ITUA20162653A1 - USE OF A GLUCOSAMINE DERIVATIVE FOR THE TREATMENT OF OSTEOARTHRITIS, METASTASIS SECONDARY TO OSTEOSARCOMA, ALTERATIONS AND PATHOLOGIES OF THE EXTRACELLULAR MATRIX. - Google Patents

USE OF A GLUCOSAMINE DERIVATIVE FOR THE TREATMENT OF OSTEOARTHRITIS, METASTASIS SECONDARY TO OSTEOSARCOMA, ALTERATIONS AND PATHOLOGIES OF THE EXTRACELLULAR MATRIX.

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Publication number
ITUA20162653A1
ITUA20162653A1 ITUA2016A002653A ITUA20162653A ITUA20162653A1 IT UA20162653 A1 ITUA20162653 A1 IT UA20162653A1 IT UA2016A002653 A ITUA2016A002653 A IT UA2016A002653A IT UA20162653 A ITUA20162653 A IT UA20162653A IT UA20162653 A1 ITUA20162653 A1 IT UA20162653A1
Authority
IT
Italy
Prior art keywords
osteosarcoma
pathologies
osteoarthritis
alterations
treatment
Prior art date
Application number
ITUA2016A002653A
Other languages
Italian (it)
Inventor
Roberto Scandurra
D'abusco Anna Scotto
Laura Politi
Cesare Giordano
Original Assignee
Cartilago S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cartilago S R L filed Critical Cartilago S R L
Priority to ITUA2016A002653A priority Critical patent/ITUA20162653A1/en
Publication of ITUA20162653A1 publication Critical patent/ITUA20162653A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
ITUA2016A002653A 2016-03-29 2016-03-29 USE OF A GLUCOSAMINE DERIVATIVE FOR THE TREATMENT OF OSTEOARTHRITIS, METASTASIS SECONDARY TO OSTEOSARCOMA, ALTERATIONS AND PATHOLOGIES OF THE EXTRACELLULAR MATRIX. ITUA20162653A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ITUA2016A002653A ITUA20162653A1 (en) 2016-03-29 2016-03-29 USE OF A GLUCOSAMINE DERIVATIVE FOR THE TREATMENT OF OSTEOARTHRITIS, METASTASIS SECONDARY TO OSTEOSARCOMA, ALTERATIONS AND PATHOLOGIES OF THE EXTRACELLULAR MATRIX.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUA2016A002653A ITUA20162653A1 (en) 2016-03-29 2016-03-29 USE OF A GLUCOSAMINE DERIVATIVE FOR THE TREATMENT OF OSTEOARTHRITIS, METASTASIS SECONDARY TO OSTEOSARCOMA, ALTERATIONS AND PATHOLOGIES OF THE EXTRACELLULAR MATRIX.

Publications (1)

Publication Number Publication Date
ITUA20162653A1 true ITUA20162653A1 (en) 2017-09-29

Family

ID=57906819

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUA2016A002653A ITUA20162653A1 (en) 2016-03-29 2016-03-29 USE OF A GLUCOSAMINE DERIVATIVE FOR THE TREATMENT OF OSTEOARTHRITIS, METASTASIS SECONDARY TO OSTEOSARCOMA, ALTERATIONS AND PATHOLOGIES OF THE EXTRACELLULAR MATRIX.

Country Status (1)

Country Link
IT (1) ITUA20162653A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216208A (en) * 1978-07-31 1980-08-05 Proter S.P.A. N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity
CA2696811A1 (en) * 2010-03-19 2011-09-19 Fakhreddin Jamali Glucosamin pro-drugs

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4216208A (en) * 1978-07-31 1980-08-05 Proter S.P.A. N-Acyl derivatives of glucosamines having antitumor chemotherapeutic activity
CA2696811A1 (en) * 2010-03-19 2011-09-19 Fakhreddin Jamali Glucosamin pro-drugs

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ANNA SCOTTO D'ABUSCO ET AL: "Effects of intra-articular administration of glucosamine and a peptidyl-glucosamine derivative in a rabbit model of experimental osteoarthritis: a pilot study", RHEUMATOLOGY INTERNATIONAL ; CLINICAL AND EXPERIMENTAL INVESTIGATIONS, SPRINGER, BERLIN, DE, vol. 28, no. 5, 9 October 2007 (2007-10-09), pages 437 - 443, XP019587694, ISSN: 1437-160X *
D. STOPPOLONI ET AL: "Effect of glucosamine and its peptidyl-derivative on the production of extracellular matrix components by human primary chondrocytes", OSTEOARTHRITIS AND CARTILAGE., vol. 23, no. 1, 1 January 2015 (2015-01-01), GB, pages 103 - 113, XP055346705, ISSN: 1063-4584, DOI: 10.1016/j.joca.2014.09.005 *
F. VERONESI ET AL: "Chondroprotective activity of N-acetyl phenylalanine glucosamine derivative on knee joint structure and inflammation in a murine model of osteoarthritis", OSTEOARTHRITIS AND CARTILAGE., 1 November 2016 (2016-11-01), GB, XP055347292, ISSN: 1063-4584, DOI: 10.1016/j.joca.2016.10.021 *
GIORDANO C ET AL: "Synthesis and properties of d-glucosamine N-peptidyl derivatives as substrate analog inhibitors of papain and cathepsin B", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 26, no. 8, 1 November 1991 (1991-11-01), pages 753 - 762, XP023870484, ISSN: 0223-5234, [retrieved on 19911101], DOI: 10.1016/0223-5234(91)90001-4 *
KOLTER THOMAS ET AL: "Synthesis of substituted chiral piperazinones as building blocks for peptidomimetics", LIEBIGS ANNALEN, vol. 0, no. 4, 1995, pages 625 - 629, XP002767405, ISSN: 0947-3440 *
LEOPIZZI MARTINA ET AL: "IKK[alpha] inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line", CHEMICO-BIOLOGICAL INTERACTIONS, vol. 262, 6 December 2016 (2016-12-06), pages 19 - 28, XP029871707, ISSN: 0009-2797, DOI: 10.1016/J.CBI.2016.12.005 *
SCOTTO D'ABUSCO ANNA ET AL: "A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes", ARTHRITIS RESEARCH AND THERAPY, BIOMED CENTRAL, LONDON, GB, vol. 12, no. 1, 29 January 2010 (2010-01-29), pages R18, XP021070738, ISSN: 1478-6354 *

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