ITTO20120861A1 - Metodo per disegnare una pluralita' di sequenze nucleotidiche sonda specifiche per una corrispondente pluralita' di specie microbiche e microarray comprendente le stesse - Google Patents
Metodo per disegnare una pluralita' di sequenze nucleotidiche sonda specifiche per una corrispondente pluralita' di specie microbiche e microarray comprendente le stesse Download PDFInfo
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- ITTO20120861A1 ITTO20120861A1 IT000861A ITTO20120861A ITTO20120861A1 IT TO20120861 A1 ITTO20120861 A1 IT TO20120861A1 IT 000861 A IT000861 A IT 000861A IT TO20120861 A ITTO20120861 A IT TO20120861A IT TO20120861 A1 ITTO20120861 A1 IT TO20120861A1
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Description
DESCRIZIONE
"METODO PER DISEGNARE UNA PLURALITÀ' DI SEQUENZE NUCLEOTIDICHE SONDA SPECIFICHE PER UNA CORRISPONDENTE PLURALITÀ' DI SPECIE MICROBICHE E MICROARRAY COMPRENDENTE LE STESSE"
La presente invenzione è relativa a un metodo per disegnare una pluralità di sequenze nucleotidiche sonda specifiche per una corrispondente pluralità di specie microbiche, a un microarray comprendente le stesse e a relativi usi nella diagnosi di batteriemia e/o sepsi.
Stato dell'Arte
La batteriemia, ovvero la presenza di batteri nel sangue dovuta a diversi tipi di infezione, è associata a elevatissimi tassi di morbilità e mortalità. E' stato valutato di recente che le manifestazioni più pericolose della batteriemia, la sepsi e lo shock settico, rappresentano la decima causa di morte negli Stati Uniti, costituendo tra l'altro un peso economico molto importante per il paese. In Europa, si stima che 135'000 pazienti muoiono ogni anno per complicanze associate alla sepsi.
Le diverse forme di sepsi sono sempre associate a batteriemia o fungemia. Al contrario, la batteriemia e/o la fungemia non degenerano necessariamente in sepsi qualora vengano trattate precocemente ed efficacemente. In ogni caso, la diagnosi microbiologica precoce risulta piuttosto difficile, perché, fino a uno stadio avanzato della patologia, la carica microbica risulta essere piuttosto bassa (anche nell'ordine di 1 CFU/ml).
Se la batteriemia (o la fungemia) non è controllata in modo appropriato, tende immancabilmente a degenerare in sepsi, una sindrome clinica correlata al processo infettivo che porta a gravi alterazioni della risposta infiammatoria e della coagulazione.
Per questo motivo, è fondamentale identificare la batteriemia (o fungemia) in modo affidabile e rapido, utilizzando campioni con una carica batterica limitata, caratterizzando il patogeno a livello di specie e determinando la suscettibilità dello stesso agli antibiotici .
Identificato il patogeno responsabile, è possibile scegliere gli agenti antimicrobici più adatti, evitando il trattamento inutile con antibiotici non efficaci e migliorando la prognosi dei pazienti. Inoltre, si diminuisce la probabilità che insorga resistenza agli antibiotici negli agenti microbici. Infine, si risparmia nel consumo di antibiotici e si diminuiscono i costi per la struttura sanitaria.
In un recente studio su una coorte di pazienti affetti da sepsi è stato evidenziato come, in seguito all'insorgere del caratteristico sintomo dell'ipotensione, ogni ora di ritardo nella somministrazione di una terapia efficace fosse associata a un diminuzione dell' 8% nella sopravvivenza .
Attualmente, il "gold standard" per la diagnosi della batteriemia si basa sull'arricchimento del patogeno causativo mediante sistemi di emocoltura automatizzati con monitoraggio continuo, seguito da colorazione Gram, coltura su agar, e successiva identificazione biochimica e test della suscettibilità agli antibiotici. L'intero processo richiede da 24 a 72 ore.
Esistono in alternativa tecnologie basate sugli acidi nucleici, che però risultano ancora piuttosto costose, laboriose e non sufficientemente sensibili. Per queste ragioni, tali tecnologie sono ancora poco utilizzate di routine.
Le tecnologie basate sugli acidi nucleici si distinguono in due categorie: saggi da effettuare direttamente su campioni ematici e saggi da effettuare su emocolture .
Per i saggi della prima categoria, è necessario eseguire un'amplificazione del DNA presente nel campione ematico per avere una quantità sufficiente di acido nucleico da analizzare. Le tecniche basate sulla PCR tradizionale sono in generale da evitare a causa dell'elevato rischio di contaminazione da carryover. Le tecniche basate sulla Real-time PCR, invece, sono più efficaci, ma risultano ancora eccessivamente costose perché possano essere utilizzate di routine.
Per i saggi della seconda categoria, la quantità di DNA estratto dall'emocoltura è in genere sufficiente senza che sia necessaria un'amplificazione, ma il saggio stesso deve avere caratteristiche di sensibilità e specificità elevatissime per poter distinguere tra numerose specie microbiche e il DNA genomico umano presente in quantità prevalente .
Vengono di seguito descritte brevemente le tecniche disponibili per saggi su emocoltura e gli svantaggi che le rendono ancora non soddisfacenti per un uso di routine.
Le tecniche basate su PCR patogeno-specif ica, come già accennato, presentano problemi di contaminazione da carryover e scarsa possibilità di analizzare più patogeni in contemporanea.
Le tecniche basate su PCR ad ampio spettro (disegnate quindi su geni conservati come quelli del RNA ribosomale), oltre ai suddetti svantaggi, richiedono inoltre ulteriori tecniche di identificazione come il sequenziamento, l'analisi di polimorfismi, o la real-time PCR speciespecifica.
Le tecniche basate su PCR multiplex consentono l'analisi solo di un numero limitato di geni in una singola reazione.
Le tecniche basate su FISH (fluorescence in situ hybridisation) con PNA (peptide nucleic acid) sono scarsamente automatizzabili e permettono l'analisi di un solo campione alla volta in presenza di un numero molto limitato di sonde specie-specifiche.
Negli ultimi anni, si è tentato di migliorare le caratteristiche diagnostiche degli approcci ad ampio spettro e multiplex mediante lo sviluppo di microarray con sonde di DNA specifici per la diagnosi della batteriemia (o della sepsi). Questi microarray sono costituiti da microchip rivestiti con un elevato numero di sonde di DNA in grado di identificare specie microbiche diverse ed eventualmente marker genetici di resistenza agli antibiotici .
Di recente, è stato lanciato sul mercato un kit di questo tipo con il nome commerciale di Prove-it Sepsis (Mobidiag, Helsinki, Finlandia). Il Prove-it Sepsis implica previe emocoltura ed estrazione del DNA e una successiva PCR multiplex con ibridizzazione dei prodotti su microarray. Il tempo necessario per eseguire la PCR multiplex e 1'ibridizzazione su microarray è di almeno tre ore. Il produttore sostiene che il kit presenta una sensibilità del 94% e una specificità del 96% ma non esistono al momento articoli scientifici che lo confermino.
Un altro kit di questo tipo, che è ancora soltanto a livello di prototipo, è il microarray descritto in Cleven B.E. et al., 2006, Identification and characterisation of bacterial pathogens causing bloodstream infections by DNA microarray, J. Clin. Microbiol. 44: 2389-2397. Il suddetto microarray permette l'identificazione in emocolture di tre importanti specie microbiche responsabili di batteriemia, Staphlococcus aureus, Escherichia coli e Pseudomonas aeruginosa, mediante estrazione del DNA e successiva ibridizzazione su microarray.
Malgrado quest'ultimo kit permetta l'identificazione di specie microbiche senza utilizzare una PCR multiplex, quindi riducendo il rischio di contaminazione da carryover, il numero di specie identificate è estremamente limitato (3 specie) e, soprattutto, la fase di ibridizzazione su microarray richiede un tempo estremamente lungo (almeno 18 ore), che in associazione ai tempi necessari per l'emocoltura e l'estrazione del DNA costituiscono un ritardo eccessivo per una diagnosi funzionale a una terapia efficace.
Si avverte pertanto la necessità di sviluppare un microarray con sonde ad alta specificità e sensibilità per un elevato numero di specie microbiche che consenta una diagnosi precoce, efficace e soprattutto veloce, della batteriemia e/o della sepsi.
Lo scopo della presente invenzione è pertanto quello di fornire un metodo per disegnare una pluralità di sequenze nucleotidiche sonda specifiche per una corrispondente pluralità di specie microbiche e un relativo microarray che consentano di ottenere una diagnosi veloce e specifica per un numero elevato di specie microbiche coinvolte nella batteriemia e/o nella sepsi.
Secondo la presente invenzione tale scopo è raggiunto mediante il metodo secondo la rivendicazione 1.
Secondo la presente invenzione viene inoltre fornito un microarray secondo la rivendicazione 6.
Definizioni
A meno che non sia specificato esplicitamente il contrario, i seguenti termini presentano il significato qui sotto indicato.
Per "percentuale di identità" si intende la percentuale di identità tra almeno due sequenze calcolata secondo l'algoritmo blastn fornito da NCBI (National Center for Biotechnology Information) utilizzando i parametri standard.
Per "porzione conservata di sequenza genomica" si intende una porzione di sequenza di DNA genomico di un ceppo di una specie microbica che ha una percentuale di identità di almeno il 95%, preferibilmente di almeno il 97%, con una porzione di sequenza di DNA genomico di un altro ceppo della specie microbica.
Breve descrizione delle figure
Per una migliore comprensione della presente invenzione, viene nel seguito descritta una forma di realizzazione preferita, a puro titolo di esempio non limitativo e con riferimento ai disegni allegati, nei quali :
- la Figura 1 è un elettroferogramma dell'analisi di lunghezza di una delle sequenze nucleotidiche sonda prodotte mediante il metodo secondo la presente invenzione ;
- la Figura 2 è una tabella in cui sono illustrati i risultati di specificità di ibridizzazione di DNA genomico certificato sul microarray secondo la presente invenzione ;
- la Figura 3 è un ingrandimento di una prima area in alto a sinistra della tabella di Figura 2 che mette in evidenza i risultati per le specie Acinetobacter baumannii, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Serratia marcescens, Enterococcus faecalis;
- la Figura 4 è un ingrandimento di una seconda area centrale della tabella di Figura 2 che mette in evidenza i risultati per le specie Enterococcus faecium, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus bovis, Streptococcus piogenes, Staphylococcus aureus meticillino-resistente, Enterococcus faecium vancomicino-resistente, Streptococcus pneumoniae penicillino-resistente e Aspergillus fumigatus;
- la Figura 5 è un ingrandimento di una terza area in basso a sinistra della tabella di Figura 2 che mette in evidenza i risultati per le specie Candida albicans, Candida glabrata, Candida parapsilosis , Candida tropicalis, Human adenovirus e Homo sapiens.
Descrizione dettagliata dell'invenzione
Il metodo per disegnare una pluralità di sequenze nucleotidiche sonda specifiche per una corrispondente pluralità di specie microbiche secondo la presente invenzione comprende le seguenti fasi.
In una prima fase (a) è fornita una pluralità di sequenze genomiche appartenenti a diversi ceppi della pluralità di specie microbiche. La pluralità di sequenze genomiche è tipicamente ottenuta da banche dati di sequenze disponibili on-line. Nella fattispecie, la pluralità di sequenze genomiche è stata ottenuta dalla banca dati dell'NCBI (National Center for Biotechnology Information).
In una seconda fase (b), è stata allineata la pluralità di sequenze genomiche per ciascuna specie microbica.
In una terza fase (c), per ciascuna specie microbica, sono state identificate porzioni conservate di sequenza genomica in base all'allineamento della precedente fase (b). Per l'allineamento e l'identificazione delle porzioni conservate di sequenza genomica è stato utilizzato un programma informatico con impostazioni standard, di cui il tecnico del ramo è normalmente a conoscenza.
In una quarta fase (d), per ciascuna specie microbica, vengono selezionate almeno cinque diverse sequenze nucleotidiche sonda appartenenti a porzioni conservate di sequenza genomica e aventi una lunghezza da 300 a 2000 nucleotidi. Preferibilmente nella fase (d) vengono selezionate almeno dieci diverse sequenze nucleotidiche sonda appartenenti a porzioni conservate di sequenza genomica.
In una quinta fase (e), per ciascuna sequenza nucleotidica sonda selezionata nella precedente fase (d), viene disegnata una coppia di primer per amplificare la sequenza nucleotidica sonda mediante PCR. Ciascun primer è disegnato in modo da avere una temperatura di melting (Tm) da 55°C a 65°C e una lunghezza da 15 a 30 nucleotidi. Ciascun primer è preferibilmente disegnato in modo da avere una temperatura di melting (Tm) da 59°C a 61°C, ancora più preferibilmente in modo da avere una lunghezza da 20 a 25 nucleotidi .
Ulteriori parametri preferiti per il disegno dei primer sono un contenuto di basi G e/o C in percentuale dal 20% al 60% e/o un contenuto di non più di due basi G e/o C in corrispondenza degli ultimi cinque nucleotidi all'estremità 3'.
Per disegnare i primer è stato utilizzato il programma informatico Primer-3 disponibile on-line all'indirizzo http://frodo.wi.mit.edu/ e sviluppato presso il Whitehead Institute e il Howard Hughes Medicai Institute da Steve Rozen e Helen Skaletsky.
In una sesta fase (f), sono selezionate le sequenze nucleotidiche sonda con una percentuale di identità inferiore al 40% con ciascuna altra sequenza nucleotidica sonda. Preferibilmente, sono selezionate le sequenze nucleotidiche sonda con una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda .
Ulteriori parametri preferiti per il disegno delle sequenze nucleotidiche sonda sono un contenuto di non più di tre G e/o C consecutive, e/o un contenuto di non più di tre basi A o T o C uguali consecutive, e/o un contenuto di basi G e/o C in percentuale dal 10% al 50% (più preferibilmente dal 20% al 40%).
In una settima fase (g) sono selezionate le sequenze nucleotidiche sonda con una percentuale di identità inferiore al 10% con il DNA genomico umano, più preferibilmente con una percentuale di identità inferiore all'1%, ancora più preferibilmente con una percentuale di identità dello 0% con il DNA genomico umano.
Il microarray per la rivelazione di una pluralità di specie microbiche secondo la presente invenzione comprende almeno una sequenza nucleotidica sonda per almeno quattro diverse specie microbiche. Le diverse specie microbiche sono selezionate dal gruppo costituito da Acinetobacter baumannii, Enterobacter aerogenes, Enterobacter cloacae, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus bovis, Streptococcus pneumoniae e Streptococcus piogenes. Ciascuna sequenza nucleotidica sonda ha una lunghezza da 300 a 2000 nucleotidi e ha una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda.
Preferibilmente, 1'almeno una sequenza nucleotidica sonda per Acinetobacter baumannii è SEQ ID NO:1-14, e/o 1'almeno una sequenza nucleotidica sonda per Enterobacter aeroqenes è SEQ ID NO:46-59, e/o 1'almeno una sequenza nucleotidica sonda per Enterobacter cloacae è SEQ ID NO:60-70, e/o 1'almeno una sequenza nucleotidica sonda per Enterococcus faecalis è SEQ ID NO:71-77, e/o 1'almeno una sequenza nucleotidica sonda per Enterococcus faecium è SEQ ID NO:78-89, e/o 1'almeno una sequenza nucleotidica sonda per Escherichia coli è SEQ ID NO:90-97, e/o l'almeno una sequenza nucleotidica sonda per Klebsiella pneumoniae è SEQ ID NO:102-104, e/o 1'almeno una sequenza nucleotidica sonda per Proteus mirabilis è SEQ ID NO:105-111, e/o 1'almeno una sequenza nucleotidica sonda per Pseudomonas aeruqinosa è SEQ ID NO:112-115, e/o 1'almeno una sequenza nucleotidica sonda per Serratia marcescens è SEQ ID NO:116-117, e/o 1'almeno una sequenza nucleotidica sonda per Staphylococcus aureus è SEQ ID NO:118-131, e/o 1'almeno una sequenza nucleotidica sonda per Staphylococcus epidermidis è SEQ ID NO:132, e/o 1'almeno una sequenza nucleotidica sonda per Streptococcus aqalactiae è SEQ ID NO:133-142, e/o 1'almeno una sequenza nucleotidica sonda per Streptococcus bovis è SEQ ID NO:143-147, e/o 1'almeno una sequenza nucleotidica sonda per Streptococcus pneumoniae è SEQ ID NO:148-159, e/o 1'almeno una sequenza nucleotidica sonda per Streptococcus piogenes è SEQ ID NO:161-169.
Il microarray comprende preferibilmente anche almeno una sequenza nucleotidica sonda per almeno una specie microbica selezionata dal gruppo costituito da Aspergillus fumigatus, Candida albicans, Candida glabrata, Candida parapsilosis e Candida tropicalis. Anche in questo caso 1'almeno una sequenza nucleotidica sonda ha una lunghezza da 300 a 2000 nucleotidi e ha una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda.
Preferibilmente, 1'almeno una sequenza nucleotidica sonda per Aspergillus fumigatus è SEQ ID NO:14-20, e/o 1'almeno una sequenza nucleotidica sonda per Candida albicans è SEQ ID NO:21-29, e/o 1'almeno una sequenza nucleotidica sonda per Candida glabrata è SEQ ID NO:30-35, e/o 1'almeno una sequenza nucleotidica sonda per Candida parapsilosis è SEQ ID NO: 36-40 e/o 1'almeno una sequenza nucleotidica sonda per Candida tropicalis è SEQ ID NO: 41-45.
Ancor più preferibilmente, il microarray comprende inoltre almeno una sequenza nucleotidica sonda per almeno un adenovirus umano. Anche in questo caso 1'almeno una sequenza nucleotidica sonda ha una lunghezza da 300 a 2000 nucleotidi e ha una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda.
L'adenovirus umano è preferibilmente human adenovirus D, human adenovirus B oppure human adenovirus C, ancor più preferibilmente 1'almeno una sequenza nucleotidica sonda per human adenovirus D è SEQ ID NO:98, e/o l'almeno una sequenza nucleotidica sonda per human adenovirus B è SEQ ID NO:99-100 e/o 1'almeno una sequenza nucleotidica sonda per human adenovirus C è SEQ ID NO:101.
Il microarray secondo l'invenzione è utilizzato nella diaqnosi di batteriemia e/o sepsi, in particolare nella diaqnosi di infezioni nosocomiali.
Il tempo necessario per 1'ibridizzazione tra il DNA di un campione da analizzare e le sequenze nucleotidiche sonda comprese nel microarray è preferibilmente minore di 2 ore, più preferibilmente minore di 1,5 ore, ancor più preferibilmente minore o uquale a un'ora.
Esempio 1: Microarray Sepsis-1H
Un esempio specifico ma non-limitativo del metodo per diseqnare le sonde, del microarray recante le sonde stesse (microarray Sepsis-1H) e del relativo uso secondo la presente invenzione sono descritti nel sequito.
Nella fase (a) del metodo sono fornite le sequenze qenomiche disponibili su NCBI di diversi ceppi delle sequenti specie microbiche.
Batteri Gram-negativi : Acinetobacter baumannii , Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Serratia marcescens.
Batteri Gram-positivi: Enterococcus faecalis, Enterococcus faecium, Enterococcus spp . vancomicinoresistente, Staphylococcus aureus, Staphylococcus aureus meticillino-resistente, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pneumoniae penicillino-resistente, Streptococcus agalactiae, Streptococcus bovis, Streptococcus piogene.
Funghi: Aspergillus fumigatus, Candida albicans, Candida glabrata, Candida parapsilosis .
Virus: Human adenovirus.
Nella fase (b), è stata allineata la pluralità di sequenze genomiche per ciascuna specie microbica.
Nella fase (c), per ciascuna specie microbica, sono state identificate le porzioni conservate di sequenza genomica in base all'allineamento della precedente fase (b).
Nella fase (d), per ciascuna specie microbica, sono state selezionate dieci diverse sequenze nucleotidiche sonda appartenenti alle porzioni conservate di sequenza genomica e aventi una lunghezza media di 1500 nucleotidi.
Nella fase (e), per ciascuna sequenza nucleotidica sonda selezionata nella precedente fase (d), è stata disegnata mediante il programma informatico Primer-3 una coppia di primer per amplificare la sequenza nucleotidica sonda mediante PCR. Ciascun primer è stato disegnato in modo da avere una temperatura di melting (Tm) di 60°C ± 1°C e una lunghezza da 20 a 25 nucleotidi.
Il contenuto di basi G e/o C dei primer è in percentuale dal 20% al 60% e il contenuto di basi G e/o C in corrispondenza degli ultimi cinque nucleotidi all'estremità 3' non è maggiore di 2.
Nella fase (f), sono selezionate le sequenze nucleotidiche sonda con una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda, con un contenuto di non più di tre G e/o C consecutive, con un contenuto di non più di tre basi A o T o C uguali consecutive, e un contenuto di basi G e/o C in percentuale dal 20% al 40%.
Nella fase (g) sono state selezionate le sequenze nucleotidiche sonda con una percentuale di identità dello 0% con il DNA genomico umano.
Le sonde sono state prodotte utilizzando DNA genomico certificato per ciascuna specie microbica e reagenti standard e un normale termociclatore per PCR.
La lunghezza e la purezza di ciascuna sonda prodotta sono state verificate dopo la purificazione dei prodotti di amplificazione. La verifica è stata effettuata mediante lo strumento "Bioanalyzer Agilent 2100" che consente di ottenere un grafico (con rispettivi valori numerici) della distribuzione delle lunghezze dei vari filamenti presenti nel campione amplificato, consentendo pertanto di verificare la presenza (e la percentuale) di eventuali prodotti aspecifici. La sonda supera il controllo di qualità se una percentuale maggiore o uguale al 95% dei filamenti che la costituiscono ricadono all'interno dell'intervallo atteso di lunghezza. Tale valore definisce la percentuale di purezza necessaria per ottenere profili di ibridazione specifici della sonda sul microarray.
A titolo di esempio, viene riportato qui di seguito un estratto dell'analisi di una sonda, che ne indica i parametri di controllo di qualità. I parametri di controllo di qualità sono inoltre riassunti nella Figura 1.
CATEGORIE DI CONTROLLO DI QUALITÀ DELLE SONDE
La qualità delle sonde deve essere valutata mediante la misura della lunghezza e della % di purezza ottenuta mediante il BioAnalyzer Agilent 2100.
LUNGHEZZA: attesa teoricamente ± risoluzione di dimensioni dello strumento (% o bp):
±5% (per sonde con lunghezza da 100 a 1000 bp)
±15% (per sonde con lunghezza da 1000 a 7500 bp) PUREZZA: > 95% area totale del prodotto a banda singola .
1/ elettroferogramma della Figura 1 mostra il picco relativo alla sonda in questione (1445 bp) , le cui dimensioni ricadono nell'intervallo di lunghezza atteso (1241-1679 bp) . Il dato "% area totale" (100%) ne definisce l'indice di purezza. Il picco della sonda è compreso tra i picchi di due marcatori di lunghezza nucleotidica nota (50 bp e 10380 bp).
Le sonde così prodotte e verificate sono state spottate (depositate) su di un microarray costituito da un supporto di vetro silanizzato e funzionalizzato con gruppi aldeidici o epossidici. Le sonde vengono spottate sul microarray mediante uno spotter che utilizza la tecnologia inkjet a non-contatto (Marathon microarrayer , Arrayjet, United Kingdom) .
Le specie microbiche rappresentate sul microarray Sepsi-1H sono definite dal seguente numero di sonde (Tabella 1).
Tabella 1
* Il microarray contiene anche 5 sonde comuni a tutte le specie batteriche ma non a funghi e virus: queste sonde fungono pertanto da controlli positivi per le specie batteriche gram+ e gram-.
Il DNA campione da analizzare viene marcato mediante reazione chimica con una serie di molecole di fluoroforo secondo tecniche note al tecnico del ramo. In particolare, è stato utilizzato il kit Kreatech "ULS™ arrayCGH Labelling", secondo cui un complesso di platino, a cui è attaccata una molecola di fluoroforo, si lega tramite legame di coordinazione alla guanina dell'acido nucleico. Il fluoroforo utilizzato per Sepsi-1H è la Cyanine3, ma possono essere utilizzati in alternativa diversi altri fluorofori.
