ITUA20162486A1 - Nanobubbles and their uses - Google Patents

Nanobubbles and their uses

Info

Publication number
ITUA20162486A1
ITUA20162486A1 ITUA2016A002486A ITUA20162486A ITUA20162486A1 IT UA20162486 A1 ITUA20162486 A1 IT UA20162486A1 IT UA2016A002486 A ITUA2016A002486 A IT UA2016A002486A IT UA20162486 A ITUA20162486 A IT UA20162486A IT UA20162486 A1 ITUA20162486 A1 IT UA20162486A1
Authority
IT
Italy
Prior art keywords
nanobubbles
Prior art date
Application number
ITUA2016A002486A
Other languages
Italian (it)
Inventor
Maria Carafa
Andrea Bettucci
Carlotta Marianecci
Federica Rinaldi
Angelo Biagioni
Original Assignee
Univ Degli Studi Roma La Sapienza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Roma La Sapienza filed Critical Univ Degli Studi Roma La Sapienza
Priority to ITUA2016A002486A priority Critical patent/ITUA20162486A1/en
Priority to PCT/IB2017/052060 priority patent/WO2017178954A1/en
Publication of ITUA20162486A1 publication Critical patent/ITUA20162486A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
ITUA2016A002486A 2016-04-11 2016-04-11 Nanobubbles and their uses ITUA20162486A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITUA2016A002486A ITUA20162486A1 (en) 2016-04-11 2016-04-11 Nanobubbles and their uses
PCT/IB2017/052060 WO2017178954A1 (en) 2016-04-11 2017-04-10 Nanobubbles and uses thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUA2016A002486A ITUA20162486A1 (en) 2016-04-11 2016-04-11 Nanobubbles and their uses

Publications (1)

Publication Number Publication Date
ITUA20162486A1 true ITUA20162486A1 (en) 2017-10-11

Family

ID=56555546

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUA2016A002486A ITUA20162486A1 (en) 2016-04-11 2016-04-11 Nanobubbles and their uses

Country Status (2)

Country Link
IT (1) ITUA20162486A1 (en)
WO (1) WO2017178954A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210052872A1 (en) * 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Drug administration method
US20230293720A1 (en) * 2022-01-21 2023-09-21 Sohini Banerjee Novel nanobubble that contains epilepsy medicine. The bubble polarizes in presence of the electric surge generated in the brain during an epilepsy attack and automatically discharges the medicine at the time and the site of the attack, stopping the seizure in its infancy without any external intervention. The bubble releases just enough medication into the bloodstream, significantly reducing side effects.
CN116370658A (en) * 2023-03-08 2023-07-04 中国科学院深圳先进技术研究院 Tumor-targeted ultrasonic contrast agent and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014054026A1 (en) * 2012-10-04 2014-04-10 University Of The Witwatersrand, Johannesburg Liposomal drug delivery system
US20140147390A1 (en) * 2010-09-24 2014-05-29 Agata Exner Stabilized nanobubbles for diagnostic and therapeutic applications

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140147390A1 (en) * 2010-09-24 2014-05-29 Agata Exner Stabilized nanobubbles for diagnostic and therapeutic applications
WO2014054026A1 (en) * 2012-10-04 2014-04-10 University Of The Witwatersrand, Johannesburg Liposomal drug delivery system

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HUANG S L ET AL: "A Method to Co-Encapsulate Gas and Drugs in Liposomes for Ultrasound-Controlled Drug Delivery", ULTRASOUND IN MEDICINE AND BIOLOGY, NEW YORK, NY, US, vol. 34, no. 8, 1 August 2008 (2008-08-01), pages 1272 - 1280, XP023176831, ISSN: 0301-5629, [retrieved on 20080414], DOI: 10.1016/J.ULTRASMEDBIO.2008.01.005 *
KOHSUKE HAGISAWA ET AL: "Enhancement of ultrasonic thrombus imaging using novel liposomal bubbles targeting activated platelet glycoprotein IIb/IIIa complex andstudy", INTERNATIONAL JOURNAL OF CARDIOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 152, no. 2, 4 July 2010 (2010-07-04), pages 202 - 206, XP028305508, ISSN: 0167-5273, [retrieved on 20100717], DOI: 10.1016/J.IJCARD.2010.07.016 *
NICOLAS SAX ET AL: "Optimization of Acoustic Liposomes for Improved In vitro and In vivo Stability", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 30, no. 1, 1 September 2012 (2012-09-01), pages 218 - 224, XP035152043, ISSN: 1573-904X, DOI: 10.1007/S11095-012-0864-8 *
TSONG-LONG HWANG ET AL: "Development and evaluation of perfluorocarbon nanobubbles for apomorphine delivery", JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 98, no. 10, 1 October 2009 (2009-10-01), pages 3735 - 3747, XP055195470, ISSN: 0022-3549, DOI: 10.1002/jps.21687 *

Also Published As

Publication number Publication date
WO2017178954A1 (en) 2017-10-19

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