ITUA20161663A1 - Derivati chimici del colano per l’uso nel trattamento e/o nella prevenzione delle malattie mediate dai recettori fxr e tgr5/gp-bar1 - Google Patents
Derivati chimici del colano per l’uso nel trattamento e/o nella prevenzione delle malattie mediate dai recettori fxr e tgr5/gp-bar1Info
- Publication number
- ITUA20161663A1 ITUA20161663A1 ITUA2016A001663A ITUA20161663A ITUA20161663A1 IT UA20161663 A1 ITUA20161663 A1 IT UA20161663A1 IT UA2016A001663 A ITUA2016A001663 A IT UA2016A001663A IT UA20161663 A ITUA20161663 A IT UA20161663A IT UA20161663 A1 ITUA20161663 A1 IT UA20161663A1
- Authority
- IT
- Italy
- Prior art keywords
- colano
- bar1
- tgr5
- fxr
- receptors
- Prior art date
Links
- IGRCWJPBLWGNPX-UHFFFAOYSA-N 3-(2-chlorophenyl)-n-(4-chlorophenyl)-n,5-dimethyl-1,2-oxazole-4-carboxamide Chemical compound C=1C=C(Cl)C=CC=1N(C)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl IGRCWJPBLWGNPX-UHFFFAOYSA-N 0.000 title 1
- 102100025353 G-protein coupled bile acid receptor 1 Human genes 0.000 title 1
- 101000857733 Homo sapiens G-protein coupled bile acid receptor 1 Proteins 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000001404 mediated effect Effects 0.000 title 1
- 230000002265 prevention Effects 0.000 title 1
- 102000005962 receptors Human genes 0.000 title 1
- 108020003175 receptors Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUA2016A001663A ITUA20161663A1 (it) | 2016-03-15 | 2016-03-15 | Derivati chimici del colano per l’uso nel trattamento e/o nella prevenzione delle malattie mediate dai recettori fxr e tgr5/gp-bar1 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITUA2016A001663A ITUA20161663A1 (it) | 2016-03-15 | 2016-03-15 | Derivati chimici del colano per l’uso nel trattamento e/o nella prevenzione delle malattie mediate dai recettori fxr e tgr5/gp-bar1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITUA20161663A1 true ITUA20161663A1 (it) | 2017-09-15 |
Family
ID=56203710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITUA2016A001663A ITUA20161663A1 (it) | 2016-03-15 | 2016-03-15 | Derivati chimici del colano per l’uso nel trattamento e/o nella prevenzione delle malattie mediate dai recettori fxr e tgr5/gp-bar1 |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | ITUA20161663A1 (it) |
-
2016
- 2016-03-15 IT ITUA2016A001663A patent/ITUA20161663A1/it unknown
Non-Patent Citations (4)
| Title |
|---|
| CLAUDIO D'AMORE ET AL: "Design, Synthesis, and Biological Evaluation of Potent Dual Agonists of Nuclear and Membrane Bile Acid Receptors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 57, no. 3, 13 February 2014 (2014-02-13), pages 937 - 954, XP055165457, ISSN: 0022-2623, DOI: 10.1021/jm401873d * |
| PELLICCIARI R ET AL: "6alpha-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 45, no. 17, 1 January 2002 (2002-01-01), pages 3569 - 3572, XP002287455, ISSN: 0022-2623, DOI: 10.1021/JM025529G * |
| T. FUJINO ET AL: "Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation", JOURNAL OF LIPID RESEARCH, vol. 45, no. 1, 1 January 2004 (2004-01-01), US, pages 132 - 138, XP055220806, ISSN: 0022-2275, DOI: 10.1194/jlr.M300215-JLR200 * |
| Y. IGUCHI ET AL: "Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor", THE JOURNAL OF LIPID RESEARCH, vol. 51, no. 6, 18 December 2009 (2009-12-18), pages 1432 - 1441, XP055165536, ISSN: 0022-2275, DOI: 10.1194/jlr.M004051 * |
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