Successivamente, il DNA campione marcato con fluoroforo viene portato a contatto con il microarray e lasciato un'ora a 60°C a contatto affinché il DNA campione marcato con fluoroforo ibridizzi alla corrispondente sonda complementare in sequenza.
Successivamente, il microarray viene sottoposto a uno o più cicli di lavaggio per eliminare di DNA campione marcato con fluoroforo non ibridizzato.
Il microarray viene quindi analizzato mediante un apposito scanner che rileva l'intensità di fluorescenza dei fluorofori e identifica di conseguenza DNA campione marcato con fluoroforo ibridizzato. In questo caso è stato utilizzato un comune scanner con risoluzione di almeno 10 pm e due canali di lettura (laser con eccitazione a λ=635 nm e λ=532 nm).
Esempio 2: Verifica della specificità delle sonde La specificità di ciascuna sonda è stata valutata eseguendo ibridazioni di DNA genomico certificato su microarray Sepsi-1H. La specificità è stata analizzata considerando l'assenza di interazione molecolare con DNA genomico di altre specie e con il DNA genomico umano; questo ha consentito di assegnare uno specifico profilo di ibridazione a ciascuna specie.
Nella Figura 2 sono illustrati i profili di ibridazione di DNA genomico certificato di 21 specie microbiche e 3 resistenze agli antibiotici su Sepsi-1H. In ascisse sono riportate le due ibridazioni per ciascuna specie microbica, in ordinate le specie microbiche con i codici delle sonde ad esse associate. Il profilo di ibridazione è definito con codice colori:
cella nera: sonda accesa in modo specifico;
cella con righe trasversali: sonda accesa in modo aspecifico;
cella grigia: sonda non accesa per variabilità di comportamento delle sonde;
Il profilo di ibridazione di ciascuna specie ha esito positivo se almeno il 50% delle sonde sono definite da celle di colore nero in assenza di aspecifici (cella con righe trasversali).
Come si può vedere dalla Figura 2 e dagli ingrandimenti delle Figure 3-5, la specificità di ibridizzazione è del 100% per 21 specie e lievemente inferiore per le altre. In media, la specificità risulta essere del 98,5%, un valore molto più elevato che per qualsiasi altro microarray noto.
Dai dati riportati sopra, sono evidenti i vantaggi del metodo e del microarray secondo l'invenzione.
In particolare, il metodo secondo la presente invenzione permette di disegnare una pluralità di sonde che permettono di distinguere un numero molto più elevato di specie microbiche e con una specificità molto maggiore rispetto ai microarray noti.
Gli specifici parametri selezionati per disegnare le sonde permettono inoltre di ottenere delle sonde di lunghezza maggiore a quelle utilizzate nei microarray noti: ciò consente di ottenere dei tempi di ibridizzazione inferiori ai microarray noti e di conseguenza ottenere dei risultati diagnostici in tempi molto più brevi e compatibili con una scelta mirata e precoce del trattamento antimicrobico .
Grazie al fatto che le sonde hanno una percentuale di identità di sequenza con il DNA genomico minima, è possibile identificare con elevata specificità il DNA microbico senza che l'elevata quantità di DNA genomico umano necessariamente presente nel campione interferisca.
Grazie all'elevato numero di sonde specifiche per diverse specie microbiche comprese sul microarray secondo l'invenzione è possibile eseguire uno screening contemporaneo di un numero molto più elevato di specie microbiche rispetto ai microarray noti.
Inoltre, il microarray secondo l'invenzione comprende anche una serie di specie microbiche che non erano incluse nei microarray noti, ampliando quindi il numero di microorganismi che è possibile identificare. In particolare, non sono comprese solo specie batteriche, ma anche fungine e virali.
SEQUENCE LISTING
<110> Molecular Stamping
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<160> 169
<170> BiSSAP 1.2
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<220>
<221> source
<222> 1..1511
<223> /organism="Acinetobacter baumannii ATCC 17978"
/mol_type="unassigned DNA"
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gtgatacagg tccttgcggt ccatgttcag aaattttctt cgaccacggt gaacacattt 60
ggggtggttt acctggttca cctgaagaag acggtgaccg tttcattgaa atctggaaca 120
acgttttcat gcagtttaac cgtactgctg atggcgtact tcacccactc cctgctccat 180
ctgtagatac aggtatgggc ttagagcgta tttctgccgt attgcaacat gttaattcaa 240
actatgacat tgacctgttc caacacttat taaaagctgc tgcaaacatc attggtattg 300
aagatgaagg tcagccttct ttacgtgtag ttgcagacca tgcccgctct tgctgcttct 360
taattgctga tggtgtaaac ccaagtaatg aaggacgtgg ttatgtatta cgtcgtatta 420
tccgccgtgc tgtccgtcac ggtaacaagc ttggcgcaac aggtacgttc ttctacaaaa 480
tgttgcaacc attaattgaa gtaatgggac aggcttatcc tgaattagaa gctcgccgtg 540
aagtcattga agcaacatta attcgtgaag aagaacagtt tgctaaaacc ttagagcaag 600
gtttaaaact tcttgaaggt gaacttgctc agttaaaaga taaaactatt ccgggtgcga 660
ctgtatttaa actttacgac acttatggtt tcccaacaga tttaactgct gatattgcac 720
gtgaacgtgg ctttattatt gatgaagcag gttttgaagt tgaaatggct gcacagcgtc 780
aacgtgcgcg tgatgctggt aaatttgccg ttgactataa caacattgta aaagttgaag 840
gcgaaactca attcgacggt tataccaaca caaccggtca aggccagatt gtagcgatct 900
ataaagatgg cgtacaagtt gatgaagttt ctgaaggcga cgaagcactt atcgttttaa 960
accaaactcc tttctatgct gaaagcggtg gtcagattgg tgatactggt atcttcaaaa 1020
acgaaacagg tatttttgaa gttcaggata cgaaaaagtc tggtggcgcc tttgttcatc 1080
aaggtattgt gactgttggt aaccttaaaa ccagtcaaaa tgtagaagcg attgttaaag 1140
cagacattcg tgaagctact gcgcgtaacc actcagcaac tcacttgttg catgctgccc 1200
ttcgtcaaat tttaggttcg catgtacaac aaaaaggctc tttggttgca agtgatatct 1260
tacgttttga ctttgcaaat gaccaacctg tgtcatttga acaactacaa caagttgaac 1320
gtctcgtaaa tgctgaaatc attgcaaata ctgccgtaac aactgaacta ctcgacattg 1380
aaactgcgaa agcaaaaggt gcaatgatgt tgttcggtga aaaatacggt gatgaagttc 1440
gtgtgctctc tatgggctct gtcattgacg agaaaaactt ctcaatcgaa ctttgtggcg 1500
gtattcacgt a 1511
<210> 2
<211> 1590
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<213> Acinetobacter baumannii ATCC 17978
<220>
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<222> 1..1590
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/mol_type="unassigned DNA"
<400> 2
tttagtcacc aatgccctcc cttatgccaa tggtccaatt catatgggtc atttactcgg 60
ttatatccag gcagacatct gggttcgtgc catgcgggca atgggtcatg acgtgactta 120
tgtatgtgcg gatgatgctc acggtacagc aattatgcta cgtgccgaag caaatggtat 180
tagcccagaa gagcaaatcg cgaatgttca aaaagaacac atccgtgatt ttgacggttt 240
tggcgtacat ttcgatcatt atgattcaac tcatagtgat gcaaacaaag ctcgttcaac 300
agatatctat attaaaaacc gtgaagccgg aaatattgca gttcgacctg taactcaatt 360
atttgatccg gaaaaaggta tgttcttgtc tgaccgtttc attaagggta cctgtccaaa 420
atgtaagtca gaggatcaat acggcgactc atgtgaagtg tgtggtacaa cttataatgc 480
gactgagtta ctcaacccgc gttcgacttt aagtggtgca acaccagttg aaaaatcatc 540
agatcactat ttcttcaagc ttccaaactt tgctgaatat ttgcaaaaat ggacccgcga 600
tgaaggtcgc ttacctcttt caattgctaa caaattggat gaatggtttg aagcaggttt 660
agcagactgg gatatttctc gtgatgctcc ttattttggt tttgaaattc cggatgcgcc 720
aaataaatat ttctatgtgt gggtagatgc cccaatcggt tatatgtcta gttttgaaaa 780
ctacatcaaa actaagcgcc cagacttgaa ctttgatgat ttctggaaga aagatagtca 840
aaatgaggtt taccacttta ttggtaaaga cattgtttac ttccatgctt tattctggcc 900
tgcgatgctt gaaggggcga actaccgcac tccaacaggc ttattcgtaa atggtttctt 960
gactgtaaat ggacaaaaaa tgtctaagtc tcgcggtact ttcattaaag ccgagacgta 1020
cttacaacat ctaaacccag agtatttacg ctattacttt gcttctaaac tttcagataa 1080
agttgaagac tctgacttga accttgatga ctttgtgcag aaagtaaatt cagatttagt 1140
cggtaaagta gttaatattg ctagtcgctg tgctaagttc attaacagca gctttaacaa 1200
tacgctatca agtacatgtg ctgaatctga cttagtacaa agctttattg atgctggtga 1260
ttcaattgct gctgcatatg aagcgcgtga attctctacg gcgatccgtg aaattatggc 1320
gcttgctgac cgcgcaaacc aatatattga tgagaaaaaa ccttgggctc ttgctaaaca 1380
agaaggtcaa gaacaacaag ttcttgatgt atgctctgtc ggtatcaact tattccgtca 1440
attagcagtg tacttagctc cagttctgcc aactttagct cagcaagttc aagatttctt 1500
aaaacttgaa agcttcgatt tcgagtcacg taaacaaatt cttgtaagcc atgagattgc 1560
acagttccaa cctcttatgc agcgtgttga 1590
<210> 3
<211> 1589
<212> DNA
<213> Acinetobacter baumannii ATCC 17978
<220>
<221> source
<222> 1..1589
<223> /organism="Acinetobacter baumannii ATCC 17978"
/mol_type="unassigned DNA"
<400> 3
tcatgcctct gtcgattctg cgcagcaaga acaacaggct ggattagatt ttgttcgcca 60
agtcattacc gatgatttag ctgccggacg tgccaaacaa atcgtaacgc gtttcccgcc 120
agaaccaaat ggttatttac atattggtca cgtaaaagca atttgcctca actttggcgt 180
tgctgaagag tttaatggtc tttgtaattt acgttttgac gatactaacc cggatgcaga 240
agaacaagag tatgttgatg ggatcgccaa tgatgtgaaa tggcttggat ttagctggaa 300
tggcgaacca cgttatgctt ccggttattt tgatcagctt tatgcttggg caattcagtt 360
gattgaacaa ggtgatgcat atgttgattt gcagtctcca gaagaaatca aattaaatcg 420
tggtagcttt gttgagccag gtaaaaattc gccatatcgt gatgcttctg ttgaagaaaa 480
ccttgctcgt tttgaaaaaa tgcgcaatgg tgaacttaaa gaaggtgaag ctgttttacg 540
tgccaaaatt gatatggcaa gcccgaatgt acatatgcgt gacccaattt tgtatcgtgt 600
tttacattca gagcatcacc aaacaggcga taagtggaaa atctacccaa tgtatgacta 660
tgctcatcca ttgtctgatg cgatcgaagg aatcacacat tcactttgta cattagagtt 720
ccaagaccac cgtccgtttt atgactggat tgttgaaaaa gttaagtcta aagctgtgcc 780
gcatcagtac gaatcttctc gtttaaacgt agattacacc attacgtcta aacgtaaatt 840
acgtaaattg gttgaaggcg gttatgtgaa tggatgggat gatcctcgta tgccaacggt 900
tgtcggtatg cgtcgccgtg gtttcacacc agaaggccta cgtgatttct gtaaacgtgt 960
aggtgtgtct aaaactgacg gtattgtgga tgtcgcaatg cttgagttct gtattcgtca 1020
atctttagag aatacggcag cgcgcggtat ggcagtgtta aatccattaa aagtaacact 1080
tacgaactta ccggaagatt tagaccttac ccatgctcgt catcctaatg tcgatatggg 1140
tgagcgcgtt attccattga ctaaagaaat ctatattgac cgtaaagatt tcgaagaagt 1200
accgccaaaa ggctttaaac gtttaattcc tgatggtgaa gttcgtttac gccatgcata 1260
tgtgattaag tgtgatgaag tcattaaaga tgcaaacggt gaagtcgttg agctgaagtg 1320
ttcaatcgat ccggatactt taggtaaaaa tcctgaaggt cgcaaagtaa aaggcgtaat 1380
acactgggta tctgcaacta aaggtattcc tgctgaggta cgtatttatg atcgattgtt 1440
cacagaagct gaccctgaaa ctggtgatga tttcttagca aacttaaatc cagattcttt 1500
gaaagtggtt caagctgtga tcgaacctgc tttagctcaa gcgaagccag aagatcgctt 1560
ccagtttgaa cgcgaaggtt atttcgttg 1589
<210> 4
<211> 1468
<212> DNA
<213> Acinetobacter baumannii ATCC 17978
<220>
<221> source
<222> 1..1468
<223> /organism="Acinetobacter baumannii ATCC 17978"
/mol_type="unassigned DNA"
<400> 4
accgaatatg ggacattgga taatatcatt gccaatgtag accaacttaa aggcaaactg 60
agccaaaata ttaaagataa tttagacaat attaagcttg atcaccagtt ggcaagcatt 120
gtctgtgatc ttcctttaga actcgactgg catgaattaa aacttactga tccaaatgta 180
gatgccttac gcaatctcta tacggagctt gagtttagaa accagttaca gtctctcgat 240
catccaaaca atccaaatag ctcaagctat aagcagcaag cttcacaaac tattgtccaa 300
aatgaagtga aacctgctca aacaattgaa acagaagatc aagcaagctt gactagtcaa 360
gatgaccagc ttggaactgc aaactatcac actgttttaa cacaagaagc atgggatcag 420
ctctggcaac gcatgcagaa tgccgatcat tttgctattg atacagaaac cacaagtctt 480
gattaccgta ttgccgagat ggttggtttt tcaatcgcat ttgatgcgaa agatgcctac 540
tatattcctt tagcacataa ttacgaaaat gcgccacaac aactgaaccg tgaacaagtt 600
ttagcgcaaa tcaaacctgt acttgaaaat gaagcagtta aaaaaatcgg tcatcatctt 660
aaatatgatg cgcacatttt tgctaatcac ggtattgaac ttaaaggttg gtatttcgat 720
agcatgctgg catcttatgt actgaatgca gcagctactc gtcatggcat ggatgatgtt 780
gctcgtgttt acctaagcca tttgaccact acttttgagc aaattgctgg caaaggtgca 840
aaacagaaga cttttaatca aattgagatt gaagttgcag cacattatgc agcagaagat 900
gcacatgtga cttatcgttt atatgaagta ctttcaaata aacttaaagc acatcctgaa 960
ttagaaaata ttttatataa cattgagatg ccagttgctc gaatcttatc gggtatggaa 1020
gaagatggaa tccgtttaga tcatgctttc ttagataaat taagtgttga atttgcgaaa 1080
actatggaag accttgaaaa tcaggccatg gaaattgcag gtgaaacttt taatattgct 1140
tcgcctaaac aggtaggtga aattctattt gataagttag gcattaaagg tggtaaaaaa 1200
actgcaactg gacaatacag caccagtgaa agtgttcttg aaaaaattga gcatccttta 1260
acggaaatta ttttagaaca ccgtggatta gcaaaattaa agagcaccta tactgaccgt 1320
ttaattgagc agtcgcataa tgacacccat cgtgtacata ccagctatca tcaagcacta 1380
acggcaacag gtcgcctatc ctcttctgat cctaacttac aaaacattcc aattcgtaga 1440
cagattggcc gtcaaatccg taaagcat 1468
<210> 5
<211> 1516
<212> DNA
<213> Acinetobacter baumannii ATCC 17978
<220>
<221> source
<222> 1..1516
<223> /organism="Acinetobacter baumannii ATCC 17978"
/mol_type="unassigned DNA"
tgcacgctag ccaacccatc gatttaatct tacttgatat taaattaccc gaattaaacg 60
gttgggaagt attaaataaa atacgccaaa aagctcagac tcccgtgatc atgttgacgg 120
cgctagatca agatattgat aaagttatgg cattacgcat aggtgcagat gactttgtgg 180
tgaagccttt taacccaaat gaagtcgtcg ctagagttca ggcagtccta agacgtactc 240
agtttgcaaa caaagcaact aataaaaata aactctataa aaatattgaa attgataccg 300
acactcatag cgtttatata cactctgaga ataagaagat cttgcttaat ctgacgctga 360
ctgaatataa aattatttca ttcatgattg atcagcctca taaagttttt acgcgcggag 420
agcttatgaa tcactgcatg aatgatagcg atgcactaga gcgaaccgta gatagccatg 480
tgagtaagct gagaaaaaaa ctagaagaac aaggcatatt tcaaatgtta attaatgtgc 540
gtggcgtggg atatagacta gataatcccc tagctgtaaa agatgatgcc taaataatat 600
taaaaaatag ctagggaata ttttatgaaa agtaagttag gaattagtaa gcaacttttt 660
attgccttaa ctattgtgaa tttaagcgtt acgctatttt ctatagtatt gggttatatc 720
atttataact atgcgattga aaaaggctgg attagcttaa gctcatttca acaagaagat 780
tggaccagtt ttcattttgt agactggatc tggttagcca ctgttatctt ctgtggctgt 840
attatttcat tagtgattgg catgcgcctc gcaaagcgtt ttattgtgcc aattaacttc 900
ttagccgaag cagcaaaaaa aattagtcac ggcgacctct ctgctagagc ttacgataat 960
agaattcact ccgccgaaat gtcggagctt ttatataatt ttaatgatat ggctcaaaag 1020
ctagaggttt ccgtcaaaaa tgcgcaggtt tggaatgcag ctatcgcaca tgagttaaga 1080
acgcctataa cgatattaca aggtcgttta cagggaatta ttgatggcgt ttttaaacct 1140
gatgaagtcc tatttaaaag ccttttaaat caagttgaag gtttatctca cttagtcgaa 1200
gacttacgga ctttaagctt agtagagaac cagcaactcc ggttaaatta tgaattgttt 1260
gacttgaagg cggtagttga aaaagttctt aaagcatttg aagatcgttt ggatcaagct 1320
aagctagtac cagaacttga cctaacgtcc actcctgtat attgcgaccg ccgtcgtatt 1380
gagcaagttt taattgcttt aattgataat gcgattcgct attcaaatgc aggcaaactt 1440
aaaatctctt cagaagtggt tgcagacaac tggatattaa aaattgagga tgaaggcccc 1500
ggcattgcaa ccgagt 1516
<210> 6
<211> 1591
<212> DNA
<213> Acinetobacter baumannii ATCC 17978
<220>
<221> source
<222> 1..1591
<223> /organism="Acinetobacter baumannii ATCC 17978"
/mol_type="unassigned DNA"
<400> 6
cacctgcacc tggcgtgagc tctggtgatg ccatgaaagc aatggaaaaa attattggta 60
agttgccttc tatgggctta caaggtttcg actatgaatg gacaggctta tcacttgaag 120
aacgtgagtc tggtgctcaa gcgccgttct tatacgcact ttcattgtta atcgtattcc 180
tttgcttggc tgcactatat gaaagctggt caattccgtt ctcggtttta cttgtggtac 240
cacttggtgt cattggtgca atcgtattga cctacttggg catgattatt aaaggagatc 300
caaatctctc aaataacatt tacttccaag tagcgattat tgcggttatc ggtctttctg 360
caaaaaatgc gatcttgatt gttgaattcg caaaagaatt gcaggaaaaa ggtgaagatc 420
tacttgatgc aaccttacat gctgcaaaaa tgcgtttacg tccaattatc atgaccaccc 480
ttgccttcgg tttcggtgta cttccacttg cactttcaac aggtgccggt gcaggaagtc 540
agcactctgt aggctttggt gtacttggtg gcgtactcag cgcgacgttc ttaggtatct 600
tctttatccc tgtattctat gtgtggattc gtagtatctt taagtacaaa ccaaaaacca 660
taaacactca ggagcataaa tcgtgatgca aaaagtatgg tctatttcag gtcgtagcat 720
tgcggtatct gcacttgcgc ttgctttggc agcttgtcaa agcatgcgcg gcccagaacc 780
agtcgtgaaa accgatatac cacaaagcta tgcatataac agcgcttctg gtacgtctat 840
tgctgaacag ggttataaac agttctttgc tgacccgcgt ttgcttgaag tgattgattt 900
ggctcttgcc aataaccgtg acttacgtac agcaacgctc aatattgaac gtgctcaaca 960
gcaatatcag attacacaga acaaccagct tccaacaatc ggagcaagtg gtagtgcaat 1020
tcgtcaggtt tctcaaagcc gtgatccgaa taatccctac tctacttatc aagtaggttt 1080
gggtgtaact gcttatgagc tagatttctg gggtcgtgtt cgtagcctca aagatgctgc 1140
tttagatagt tatcttgcaa cacaaagtgc tcgtgattcg actcaaatca gtctgattag 1200
ccaagttgct caagcatggt taaattattc gtttgcaaca gcaaacttaa gactggcaga 1260
gcaaacgctt aaagcacagt tagattctta caatctcaac aaaaaacgtt ttgatgtagg 1320
tattgacagt gaagttccat tacgtcaagc acagatttct gtagaaactg cgcgtaatga 1380
tgtagcgaac tacaaaactc aaattgctca agcacaaaac ttgttgaact tgcttgtagg 1440
ccaacctgtt ccacaaaact tgttacctac acaacctgta aaacgcattg ctcaacaaaa 1500
tgtgtttact gccggtttac caagtgactt gttaaataac cgtccggatg taaaagctgc 1560
tgaatacaac ttaagcgctg cgggtgcgaa t 1591
<210> 7
<211> 1558
<212> DNA
<213> Acinetobacter baumannii ATCC 17978
<220>
<221> source
<222> 1..1558
<223> /organism="Acinetobacter baumannii ATCC 17978"
/mol_type="unassigned DNA"
<400> 7
acgatgacgc aaaccgtgcg ctcatgggtt caaacatgca acgtcaggca gttcctactt 60
tacgtgcgga taaaccgctt gtaggtacag gtatggaagc gaacgttgca cgtgactctg 120
gtgtgtgtgt aatcgcaaac cgtggcggtg taattgaata tgtagatgct tctcgtatcg 180
ttattcgtgt aaacgaagat gaaatggttg caggtgaggc gggtgtagat atctataacc 240
tcatcaaata tacacgttca aaccaaaata cttgtattaa ccaaaatgtt atcgtgaact 300
tgggcgacaa agttgctcgt ggtgacatct tggcagacgg tccgtcaaca gacatgggtg 360
aacttgcgct tggtcaaaac atgcgtgtag cgttcatgac atggaatggt tacaactacg 420
aagactcgat cttgttatct gagcgtgtac ttcaagaaga ccgtttaacc tctattcaca 480
