country | Link |
---|---|
US (1) | US20180216112A1 (it) |
EP (1) | EP3325625B1 (it) |
IT (1) | ITUB20152371A1 (it) |
WO (1) | WO2017013585A1 (it) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019089603A1 (en) * | 2017-10-31 | 2019-05-09 | Dana-Farber Cancer Institute, Inc. | Methods for determining and treating cellular resistance to adp-ribosylating toxin |
CN114410680B (zh) * | 2022-01-25 | 2023-03-31 | 乾元康安(苏州)生物科技有限公司 | Dph6基因在制备具有毒素抗性细胞系中的应用 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007143858A1 (en) * | 2006-06-16 | 2007-12-21 | Manuel Caruso | Dph2 gene deletion mutant and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002081628A2 (en) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies |
-
2015
- 2015-07-21 IT ITUB2015A002371A patent/ITUB20152371A1/it unknown
-
2016
- 2016-07-19 US US15/745,829 patent/US20180216112A1/en not_active Abandoned
- 2016-07-19 EP EP16757079.5A patent/EP3325625B1/en active Active
- 2016-07-19 WO PCT/IB2016/054293 patent/WO2017013585A1/en active Application Filing
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007143858A1 (en) * | 2006-06-16 | 2007-12-21 | Manuel Caruso | Dph2 gene deletion mutant and uses thereof |
Non-Patent Citations (2)
Title |
---|
GABRIELE PICCO ET AL: "A diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells", SCIENTIFIC REPORTS, vol. 5, 30 September 2015 (2015-09-30), pages 14721, XP055245105, DOI: 10.1038/srep14721 * |
VINCENT ROY ET AL: "A Dominant-Negative Approach That Prevents Diphthamide Formation Confers Resistance to Pseudomonas Exotoxin A and Diphtheria Toxin", PLOS ONE, vol. 5, no. 12, 23 December 2010 (2010-12-23), pages e15753, XP055245675, DOI: 10.1371/journal.pone.0015753 * |
Also Published As
Publication number | Publication date |
---|---|
EP3325625A1 (en) | 2018-05-30 |
US20180216112A1 (en) | 2018-08-02 |
WO2017013585A1 (en) | 2017-01-26 |
EP3325625B1 (en) | 2019-12-04 |
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