ttcaagaatt gtcatgtgta gcacgtgata ctaagttagg tgcagaagaa attactgccg 540
atattcctaa cgtaggtgaa gcggcgcttt ctaaacttga tgaatcaggt atcgtttata 600
tcggtgcaga agttactgct ggtgacatct tagttggtaa agtaacgcct aaaggtgaaa 660
ctcagttaac tcctgaagaa aaactgcttc gtgcaatttt tggtgagaaa gcagctgacg 720
ttaaagactc atctttacgt gttccatctg gtactaaagg tacagttatt gacgttcaag 780
tcttcactcg tgatggctta gagaaagatg accgtgcttt agcaattgaa aaagcacagc 840
ttgattctta ccgtaaagac ttgaaagaag aatacaagat cttcgaagaa gcggctcgtg 900
agcgtgtaat tcgtttgctt aaaggccaag agtctaatgg cggtggttca actaaacgtg 960
gtgataaact ttctgaagat ttattatctg gtttagagct tgttgactta cttgaaattc 1020
aaccagcaga tgaagcaatc gctgagcgtt taactcaaat tcaagtgttc ttgaaagaga 1080
agagcgcaga aatcgatgag aaattcgctg agaagaaacg taagcttgca acaggtgatg 1140
aattaacaac tggcgtatta aaagttgtta aggtttactt agctgttaaa cgtcgtattc 1200
agcctggtga taagatggct ggtcgtcacg gtaacaaagg tgttgtatct aacatcttac 1260
ctgttgaaga catgccacat gatgctaacg gtgtgccagt agatatcgta ttgaacccgc 1320
tgggtgtacc atctcgtatg aacgtgggtc agattctaga gactcacttg ggtatggcgg 1380
ctaaagggct tggtgacaaa atcgaaaaaa tgttgaaaga acaacgtaca gttttagaac 1440
tgcgcgaatt cttagacaag atttataaca aagtcggtgg tgagcaagaa gatcttgata 1500
gcttgactga tgaagaaatt ctagcgcttg caggtaactt gcgtgcgggt gtgccttt 1558
<210> 8
<211> 1475
<212> DNA
<213> Acinetobacter baumannii AB307-0294
<220>
<221> source
<222> 1..1475
<223> /organism="Acinetobacter baumannii AB307-0294"
/mol_type="unassigned DNA"
<400> 8
aatctggctc gccagcaccc aaaccaatca cgttcttgcc agcagcttta agctcagcag 60
ctttattagt tacagcaagt gtaggggacg gtttgatagc attgacacga tcagaaagac 120
gtacgtccac ggcaatattc ctcttatggg attaaaaata aaaagcacac tatcttatcg 180
caaaaattaa gcaatttgcg gatgtgggga tttttagatg taaaaaagtt taatttagga 240
aagatcttgt tgcggtttta ttcaattgaa gcttttttcg aaagaaacaa gaaaaatcct 300
ttataataag ccgcaatcga aatatcgaga atgaatcatg actgagcaac agccaaaaca 360
gaaaaaggct ttggtgaaat tgccatttcc aatgccgaat gaaagtaacc aagcaggcga 420
tgctgtacac aaccaagtac gtccgaaacc tgaacaatat gcagatagaa cttggatgcc 480
accgcgtggt actcgtcgtt ctatgggtaa gcgctaattt aaataaaaaa acaggcaata 540
tgcctgtttt tttatggtag aagaatttct tgataataac tttttttctt ttgatacata 600
tgatgatctg cgcgttttag catatcttca acttgttcat tttcttttgt tgtggcgtgc 660
ccaatcgcaa tactaatagg gtgacttgaa taatattgat tatctatatt aaaaagctcc 720
tgaatggttt gcagcatcat taaaacattc gcttcatctg caccaggcat taaaattaca 780
aattcgtcgc caccgattcg agaagctgta taagcagtat tcataattgc ctgatttaaa 840
atattaccta ctcgacgtaa taaaccatca ccaatatcat ggccaagttg atcattggtt 900
tcctttaggc cgttcatgtc taaaaaaatt gaagaaacag ggcgaataat actgcgattt 960
aaacgattaa gctcttctgt aaaaaaagct cggttataaa gtttggtcag tacatcatgc 1020
tggcctaagt attctagata attttcggct ttctttcgtg cagtaatatc tgtaagcgca 1080
acctgtacca atccccaagt ctcttcataa ccggggaata cggtaaattg caataagaca 1140
tttctaattt ggccatctaa cgcatagtta acggcttcac gcttgtggtg aatatttcct 1200
tgccagagtt caatcagctg ttctctaaaa gtttccacca tctcttcggc aaaaatttta 1260
tgggtatttt ttaacagagt ggttttatct ggtgctttaa ataaatcgag agtcgactga 1320
ttgacgtcta aaattaaaat gtcttctatg cattggcgaa caaattcagg atgtacatct 1380
aaaaaagtcc taaagtcttc aattcctaat agcctaagct gatcaattct atttttaata 1440
cggctaaaat cttcaaccca aagcgaagtt gggga 1475
<210> 9
<211> 1473
<212> DNA
<213> Acinetobacter baumannii AB307-0294
<220>
<221> source
<222> 1..1473
<223> /organism="Acinetobacter baumannii AB307-0294"
/mol_type="unassigned DNA"
<400> 9
acatgcggct ttgtcagcac aagataatgc ggacataaat acacgtgagc aaaatgatac 60
gttccgttat ttcaacttaa aaggtttaat gaacctaagt actgctgagt acgacgctct 120
acaaccagtg caatggccag tctggagtaa aaaccaggac gctaaagctg ttcaacaact 180
gtttggcaag ggccagttta gtcacaaaaa taccaaggca aaattgattt cgactgttgc 240
aatcgatccg gtacatgcag tttcagaaga ttatccgctc attttgaaca cgggacgtat 300
tcgtgatcaa tggcacacca tgacgcgtac tggtttgtca ccaaatttga ccagtcaccg 360
tgccgaacca ttttgcgaga ttcatccgag tgatgccttg aaatttggtg tgcgtgatca 420
aggcttggta gaagttcgtt cgaaatgggg cagttgtgta ctacgcgtga cattctcatc 480
aggtgtccgt cgtgggcaaa tttttgcacc gattcactgg actgaacagg tcgcatccga 540
cgcccgtatt ggtaaagtcg ttaatccaga agttgatgca atttcaggtg agcccgagtt 600
caaacatacg cctgtaacca ttcagccgtt ctataccact tggcaaggtg tgctctatat 660
tcgtgaagga tacgagtcgc acattcaaga atcgctacat cactgtgcat ggtggactaa 720
agtcaaaatg gtgaaaacca atcgctatga acttgcagac cgccaaactt ttaatgatac 780
tcaaaagaat ctgaaaagct ttttgccatt tgctgatgaa acctttgaat ggttaagcat 840
agaagatatt tcttcacagc tgagccatag cgttattttg aaagatggca ttgtaattgc 900
aagtctatat attgcaccgc cagatttatt gccagaccgt gactgggtag caagtctgtt 960
taaacgagaa cgtttgagcg ccttgcaccg taaagcttta ctagcaggta tgccaatgtc 1020
ggctaccaat aatgatgggc ctttggtgtg tagttgtttt aaagtaggta agaataaaat 1080
tatcgaagca ataaaaacac aaaacattac ccatgaaaaa caggtcactg cttgtttaaa 1140
agctggtggc aattgtggat catgtttacc tgaaatccgt ggcttaatta aagcttgcca 1200
gcaagaggta gaagtgtgaa taagggatat cccataactg atctggtcat tctggcgggt 1260
ggacaagccc gccgtatgaa tggtttaaat aagctgttgc agcaattcga tggcgatacg 1320
caacttctta agattcatca aaagctaaaa tcttcagtat ctgaaatttg ggtgaatagt 1380
catcgagact attcaatcta tcaaagtatt gtgcctgata ttaaatgttt tcaagatgat 1440
gcttctggtt ttttcggccc gcttatgggg atg 1473
<210> 10
<211> 1441
<212> DNA
<213> Acinetobacter baumannii AB307-0294
<220>
<221> source
<222> 1..1441
<223> /organism="Acinetobacter baumannii AB307-0294"
/mol_type="unassigned DNA"
<400> 10
acattcgtgc acgtgttgct gtagaagcag ctcacgttga ctactggtgg aagtttgttg 60
gtcttgatgg caaagtaatt ggtatgacaa cttatggtga gtcagcacca gcaaaagact 120
tgttccaatt cttcggtatt acaactgagg ctgtagttgc tgcggtgaaa gagttaactg 180
cttaatcttt tgagcagaat aaaaagcgtc ccgattgggg cgctttttta tgggctattt 240
aaatgttaag ttcagtttgg atcgtaatat tagaagttaa aagcttatga atagggcagt 300
tttcagcaac ttttaataat cttttatgct gatcctcagt aaattcacct tttagagtaa 360
ttttacgctc aatattattt tgacctgctt ctggatcacc atttggattt aatgctaaat 420
caacttgtac atgctcaatt ttgatgcctt tgtgatttgc atacatttct agtgtaattg 480
tagtgcaagc tcctaaagcc gataataaaa gctgaaccgg atttggagct gtatcttgtc 540
cacctttgtc ggtgggttca tctgcaaacc attgatgacc cgaaggatcg gtaagtgtta 600
ctcgataagg aattgaagta ctttgtgctt gggcagtgtt aaccatgttt taccttgtta 660
tttatcaata aaatcgtagt aaaaattaat agatctgaaa gcttcgaata gaagaatacc 720
tatactttat aatatggttt ttgaataaca actgtaacgc ttttattgtt gcatggatga 780
aacatatcgt tttataaaga atagtgaatt aaattacttg atgtatacac taacgactat 840
atcaataaag gatacgaaaa atgcatctta aaacattaag cttcagttta gcagtagcat 900
tggcaagtac agttacatta gctgcaccag tggactataa aattgatcca acacacacag 960
ctactgtttt ctcgtggaat cacttcggct tttcaactcc aagtgctaac ttctcggaca 1020
tccaaggtgt aattaaagtt gataatgcta aaccagcaaa ctcatctgta aatgtgacca 1080
ttcctttaag cagtgtgaat acaaacgtac ctgctttaga taaagagttc caagaagaag 1140
cttggtttaa tgcggctaaa tacccaaaca ttactttcaa aagtacgaaa gtagaaacta 1200
aagataaaaa acattttaaa attactggtg atttgactgt taaaggtatc actaagccag 1260
ttgtacttga tgctgtctta aataagcaag gcgagcaccc aatggcaaaa gttccagcga 1320
ttggttttaa cgcgacaact tcgttcaatc gctctgactt tggtttaggt aactatgtac 1380
caaacgtggg tgataagatc actgtaaaca ttacaactga agcaactgcg gctagtgcag 1440
c
1441
<210> 11
<211> 1409
<212> DNA
<213> Acinetobacter baumannii AB307-0294
<220>
<221> source
<222> 1..1409
<223> /organism="Acinetobacter baumannii AB307-0294"
/mol_type="unassigned DNA"
<400> 11
acccgggcat gtgcgcaata atagaggaca agtgcgcgat tggcaagaga aaaacagaga 60
gtttgcttta ttttcaatca gttcttatca gtatttatat aaattaacca atttatgtca 120
tgatttgttc atcaaactga gatcagttgt tcatcttctc tacttaagtt taagacactc 180
attgcttaaa acttaggtaa ttttatgtca gagaaaattt cacgccgaga attaattcaa 240
aaaagtctac tcggttttgg ggctttatct atacctgttg cttttacagg ttgtaatgat 300
ggctcagatg atgaaagccc agaaatacaa gcagattttc ttcatggtgt ggcaagcggg 360
gacccactac aagataaagt tattttgtgg acacgagtaa caccgacaga ctctggggtg 420
cgcttaaaag ttgtatggga aatttcaacc gataatcagt ttaaacaaaa tttaaagacg 480
ggaatggttg aaacaagcaa gactgatgac tttacagtga aagttgatgc agctgggtta 540
caagcagata cggtgtacta ctaccgtttt aaatttggta ataaagtttc accggttggg 600
cagacgaaaa cattaccaac atccaccaat aaagtgagct ttgcagtatg ttcttgttct 660
aactatcctg cgggttactt ttatgtttat cgtgaaatgg caaaacagaa tgttgatgtc 720
attattcact tgggtgacta tatttatgaa tatggggcag atggctatgc gacagaagat 780
gcaaccaagt taggccgtaa tttacctgcc gataataata aagaaattat taaattagat 840
gattaccgca aacgttatgc gctttatcgt caagataaag atttgcaagc agttcatcag 900
cgccatcctt ttattgtgat ttgggatgac catgagttgg caaatgatgc ttggcgtgag 960
ggggcggaaa accatcaaag taatgaaggg gccttttcgg accgtaaatt agctgcccta 1020
caggcctatt ttgaatggat gccaattcgt ccagtttcta gtacagatca tttaaatatt 1080
tatcgccagt ttaactttgg ctctcttgtt cagttaacca tgctagatac gcgtattatt 1140
gcgcgtgata agcagcttgc atatacagac tacatgacgg ctacaggctt ggatattgct 1200
aagtttcagg cagatttaac taatccggtg cgtactttga tggggtatac gcaaagagat 1260
tggttggttg ataaattaaa gcaatctaca gcaacatgga atgtagtagg acagcaagta 1320
ttaatgagta aaatgtggat tccagctgag ttgttggcgt ctttagggca aattacttca 1380
ggaggaactt cgcctgaagc gcttgccaa 1409
<210> 12
<211> 511
<212> DNA
<213> Acinetobacter baumannii MDR-TJ
<220>
<221> source
<222> 1..511
<223> /organism="Acinetobacter baumannii MDR-TJ"
/mol_type="unassigned DNA"
<400> 12
taaaagggcg agtgaatgct aatattccta ttaatgagaa gttaaatatt cctttgacgc 60
agactttaac accacgtgtc tatttcgata atatggtgcc gattagtacg gttattccag 120
ttaaagaaac tttaaaagtt gaccaaagtt tgccaattga cacgaaagtt caggtgagag 180
tacttggtaa agatattact ttgccattaa aaggtaatat tcctttacag ttggatgtac 240
ctattgatat acaagttcca ctcgatcaaa aagttcattt gaagtttgat gcgccagtaa 300
aaacggtctt aaaagaaaat cttcatattc cattaaatgc tcaattaaaa acaaatattc 360
caattcaggg aagtttgaat gtccctgtga aaacagcttt aaatgcgtcg gtagatgtaa 420
aaaatacctt gccagttaaa atcgagcatg gtgagttaaa aataccacta tcgagcatga 480
gcctgaatcg cgttaaatct ggcgaagatc a 511
<210> 13
<211> 704
<212> DNA
<213> Acinetobacter baumannii ATCC 17978
<220>
<221> source
<222> 1..704
<223> /organism="Acinetobacter baumannii ATCC 17978"
/mol_type="unassigned DNA"
<400> 13
gagcgagaat tgctgaatta ccagtatgta aacatccggc gatcgaagtt ttaaataatg 60
gattgcttga taaattcact ttaacaagaa ttcatttaga atatcgtcat gcgattgttc 120
agatctttac tgatgcctta ttaatggccc agttccagac aaaacaattg gagcctaaac 180
tccattctgg agctaaaatg tttccacgtg ttttattaag tttaaatgta cttgatgaat 240
ttggttttag accaggaaca gacccggaca attattatct aggtaatccg gagtatgcgc 300
attatccttt atatgaagat ttattgaatg attatggttt gagtgagaag gaccgtagag 360
agtatcaacc ttcaaaaatt gcagatcagg taagaaattt tctagaatca tcttatgata 420
gttatattaa agtagttgct ttacttgcag tggcggaaga agaagtgatt ctttttagcc 480
caccacttcg tgaagcgact aaagccattg gcgtcgatgt tgaaggtggc ggctattacc 540
atgttcatgg ggtatctact gacgaaacct cagaagcagc agatgatgat catgaagatg 600
atctctggtt tgcgttagcg caagcaataa ctaaagaaga ttatgagagc ttaacaacgc 660
tttgtatgga ttattgtgct ttatggaatg agttttggga ttca 704
<210> 14
<211> 600
<212> DNA
<213> Acinetobacter baumannii ATCC 17978
<220>
<221> source
<222> 1..600
<223> /organism="Acinetobacter baumannii ATCC 17978"
/mol_type="unassigned DNA"
<400> 14
taatgatcat ccccatcgtg gattcgaaac ggtaacactt gtttatgcag gtgaactaga 60
acacaaagat tcatctggtg gaggtggatt tataagtgct ggtgatgtgc aatggatgac 120
cgcagcctct ggtgtgattc atcgggaatt gtttagtgaa gagtattctc gatctggtgg 180
tccttttgaa atgattcaac tttgggtcaa tttaccagca gcaaataaaa tgaactctcc 240
gcgctatcaa agtttaaaga aagctgaaat accgatggtg aaactggaaa atgaggctgg 300
atttgtacgt attattgcag ggcagtttaa ccatgttata ggtcctgcac ttactcacac 360
tcctattacc gtattagatg tagagctcca tgcaggtcaa caagccgcct tccctgctca 420
atctggtgaa acagctttag tttatttacg ttcaggtcgg gcacaatttc aaaaagatga 480
agacgtttta gaggaacaag gcctagcagt catgtcaaac caaggagagc atttctctat 540
tactgccctg caaagttgta aattacttat tttgacagga caacccatca cagaaccgat 600
<210> 15
<211> 1468
<212> DNA
<213> Aspergillus fumigatus Af293
<220>
<221> source
<222> 1..1468
<223> /organism="Aspergillus fumigatus Af293"
/mol_type="unassigned DNA"
<400> 15
tccatacttc gcatcactcg ggtaccatat ttcctcatca ttctttgtat atctcttccg 60
aagcatcaca ttgactgaca tataaaaact tcattatggg tatcaggaaa tcaagcatat 120
ccagcacaat gcagatctct gtatgtcctt actcaagcaa ggcttgcttc ccactcgcaa 180
tctaaagcct tactgactga cgtttcttct tctatagcgc tcgctgtggc gtataaggac 240
tctgatattc gcaatgttgc cgctattgtg ttgggaaccc cggggactcc ttatcagttc 300
ggtctctttg aggtttgaat tcattcacac tgaggatgag gcccatgggc tgactgccag 360
ctagttcagc atcggttttg gcaaaggtag gaccgctgat cgcttgatta caatctgcgg 420
tgagtgtcaa atggctgata ttgtttcaga ctatcctgct actccaccta ttgtccaaat 480
tacgacgacc aacgcaggac gatgccgttt cggtcctaat ctctatgctg gggggaaggt 540
ttgcttgtga gttacggatc atgcccatgc cgacatagat gtaatgttga cagtgttggc 600
actataggtc aatcttaggg taattagaac ctgctgaaaa tcggcttgcc aataatgctg 660
acatcttcgc cttgcagtac ctggggtgct cagcgcgggg aggaatggtc gtcggctcaa 720
ggactggagt ccattctgat ctccattcag agcctcatgt cgaacaatcc ctatgagaat 780
gagcctggat accaaggggc acatgcaacc gaggatcagg aaaacagcca ggcttatatt 840
gaaaaggtaa gtttgtccaa ggtaggatgg tcaactgtgc gctcacctcg ccttgagata 900
cgccatgaaa ctcttcgcat tgcagttatc caacccttgg aatcgtcact gggcatccag 960
tcggacggaa cagtcaagcc atccgagagc aagaatatag gcgaggatga tgattgtgat 1020
gactcgttcg atgatgaaga cggcactttc gtggagccct ttgcagatct tcgcaagaga 1080
cgcttcttat ggtattttga ctcctacatg caggcaatca aagaagcaga acctcaggtt 1140
agacgccgcc agagattcga aaccatgcct tttgagaccg aagataattg catgaggggc 1200
cattttaatt atcccgaatt gagacgacgc ctcatttgtg tcaaggaagc catcctcaaa 1260
gagacgcaca attggccaat agaaggtctc gaggcaaaaa agcaggaggc tagccttgct 1320
gtgagcctgc aaagtcagta cgagcagatt gttgaggatt tcaagcatcg ccacaacttc 1380
acagcggatc tgcgccttgt ccaagaaaac ccgttcctct gggaagtgat ctactttggc 1440
cgccccatga cacaacttga cggtggtg 1468
<210> 16
<211> 1475
<212> DNA
<213> Aspergillus fumigatus Af293
<220>
<221> source
<222> 1..1475
<223> /organism="Aspergillus fumigatus Af293"
/mol_type="unassigned DNA"
<400> 16
tacctatgtg gaagggcgac tgcaatcctc catccgcatc tcggatctcc aaaacctatt 60
gctgtactgt ttcgcggatg gcattgcacc gcagtggatt tccatcaaac attcgggtca 120
tattagaaag attgtcgtgt tgatggttcc cggtttagaa atggggatgt ttgacgggac 180
tgttccgttg aaaccgcaac ctgaagatga ggattcacga tcgtctcaag cttccaacgc 240
agagcagaaa gaccccgatg ctaacaagtc ggccgaagag gacgaggaca aggccaactt 300
ccttcgctgg aaacaaggcc ttccgctgga agatcgatcg caccgattca acccccgctc 360
tttaacgcga gacaatcttc cggaaccatt acagccatta gcggacatgt ttccacacat 420
ctggcccgtc aaagctcctg gggactcaaa gtataacaag gtccattctc ctcttcaagc 480
catcttactt tcttctttac cgaagaataa agaaagtggg ggcaagggcc ctaaaccgcc 540
taaggtagac aaaagctatg tccctaagcg tacgcctatc acggcattta ttagcagtgt 600
tgacaatctg cgcgaaaacg actatgttct tcatccggcc ctcttgtcaa ctgaaaagga 660
aaagttggcg ttggcggaaa atcgcaaaag agctggccag tcgacggagg atggttgggt 720
cgatacacat gtctcgagct gggaagcggg gcaagttcct gagcatgaga tccagcaagg 780
cagtgtaact gccggtcgcg atatactggc tctggattgt gagatgtgca ttacagaagg 840
tggtaaatca gaacttacac gtatcagctt ggtacggtgg gatggcgaag tggtgttgga 900
tgagcttgtg aagccacagt tgcccatcat tgactacctg acccgctttt ccggaatcac 960
aaaagagaaa ttggattctg tcacgaccac cctcgccgac attcaacaaa agttactcaa 1020
tattctcact ccgcgcacgg tgctggtggg ccactcgctc aattccgacc tgaacgcgct 1080
caagcttacc catcccttca tcgttgacac cgcaatcatc tatccccacc ctcgcggacc 1140
accactcaaa tgcagcttga agtggctcac tcagaaatat ctcggaaagg aaatccaaaa 1200
gggccaaact ggccatgact ccgtggaaga cgcccgtgcc gtgctggaac tggtaaagca 1260
aaaatgcgaa aagggtgagc gatggggcac aagcgacgcc tcaaacgaga gcatcttccg 1320
gcgtcttggc cgttccccgc gcccagggaa agcaaccacc tctggcgagg gccgtacagg 1380
agccgtcgtg gactggggca accccgagcg cggattcggg tcgcaggcga ccgtcgctat 1440
tgggtgtcag aacgacgaag aagtagtcca aggcg 1475
<210> 17
<211> 1508
<212> DNA
<213> Aspergillus fumigatus Af293
<220>
<221> source
<222> 1..1508
<223> /organism="Aspergillus fumigatus Af293"
/mol_type="unassigned DNA"
<400> 17
cgcaggcaat ctttaagagg ctttacgata atggatacct aacggagaag accgcggaac 60
agccattctg cgaggcgcac gggtcttttt tagcggaccg ctatgtcgag ggagaatgcc 120
cgcgatgcca ctacgaagat gcacgaggag atcagtgcga caagtgcggc caccttctcg 180
atccttttga tctcatcaaa cctcgctgta agctcgatgg agctacgccc gtgcgccgct 240
ccacgaaaca tattcacctt cttcttgaca agctgcagcc tgagattgag aactgggttc 300
ttcccgccat ggagaaaggc aactggccca agaattctag ggacatcacc aaggcatggt 360
tgaaagaagg cttaaaggac cgtggcatca ccagagatct caaatggggt gttccagttc 420
ccctccctgg attcgagaat aaagttctct acgtgtggtt cgaagcctgc atcggctatc 480
cgtcgatcac ggccaactac actgcagact gggagaaatg gtggcgcaat ccagaggagg 540
ttgaattgta tcagttcctt ggcaaggata atgtgccctt tcacagtgtg attttccctg 600
gatgcgagct cggaaccaag gataagtgga ccatgctgca ccatctcagt accactgaat 660
atctgaacta cgagggaggc aagtttagca agtctagagg agtcggcgtc ttcggaaaca 720
acgccaggca gactggcgtg cccccggatg tgtggaggta ctacctattg aagaatcgtc 780
cggagactgg cgacacccag ttcgaatggc gttcgttcgt cgaatgcaat aacagcgaat 840
tgttggccaa attgggtaac ctggttaacc gtgtcgtcaa gctgatcgca gcttcgtata 900
actccactat tcctgagttc accgttcccg agagttttca gccgaacttg gacgagatca 960
caagcctcct gcgacagtac attgaagaga tggaaggtgt gcatcttcgt ccaggtatta 1020
acaccgcgat gaggctcgcg gaggctggaa acggtttcat ccaggccaac cgacttgaca 1080
acgccctcat tgccaacgaa cctgaccggg ctgccgcagt tgttggtacc gtcatcaatc 1140
tgatccacct tctctccagt gtctttgctc cttaccttcc tgctacctcc aagtctattc 1200
tcgagcagct gaacgcgccc tttggagtca tcccatctct cgatgaactc aaagatggct 1260
ggaaaccagt ggccctgaag ggaggccaca agatcggtaa ggccaaatat ctcttctctc 1320
gcatcgaccc gaagaaggcc gatgaatggc gtgagctctt cggcggttct caggcagaca 1380
gacagaagaa ggaggatgaa gctgccaaag ctgctgccaa gaaggcagcc aacaaagcga 1440
gcaaattgaa gaagaaggag aagaaagcgg cacaggcagc tggaactagt gttgaggctt 1500
ccgctaag
1508
<210> 18
<211> 1464
<212> DNA
<213> Aspergillus fumigatus Af293
<220>
<221> source
<222> 1..1464
<223> /organism="Aspergillus fumigatus Af293"
/mol_type="unassigned DNA"
<400> 18
tgatggcaaa accagtacca ttcctgccaa cgagattgtc cccggggaca tgattgaact 60
caaagttgga gacacggttc ctgcggatct tcggtgcgta aagagttacc agaaaatatc 120
gttcccgttc actaaccgcc gataggctcg ttgatgcaat gaatttcgaa accgacgagg 180
ccctcctgac tggcgagtcg ctgccggtgc agaaagaggt cgataccact tttgacccag 240
acacgggacc tggtgatcgg ttgaatattg cgtatagttc ctccacggtg acgagaggcc 300
gcgctcgggg cgttgttatc agcacgggga tgcaaaccga gattggagcc atcgccgctg 360
ctctccgcgc cagcgactcc aagaggcggc ccgtcaagcg cggtcccgag ggagaaacca 420
agaagcgatg gtacgtgcag gcgtggaccc tgacttgcac ggatgccgtg ggacggttcc 480
tgggaatcaa cgttggcaca ccgctgcagc gcaaactctc gaaactggct ttggcccttt 540
tcgccattgc catcatcttc gccatcattg tcatgggcgt caatgggttc cgcaatgaca 600
aggaggtcat catctacgca gtcgcaacag gtcttgcaat gatcccggcc tgcctggtgg 660
tggtcctgac cattaccatg gcggttggaa ccaagcaaat ggttgaaaga catgtcattg 720
tccggaagct tgattccctt gaagccctgg gcgctgtgac taacatttgc tcagacaaaa 780
cgggaaccct cacccagggg cgcatggtcg ccaaacgggc gtggattccc tctgttggca 840
ccttctcggt ggggtcttct aataacccct tgaacccgga agagggcgac cttagcctgc 900
tgcctgaccc gccggtcaaa gttggccctg acgctcatgg agagccttcc cggccggagg 960
atctgctcaa ggacaatcct cttttggagc aatatctgaa cgtggccgcc atggcaaacc 1020
ttgcccatgt gcacaggtcc gagcacaatg aatggcaggc tcgtggtgaa ccgaccgaca 1080
ttgcgattca ggtgtttgcc tcgcgcttta actggggacg cgatcgctgg accaaaggcg 1140
agaagcctgt ttggcgccaa aaagctgaat atccatttga ttctactgtg aaaaagatgt 1200
ctgtcatctt taagaacacc aatgatgatc gggagatgat cttcaccaag ggcgcggtgg 1260
aacgtgtcat cgaggcttgc accaccgtca cctggacagc tggttccgac ccgatcgcct 1320
tggacgagaa cataaaggag gaaatcttgc agaacatgga agctctcgca aaggagggcc 1380
tgcgagttct ctgcctcgcc tgtcgggaga atcacaaccc cgtcaaaggg gaagttgtcc 1440
ctgcgcgtga ggaagtggag aaag 1464
<210> 19
<211> 1525
<212> DNA
<213> Aspergillus fumigatus Af293
<220>
<221> source
<222> 1..1525
<223> /organism="Aspergillus fumigatus Af293"
/mol_type="unassigned DNA"
<400> 19
cgattagaat ggctttggga tgttacccgc ttcgttcttc ccgaaaacag gactagtagt 60
gcacatggtt gtacaggctc cgccctgatt gattatcttc gaacagaatc ccaaacaggc 120
tatcttgacc tcgaagaaat cgcgctgcac ctgatcactg tggccgaatc cgcgtggata 180
aggcagctat cgacgtggct actgtatgga aatctgccga tctttgggaa ggacgacttt 240
ttcattcaga aggataactc gagccaaatg gatgattcgt catccatcac gaattttgta 300
atgcagacaa gcctactccc aaagtttgtt tcattgcaca cggcgtcgtc aatcttattt 360
atcgggaaga ctttgaatca tatcacggcg aagcggaaag gtgccacaat gggatttgat 420
tctggggcac cgccagtaac tcttcaggga gagcatattg cgcacctcgc gtcgttggga 480
tccccaatat cagcctcaaa actatccaac gcggtagatt ctatccgctt gtccttgtca 540
caaagtgttc tttcgaagct actgccgtta cccaagatcc tcgagattct ttctgtgctg 600
catgattttc ttctactggg gcgcggagaa ttcgctactg cgcttgtgtc tcatgctgat 660
gccagattga gtgagcgaca tcgaataccg gagctcctcg ctggccgggt cagagcgcaa 720
acggagcttg aagggcttgt cgtcaaagat ggggatgttg tacatgctct ggcacacaca 780
tgggccgagc tttattcttt acaaaatgag gaagaccctg tggatgaatc tcttgatctt 840
gcccgagacc ttgttcgctt atccatcact gacagtaaga atagacatac agttgcaacg 900
cactcagacg agattggaag tgatttagta gcggagctct cggacgtctc atttgaggac 960
ctactttttc caacgcgaac ttccatctcg gttgaagtac gtgcgcccct tgacctgttt 1020
ctatcgacgt ccgatatcgc tgtgtactca aggattcatt catatctatt gggaattcga 1080
cgtgcgcaaa tacgaataaa tgatctctgg aagcactctt ttcttcgaaa aagttatcct 1140
tctccatggg gcccaccacg aagcaacact ccctttggac agagtaagct taagctggga 1200
aggcagagag acaatatccg gcttagtcaa atgagaccag tatgggcaac gagtagtgct 1260
gcgctcttcg tcttatcaga aattggtagt tttttccagg gtgaagttgt caatggttgc 1320
tggcagcatt ttcgtgagtg gattcaaggt ggactggcca ctgccacgtc ctcgacgagc 1380
tctcgacctg aaacatctgc gtctttgaaa agcaggtata gcgacagtcc gattgagggc 1440
agagtgggta tcgatcagtc aagtcactct gcgccgcaac gactcgatcc cgaaactttg 1500
acagtcgccc atcatcgcta tctat 1525
<210> 20
<211> 1007
<212> DNA
<213> Aspergillus fumigatus Af293
<220>
<221> source
<222> 1..1007
<223> /organism="Aspergillus fumigatus Af293"
/mol_type="unassigned DNA"
<400> 20
caccgttcat ctctggaagg ggttatcgtt ccttcgtctc aacccttgaa tcgagttttt 60
gataaaatca ttctgcacct tgagccttgt caggcgagcg atatcggcta tgaaccagtg 120
acactcatta aacttatgaa taatgaggtt tttgaaaagg atgagtttct ggacctcttc 180
ttcactttta ttcagcaaga gctgctcggt gagacggaag ggactggtct agagcaaatc 240
ttatcccaca ttgacagatt ttgtgtctgg tcagctgaag agacaaatgc attacgtgac 300
tgtcttgttg ttttcgccaa gtacttggtg gacaacttct taccattaaa agcgttggca 360
gtaaaaactc cccaacccac cccggctctt tcccattcta ggactccgga agccaccatt 420
ggcactcctc aacgtgtctc aaatttgcga caagcctgtc ttatacgtga ccgccaccga 480
tgtgccatta atcggaaatt cgaagcccaa gaaggccaga gacgatataa gcgggatggg 540
cctaatttga aggatgatga tggcaagtca ttgcttgagg aacgtgataa tatggcattt 600
ttggaagtcg cgcatattat acctcactct cttatgtcac ttaccagcga agaaggcgaa 660
ggggagactt attcaaagct gatggcttat aggatcttga ggatgttcaa ccccggcgct 720
atccacctaa ttaatggggt tgatatcgat cggccgatga atgcgctgac cctgactcat 780
gaccttcaca agttatttga ccgcatgggt cggatggaaa ggctcccagt gactcgtaca 840
ctttatctta caccagatcg aagtatagat ccgccttctc ctcagcttct caaaattcac 900
gctgctattg gacgcatcct tcatctcagc gctgccggtg attgtattga tgatatcctt 960
cgggatatag aggaaatgga ggctggcgaa gtgatgccga atggatc 1007
<210> 21
<211> 1581
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..1581
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 21
cttcaggaca cgtcgacaga ttttcggact ggatgtgtaa agatttgaaa acaggagaaa 60
ttttccgtgc tgaccatttg gttgaagaag ttttggaatc tagattgaaa ggtgataaat 120
tggctcgagg tgttaaaatt gtcgaagaag aggatgaaga caaaaagaaa agaaagaaga 180
aagtcaagga aattaagaat gtcaaattag aagacgaagt tgttaaagaa tatgaatcaa 240
ttttggctca aattgatggg ttttcaggac ctcaattagg tgaattgatt gttaagtacg 300
acatcactaa cccttctact gggggtaaat tagaaccacc tgtggaattc aatttgatgt 360
ttgacactgc cattggacca tcgggaaatt tgaagggata cttaagacca gaaaccgctc 420
aaggtcaatt cttaaatttt aacaaattat tggagtttaa taatgacaaa atgccatttg 480
cctctgcctc catcggtaaa tcattcagaa acgaaattgc accaagagct ggtttgttga 540
gggttcgtga attcttgatg gccgaaattg aacattatgt tgaccctgaa agtaaatcac 600
atccaaaatt cgaagatgtt aaggacatca aattgaaatt tttgccaaaa aatgtccaag 660
aatcgggatc aacagaatta atcgaggaat ctattggcaa agctgtatca tctggcatgg 720
ttgataacga gacattgggt tactttattg ccagaatcta tttgttttta gtcaagattg 780
gtgttgacac taatagattg agatttagac aacatatgtc taatgaaatg gcacactatg 840
cctctgactg ttgggatgct gaactagaaa cttcttacgg ttggattgaa tgtgtcggtt 900
gtgctgatag atctgcttat gatttgtctg ttcattctgc cagaactggt gaaaaattgg 960
tggccagaca aactttagct gaacctcgta ctgttgaaaa ttttgaaatc gagattgcta 1020
aaaagaagtt tggacccaaa tttagaaaag atgctggtac cgtcgaaaaa tggttaacct 1080
ctagaaccca atgtgaatta gaagaattgg gtaaagaatt aagtgaaaag ggtaaaattg 1140
ttgtccaaat taaaggcgtg gaaggcgatg ttgaattaga tggtgattta attaagattg 1200
acaaagtaaa gagaactgaa cacgttagag aatttgtacc caacgtcatt gaaccttcat 1260
ttggtatcgg acgtatctta tattccatct ttgaacacca attttggtgt agaccagatg 1320
atgctgatag aggtgtattg tcacttccac caattgtggc ccctactaaa gttttgttag 1380
ttccgttatc taacaactca gaattgcaac caattgtgaa gaaagtttcc caagctttga 1440
gaaaggaaaa aattccattc aaggtcgacg actcttctgc ctccattggt aaaagatatg 1500
ccagaaacga tgaattgggt actccatttg gtattaccat tgattttgac tctgtcaaag 1560
atgactccgt tactttgcgt g 1581
<210> 22
<211> 1518
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..1518
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 22
attccaaacc aagcaccaag gtgaattacc agctccatac aatgaacaag atgcaactga 60
agcatttaga tatgctgaag aattggctac tcaaaatcca tcaattttgg gcgaagacaa 120
acttgacgaa aaatacctca aggaattgtt ctaccaagct cgtggtgata ttcctggggt 180
tgttgcattt tatggtggat taattgccca agaagtttta aagaactgtt cttccaaatt 240
cacccctatc aaacaatggt tatactttga ctccttggaa tcattgcctt cagaaacgga 300
atatccaaga aacgaagaga acaacaaacc aattggatct agatatgatg gacaaattgc 360
cgtttttggt aaagcattcc aagaaaaaat tgccaacttg aaagtatttt tagttggttc 420
tggtgccatt ggttgtgaaa tgttaaagaa ctgggcaatg atgggattag gatccggacc 480
cgaaggtaaa attttcatta ctgacaacga ttccattgaa aagtcgaatt tgaaccgtca 540
atttttgttt agacctaagg atgttggtaa aaataaatca gatgttgccg ctttagctgt 600
tcaacagatg aaccctgatt tgaaaggtaa aattgattcc aaattagaca aagttggacc 660
agaaactgaa gatattttcg acgacaaatt ctggactcaa ttgaatattg tcgtcaatgc 720
tttggataac gttgaagcta gaacgtatgt tgatcgtcgt tgtgtctttt acaaaaaacc 780
attgttggag tctggtactt tgggtactaa aggtaacact caagttgtca ttccaaactt 840
gactgaatct tattcatcct cccaagatcc accagaaaag tccattccgt tgtgtacttt 900
aagatcattc ccaaacaaga tcgatcatac tatagcttgg gcaaaatcat tattccaagg 960
ttattttgcc gaatctccag aaagtgttaa tttatacttg agccaaccaa attacgtgga 1020
acaaacttta aaacaaaacc cagatattaa aggcacattg gaaaatatct ccaagtattt 1080
gaacaatcgt ccttacactt ttgaggattg tatcaaatgg gcaagacaag aatttgaaac 1140
caagttcaac cacgacattc aacagttgtt gtacaatttc ccaccagacg ccaagacttc 1200
tactggagct ccattttggt ctggtcccaa aagagcaccc aaaccattgg agtttgatat 1260
taacaataag gatcatttgg acttcattat tggtggagct aatttattgg catttatcta 1320
cggattgaaa gaacctaatg caactgttga tgatttcaag aaagttttag aacaggttat 1380
cattgaacca ttccaaccta aatctggggt tgaaattgct gccacggatg cagaagccga 1440
agaacaagcc aacaatcttt ctggatctat tgacgatgaa caaattagaa agattgctgc 1500
ttctttgcct gaaccaag 1518
<210> 23
<211> 1005
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..1005
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 23
accaaacggt gaaagaaacg acaaatactc attagctcca gttgctactg aattggaaaa 60
attgttgggt caaaaagtca ccttcttgaa cgattgtgtt ggtccagaag tcaccaaggc 120
tgttgaaaac gccaaagatg gtgaaatctt tttgttggaa aacttgagat accacattga 180
agaagaaggt tcttccaaag acaaggatgg taagaaagtc aaggctgatc cagaagccgt 240
taagaaattc agacaagaat tgacttcatt ggctgatgtc tacattaacg atgcctttgg 300
tactgctcac agagcccact cctctatggt tggtctcgaa gttccacaaa gagctgctgg 360
tttcttaatg tccaaagaat tggaatactt tgctaaggct ttggaaaacc cagaaagacc 420
attcttggcc attttgggtg gtgctaaagt ttctgacaag attcaattga ttgacaactt 480
gttggacaag gttgatatgt tgattgttgg tggtggtatg gccttcactt tcaagaaaat 540
cttgaacaaa atgccaattg gtgattctct tttcgatgaa gccggtgcta aaaacgttga 600
acacttggtt gaaaaagcta agaaaaacaa tgttgaattg atcttgccag ttgattttgt 660
cactgctgat aaattcgaca aagatgccaa aacttcttct gctactgatg ctgaaggtat 720
tccagacaac tggatgggtt tggactgtgg tccaaaatct gtcgaattgt tccaacaagc 780
tgttgccaaa gctaagacca ttgtttggaa cggtccacca ggtgttttcg aatttgaaaa 840
attcgccaac ggtactaaat ccttattgga tgctgctgtc aaatctgctg aaaatggtaa 900
cattgttatc attggtggtg gtgatactgc tactgttgct aagaaatacg gtgtcgttga 960
aaaattatcg cacgtttcta ctggtggtgg tgcttcattg gaatt 1005
<210> 24
<211> 1187
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..1187
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 24
agcaatggac gacatcatca aatgaagcat tgaaattgtt tgtcaccaat cctgaagcag 60
cacttaattt ccaacctaca tttacttatc caatatttgg tgatgccgaa acaatctatg 120
ggtataaaga tttagatata tttttatgtt ttgatcatta tacatttaaa ccatttttga 180
atattaaata tagtgccaaa ttgactgacg atccagaaat tattgatatc aaaaaaacca 240
ttgatgaatt cttacctaaa ctgacgattt tcaaagatga agtgaaatgg gtcgattcaa 300
taaaggaaga aaaagataat gggtataaaa tacctggaaa attaatcgat tcatttagtg 360
agaatgataa agaatacgat atttataaaa ttgacttgaa gtcagacaat ggatatgaat 420
tacatcaacg attgcaaatc ttagtcttat tgttcattga ggcagggtca tttattgatg 480
ccaaagatga attatggaac ttgtatgttt tgtatgaaaa agacaataaa tctacatcca 540
ataatgaacc ttctatagtt gggtttacca cggcttataa ttattggaaa tatcctggtg 600
ccaaaaaatt cgattcaact gaacaagaac tgagaatcaa gatatctcag tttataatat 660
taccaattta ccaaggtcaa ggcttaggac aattatttta ttcccattta tttgacaagt 720
ggttagcaca agatgatata attgaagtag tagttgaaga ccctaatgaa agttttgatg 780
atttaaggga tagagccgat ttgaaaagat taaatactag tgagcaattt gatttcaaag 840
ctgttactcc gaaagtagac aaggagtggg ttgaaaaaac aagacgagca ttaaaattag 900
aaaagagaca gtttgcaaga ttgttagaaa ttatattgtt atacaagttg aaacatggct 960
atcctggtat caccaagaga gacgtgaggt tattcatcaa aaaaagatta tatgacaaga 1020
ataaggaagg attagccacc ttagatgata acaccaagaa agataaatta cagactgctt 1080
atcaagcttt ggaagatgat tattatagaa tattgggaga cttgaagttg aacattaagc 1140
gtgagaatga tgaagaggaa actgacaccg tttccaaaaa gcaaaaa 1187
<210> 25
<211> 1486
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..1486
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 25
tatgcgagct tgttttgacg ttagcgttgt gtcataatgt cacaccaacg tacgatgatg 60
atgaagatgt aggttttggt gaagtaacat accaagctgc ttcacccgat gaaattgcta 120
ttgtaaagtt ttgtgagctg gttgggttaa agttgtacaa acgtgatcga cactcaataa 180
cattgttaca tgtctacacc aataagtttt tggaattcga gatattgtac aattttccat 240
ttagctcaga aactaaaaga atgggtatta ttgttaaaga caaaaacagg gaagatatat 300
ggtttatgca gaaaggtgca gatactgtca tgtcaagtat agtcagctca aatgactggt 360
tggatgaaga gactggcaat atggctcgag agggtttgcg tacgttggtt attggtaaga 420
aaaagttagg ttccaaatta tttgaggact ttgtcgacaa ctacaaacaa gcgtcattgt 480
cgatgcacga cagagatagt gatatgcaaa aagttgtcag ttattatttg gagcaagatt 540
tggaattact tggtttgact ggtgttgaag ataggttgca acgtgatgtt aaaacttcta 600
ttgagttatt gagaaatgca ggaattaaga tttggatgct tactggtgat aaagtggaaa 660
cggcaaaatg tgtatctatt agtgctcggt taatttcccg aggacaatat gtgcatcaga 720
ttactaaact ttctcaccca gatatggcga tgaaccaact agaatattta cgtatcaaca 780
ccaacgcatg cttgttgatt gatggagaat cattgggcac ttatatgaag catttttctg 840
atgaattttt caaagtagta attaatttac ctgcagtgat tgcatgtcgt tgttcaccac 900
aacaaaaagc cgatgtggct gttatgatac gaaaaattac agggaagaga gtttgttgta 960
ttggtgatgg tggtaatgat gtaagtatga ttcaatgtgc cgatgttggt gttggtattg 1020
ttggtaagga aggtaaacaa gcatctcttg ctgctgattt cagtattgat caattttgct 1080
atttgtcgaa attgttatta tggcacggaa gaaactcgta caagcgttct gccaaattgg 1140
gacagtttgt tattcatcgt ggtttgttga tatctgttgc tcaggctgtt tattccattt 1200
catccaagtt tgaacctttg gctttgtatc aaggatggtt gatggttggg tattctacaa 1260
tatataccat ggcacctgtt ttttcactca ctttggattg tgatattgat gaacatttga 1320
caaagttgta tccagaatta tacaaagagt taacattggg caaatcttta tcatataaaa 1380
cattttttat gtgggtattt atttccttat atcaaggatg tatgattcaa ttgctttctc 1440
aacgttttca aacattattg gacaagaggt ttactgccat ggttgc 1486
<210> 26
<211> 832
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..832
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 26
acaatgccca acaaaaggag gatgaggaag aacttgaaga tataaacaaa caaaataatg 60
atcatgatca cgatcaatat cttgaacaat atttgaatat tttagaaacg aaaaatttaa 120
atgaatttga ttatattaat tctaaaatgt atgaacgagg attagttgaa atgttaatgc 180
cggaaaagaa agacgatgat ggtaaagaat ttatagaaca agatgaaaca attgctgaat 240
attggatata tgaaaatcaa aacatcaagg gaggagaaga agaagaagaa gaagaagaag 300
gattaccaat agaatctgat tcagaggagg aagaaggaga agtgatagac gcagaagtag 360
aagcagaagc agaattgagt gagattcaag aacaggcaca agaacaagaa gaaactttaa 420
atgaaactaa ttatcaagat gaagaactat tatatatcga tccagaactt tttgattcag 480
attatatgaa taataataat aataataata ataagagtac cgacaatctt tcatcggatc 540
tagtggtcaa accatcatca actcaatcaa ttgacaaaga agttctacct aataaagata 600
ctaaaactaa agataaacat actctaataa cgataatagg aggtgaagat gaaattgaac 660
aaatgacaat atcacaattg aaaaaattat taccaattcc cagaaaatca aagagtagtg 720
atacaacttc aacttcaact tcaacttcta gtggtagtgg tggtattact aaaaaatatt 780
caaataaatc cattactaaa aaattaaata aattaaatca acaatttgcc ca 832
<210> 27
<211> 1088
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..1088
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 27
cccagaaacc gctacaaaaa tttcagaatc ttctagtagt gaagaagaaa ttgccaataa 60
tccagaaact cctactatgg atatagatga atcatcttct agtagtggtg aagaaatggc 120
tagtaacaca agcaaagtgt cggacggctc ggcttctagt aatgataaag aagttgccaa 180
taaccctaca aaggtatcag atggtttggc ttctagtaat gacgaagaaa tttccaataa 240
tccagaaacc cttacaaagg tttcagaaga ctcatcttct agcagtgatg aggaagccag 300
cgactctgct gttatgttag atggcacatc ttctggtagt gacaccgaaa gttccactaa 360
cccagaaaca cctcctaaat tgaatcagaa gcaaccaatt gcaaacgctg gtggtgataa 420
gaatgtttca aacaagtcag aaattatggt tgcaccgttg ccaatagcaa ctccacgtgt 480
gcaaggtttg gcgttgactc caactgcaag tacaagacgt gctaaaatgg ttttgagtaa 540
agaatttgtt ctggatagtg atgatatcac agatgaggga tcaaatgcaa atgatggtat 600
cgagaaggat aaagatgatg taaatttgaa atccattcct gtcaagaagg ctaatgatcc 660
aactgtgtct atgtctgaaa aagtgccaca accagatagt aaggatagtc tgagtgaatc 720
aagtgacgat tctgagtcca gtgaatctgg gtcaggatct gattctagtg agtcaagtga 780
cgattctgat tccagtgaat ctgggtcggg atctgattca gactcaagtg atgagtcaat 840
ggattcgtct gatgaagagt cgtctgagtc cagctctagt gatgaatctc cagcagtcaa 900
gaaacctgaa ttgaaaacaa ctggatctaa agagaagcct caaccagtga aagtccaaaa 960
aacaccaaaa cctatcgctt cttctattgg cgaacctaag aaagtacctg tacctgcacc 1020
agcaccaaaa acgactcaac ggttggcttc attaaaagat ttaaagcatc cacgtaccac 1080
cattgaga
1088
<210> 28
<211> 1012
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..1012
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 28
tgaatatcgc cttttgtaaa atctattttt tgatactcat caacaatatt tttaattttg 60
ctttagttaa aatgaaaacg atttcaattc tagctttttt ggtattagct agattaattg 120
aagccaatga tttattccaa gttaaaacca ttatagatta tcaagatttg taccttcata 180
ttaatccaaa taattttcaa gttaaattaa gtcattcatc tactgatgtt ttcgaatttg 240
atgaaagttc caataaattg ttttgtgctg gtacaaatga tataattact tataataaag 300
agaattgtcc ttatcttatg aaatttgctg atgagtcact gtcctcagtt ttaggttggt 360
cattggatag acaaacactt agatttgatc atgatttgta cttttgtggt accaaaccgc 420
cctattccct tttagctgat ccatcgggtt ctgcaaattg caggaaatta aacatcttta 480
ggacagtctt agaacccaaa gtagaaaaag aagaagagga agaagaatac gatggtgaag 540
aagatgacga cgatgaatct ttaacggaat ttgaatcctc gactgacttt ccaacaatga 600
ctgacgaatc aacggaagtt gagccctcaa ctacaactga gtctgcaatt tcaacaaccg 660
agacttcaaa agatgaagaa tcttcaacaa cagttgagtc tacaacaaca ccaaaaacta 720
caacaaccac gtcagttgac tctgtaacaa caacttctaa atcaaatgag tcattaacta 780
caactgaatc aaatgaatca tcaactacaa ctgaatcaaa ggactcctct acgacaactg 840
acgagtctac accagaatca tccactactg aaactgataa gacagaaaca acaattgaag 900
aacaagagga agaaagtacc acatcttctc aatctgaaga aaccgaagga ccatcaggag 960
gaaatgtcga ttccacagtc gcaatggtca tatcagcaat gtttcaaggt ga 1012
<210> 29
<211> 1084
<212> DNA
<213> Candida albicans SC5314
<220>
<221> source
<222> 1..1084
<223> /organism="Candida albicans SC5314"
/mol_type="unassigned DNA"
<400> 29
gatgccactc aaggttggat tattaacgat gaaggtatat ttttggtaca agatggattt 60
tattctgata gtgttagttt tagtgcttgt ggtcatgatt cagggtatcg agtttatttg 120
ggtgaagaaa atggttgtga acctttaaat caatttagaa ttatgaatat tgaagaagat 180
gaaattgatg aaactgagac gacggaatct actaagacga cagaaactac taaaacgacc 240
ggtcctgctg agacaactga cccggctgaa tcgactgatg atctgaatga gtcgagtgca 300
ccaccaccaa ctgaagatcc tagtgatatt ccaagtgcta ctactactga tgaagccact 360
gttgatccat ctgatgaaca gtctattgct ccaactagcg agccaaatga tgaatcaact 420
gaatctgaag agcctaatga gtctgcaaca gtgactggtg ataccaccac agatactttt 480
gaacaaggat tgacaacatt cactacagag accaccgcta ctgttactga ttgtgaggat 540
ggtgatgatt catgtacacc aagaactacg attcgtagta ccgttatcac cacccattgt 600
ccaatagtca ccaagactga agttgaaaca attgttactg atttaacaat cacccttact 660
acatgtattg atgagactat ttgtgaagct acaactttgg ttgtttcaac cactgtggtt 720
actactacct tgactaccca tctggtggtg acagaatatg ttctgagtgc tcatgaaggt 780
gatggttcct ctactattgc taatgaagat aaacataatg atgctattgt gacaccacaa 840
gaaaccgtag ctccagatac caatagtcct gatgcagatc aagaacaacc tgattcagtg 900
gaaccagata atgaagccac tgatgctcca ataaatgtcg aagatgatgc tactgctttg 960
atttccgatg aagatactac aacttcaaca atcacaactt tgatttatat cacccaatca 1020
ggagatcaac caattaaaac tcctgttcca atttttgata atgctgctaa tttggctggt 1080
tcaa
1084
<210> 30
<211> 1562
<212> DNA
<213> Candida glabrata CBS 138
<220>
<221> source
<222> 1..1562
<223> /organism="Candida glabrata CBS 138"
/mol_type="unassigned DNA"
<400> 30
actggtggta aggatgctgc tgctgcaaga tatatctaca ctgagctgaa taaaattgcg 60
agaaaagtat tccatcctgc tgatgatcct cttttccgct atgttcaaga agatgaaaag 120
actgttgagc ctgagtggta tcttccagtc gtaccaatgg tgctaattaa tggtgcagaa 180
ggtattggta ctggttggag taccagtatt cctccattta atcctctaga tgttgttaac 240
aatatcaggc atttattgaa tgatgaagaa atggatgata tgcacccatg gtttagaggt 300
tggactggta caatggaaaa aattgagtca cagagataca ggatgtatgg tagaattgaa 360
caagttggtc caaatacact tgaaattact gaacttcctg ctagaacttg gacttctacc 420
attaaggagc atctattgct aggtttaggt ggtagtgaaa aggttaagcc ttggatcaaa 480
gatatggagg aacagcacgc tgaaactatc aagtttataa ttaaattgac agatgaagaa 540
atgactaaaa ctagaaaact tggattttat gaaagattta aactgatatc gccaattagt 600
ctacaaaata tggtcgcctt tgactacaga ggtaagatca agaaatatga tcatgttcat 660
gaaattttaa aagatttcta tgaggttaga ttagaatatt atcaaaagag aaaggattat 720
atgacaggta gattacaatg ggaggctgaa aaattgtctt tccaagttaa atttatcaag 780
atgatcattg ataaatctct aattgtcaca aataaaccaa agaagcaatt gatatccgaa 840
cttgaggaat taggtttccc tagaatcaat aaagaaggaa aaccacactt cggtaagatt 900
gatgaagaag ttgaagctat aattagtgaa gacgaagatg aggacttgga agagagtgaa 960
gaagctacta gaaagaagga caaggacgat gaaagtactg ttaatgggcc tgaagaactc 1020
tttggtactt atgaatacct gttaggttta aagatttggt ctttaacaaa agaacgttac 1080
gaaaaacttt tgaagcagaa gcaagaaaaa gaaactgagc tcgaaaatct gttgaaactt 1140
tctgccaagg atctatggaa taatgacttg gatgactttt tgactgcgta tgaggacttc 1200
caaaaaatgg acttgttctt gcgtaacagt gctgttccaa aaacaaaagg tgggaaaagg 1260
aagagaaaag gtggtgatga cgatgactat gatccatcgg gtaagaagaa acctgcaaga 1320
agaattaaga aaattaagaa ggaagacgat ttcgatagaa ttttgatcaa acctcaggcg 1380
aagataaagg ctaagaggcc cgttaaagta aaggtcgaac caccatcttc agctgcatca 1440
acacccagcg taaaagaaga acttggggtt tcagatgtaa cgagtaacgc ttctacccca 1500
tcaactacta tatttgatca aaaggtcaaa caagagaata gtgacgagag tggaataagc 1560
gc
1562
<210> 31
<211> 1542
<212> DNA
<213> Candida glabrata CBS 138
<220>
<221> source
<222> 1..1542
<223> /organism="Candida glabrata CBS 138"
/mol_type="unassigned DNA"
<400> 31
caccgaatca agctcaatca aaaatcgatg agtctagtag aaaggaaaaa aataacaatg 60
atctaggcgt cgaaatgacc agcgttgatc ctgctttaac aggtgaggat atgaatgagg 120
ctcacactaa agagactgct gcagaacaaa atggtgaaaa aggcattttt aatggtatgg 180
tattctatct taaccgcgat tccaacgccc atgactcgat tataattgta gagcaattga 240
aaaatttaat tttattaaat ggaggtgata ttgtgaataa actaccaaat aaggattctg 300
cagaagcaaa gcacattatc gtggtttctc catacaacaa tactgaatta aaaactgtca 360
catctacttt catccgggca tgcgtccaga gcaacaaatt actggacatg aaaaactatt 420
tagtaccata tgatagtttt aatgcgcttt tggatgatgc gatgtcccca ccatcaagac 480
aagaaccaac aatttctgaa tccagttctg taaacgaagg gcaacctaca gcttcgaaac 540
ctccacccca aaatattgca aacaaaagag atatcccaac aaaaaaggta tctgcaaata 600
ctggagttag caagacatca tttactgaag aagaagatga atttatttta gatgtcgtta 660
ggaagaatcc catgagacgt actacacaca cattatttga tgaaatttcc cactatgtac 720
caaatcatac aggtaactca attagacaca gatttagagt gcacctatct aagcgtctag 780
attttgtcta ccaggtcgac cagtatggta aacttgtcag ggatgagaat ggtaatctaa 840
taaaaacaaa agttttacct ccatcaataa agaagaagtt cacagccgat gaggactatg 900
agctcgcaat tgcaattaaa caacagtttt acaaggacat ttaccagtta gacccggtca 960
ctggtcagtc tttgatttca gacaatgatc caccagcgcg tgtagccaaa aggcaaatga 1020
tgatggatcc taacgtacaa cgaggatctg agcccccatt tagtaaatac agggtgggaa 1080
ctagaagagg accaattgct agggagttct ttaaacaatt tacagaaaac catccaactc 1140
atacggagag tgcatggaga gataggttta gaaaattttt gttagagtat ggagtcgaca 1200
aatacattga atactatgaa acacagaagg ctaacaatga cgagcccgaa gccatgaaaa 1260
atttgacaat tagaactaag agagacaact ttccaactcc aggaaactat ggtaatgctg 1320
ccaagagaca gaaatatgaa gtttcctcaa atgtcgaaaa tacattgaag tctaaaggcc 1380
aagccggtga tattcctgat gctgaattac tagatgagga tacaatgaag tttatatctt 1440
ccttgaaaaa tgatctgtct aaaattgata acaactttgg ctttgactac acaaacgaga 1500
tagctgaagc tataaggaac gatttttctg aggaggaagc ca 1542
<210> 32
<211> 1034
<212> DNA
<213> Candida glabrata CBS 138
<220>
<221> source
<222> 1..1034
<223> /organism="Candida glabrata CBS 138"
/mol_type="unassigned DNA"
<400> 32
tggggcacaa agaaggttag tgctggtttc aaccgaaaat attccaacca tgcaagatga 60
tccaacgaag cagatgtctg tccatagtgc taacaagatc aataagatac tagaattggg 120
actgttaaaa ttaacatcac tgtcctacca ttcagaaggc tctaataccg ctatagatac 180
atatcggtta tgtggttgga taccagatat atcaagtata aatgagttta actttctcaa 240
agtacacaag gctttcagta gaggcgaatg tctcatagct atgggaactg gtggatttgt 300
tcctaaagag aacatattcg gagttaaatt acgtaaatat cacgattacg ctgttctgga 360
tatagatatg ataaatgagg tagttacatt gcgtgatcca ttgataagtg ataccttgtt 420
aactattaac tttgacagta tcagaaaata tttccttcaa gtttattgta actgggacag 480
ttctaagcta tttatgttca caaaggatac acagattttc tattctgata agaaatttaa 540
tccttaccaa actttggcag gaaagcctac tttctacctc aagaataatt ctgataggga 600
tgagtatgca tgggttctgc tagaattcca tctagacaaa aataataaca ccacagctta 660
tttacaggaa ataccagaca gaatttcaac agttagattg ggatataatg ataattcagc 720
ggaaacggga ttccaattaa taaagataag gttgaaaccc aagcaatgta tttggtattt 780
ttgttacagc tctacagata agatgttgac atttcataca tactctacca gtagtgatgt 840
tgtgtttgtg agatctaaga tgccgggctg tgattttgat gtcactgaat gtgccatact 900
accggaaaac atagtaccca tgcaataccc taatcattct gaaaccgata tctattacct 960
tgcatctatt gatttttcaa tagaaggaga acctggaatt acaataataa ctgatatggt 1020
cgtgtgcttg gaaa 1034
<210> 33
<211> 1025
<212> DNA
<213> Candida glabrata CBS 138
<220>
<221> source
<222> 1..1025
<223> /organism="Candida glabrata CBS 138"
/mol_type="unassigned DNA"
<400> 33
ttcttggcag cagtcacatc tagctttgga ttaatattac ttgccaaatg ctcaaagaca 60
ctgataaacc ccaggaactc ttcattcttc actatatgta tgcttacgta cccatctttg 120
gctccacttt ttgatttggc tatggttgta caatgttttg gggtaggact aagctatcta 180
gtgctcgtgg gagacttttt ccctgattta tttggtggtg agaggaaata ctggatattg 240
ttatctgcta tacttgttgt tcctctatgc tgtttaaaga aactagacaa cttgaaatat 300
tctagtattg tgggagtgat agcacttcta tatttatcgc tattaattgg gttcaggtat 360
ctaacagatg ttgcattcgc acctgagatt agtttcgaaa gaggagaaat ctcatggttt 420
aaagtttatg attataaggg attattgtca acgttttcca ttattatctt cgcttatgtc 480
ggcgctatga acatattcac aatcgttaat gagctgcagg ataattccat gactaacgtc 540
agaaaggtag tggatagctc tattttaata tcaaccattt tatttttatt tgttggtttg 600
tttggttatc tgacttttgg tagtctaaca atgggaaata ttcttttgaa ttacgactcc 660
gattcattag ctatcggaat aggtaaattc tgtctagcta tgatgttgat tctcacattt 720
ccacttttat ttcatccatt gagaactgcg attaataaca tagttgtctg gtttatcatc 780
aaatttgaga agtcgagtct tacgcccgaa atttcagcaa gggattctga agcttctaat 840
tatgtcacag ctgaaacaca tacctccaga cccattaact taattattaa tgatgatgaa 900
gttaatgatt gtgaggaatt aaatgaagat ctcttggaca gtaataacgt tatatatcag 960
gagcatggtc atgaggaaga accgcccaaa ggtgggctga atggcgttga gcatgacgtc 1020
ccttt
1025
<210> 34
<211> 1170
<212> DNA
<213> Candida glabrata CBS 138
<220>
<221> source
<222> 1..1170
<223> /organism="Candida glabrata CBS 138"
/mol_type="unassigned DNA"
<400> 34
ggtagtggcc gaggtaaaca acaaggattt accagcaatg gtattaataa agatcaaact 60
agatcggaag ggaaatctgt tgcatttgaa gtcggtgatg agagagagac tagtcaggac 120
acgattttgg gagatggcgg gatgactcag aacggggaca cgtcagggga gttcacagac 180
agggatgaca ctagccaaaa taggatgaat ggctcactac aaagtgaagg actagtcttt 240
gaaaagcgca aagtcattcc acaacggaga acccagtctc agcagagtat gctgtccagt 300
atttcactca ggtctatgat acaagagcaa cagcatgtaa ataatcaaca gcaacaacag 360
cagcaatcaa tgcatagaaa cagtatgggt tctaataaca ctaataatga tcagaattta 420
atcagccata gtttactaaa catgagtcag cagataagat caccggcaat gttctccatc 480
aaaagaacag ggtcgctgat gcattccgct agtaggacag ctagtaattt tggaaaacag 540
gaaacgatat atgattcaaa tagtctggat tcaaatgaaa taggtaaaaa actaccattc 600
acaaatgacg aaaggataca gataggaagt aagaaagaat ctccaacggt gccgagaata 660
agaaatgaaa tagtggataa tgctacacct actgctctac gtgagttacc ggaagttata 720
tcagatttga aaccagaaga cgaagatgaa atttctcaaa aagatttaac tacacaagca 780
ttaaggaagc tgtccaactt taaagggtca aatttgaatg aggcattcag tgagcatacg 840
acgagcaccg gtactccaac aacaaatgta tctgagaatg agaaaggaaa aattatgaga 900
gagtcgagta acttcttagt tgcagataaa agctctccat ctcctatgaa agcttcatcg 960
gaagcgccca agaaaactgt aaaactaaat gatcagagta gtactgatac tgatttgagc 1020
cgaacatcta gttccaatat actaaacttc acgacaaact cacactccat gatgaatatg 1080
aaatttggtg atagaaacat aacagttgaa aataatccag aaatgacaac caacacacat 1140
gcccaaaact ttattgcaga tgccaagcag 1170
<210> 35
<211> 1035
<212> DNA
<213> Candida glabrata CBS 138
<220>
<221> source
<222> 1..1035
<223> /organism="Candida glabrata CBS 138"
/mol_type="unassigned DNA"
<400> 35
atctgcatca aacccctacg ggaacgcctc ttatggatcg acacctggtg tcaatgacag 60
accggcgggt tcaaatccat atgctgcgat tagtggtgac tcatacctaa acggtacacg 120
atcaggaaat atctcaagat ctggtactaa tccatattta agaaggaatg ctagcaatag 180
cgtaccgcct caggctggat atatcacacc tgattcgaac aatgttgcac tagcggagga 240
agagaaccaa caaaatcagg atgaattgga cttaaacgat gctcccgaag atgctaatga 300
gtttgtcttt gaggacaaat acatgggtag agaatctaaa tatgcagaaa actctgctgc 360
gctggacgaa ctagatttga atgccactat aaatgaccgt ggggaagatc ttaatgccac 420
tggatacggt aacatgtatg aacaacaaca gcaaccgcaa tggcaaagag aagaagagga 480
atacggttat ggtacccaag atgatatgaa cagaggctat aagacttttg atgagataca 540
aagagaagaa gaagagcgtc aaaaagaaga agaagatcag gctgttgatg aaatcaaaga 600
gcaaattaga tttacgaagc agagctctgt tgcttccact agaaatactc tgaaaatggc 660
acaagaagct gaaatggctg gtatgaatac actaggtatg cttggccacc aaagtgaaaa 720
actgaataat gttgagagaa atcttgattt gatcaagata cagaatacag ctgccgatga 780
aaaggtagct gaattgaaga agctgaacag aaatattttg gctgttcatg tctctaaccc 840
atttaactct aagagaagaa gacgtgagcg tgaagacatg attaagggtc gtaagatgga 900
agacaagatg agagcagagc acatgtcaca agaattacac caatctactc aaagaattga 960
gggagcccta ggtggcggta atgagactag tgctgtgaga gagaaatatc aaagagaaaa 1020
agtacttgcg gcagc 1035
<210> 36
<211> 1600
<212> DNA
<213> Candida parapsilosis strain CBS 6318
<220>
<221> source
<222> 1..1600
<223> /organism="Candida parapsilosis strain CBS 6318"
/mol_type="unassigned DNA"
<400> 36
ttgccatcat ggatggatta atgaggttaa actcattaca tgaatatcta agtacagagg 60
gcttagccaa cgagctaatc tctgaaggtt gtacgaaatg gggaaaaata caaactctca 120
gtgaagtatt tagtactcta gatatagctt tagtggtaat attaagttta atgagaatga 180
atccttatta taaaattggt tcagcgatac tagggtcttc tgagattaat agtagatcaa 240
agagcttcat atatgaaaga aataaagatg aatgcattta tttcaaatcc atcatcagaa 300
gcaccaaaac agaggaggat ttaatattta tccaagacgg taatagtctg aaggcttact 360
taaccaaaca cgggaacctc ggaaagggta tattattgaa gtgaaataat gtcaaatttc 420
acatacttaa atcttgattt aaggttactg taatatatct gtatgtatat tcattattgg 480
gtatagttag attatataac ctatttatta taagtttcat acaaatcata aatagaatac 540
acgggggcaa gataagtgag gaagcaaaag ttctaagtaa cgttagaaat accataaaac 600
atcaatctag ggatagattg ggtttacaat ggccaagagt tgaacatatt ggacaaaagc 660
tgaattcacg atgccttagt atgaatgaac tttatatcca gaaacgtagc tattcaaaga 720
ctagggagga tataagcgaa tttcaattat atctgaagtc tgtagttaat ggagtgtttg 780
tatgaccaaa tagttttgtc ttagggcata ttaggaaagt tgtacatgaa caacaaatgg 840
aattagttca tttagctaat atacatggtg ctaaatctga attagtcatg aagagacaaa 900
tgatgttagt aaattcaata atatttagat tacatgctgt ggataaatta tctcattcta 960
gaggttctct aacatctgga gtggataatg tatgtattga aggagtagat aaggatagag 1020
ccttactcgt ggaaatagtc gaatgactag gaacaacagt aaaacatcct aagttatata 1080
agagtgatcc ggtaaaaaga gtttgaatac caaaaggaaa tgagaaactt agacctatag 1140
ggattcctac tcttaaagac agaggtttac aatatttaat taatttagta gttgaaccct 1200
tagttgaaat gactagtgat cctcataact atgggtttag accttatcgt tctacgaaaa 1260
atgccattgc ttatttgaga tctcatttac atactattga tagttctaaa aagggaaatc 1320
attttacaac tgcatcaaac gttgagaata atttattaag attattacca gaaaataaat 1380
gaattctgga tgctgatatc aaaggtttct ttgataacat taatcatgat tgattactta 1440
ataacttaac ccttcatcct aaattattac tcattattaa agcttgatta aagagtggag 1500
taatagatgg taaaatattt caattaactg aaagtggtac tcctcaagga ggtgtcatat 1560
ctcctacttt agttaatttc actctgaacg gcttggagaa 1600
<210> 37
<211> 1000
<212> DNA
<213> Candida parapsilosis
<220>
<221> source
<222> 1..1000
<223> /organism="Candida parapsilosis "
/mol_type="unassigned DNA"
<400> 37
gcacacagcg caactacact actactactc ccattatgag cattaagtta aattcaggac 60
acgaaatgcc aattgttggc tttggatgtt ggaaagtcac caacgagact gctgccgacc 120
aaatctacaa tgcaattaaa gttggctaca gattattcga tggtgctcaa gattacggca 180
atgaaaaaga agttggtgaa ggaatcaatc gtgctattga tgaaggactt gtttcacgtg 240
atgaattatt tgttgtatcc aaattatgga acaactacca tgatcctaaa aatgttgaaa 300
ctgcattaaa caagaccttg tctgatttga atttggagta tcttgattta ttcttgattc 360
atttccccat tgcattcaaa tttgtcccca ttgaagagaa atatccacct ggattttact 420
gtggtgatgg tgataaattt cattatgaaa atgttccttt gttggatact tggagagctt 480
tggaatcctt ggtgcaaaag ggaaaaatca gatccattgg tatttccaat ttcaatggtg 540
ggttgattta cgatttagta cgcggtgcca agattaaacc tgctgttttg caaattgaac 600
accatccata cttacaacaa ccaagattga ttgaatttgt tcaatctcaa ggaattgcca 660
tcactggtta ttcttcattt ggacctcaat catttttgga attggaaagt aaaaaggcat 720
tggatacacc aactttgttt gatcatgaaa ctatcaagtc cattgcttcc aaacataaga 780
aatcactggc tcaagtgttg ttaagatggg ctactcaaag aggtattgcc gtgattccaa 840
aatcaaacaa tcctgatcgt ttggcgcaaa acttgaatgt tagtgatttc gagttgagta 900
aagaggattt ggaggcaatc aacaagttgg ataaagggtt gaggtttaat gacccttggg 960
attgggatca cattccaatc tttgtctaga ggaggagcct 1000
<210> 38
<211> 1020
<212> DNA
<213> Candida parapsilosis strain CDC317
<220>
<221> source
<222> 1..1020
<223> /organism="Candida parapsilosis strain CDC317" /mol_type="unassigned DNA"
<400> 38
tgcacaaggt gcagctattc cagaggaggc tgctaaaaga gacgacaatc ctgggtttgt 60
tgccttggac tttgatgtgc ttaggaaacc attgaacttg accgaggcgc ttctccgtga 120
aaagagagac tccatttcgt tgtcgttgat caatgaaggt ccatcatatg catctaaagt 180
ttcagtcggt tcaaacaaac agcagcaaac cgtcattatt gatactggtt cgagtgactt 240
ttgggtagtg gattcaaatg cccaatgtgg aaaaggtgtt gattgcaaga gctcagggac 300
ctttacccca tcatcgtctt cttcatacaa gaatttagga gctgctttca ctattcgata 360
tggggatgga tctacatcgc aaggtacatg gggtaaagat accgtcacaa tcaatggagt 420
ctcaatcact ggacaacaaa ttgcagatgt cactcaaaca tcagttgatc aaggtatatt 480
gggtattggc tacaccagca atgaagcagt ttacgacacg agtggtcgtc aaaccactcc 540
aaactacgac aacgttcccg tgactttgaa aaagcaagga aagatcagaa ccaatgctta 600
ctcattatat ttgaactctc cttcagctga gactggtaca atcatctttg gtggtgttga 660
taatgccaag tactctggca agttggttgc cgagcaagtt accctgtcac aagcgttgac 720
tatttcgctt gcttccgtca atttgaaagg ttcatcattt tcatttggag atggtgcttt 780
gttggactct ggaacgacac tcacttactt cccaagtgac tttgccgcac aacttgctga 840
taaagctggt gctcgtcttg ttcaagtggc tagagaccaa tacttgtact ttattgattg 900
taacaccgat acatctggca caacggtgtt taactttgga aatggggcaa agattaccgt 960
tccaaacaca gagtacgttt atcaaaatgg tgatggtact tgtctttggg gtatccaacc 1020
<210> 39
<211> 1073
<212> DNA
<213> Candida parapsilosis strain CDC317
<220>
<221> source
<222> 1..1073
<223> /organism="Candida parapsilosis strain CDC317" /mol_type="unassigned DNA"
<400> 39
cattttccat tttgcggagt agcgcgtttc acaaagggtg tccgacttgc atggtctgcg 60
catcggttta aaaaaaaaag ctcgtttttc ctaattaggt aaagttcttt tatctccagt 120
ggtaagattt ttcgaaagta cacattagtt tatgtgtaaa cgcatgaaat ctatttccta 180
atatgtcaat tctatggggt tgcagtttgg aatgttccat tgttaaagaa ccaagtgtgg 240
tccacaaaac aacatgaatt cctcaaatgt ttgttaatcc tcgcaatcac tctcgcataa 300
tggcttcgat ttatgagctg agttctccac catatgaaaa gcggatttat ttctgctttc 360
acttccgcaa tggtataagt ataagtataa aggtgcagcc ttctcaaagt cggttcacag 420
aatatccaag gcatctcccg tcacttccct ccctaaacca tgcatttttg gttcctatcc 480
atattcctca ttcaaggagt tttcgcagcc gtcattgccc cagttaaacc atcacaagat 540
aacttttata ccccacctga tggttatgag aatctgaaag tgggcacaat acttaaattt 600
agaaataccc catttccatt atctggaata attaatactg tcaatgttca gaactcttgg 660
cagctacttg tgagatctga ggatacattt ggtaacccca atgccatagt cacaaccgtt 720
attcaaccat tcaacgcaac ttctgacaag gtggtgtctt accaaacatg ggaagatgca 780
gcaaacttgg attgttcacc gtcatatgga attcaatatg gtgcagattt aaccacattg 840
atttccctgt ttgagatgta ttttatgtca gcattgttgg atcaaggtta ctatgttgtc 900
actcccgatt acgaaggtcc aaagagcaca tttaccgttg gattacaatc aggcaaagct 960
acattgaatt caataagagc tgcacttggt tcagggaact tgactggtat cgattccaac 1020
gctgaagtta tgatgtgggg ttattcaggt ggcactattg catcaggttg ggc 1073
<210> 40
<211> 1015
<212> DNA
<213> Candida parapsilosis strain CDC317
<220>
<221> source
<222> 1..1015
<223> /organism="Candida parapsilosis strain CDC317" /mol_type="unassigned DNA"
<400> 40
gctgaggatg aggctactgg tcacataact gaagtctttg tcggggcgcc ggctgctttg 60
acttggatca tcaataggtt taatggagtt gagcctgttc aaggttgtaa tcatacatca 120
agagcatcca attttgatta cccgggaata agtcaatcct atgtcgaata tttcacggct 180
gcgttaaacg ttgttcttgg tataaatatg gggccattga caaagagaga ggttaacagt 240
atacaagatt tgaacaactt agagtatgta aaagtgtaat tgcaaagtat agtgaaaaaa 300
acaatagttg catacgtgag atgagcattc gatgagtaac tttatcaata caattgaata 360
caccaagcga ctcagccccc atagtgctta taagcaattg agccatccct cgtgcagaaa 420
cgataatcat gcttttctgc atagcacttt atcgcaccta tgaccattca ccaagctatt 480
gggtagcgga ccattgcgca attaatggcc atgataagaa acacatctgt ctgcaaaaca 540
ggtttcttct aaatcaaact aataatacat tctgtacata atgatacaaa tttctaaacg 600
caatgtttta catcatctaa aaagcaaaac gttccaactt gagcaatccg cccaaagtaa 660
ccttatctct cttaacatct ggacccaaat caaagcccaa aattgcgtgc aatgcagctt 720
caaagtaatt cttgattgat tgtggagttc ctggatattc caagtttgaa gctctcacat 780
tatgttgaca tccatcaact ggaggctgtc cattgaaacg attgataatc caagtcaaag 840
cagctggtgc acccacaatt gattcagtaa tgtgtccatt ggtcaaatct tcattatatt 900
caccagattt gagtccccaa tcacaccatt gttggaatgt ctttcttgag ttgacaatgg 960
ggacaattgc atccaaggta ccgtggtaga tgaataatgg aatttgtggg gtcaa 1015
<210> 41
<211> 1490
<212> DNA
<213> Candida tropicalis MYA-3404
<220>
<221> source
<222> 1..1490
<223> /organism="Candida tropicalis MYA-3404"
/mol_type="unassigned DNA"
<400> 41
aatgcctcga gcactgctat gtctgctagt agttcaacca attctacaac ttcaaaaaaa 60
tcaaaaaata tcccactaga attgacagcg tttggtacaa ctccatcagg taaaccaaga 120
ttatttgttt gtcaagtttg taccagagca tttgccagat tggaacattt aagaaggcat 180
gaacgttctc atactaaaga gaagccattt agctgcggag tttgtcaacg taaatttagt 240
cgtcgagatt tattattaag acatgcacaa aaattacacg caggctgctc tgacgcaata 300
acaagattaa gaagaaaatc aatcaagcgt tcgcaaaatg gcgaggatga cgatgatgat 360
atgcaagatg aagaagagga attacaacaa gagtcaactt caggaaagtc taaaaaactg 420
aaactggacc ctcctccaga gtttaatttg aatttatttg atggaaaacc aaacactacc 480
aaatcaaaag tatcaaaggg ttcaaacaaa aagagttctt caatctctac atccaaccca 540
actagaaaga attcattaca gaagcaagta tttgatcatc gtaaaaaggc tgctgattcc 600
caaattgtag gtaatactgg taccgtggga ctttctataa ctccaacaag acaaagaaga 660
ggtgcttcat tttctgcaca atcgggtgca aattatgcaa ttaatgttcc agaattcaat 720
gatgtatatc cgcaacctga taatgttgaa ttttcaactc cccaattcct tccttcttct 780
tttgaaaatg aaatgacatg gttaaactct cttcctggta ttccaggaat gtctgattct 840
actgttgctt caaaattact tcgtcaatca tcaatatcaa caaataatga tcatggtacc 900
ccaccaatga atgttagtca gcatggctca ttctctcatc cttctacatt aacagctaca 960
catatgggac aaagtggatc tgacagtctc aacagtctca acactccatt tgatggttca 1020
tatttgatgc cgacagctac gatcagcaat caagaaatac aaaacggtgt cgctgctcac 1080
caacacaagc atcatttgac aaatggatta agttcaacac gacaaccaga agttattcaa 1140
gaagaaactt atggatattc attttatgat attcctgaaa gtatgctcag tttccctggt 1200
gatcaatctg ttggacattc atccacttca ggaactggag caaattcacg tcctcatcat 1260
atgtttaaag cattgactcc tattaaacaa gaagttgatg acgatatcat ggaagatatt 1320
accaagaaca ccgacaataa taaccataat gagaatatga attttgattt gaattttctc 1380
aatgatattg atgatattgg acaagatacc atttctagat ttatgcccgg tgggtactca 1440
ttttatggag gtgataatac ttctattcct tcgtcggcaa atgattacaa 1490
<210> 42
<211> 1140
<212> DNA
<213> Candida tropicalis MYA-3404
<220>
<221> source
<222> 1..1140
<223> /organism="Candida tropicalis MYA-3404"
/mol_type="unassigned DNA"
<400> 42
cagcaaatac cagacgcaga tcaaccactc atttccatgc acaacaccaa cctagtttac 60
ctttgacaaa taagaatttg caatcgttgt tgagaaaatc ctcgtcaaat gacgaccctg 120
tttcccctac agccgtaact ttagatatgg accaatttgc caacgaacaa cgacaacttg 180
ctgccacaac cccctggcgc gacgatgccg acaatgaaag atactcgatt tccgaatttg 240
gcgagtccaa cccttcatca gaacactcca gcgattcaac ctcactagac gatgtgtgtt 300
tccctgattt tagagaagat ataaaaacca ccaacaactg gcccgatttg caagtattgg 360
aagagtacat caaagaggaa atggaagagt tccatgaaga acaggaagca gtggtgaatt 420
ttggtaaaga catcattcat gacgaagatc aaccagctac cgaaaacacc ccgttaatga 480
acaactacaa agtgaatgaa gtagaatcat tggatctggt caaccagtca ttcaagatcc 540
gtcccactcc aattcaacct tgggaacact ctagacagag tatccatcct gtatctaaac 600
atgacggcaa agaagtatgc agatttacat atttccgtga ggagttgcca aaaactattc 660
atgcacctac aatactgggg ttggtggaag ataaatccaa gatccttgaa agtctccaag 720
aactattccc tgtctctgtt tcaaaaccac catcagtgca taccaaaata gattccattt 780
catcttccaa tttacctcat ttgacaaaat cacgtcccga aacgccgctt cctgctgatg 840
gtgttgatag aagagaaccc ttttggcttg acgtgcttga cccgacagaa gaagaaatga 900
aggttctttc caagacattt ggtatccatc cgttaaccac cgaggatatt ttcctcggcg 960
aggctagaga aaaagtcgaa ctattcaaat catactattt tgtttgtttt acttcgtttg 1020
atgttgtcta tgagaagaga agacaacgtg ctaaagaaca agaaaagaaa ctcaacaagt 1080
tgcaagaaat gtacgaaagt ggatctgacc atggaagtgt gcttgaatcc cactcaccat 1140
<210> 43
<211> 1142
<212> DNA
<213> Candida tropicalis MYA-3404
<220>
<221> source
<222> 1..1142
<223> /organism="Candida tropicalis MYA-3404"
/mol_type="unassigned DNA"
<400> 43
tgggacaagg tgacaacaaa actccattgg ttggttcgtc cttaaaatca gttgagaatg 60
acaccgagcc attatcgtta tcaaagacac acaaaccaca atcagttccc gtgcaccgcg 120
aatggattag tgattatcgt gttccccata gtgtattgaa atacaatcta tcaagagaag 180
ggcccggcaa tagaatcatc aataccgata tagatttcca gtatctgttc acccctgaaa 240
tggatttaaa cgctattgat caacaaggtt tgggcacggc tgggtcgcac ccctcacaat 300
ttgataacac acaagaaacc accaatgagg ataatgatca caagattgat gaacacattg 360
gggcattttc aggttacttt gctgtaccaa cattgactgt taatttgccc aatagatgca 420
gagatgatgg tgaagaacca gaatttatga gagatgttcc caaaatttgt tatcagaacc 480
actttgaact ggacgattcc acatttatgt ttggaggtgt ttatgcttca gcatccatga 540
attttactca tttgggaatt cctgcagaag tggatgttag caaaatcaaa gtctactttc 600
cttatcaatt gccaccattt gtggatacaa agattctaac aaatccttat atgatacctc 660
atccccattt cttgcagtac aatgcaacga gagggtctgt cacatattta gatacttcag 720
aaatggagga tttccctgga cgattttccg gtatggcatc cacaagaatc tcgccacagc 780
atttcttctt ctatggtgga tttgaactca aagacaagtc agttaaacac attgaaaaag 840
atgatttgtg gatagtagag aaagatatta tcatgaatga agatggattt atcatcgata 900
cttctacttt aagatttagg aaaattgagt tgaataccaa taacttggca ataaaaattg 960
gtagaattgg gatgggaatt tgttcgaatg tgtacgaatc aaaagaacca aatgataata 1020
ggccagagat aataaatgaa tattccttgt caaatgtcat gttagagtcg aaaaataatt 1080
ccactaaacc aaagtaccca gttgatatgg ctgatagtat tcgtgttgac gcagctactc 1140
ca
1142
<210> 44
<211> 1008
<212> DNA
<213> Candida tropicalis MYA-3404
<220>
<221> source
<222> 1..1008
<223> /organism="Candida tropicalis MYA-3404"
/mol_type="unassigned DNA"
<400> 44
tttgggttgt ggcacttgta aaaaaagaag aatcaaatgt gacgaaacct tgccggcatg 60
tttgaattgt ctaaaaggga aattgcattg tgcttatttg aatttagata ataatgccag 120
aaatgccctt agaattgctc agtataacca aaatattcga caggaaaaat tggattccaa 180
tggtaagttt attgatgaac tgagaagtac tacaagtggg aatggtgcag gtgttaataa 240
tataattcct caaccaggta tgatgagtgc acaacatgga caacctatag caatggctcc 300
aggaagtgct gcattaccgg cttatccatt gagtgctgca cctggtgcta gcgtattggc 360
ccccaatatg tctatgagtg ctgctgcagc cgctgcaagt tcagctaatt tatcaccatt 420
tattaattca gttattgctc caggaattca accaccgcaa aacaacactt cgtcatctcc 480
gcaaacaaat tctacgaatt caacagctgg cactgttcgt actccgcccc aacaacaaca 540
aactcagcca cctccaacac aaggccaaca acctccacag cagcaacagc aacaacaaca 600
acctgctaca atgacccata taccgccagg acatatacct tcaccacaga ttgttcaatc 660
tccatatggt ccattggttc ctgtattaac acaaactggt tcagttgttt atgcaccaac 720
aagtaccctt tcagcccaac ctacaccaat gattacaact gctttagctc cacagccaat 780
aacaattcaa caacaacaac aacaaggtca tccaggacaa ccagcaattc aaactttacc 840
acctccaatt cctcaacaag gtaatgcaca aagtacaatt ctcactccac agcctcaagt 900
accgtcttca caaccattga gtaatccatc aagtgttcct catttgtcac ctattttgtc 960
tcaacaacct tcagtagttc caattacatc aaatgctgga agtgttgc 1008
<210> 45
<211> 1065
<212> DNA
<213> Candida tropicalis MYA-3404
<220>
<221> source
<222> 1..1065
<223> /organism="Candida tropicalis MYA-3404"
/mol_type="unassigned DNA"
<400> 45
tcaaagctag tgccgcataa taaactaggg acattgtcat gtatatcatt aattgttaat 60
aaaataattg gtactggtat cttcctgaat ccttcgccta tttttcaata tttaaatggt 120
aatgttggac tttttttatt attttttctt attggtggaa taattatatt tagtggatta 180
cttatatatt tagaatttgc attgaattta ccatttaaaa acggtggaga attaaattat 240
ttgataagag tcatcccaaa tcctcgagga ttaattggat gtgtatattc attttcaatt 300
gtattattgg gtttcagttc tggaaatagt tttgccttcg ggaaatatgt cttgtatgct 360
ataacaggat ctgaatctgt cgatgataat cttgtaaaac taattggagt cggatgtatc 420
agtttttgtt gtttcttgca catgaaatat ccaaagcaag gttctaattt gttcaatttt 480
cttggaatat tcaaaatatt aattcttgtg ttaatcataa ttattggggc tcttgcattt 540
tctggatttt tagaattact gcccacagac aatttcaaag atatctggtc cttccatgaa 600
ggaaataaac ctagtatcta ttccatatcc gttgctttat tggaagttat atattcattc 660
aagggttggg aaaatgtaaa ttatgtgttg aatgaagttg atgatccgta tcatatactt 720
accgtagctg caccattggc agttttatta acaacagttt tgtattttat ggtaatttta 780
gcatacttgg ttgtggttcc taaagatgaa atgttatcaa gcggagtgtt gatagcaggt 840
atatttttta acaaggtatt tggagcaagc ataacagcaa gaatgttacc aattttgatt 900
tctttttcta acttgggaaa tgtgttggta gtatcatatg ctcatagtgt ggtgaatcaa 960
gaactcgcct ataataacta tatcccattt agtagtattt ttcaaaattt caactactcg 1020
ttaatgttgc attggtttgt cactgttgtg gtattggttg ctcca 1065
<210> 46
<211> 1547
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1547
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 46
atttgtcaaa gcggctgact cgctatactt tcggcacttg ttattaagtc agggagtgaa 60
acatgcatta tttaaaacgc ggcgtagcgc tggcgttatt cgccgcctta tcgctgggca 120
gcctgtcagc gcaggcctat gagcaggaca aaacctataa aatcaccatc ctgcacacta 180
acgaccacca cggtcatttc tggcgcaacg actatggcga atatggcctt gcggcacaga 240
agacgctggt ggacggtatc cgcaaagagg tggcggccga aggcggtagc atcctgctgc 300
tgtccggcgg cgatatcaat accggggtgc cggaatctga tttacaggat gcagaacctg 360
attttcgcgg catgaacctg attggctacg atgccatggc ggttggcaac catgagtttg 420
ataacccgct cagcgtgctg cgccagcagg agaagtggtc gaagttccct ttcctgtcgg 480
ccaatatcta tcagaaaagc accggcgaac gcctgtttaa accctgggcg ctgtttaagc 540
gcggcgggct taaaattgcg gtgattggct taacgaccga cgatacggcg aaaatcggca 600
acccggaata tttcaccgat atcgaattcc gtaatccggc ggcagaagcc aagctggtga 660
ttcaggaact gcagcaaaat gaaaagccgg acgtgattct ggcgaccacc catatgggcc 720
actatgacaa cggtaatcac ggctctaacg cgcctggcga cgttgaaatg gcgcggagtt 780
tacctgcggg atcgctggcg atgatcgtcg gcggccattc gcaggatccg gtctgcatgg 840
cctcggaaaa taaaaagcag gtcgattata tccccggcac cccgtgcgcg ccggatcgcc 900
agaatggcat ctggatcgtg caggctcacg agtggggtaa atatgtcgga cgcgccgatt 960
ttgaattccg caacggggag atgaagctgg tgcactatca gctgatcccg gtcaacctga 1020
agaagaaagt cacctgggat aacggtcaga gcgagcgcgt attgtatacg ccgcaaattg 1080
ctgaaaaccc gcagatgctc tcgctgttaa cgccgttcca gaataaaggt aaggcgcagt 1140
tacaggtgaa aataggcagc gtcaacggcc atcttgaagg cgatcgcagc aaagttcgct 1200
tcgttcaaac caatatgggg cgtctgctgc tggcggcgca gatggcgcgc agcaatgctg 1260
atttcgcggt gatgagcggc ggcggtattc gcgactctat cgaagcgggt gatattacct 1320
ataaagacgt gatgaaagtg cagccgttcg gcaatgtgct gacttacgtc gatatgagcg 1380
gtaaagaggt gactgagtac ctgaccgccg tcgcgcagat gaagccggat tccggcgctt 1440
atccgcagtt cgccaacgtc agtttcgttg ccaaagatgg caagcttaac gatctgaaaa 1500
tcaaaggcga accggtggat ccggcgaaaa cttaccgtat ggcgacg 1547
<210> 47
<211> 1238
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1238
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 47
gcacgccttt agcatgccac ggcacgccgg tttttttcca caaaacgagg caaaatttga 60
tgcaagataa cacgtcttat tgaatatgat tgctatttgc atttaaaatc acggcatcat 120
ttttcaacag aaacgactat gagcgcaatg acccttgatt tacctcgccg ctttccgtgg 180
ccaacgctgc tgtccgtggc tatccacggt gccgttgtgg cggggttgct ttatacctcg 240
gtacatcagg ttattgaaaa gccttcgcct tcacagccaa tcgaaatcac gatggtggcg 300
ccggcggatt tagagcctcc gcaggcggcg cagccggtcg ttgaacccgt tgttgaaccg 360
gagccggaac cggagcctga agtggtgcct gagccgccaa aagaggtgcc agtggttatc 420
cacaaaccgg agccgaagcc caaacccaag ccgaaaccaa agcctaagcc ggagaaaaaa 480
gtcgagccga aacgcgaggt gaagcccgct gagccgcgcc cggtctcgcc gtttgagaat 540
aacaatacgg cgcctgcgcg tactgccccg agtaccacgg cggcaacggc aaaaccgatg 600
accaccgcgc cgagcgtccc taaagcgttg aaacgcggcg acccgtctta cccgcaacgt 660
gcgcaggcgc tgcgtattga aggtgacgtg cgcgtgaaat ttgatgtcac cgccgatggt 720
cgggtggaga atatccagat actctctgcg aagccggcca atatgtttga gcgtgatgtc 780
aaaaccgcga tgcgcaaatg gcgctacgag gcaggcaggc cgggaacggg tttgacgatg 840
aacatcaaat tccgcttaaa cggcgtaaaa atggattaag ctcgctgatg aaaaaggccc 900
ttttgagggc ctttttttac gcctattgca gggcttcatc gagcgctttt tgcgcggtga 960
ccaggtgctg gccgccgaac agaattgccc gattaagtaa agtgtatagc tggtaaatcg 1020
gttgccgttc aaggaaacca gcgggcagcg gcgagaccga ctgatagcca tcgtaaatct 1080
gcggcggttg ttccggatgc agaggcagca ttgccagatc gcattcgcga tcgccccaat 1140
aacatgccgg atcgaaaata tacggcccat tgggccctag cgcgcagttc ccggaccaca 1200
agtcgccatg taataaagaa ggctgcggct gatggctg 1238
<210> 48
<211> 1037
<212> DNA
<213> Enterobacter aerogenes strain CF379
<220>
<221> source
<222> 1..1037
<223> /organism="Enterobacter aerogenes strain CF379"
/mol_type="unassigned DNA"
<400> 48
agcagctgcg cgaactggtc aatcagacca tcaccccgtt aatgaaagaa cagacgatac 60
cgggcatggc ggtggcggtg atctatcgcg gcaaacccta ctatttcacc tggggccagg 120
ccgatgttgc cgggcagcgt ccggtgacgc gacagacgtt gtttgagctg ggctctgtta 180
gtaagacttt caccggcgtg ctgggcggcg atgcggtggc gcgcggtgaa attaagctca 240
gcgatccggc gcagaagtac tggccgcagc tcaccggcca gcagtggcag gggatctcgc 300
tgctgcatct cgccacctat accgcaggcg gtctgccgct gcaggttccg gacgaggtga 360
cggatgaagc ggcattactg cgttactatc agaactggca accgcagtgg gcgccgggta 420
gtaaacggct gtacgccaat gccagcattg gcctgttcgg cgcgctggcg gtgaaacctt 480
ccggcatgag ctttgaacag gcgatgagcc agcgggtttt gcagccgtta aaactgagcc 540
acacctggat taacgtaccg cccgcccaga gcaaggacta cgcctggggt tatcgtgacg 600
gtaaagcggt acatgtttcg ccggggcagc tggacgctga ggcttacggc gtgaagtcga 660
gcattgagga tatggcgcac tgggtgctgg cgaatatgaa cagcgaagcg gtgcaggata 720
aaaatctgcg gcaggggatc cagctggcgc agtcgcgcta ttggcgggct ggggagatgt 780
atcaggggct cggctgggag atgctgaact ggccggtgcc ggccgaggta gtaattaacg 840
gcagcgataa taaggtagcg cttgccgcga cgccggtaac ggcggtcaat ccgcccgcgc 900
cgtcggtgaa agcctcctgg gtacataaaa ccggctccac cggcggattc ggcagctacg 960
tggcttttat cccgcaacag gatctcggta tcgtgatgct ggcgaataaa agctacccca 1020
acccggagcg ggtgaag 1037
<210> 49
<211> 1086
<212> DNA
<213> Enterobacter aerogenes strain B
<220>
<221> source
<222> 1..1086
<223> /organism="Enterobacter aerogenes strain B"
/mol_type="unassigned DNA"
<400> 49
cagcactgca ggtagcgggc gcagcatatg cggctgaaat ttataacaaa gacggcaaca 60
aattagacct gtacggtaaa atcgacggtc tgcactactt ctcttccgac gacagcgtcg 120
acggcgacca gacctacatg cgtatcggcg tgaaaggcga aacccagatc aacgaccagc 180
tgaccggtta cggccagtgg gaatacaacg ttcaggcgaa caacactgaa agctccagcg 240
accaggcatg gactcgtctg gccttcgcgg gtctgaaatt cggcgacgcg ggttctttcg 300
actacggtcg taactacggc gttgtttacg acgtaacttc ctggaccgac gttctgccgg 360
aattcggtgg cgacacctac ggttccgaca acttcctgca gtcccgtgct aacggtgttg 420
ccacctaccg taactctgac ttcttcggtc tggttgacgg cctgaacttt gctctgcagt 480
accagggtaa aaacggcagc gtaagcggcg aagatcagac caacaacggt cgcggctacc 540
agaaacagaa cggcgaaggc ttcggcacct ccgtgactta tgatatctgg gacggcatca 600
gcgctggttt cgcgtactcc agctctaaac gtaccgatga gcagaacagc gttaacactc 660
gttatactga ctccaacggt gtttcccgtc gcgtactggg tgaaggcgat cacgctgaaa 720
cctacaccgg tggtctgaaa tacgacgcca acaacatcta cctggcgact cagtacaccc 780
agacctacaa cgcaacccgc accggtatca tcggttttgc taacaaagcg cagaacttcg 840
aagtagttgc tcagtaccag ttcgacttcg gtctgcgtcc gtccgtggct tacctgcagt 900
ctaaaggtaa agacatgggc cgttacggcg accaggacat cctgaaatat gttgacctgg 960
gtgcgactta ctacttcaac aaaaacgtgt ccacgtacgt tgattacaaa atcaacctgc 1020
tggacgacaa ctgtttcact aaagatgcaa gcatctctac tgacaacgtt gtggctctgg 1080
gcctgg
1086
<210> 50
<211> 851
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..851
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 50
cgcgccatgc cgggtattcg aaatggcatc tgcaacggct gtttttacag tacaaagggg 60
aaagtctcgg gcgctacatt cgcgagcgta aactgctgct ggcggcgcgc gacctgcgag 120
ataccgacca gcgggtttat gatatctgcc tgaaatacgg ctttgattcg cagcagacct 180
ttacccgtat ctttacccgt accttcaatc agccgccggg cgcgtatcgc aaagagaacc 240
acagccgcgc gcactgagcg ccggccgcat accagtccgc ctctatcggc gggctttttt 300
tgctctcttg cggcttaatc tgccagcgag aaccagcggc gccataccca gcgcaatacc 360
agatactcaa cgactcccag cgctaagaac cacaggcaga agatcagggt atagagctgg 420
ttgagatcca tcaggtggaa ggatgtgacc aatttttgcg ccagcgtcag gccgagcgag 480
ggcgccggca gcaacagaca cgaaatcagg gctaacagca aaatgccggc ggcggataac 540
agcgtttcca gcgggtgttt cattatgatg ttaatcgtca gttaaaaaac atattgtccg 600
gtaaaaaggc cgttaacgca atatgcttta tccgcttatt aatttacgtt attcatatta 660
tttctaatac tattaattaa accccctctg ttaatttatt gagtaatatt tgtgattaag 720
ttaattgcac cgcgatgtaa attaacgtca tttattatcc cagcattttt acaaaagtat 780
aggtactata tcccactatt gtggcgataa taattgccag tgcgacatac agcactagac 840
ggcgtccacg g 851
<210> 51
<211> 1199
<212> DNA
<213> Enterobacter aerogenes strain KNUC5012
<220>
<221> source
<222> 1..1199
<223> /organism="Enterobacter aerogenes strain KNUC5012
/mol_type="unassigned DNA"
<400> 51
gctctcgggt gacgagtggc ggacgggtga gtaatgtctg ggaaactgcc tgatggaggg 60
ggataactac tggaaacggt agctaatacc gcataacgtc gcaagaccaa agagggggac 120
cttcgggcct cttgccatca gatgtgccca gatgggatta gctagtaggt ggggtaacgg 180
ctcacctagg cgacgatccc tagctggtct gagaggatga ccagccacac tggaactgag 240
acacggtcca gactcctacg ggaggcagca gtggggaata ttgcacaatg ggcgcaagcc 300
tgatgcagcc atgccgcgtg tatgaagaag gccttcgggt tgtaaagtac tttcagcgag 360
gaggaaggca ttaaggttaa taaccttggt gattgacgtt actcgcagaa gaagcaccgg 420
ctaactccgt gccagcagcc gcggtaatac ggagggtgca agcgttaatc ggaattactg 480
ggcgtaaagc gcacgcaggc ggtctgtcaa gtcggatgtg aaatccccgg gctcaacctg 540
ggaactgcat tcgaaactgg caggctagag tcttgtagag gggggtagaa ttccaggtgt 600
agcggtgaaa tgcgtagaga tctggaggaa taccggtggc gaaggcggcc ccctggacaa 660
agactgacgc tcaggtgcga aagcgtgggg agcaaacagg attagatacc ctggtagtcc 720
acgccgtaaa cgatgtcgac ttggaggttg ttcccttgag gagtggcttc cggagctaac 780
gcgttaagtc gaccgcctgg ggagtacggc cgcaaggtta aaactcaaat gaattgacgg 840
gggcccgcac aagcggtgga gcatgtggtt taattcgatg caacgcgaag aaccttacct 900
actcttgaca tccagagaac ttagcagaga tgctttggtg ccttcgggaa ctctgagaca 960
ggtgctgcat ggctgtcgtc agctcgtgtt gtgaaatgtt gggttaagtc ccgcaacgag 1020
cgcaaccctt atcctttgtt gccagcggtt cggccgggaa ctcaaaggag actgccagtg 1080
ataaactgga ggaaggtggg gatgacgtca agtcatcatg gcccttacga gtagggctac 1140
acacgtgcta caatggcata tacaaagaga agcgacctcg cgagagcaag cggacctca 1199
<210> 52
<211> 1116
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1116
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 52
gtatacaaag ccacattccc tgggtataag gtaaaattct ttatacgctc agttacaata 60
tcaaagctat cctgtgaatt tttgtcattc attaactcaa ctttataatc tgaataaggt 120
ggcaaaggaa tgaaattatt actaccgcta agtcgatagt gtcggccgtt aacctgagcg 180
gcaagaactg catcatcaga aacttcggta ttaataatca caccagattt ttcctggata 240
ccgctagctg caatattcct actgctataa gcgactgaac cacgcgctgt tacattacca 300
ttcagccttt cactatctgg cctggataat gatagcgtcc cactactgta tttagtatcg 360
aacgcagtat aaccggatat cgaataatcg ctctcaccat ttttcttatc cttaagtaac 420
ttagagagat tcaaccctgc tgagctaaag gccgaatctt caaaattttt ggtcgccgtt 480
aaattagctt taatattacc attatttgat gacattcctg tactcaacca cgtcgccaga 540
ggaagcgaaa aatcaagtga aatataacgt tgatttgagc tatttgattg ataatcatac 600
tgataacgtt gtatacctgc acgaagatta acattccccc aacgtccaga gaaaagtgac 660
gttgtatact cgaaattatt tgaattacta cgaacacgtt tatcaaccgt atggcttaca 720
gtaacctgtc cagcatgatc tataatttga ttaaaattaa gcgtgccacc aaaagaatag 780
ttatttgttt cataaattgg cagtttatca ttaatgtggc ttttttcacg attaacccaa 840
accgatccaa atccttctgg cagctgcatt gttgcgttaa taatattcct gtgcacgcct 900
ccctgggata tcaaaccctg ccaaccaatg ctaccatact ttagaatcgt tagattcaaa 960
gatgattcat taatatagtt actgtcgaaa ctataagtgg atgtttgcag agttagtcct 1020
gataaaacag gataactaac ggatgttgaa aaccctgcaa gccaagtctg atatgaatca 1080
gggctgtgat ttgtttcctc actttcagcc gtatat 1116
<210> 53
<211> 1185
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1185
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 53
aatattttca gtgaatccgc agatattctc ccgaattgag ccagaaaaca gccggtcatc 60
ctgcattacg caggcaatca agcgatgata gttatttatc cccagttgcc tgatatccgt 120
accattcatt aagacagtcc ctgatatcgg ttcagacaag ccgcacagta ctttgagcag 180
cgtggttttc cccgaacctg agggcccggt aatggccaca ctctcgccgg ctcggatcct 240
gaaactaagg ccgctaaaga cgggtgctga ctggctgtcg taacggaagc ttagcgcttt 300
aatctccaga ctagccggag acatggttgc ctttaatcct aaatccggtt ttctttcttc 360
cttttcattc aaagcgatat ccgaaatcct ttcgttgtgc aggctcatca tacgcagctg 420
taataagaag ttgaccagcg atcctacccg gtcagaaaac tgcgcgcgga atgcgccaaa 480
tgccacaaac atgccgatag tcatttggtt ctccataacc agactgatgc ccagccacag 540
aatagtcacc tgatcgcacg tcgccacaaa cgtgttaatg ccgccgaaga acatatcaag 600
tcggctgagt ctgataccgg tattgatggc atcaatcttc aggttcagcc agtggctccc 660
acgccgttct gccattccct gcattttaac cgtagctatt ccgtagagtg tttccataaa 720
atatgaacca gcacgggctc cggcgattaa cgcttcttcc gacagctggc ggtaccggct 780
ataggtcaat atacgaatga agacatatac cgctgtaaag cccagtacaa aaaccgtcaa 840
ttttccaccg tacaggataa gcatcaacaa gagaccggca accatgatgc tgtccatcat 900
tgcccccacc acacaggttg taaacgtggc gcgaagcgca tccaacgagc tgaagcggga 960
gtgaatatcg cccatctttc gtcgctcaaa ataggtcaac ggcaactgaa gcagatgacg 1020
gaatagcccc gactgccatt gcacatttat caatgactcc atcgcaaggg atgaccatgc 1080
gcggatcacg ctaaccaaag tacgccccaa aataaaaaac atcaggactc cacagataag 1140
catgagcagt ccccggtcat tcgcaggaat agcatgatcc atcac 1185
<210> 54
<211> 1099
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1099
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 54
ctcaagatcc agaacgtagg cctgcggaat ttctaaatca agctgaaaaa tattgatatt 60
aaacgtataa ctgccgctcc gcaccgcgga tttaagcgtc atgcactggt tatcttttgc 120
caacggcgcg ctatccgctt tgattcccaa ctgatgtaat aatgccgatg acaggcaggt 180
atcatccgga ttactggcga ctacgattgg atatttacca cgccattgtt tattgacgta 240
aatatccaat tcatattccc caggcagtgg ttgattatcc gcaaagcgaa agcttgatga 300
tttttcacct ttcattccgc cgatcatgaa attggtatca aaagtctctt cagcggcctg 360
cagctgaccg gataataaaa ccaacagtat cattgaggaa agcggcgtca tccttaacat 420
ggccaactcc attatttatt attttacatt gagcctgtcg ctaataaagt ttccattatc 480
atcaatcatc gttagcgaat actggcgggc gagattattt tttaaaaaga catcctgact 540
tgataacggc gcaagcataa cgctgcgctc attgacttta acgttactga gtttaatttc 600
agtaatcgtc aaccaatttg ccgaaccatt ggcaatatgc agagcgtttt tgcgcgaaga 660
caacgaaata cttttaaatg tatctttatt taccgctgcg atacctttag ggcgataaaa 720
aagcttaatg cggttttgca tggcaaaccg cagcgtattc gccccctcac ttcctggtgt 780
attcggagga atatcgagta cgttgagata aaacagcgac tctttgttcg ccggaagttt 840
gttggctaac tttttaattc gcagctgctg accggagtta cccgttatgc gcgccaccgg 900
cggcgacagc aggaaaggca cgttgatttt ttccggcggc aatgaagtat tgccatcgtc 960
aatccacgac tgcaccagtg aagagcgggt gccatgattc atcaactgta cgaccacttc 1020
ttgtttctca gccggataaa ccacccgggt accgaaaatc accactccgg catgcgcggg 1080
ctgcatagcg ataaataaa 1099
<210> 55
<211> 1209
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1209
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 55
attatgggta aaacaggtgc aggtaaaagc agcctttgca acgcactatt ccaggagcaa 60
acttgtctga ctagcgagct tatggcgtgt acccgagaac cacaacgctt ggtcctcact 120
gtgggcgaac gcagcataac cctggtcgat cttcctggcg ttggtgagac tcctgagttc 180
gatgctgagt atatggcgct ctatcatcgt ttgtttgttg aactggacct agttatttgg 240
gtattacggg ctgatgatcg cgcccgggca atagatatta caacacaccg attgctactt 300
tctaatggcg cagatccatc acgtttctta tttgtgataa ctcaggctga atgtattcct 360
ccgttaccaa ctaactctga atgccaggat cggccttctc caacacagtg cctttcgttg 420
gccaccatca gcgcccaaat tgcgggtcag tttccatctt cttatccggt aatagcagtt 480
tctgctcata ctggctacaa cttgacggtc cttgtagagc ttatggtgca tgcattaccg 540
atacaggcta gcagcgcctt ttatcggcaa ttgaaaccag agcacctgac taaagagagc 600
aacgatgctg tacgccagcg gtttggtgag atggcaggaa atgcatttga tacggtgata 660
aacccggact ctttcccgtc aggctggacc agctttttga gaaaactgcg ccaaaaatta 720
gtgcagcttg ccaccgtgtt atgggacaga ttttttggct aacaccacat ccgtcaggtt 780
gtgtcgctat gatgaatgtt tatcagacaa aacctttctt aacaaggcgt tatcgtgccg 840
cactattttt cagatttcat tattttacct atctttgccg acataacgtg tccggcctgt 900
gctgcataat aactgcatga aatagaacca tatttgttgc cctgagaggc catatgtccg 960
tcaacgagca agactcacgt tacgaccgac tggcgatcag attatcggtc attattagcc 1020
gcctgcttgc gggagaaaca ctctcactca aatctctggt ggatgaattt ggtgtctctg 1080
aacgcactct acaacgtgac ttcaatcaga ggctaatcca tctggatatt ctggatgaaa 1140
atggacgata ccgtttgaat gattgccaac cacccgatca ttcatcgggc gcattctcgt 1200
ttatacgta
1209
<210> 56
<211> 1192
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1192
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 56
tcgacgcata gatactctcc tcgggatttt tctttttatc tttctgttct aaaatgtcac 60
tttctggcag ctaacatttc taaaaaaatc ttgttaaaag cttaattata gttttgataa 120
atgtaaaaca atttctttaa atagttttat ttaaaaaata catgcatgtt tctttagtga 180
ttttataccc atttcagtat ggatgaagca ttctgatgat ggaaacgtat cacctgtttt 240
atgggagtga agtggaagcc tggtatcgaa aatccctgac atcggttgag tagaagcacc 300
agggagtact gcctgggtaa ttttttacat ccgtcgacat gatatgagtt gcataaccgt 360
ttacctcccg gtggaaatgt agcacgttaa atcacctggt tattctggga tttggctcga 420
cttctgattg agattagctt tatggtttgc gctagtgagc agtctggcta acttgcgatt 480
atctgttctt catttatgct gaagttaagt gcaattgcag aacagataat tactataggt 540
agtattaaat tttatgcctg atgtgagttg ctaacttgag agtaatttaa tccttctttt 600
ttgtcaaaaa accgctacta tgatgtctgt taaaatactg ctgataacct gattagggtc 660
ggtaatagta atatatattg gtttgtgtta tatattgatg tctattagta tcacatttaa 720
tcaatgagta tcattggtaa gaacactgta cctaactatg aaatgatgta catcactacc 780
agttattaat agtgaggaca cttaatgttc atttgagatt gttattaggt attccagtta 840
ttgtttgtct tttagtgtgc attaatgcaa ggtttaacgt taaatggcaa cgcaacatgt 900
ttgagcaata gcgtaaccag aatctacccc gcgtattaac gcattgcttc atccagttct 960
gactcctgat gttaattatc ctgcaatctg atcagtaaca ccatttcgct gcaataaaat 1020
ccatctgcaa ctgattggca agtcagtcat agctcaattg agtatttatt atcaatgccc 1080
gtaagagatt actttatgtt tgattcagaa ttacttgatc atcgccatgg ttcattaaac 1140
gccaattatc ttaagaaaat agaaaatgtt ctccagtacg ctctcaatga ac 1192
<210> 57
<211> 1004
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1004
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 57
tttggtaaat ctttcgtcgt gcagtcgggt gaagaatttt cactatacac agagcagagc 60
agccgcattg tgttgcttga gtccggtatc ttctcaattt gccgcagtga tcgaggcttg 120
aacgtgctat cggttttcgc cccgtcaatt gctggactga tagatagcta cggtgtgaca 180
tacgatgttc ccacccgccc ggagcatttt ttgattgctg aaacagaatg ccgtggtcgt 240
gcagtctcgt tagcggactt tattaaggtg acggatgagt gcaatctttg gcacgacgta 300
gctcgttttc tcgcttatcg tctgatggtg atgaacgttc gtgaccggga gctggttggc 360
gttgactctt atcttaaggt tcgtgcgtta ttaatcgaaa ttgccgccta caacgacgaa 420
tatcgccaga gcattaatgt tctgaacttt attcaacgtc gtaccggaat atcgcggagt 480
cgtaccatga agcttctttc tgaattgcga aagggcggat atatcaatat tgatggtgga 540
cgtctgttag ggattaaaaa actgccactg gcttactagt tgctgtatct aaataacagc 600
tataacgatt tatttactgt aaaaacagtc agttaatggt ggtcctataa aaacagtttt 660
tgtcgattgc aactctctgg ccaatttata ataattaaat aacggcagaa attaattatc 720
tatcggcgct tataaataag cgctggtttg ctattcattg aatatagtat ttctgtacgc 780
tacaaacttt aacgtttttg cgcccggtac cagcaagaga tctctgtgaa gagggctcgg 840
tactaaaatt cgttattaat tctattttcg acttgtgtat ttaaaaggtt atttatgaaa 900
aaacatcttt tagtgatggt catgactgcc atgacggcgg gcggtatgag ctgcgcggcg 960
aatgcggata ccgcgacggt ctccggtggt acggtgaatt ttac 1004
<210> 58
<211> 1024
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1024
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 58
aggcgttata cctttttagg tagacttttg caaaaagagt ttgatgtaaa ccttgtcaat 60
acgatgatac ttcctgggat aaatagcaaa cctttgtggc ttagattggt tattttcttc 120
acccttcagg ttttctggat tgtgactgtt agtctgttgt tgaaactttt agggtgggaa 180
atatattttt atgcatattt tattttatgt atgatacctg cgataggata cttttacttg 240
catgtctatt ggaagtggca tgaagattac atgactgcct gtgatatgta tctcagatgt 300
ggtgaaaata ataaaaatta gaaattgaaa ggaaaataag gccagtcaga atgctgactg 360
gccttattct atttagcttt gcagggcatc aacaacgccg ccccaatcag tcgcagcatt 420
ataaacaaaa ttagaccaaa ccccagattc ggcatacagc agggagttga tatggtcggt 480
cagaatgctt cccaggctgg atggcgaacc accaagaata ttggaaacca ggtcaatcgt 540
ggtttccaga gcggaggagg ccagaatcat accagcatta atacccgcag caaccagacc 600
cagtgcagat tgaatcgtga aatcaaccaa agcacaaggc aggtcgataa tacctgcacc 660
agagatatat tccatttcgt ttgcggttaa ttctttcatt ttaaattcca tcctagatta 720
atgaattgtt aatgatgtac ctttgcacac cgggcaatat actaatcaga gggtttttta 780
tataatagtg aatatttaaa tgatctatta attttaatgt gaattaaact tcacaaacga 840
cgcttagata agcgatgggt attatttcgc aacttcatat ttgaaaacag aagatactcg 900
agagtatctt ctgtatgagc aattgttcga cttattgttt agaggtcaga aattcaggtc 960
tattatgaag ttgcaatgat ggtctgttca acctcggagc ggttggtcac tttgctgtca 1020
attt
1024
<210> 59
<211> 1081
<212> DNA
<213> Enterobacter aerogenes KCTC 2190
<220>
<221> source
<222> 1..1081
<223> /organism="Enterobacter aerogenes KCTC 2190"
/mol_type="unassigned DNA"
<400> 59
gtcaattaca ggagagcagg ccaaattcac tcttctttag cagaatattg ttacgaacta 60
agataattag aatttgaact attttaagat tattctaatt gccatcttga ttttatttat 120
tttttcatca aaattcacag tttcaccttc tgttccccat caaaaacgac cgtaaaggga 180
ttactgtgaa cacgatatac ataccattag acagtggaga gtctgcggtc ctcaaggatc 240
cagatacctt acttcctcgt aaaatttacg aacagcttgc ccagttcatt gaaaaggctg 300
ttaaggatgt tgatgaagta ccgaaaaatt cagaatcgtt taacgaaacg cgcagtcata 360
aggcaatatc gattgacggt gaaagaggta cgggtaaaac atcggtacta gtgaatttaa 420
gagattacct ggaaagtaat cataaagagt ttgctggaga tattcatatt ctcgatccca 480
tcgacccgac tctgcttgaa gatggtgaat cgctgttttt acatatcatt gttgctgcag 540
tacttcagga taaaaaaatt aaagaggcgc aaagtaaaga ccttgataaa tcgagactct 600
ttatccaaaa acttgaaaat ttagccaatg gccttgaatc cattgacctg caacacagtc 660
agcgagggat ggataaaatc cgttccctct atggcagcaa gcatctggca aattgcgttg 720
aagcattttt aaaatccacg ctagatttaa ttgggagaaa attattaata ctgccgattg 780
atgatgtgga cacttcgctt aaccgggcgt ttgaaaatct ggaaatattg cgtcgttatc 840
ttacatctcc ttacgtattg ccgattgtga gtggcgatcg tcgcctgtat gacgaagtat 900
gctggcgaga ttttcatgga cggttgaata aagactcatc ttatgaacgt aagaagtctt 960
atgatatagc caaggaattg gcaattgagt accaacgtaa aatattacca ctgccgcgta 1020
gattaagtat gcccgccgtg agtgattatt ggcagcaaga cggtatggat gttaccttgg 1080
a
1081
<210> 60
<211> 1332
<212> DNA
<213> Enterobacter cloacae strain 344
<220>
<221> source
<222> 1..1332
<223> /organism="Enterobacter cloacae strain 344"
/mol_type="unassigned DNA"
<400> 60
tgcttcgctg acgagtggcg gacgggtgag taatgtctgg gaaactgcct gatggagggg 60
gataactact ggaaacggta gctaataccg cataacgtcg caagaccaaa gagggggacc 120
ttcgggcctc ttgccatcgg atgtgcccag atgggattag ctagtaggtg gggtaacggc 180
tcacctaggc gacgatccct agctggtctg agaggatgac cagccacact ggaactgaga 240
cacggtccag actcctacgg gaggcagcag tggggaatat tgcacaatgg gcgcaagcct 300
gatgcagcca tgccgcgtgt atgaagaagg ccttcgggtt gtaaagtact ttcagcgggg 360
aggaaggcga taaggttaat aaccttgtcg attgacgtta cccgcagaag aagcaccggc 420
taactccgtg ccagcagccg cggtaatacg gagggtgcaa gcgttaatcg gaattactgg 480
gcgtaaagcg cacgcaggcg gtctgtcaag tcggatgtga aatccccggg ctcaacctgg 540
gaactgcatt cgaaactggc aggctagagt cttgtagagg ggggtagaat tccaggtgta 600
gcggtgaaat gcgtagagat ctggaggaat accggtggcg aaggcggccc cctggacaaa 660
gactgacgct caggtgcgaa agcgtgggga gcaaacagga ttagataccc tggtagtcca 720
cgccgtaaac gatgtcgact tggaggttgt gcccttgagg cgtggcttcc ggagctaacg 780
cgttaagtcg accgcctggg gagtaccgcc gcaaggttaa aactcaaatg aattgacggg 840
ggcccgcaca agcggtggag catgtggttt aattcgatgc aacgcgaaga accttaccta 900
ctcttgacat ccagagaact ttccagagat ggattggtgc cttcgggaac tctgagacag 960
gtgctgcatg gctgtcgtca gctcgtgttg tgaaatgttg ggttaagtcc cgcaacgagc 1020
gcaaccctta tcctttgttg ccagcggtcc ggccgggaac tcaaaggaga ctgccagtga 1080
taaactggag gaaggtgggg atgacgtcaa gtcatcatgg cccttacgag tagggctaca 1140
cacgtgctac aatggcgcat acaaagagaa gcgacctcgc gagagcaagc ggacctcata 1200
aagtgcgtcg tagtccggat tggagtctgc aactcgactc catgaagtcg gaatcgctag 1260
taatcgtgga tcagaatgcc acggtgaata cgttcccggg ccttgtacac accgcccgtc 1320
acaccatggg ag 1332
<210> 61
<211> 1454
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..1454
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 61
cgcgacggga cgtatcggtg atggtgcgcc tgcgctgtgg ttcgataaca ttcgcgggtt 60
taccgatgcc agggtggtga tgaacaccat cggctcctgg cagaaccacg ccatttcgat 120
ggggctgccg gcgaataccc cggtcaaaaa gcagatcgat gagtttattc gccgctggga 180
taaattcccg gtcgcaccgg agcgccgggc caaccccgca tgggcgcaga atacggtgga 240
cggtgaggag attaacctgt tcgacatcct gccgctgttt cgcctgaacg acggggacgg 300
cggtttttat ctcgacaaag cgtgcgttgt ctcgcgcgat ccgctcgacc cggaccattt 360
cggcaagcag aacgtcggta tttaccgcat ggaagtgaag ggcaaacgta agctcggcct 420
gcagccggtg ccgatgcatg atatcgccct gcatctgcat aaagccgaag agcgtggtga 480
agacctgccg attgcgatta cgttgggcaa cgatccgatc atcaccctga tgggcgcaac 540
gccgctgaaa tacgatcagt ccgagtatga aatggccggg gcgctgcgtg aaagcccgta 600
cccgattgcg accgcgccgt tgaccggctt cgatgtgccg tgggggtctg aagtgatcct 660
ggaaggggtg attgaaggcc gtaaacgtga aattgaaggg ccgttcggtg agtttaccgg 720
gcactattcg ggcggacgca atatgacggt ggtccgtatt gataaagtct cgtaccgcac 780
caaaccgatt ttcgaatccc tctatctcgg gatgccctgg accgagatcg actacctgat 840
ggggccagcc acctgtgtgc cgctttacca gcaactgaaa gcggagttcc ctgaagtgca 900
ggcggtgaac gcgatgtata cccacggtct gctggcgatc atctccacca aaaaacgcta 960
cggtggtttt gcccgcgcgg tcggtttacg cgccatgacc acgccgcatg gcctgggcta 1020
tgtgaagatg gtgattatgg tggatgaaga tgtcgatccg ttcaacctgc cgcaggtgat 1080
gtgggcgctg tcatcaaaag tgaacccggc aggggatctg gtgcagctgc cgaacatgtc 1140
ggttcttgag cttgatcctg ggtccagccc ggcaggcatc accgacaagc tgattattga 1200
tgccaccacg cctgttgcgc cggataaccg cggtcactac agccagccgg tgcaggattt 1260
acctgaaacc aaagcctggg ctgaaaagct gactgcgatg ctggcagcac gccaataagg 1320
aggaaaagat gatttgtcca cgttgtgccg atgagcaaat tgaggtgatg gccacatcac 1380
cggtgaaagg gatctggacg gtttatcagt gccagcattg cctgtatacc tggcgcgata 1440
ctgagccgct gcgt 1454
<210> 62
<211> 914
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..914
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 62
gcccctgatg aaggcgcagg ccatacccgg aatggccgtg gccgtcattt atcagggcca 60
gccacactat tttactttcg gtaaagcaga cgtcgcggcg aataagcccg tcacgccgca 120
aaccttattt gaactgggct ccgtcagtaa aaccttcact ggcgtgctgg gtggcgatgc 180
cattgcccgc aaagagattt cgctggccga cccggtcacg aaatattggc ctgaattgac 240
gggcaagcag tggcaaggca ttcgcctgct cgacctggca acctatacgg caggcggatt 300
gccgttgcag gtaccggatg atgttaccga taacgcctct ctgctgcgtt tctaccagtc 360
ctggcagcca aagtgggccc cgggtaccac gcgtctgtac gccaacacca gcatcggcct 420
gtttggctca ctggccgtta aaccgtccgg catgcgcttc gagcaggcca tggcggagcg 480
ggtctttaag cccctgaaac tcaaccatac gtggataaac gttccacacg ctgaagagcc 540
gcactacgca tggggttatc gtgagggaaa agcggtccac gtttcgcctg gtatgctgga 600
tgcagaagcc tatggtgtga aatctaacgt caaagatatg gcgagctggg tgatggccaa 660
tatggcacct gagacactcc cgcagtccac tctgcagcag ggtattgcgc tggcgcagtc 720
tcgctactgg cgcgtgggtg ccatgtatca agggttaggc tgggagatgc tcaactggcc 780
ggtcgatgcc aaaaccgtgg tggatggcag cgacaataag gtcgcactgg cgccgttgcc 840
ggtcgcagaa gtgaatcctc cggctccgcc agtaaaagcc tcctgggtgc ataaaacggg 900
ctctacgggt gggt 914
<210> 63
<211> 1190
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..1190
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 63
atcaacacaa attcctcacc gccaatacgc gcggcaatat cctgaggccg tacggaatcc 60
atcagcagat gcgccacaaa ctgcaacact ttgtcgccct gcagatggcc gtagcagtcg 120
ttgatgcgct tgaagcggtc gagatcgctg acgataaccg aaaccggacg gctggcttta 180
caggcaccga gtgcctggtt tagcgagtcg taaaaatagc tgcgattgta gaggcgggtc 240
aaaggatcgc gaatcgagtt ttgatacgac tgttgatatt tcaaatgcga gtcgcgatag 300
agtctaaaga catcataaag cagaacaaaa ataatcaata acgtcgcaca gtttcaaata 360
agcgcgctcg ataccaggaa atatcctccg cgtgtccgcc tgctaatagc atcgcgagcg 420
tcacgatata acagacacat aaaaaattac cgcccaccca aaaaatattg cgtacgcggg 480
taataaccat tagcgttgct aatgtcacca cccaaagaat aatcaagacg atatttattg 540
catggctcca gagaaccata aattgatggg tttcattatc caccaggtct aacgacatta 600
atgatgagtg gctggagcta agccaggcca acagcaccat gcccaccata aacagaaatg 660
taccggcaac aatggtgata tgcgccgcac gtgaaagcgg attatccctg acgatataca 720
gcagggccga cgcaatcatc agcaccgcca ttaacagatg gcggtacata aagaagatca 780
tcgtatcgtt atagtccacg acgttgagct ggtagagatc aagccaggcc gggaaactgg 840
taagcgtacc caccatcagt atggccgaac cggcaaaggc aaaagcgata gcaatcaggt 900
acaaccgtct tctgtcacac cagtatttca tggccataaa gcaggcaata aacagatgga 960
ataccagtaa aaaaatggtg agtgtaggga ataaaagcgg tgagaaagag ggaacccatt 1020
cgaccagttt taaaaataaa atttgtaata ttccaatgac gacaatgcac cctaaacaga 1080
atggaatata gggctttttc acgtaccggg agatcgcaag cataagtatg tttcaacgaa 1140
aataataaat aaaaagttaa ttgagattag cctaatgcaa aagagaggag 1190
<210> 64
<211> 1191
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..1191
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 64
atgtttttga taacttcggg cgaaaaattt catcaacatc tgaaattaat atgatgtcat 60
tatcttttgc attttttaac ccgcgcatga ttgcattacg ggtagctgct tcatttttcc 120
aggcgtcgta ctcacccgca ataccatttt tcaattttgg gagatcgtta tatatcacat 180
aaattatttt atctttaaat ttttcaaatt tagaaatatc gaaatttaat tttttaggtt 240
tgccagtgaa tgtgtgtgtg gattctacaa taacgaagta atcaacaaca tcatttagag 300
tattaagacg aatatctagc aacatatctt catcgtaata taaaaaacaa tcataaatca 360
tcatatacat ccttaataat tacgcttact tggcgcattt cgtacgtttc aaccagcaat 420
tcgtaacgga atgctaaccg agcagcctcg ctgtatgcaa tagcagactg ccctgtagag 480
ttaaaattgg atccaactat cctggacttg tcatgctatg gcgatcattt tctctatctt 540
accggaggtg aatttttctg cgttatcaca tggcattact gcaaagccgg aacggatcac 600
atgtgccagg catgaatttg ggttcataac tacttcgcca gtcataagag ggtgcaggcc 660
acagggagat cttttttaat tggtgatgtt tgcgtaatgt agtcgatcat cagtctgctg 720
catctgagtt gatggcttca taacctcttt gccgaaggtg tctaatacgt acctacagaa 780
ttcttttgca ttcggcgttc cgacaaacat ggcgataaaa tgtgcactac agagggagaa 840
agatcgcact gtttattata gttcacagag acggtcaaat tgaccttctc agtgattcgg 900
gcagaaaact ctttgtggtt gtggttatag attctggcaa ttgagtcgtc tgatctattg 960
cagaggactt gggtaagctc tgaagatgtg agccagattt ggttgttatc ggtaaagaca 1020
ctgaactgaa cgctatttaa aattagttga gtattcatgt ggtgttcctt gactgaggag 1080
gtttgcacca ctgcgacgcc aatcattgag ttggtgagat gtacagggtt ggcaaaagca 1140
agacgcaggg ttaaaagcgg gcgttaatgg ccgttttaat ttcatcaagc a 1191
<210> 65
<211> 1183
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..1183
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 65
aattttgtca tctactgccc gcaggttctg acaactgaca atctgctcaa ccccatgaag 60
ctattgatgc gagagcacaa ttatgaaata gagcttcatg acatgctgct gtccgcggat 120
tccgcagaag acctgcttgc ctaccgtaaa gcagacttaa ttttctccat tgcgcctatc 180
aacaatcgct caatggtatg cgttccctat gttaattacc gaatgattct ggtgtgcagc 240
caggatcacc cccgtctgca ggagaccgct accctggaag agctgcagaa agagaagttt 300
acgatcttcc tgagcgatga agcgggtgtg aaacactatc agtcaaagac tgaggaagtg 360
catgccgaca ggacaatcgg ttttcgctgc gactctctct tttcaatcat ggccatgatc 420
agcgcatcgc atttagtggg atatatcccg gaagtcctgt atgaaaaata ccgtgacgta 480
ttgcgactga aaaaagttga cgcacccttt acgctgcctc aaatggaagt cttcatggtt 540
tataaccgct cagcgcttaa cagctcggtt ttctcgaagt ttgttgagca gattacgcaa 600
aaataaatcc gaatggctgt aatatttaca gccatttctc tcatcaaaat ataatcctca 660
tttatagata ataaaaaatc tgcctttttt gatttacctg cctttatttt cactactatt 720
attctctctc ctgcattgac atgaacgtcc ggtatttatt tccaggagga gttgcctttg 780
tcaatttata agcatccact taatcaaaat gtccttgacg ctgccacaga gcgcataaca 840
tggacgcttg agaatctgcc aagggtctgt gtttcatttt ctggcggaaa agattccacc 900
attatgttcc atttaacggc ccgacaagcc cgaaaaatgg gaaagaaaat ctgtctgtta 960
tttatcgact gggaagcaca gttcacctgt accattcagc atgtgaataa catgatcgca 1020
caatacgccg atgtgattga aaaatgctgg tgggtagcgc tcccgttgac ctcgcaaaat 1080
tcactttcac aattccagcc cgaatggcag tgctgggagc cgggtaaaaa ctgggtacgc 1140
acgcccccgg aagaggcggt aaccgatcca gattacttct cgt 1183
<210> 66
<211> 1101
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..1101
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 66
attctatgtc accttctgcg taatattcgc cctgttgatt atttcactgg ccctgtcgac 60
gacgattcgg cagccgcagc gcgaagtgtt taatgaagca catgcttaac ctaaattaaa 120
gaggccttaa cggcctcttt aacctttatt tgatatgctt ccagacttgt tattttgtaa 180
aaatttgcac cgatcacatt ctccgctgcc acttttctct cccgctgtgg tctacttacg 240
gcgcttgtag acgtttctga taacgctttc ttacgcattt acttactctg tccgctttct 300
cactgagatt cggcgggttt ttatacccct tcccccaggg ttgtttgcat gaaatacatt 360
aggtctatta cccagcaaag attgtgtctg atgctggctg tctatatcgg attatttctg 420
aatggcgcgg tgctgttcag acgagtggaa ggttatttcg aagacctcac cgtaagaaat 480
ggaatttttg ccgctattga agtgttcggc tccgtcctcg cgacattttt cttgttacgc 540
ctgttatctc tcttcggccg tcgcacgtgg caaattctgg cctcgctggt ggtgataatt 600
tccgccgccg ccagctatta catgaccttt atgaacgtcg tcattggcta cggtatcgtt 660
gcgtcggtaa tgaccactga cattgatctc tcgaaagagg ttgtgggtaa aggctttatc 720
gtctggacaa ttttaacctg tctgctccca ctcttcttta tctggagtaa tacctgccgc 780
tatacgttgt tacgccagtt gcgcactcgt ggacagcgga tccgcactgt cgccgtggtc 840
ctgctggccg gtttgctggt atgggcgcct attcgcctga tggaaaaaca gcaaaaacgc 900
atcgaaaagg caacgggtgt cgatatgcca agctatggcg gcgttgtggc caactcgtat 960
ctgccgtcaa actggctttc agcgttaggt ctctatgcct gggcgcaggc ggatgaatcc 1020
agcgatgtga aatcgctgat gaatccgacc aaaaaattcc actacgaggc acccgctgac 1080
gggctcgatg atacttacgt c 1101
<210> 67
<211> 1175
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..1175
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 67
cattaatttc gcctaaatcc cacttgtttg ttgacgtgta tcacgccgat ttgtaccgaa 60
aaaaatgaaa caaataatta cgatcttgct cactaaaata gcatttatta aaaaataaac 120
tgccatttca taaaaatgaa acgttatttt aattgagggt ttttgtcatg tttaacaaat 180
ctctggttgt agcttctctt attggtactt ctttcgccgc gcaggcggtg accgtcgatc 240
tgcgtcatga atacatcgac agcggcgcaa atgcagatcg tgtttcagtc tcgcatcgct 300
ttgcgaatgg cgtcggtttt tctgtagaag cgaaatggaa atcgggtggc gataaggccg 360
accagccgtt tgcggatgtg gtgggtaacg gtcatgaaga tcaaattagt tggcgctgga 420
aagcgacaga gaatattgcg ctgactcccg cgttcacgct tgagagtaac gacagccgta 480
ccatttataa accgaacctg cacctgcaat acagtttcga taatggcttt tacgtggccg 540
cgcgttaccg ttatgaatat acccgttatc cgtcgagctc taataaagac gatgacaaag 600
ttaaccgtgg tgatgcctgg gtcggctggg ttatgggaga ctggcgtacc gaactgaatt 660
atgtttatgc aaaaagtacg gaagggatgg tccgtaataa taataaagat tattccaccg 720
aatataacgc gaagctggcg tataaatggg ataaaaactg ggcgccatat gttgaggtgg 780
gtaacgtggg tgtgaaagag agcgatgaac gtcagacccg cttccgttta ggcgtggcgt 840
attccttctg atatttccct ccaggcccgg tgagcgcagc gtcaccgggc aaaacgttca 900
gagcaaaaaa agccctccgt aaggagggca aggccagtta cagaaacaca tttttaaatc 960
atgcagacaa catatccggt tgcgcgggaa gtttcgcaat atagagggca ggtttgccgt 1020
ctttatcgga actgaacagt accgctttct cgtccggtgt aaaggaggga tgcggatggg 1080
tgacctggcg gctattttct accgtcgccc aggaggtgtc atgacgggcg atgcgatagt 1140
agcgcttttt ggccacgtca aaggcgtaga gatag 1175
<210> 68
<211> 1027
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..1027
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 68
tactgttcca ggtgataccc gcacgcgttt gatcggtaag cgccattaat aaccccagac 60
ggtagctcat tacccagtca ttatctttct cttttacgtc gttatcgtcg acattacgcg 120
ttagcgaaag gaatccataa tttacgttaa cggatccccc cacggaaaca cggtcgctga 180
gcttataagc cagggacggg cttaatgtca ttgcaaccat tgtacttttt ttaataaggc 240
gatcgccggc ccagttacca aaatcaattc ccagaccata attgccatat aaacctacac 300
cggcatatag tctgtcattg actttttgcg aataaaaggc gcttgcatta gggaataaat 360
tcatcacatt accgggactt ttgtgaccag acgcattatc caggtcatag gaaatatcac 420
catccatggc ctgtaaaccc ccggtaaaca tatgatcggg aagccgcgtc atgcccgccg 480
ggttggtcac gattgtggac gcgtcctgag cacgtgcagc ctggcccgca ccggcaagcg 540
cggcatcttc ggttccaatc tcatagaaat agagtgcgct ggcctgcgtt gcgggtgaaa 600
gaaacgttat caaataaaac aacgccgttt ttctcatatg ctattttcct gttatcgaat 660
gataatttta cttccgcgtt cttttttgcc atcaccctgc taccgtcagg ctgtattacc 720
ctttttaacg acgtggtata tacattaaat acacagcaac gttccgcact ctcattattt 780
ttcaggcaga cgcaatcctg ttgagcatag accagccttc ccgttccgca atgtcgcata 840
acgttaccct gcctggagaa aaaaagaaaa cccgatcgtt gcgtaaattt attattaaac 900
aactcttaag gttacatttt tgaaaagtta actattctta aatggcattt gacatgtatc 960
agtgccagac gaggatgtgc ttaagcgttt caaaggcata tgccgctggt ttcttctgct 1020
cactcaa
1027
<210> 69
<211> 1021
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..1021
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 69
aataagaagc tgataagcgg tgattatttc agtgaaaccg ggtgggtggg tttatattgc 60
tttacgttcc gggatgccgg acaatgacat ttttaactga cgattaacat tacgatgaaa 120
cacccgttag aatcgctgct cactgcgggc ggcattttat tgctggccct gctttcgtgc 180
ctgctgctac cggcaccctc tctcgggctg gtgctggcgc agaagctggt tcagaccttc 240
cacatggtcg accttaacca gctctacacc attctgttct gcgtgtggtt cttactgctc 300
ggcgccatcg aattctttgt gctgcgtttc gtctggcgcc gctggttttc tctggcgtcg 360
taagcgtgat gcaggcccgg tcaggcgaaa ccgccaccgg gtaaaacagc tcagtgtgcc 420
ctgctgtggt tctctttacg atacgcccca ggcggctggt tgaacgtgcg ggtgaagatg 480
cgagtgaagg tctgctgcga gtcaaacccg taacgcaggc agatgtcgta tacccgggcg 540
tctgattcgc gcagatcccg cgccgccagc agcagcttgc gttcacggat atagcgcccc 600
agactctccc ctttgtattg cataaacagc cgctgcaggt gccatttcga gtaacccgca 660
tggcgggcaa tctcttcgat acgtaatggc tggtgcaggt tatcgtcgat ccactcgacg 720
atagtgtcga tgacttgagc ggaaatggtc atactgctct ccccttcagc ttcctgattg 780
atcattattc ccaccactca cgaaatgttt gcgtgggatc actcacccgg acaggctcgc 840
ccagcgcggg tgtcaacagc cgataatttt tgtccttgct ggcttttgcc agttggatca 900
gcggatcgtt ccaggtatgt ttcgccagca cgaagcgccc gttatgtccc ggcaccacgg 960
ctttcgcgtt cagatccacc gaggcctgcg ccgtctcttc cggcagcata tggatgtact 1020
t
1021
<210> 70
<211> 756
<212> DNA
<213> Enterobacter cloacae subsp. cloacae ATCC 13047
<220>
<221> source
<222> 1..756
<223> /organism="Enterobacter cloacae subsp. cloacae ATCC 13047"
/mol_type="unassigned DNA"
<400> 70
catgaaaacc tgctgctgaa gctgcgccag gaggcttccg ggtacagccc cacgcaaaaa 60
aaactgggag agtttgttct caacgatccg gcccgggtgc tctacctgac gatcaccgaa 120
ctggcacggg agagccacac cagtgaagcc agcgtgacgc gtctttgccg gacgctcggc 180
tgcaaaggct ataacgaatt caagatggca ctggcgctgg atattcagca gggtcagccc 240
gcacgcgtgg ccggggacga aattgataac gtcgtcgatg agtctgttca ggcgctgcag 300
gataccgcca gactgctcga cagagcactg ctggaaaagg ccgctcaggc gctgcatcag 360
gcgcaagccg tacaaatata tggggtggcc gccagcgcga tcctcggtga gtatttacat 420
tacaaactgt tgcgactcgg caaacctgca cagcttttta gcgatatgca tcgtgcggcc 480
atgaatgcag caacgctttc agaagggacg ctggtggtgg ccatttccag ttccggttca 540
acgcgggatt tgctccatgt cgtaaaactt gcacgcaaac gcggcgttaa ggtgttatcc 600
cttagcaata cgccccgcag cccgctggct tcgcttagcg atatgcagct ggtcgccgca 660
aaaccggaag ggccactcag cgcaggcgcg ctcaatgcta aagtgggcgt aatgttactg 720
gttgagttac ttacaacttc cctgattgcg attgat 756
<210> 71
<211> 1525
<212> DNA
<213> Enterococcus faecalis OG1RF
<220>
<221> source
<222> 1..1525
<223> /organism="Enterococcus faecalis OG1RF"
/mol_type="unassigned DNA"
<400> 71
caagtggtca cgaagtcgaa ttagttaaag aagaatccta tttcttccgc atgagtaaat 60
atgcggatcg cttggtacaa tattacgaag aacatccaga atttattcaa ccagaatctc 120
gtaaaaatga gatgctaaat aactttatca aaccaggatt agaagattta gccgtttcaa 180
gaacgacttt ctcttgggga attccattaa aaaatgatcc aaaacatgtg gtttacgtat 240
ggattgatgc gttatcaaac tatattacag cactaggtta tggttcagaa gatgattcat 300
tattccaaaa atattggcct gcgaacgtgc aaatggttgg gaaagaaatc gtgcgtttcc 360
atacgattta ttggccaatt atgttaatgg ccttggattt accattaccg aaaaaagtct 420
ttggacatgg ttggttattg atgaaagacg gaaaaatgtc taaatctaaa ggaaatgttg 480
tttaccctga aatgttagta gaacgctacg gtctagatgc gttacgttat tatttattac 540
gagcaattcc atttggtagt gacggcgtct ttacaccaga agatttcgtt tctcgcttaa 600
attatgattt agctaatgac ttaggaaact tgttgaatcg aacaattgcg atgattaata 660
aatattgtga tggcaaagta ccagcctatg cttcaaaagt taccccattt gatagtgaac 720
tatcgacaac tgcggctaat gttattggaa aatatcatga agcaatggaa aaaatggaat 780
ttaatacggc cattgcagaa atttggacgc tagtttctcg tgccaataaa tatattgatg 840
aaacagcgcc ttgggtattg gctaaagaag aagagaaacg caatgaatta gaaagtgtca 900
tgatccattt agcggaaagc ttacgaattg tggcaatctt attgcaacca gtcatgacag 960
aaacaccagg gaaaattttc gaacaattag gcttagatcc agaaacaatg aacatggaaa 1020
atattcattt tggtgagttc ccaacagacg taacagtaac aagtaaagga acacctattt 1080
tcccacgttt agaaattgaa acagaagtaa cgtatattca aaagaaaatg tcccaaagcg 1140
aaagtgctac agaagaggat attaaatgga atccagaaga aacaacgttg gtttcaacga 1200
aagaaaaaca aattaagtac gatgatttcg ataaagtgga attaaaagtt gccgaagtta 1260
ttgactgtaa aaaagtcaaa ggagcagata aattattgca attccgttta gatgctggag 1320
atgaaaacca tcgtcaaatt ctttcaggta ttgctgaatt ttatccagat ccagctgcgc 1380
taattggcaa aaaagtagtc attgtggcta acttaaaacc aagaaaaatg cgtggtcaaa 1440
ttagccaagg aatgattctt tcagctgaat caccagaagg gaaacttcaa attgttgaag 1500
caccaaaaga aatgccaaat ggtgc 1525
<210> 72
<211> 937
<212> DNA
<213> Enterococcus faecalis 0G1RF
<220>
<221> source
<222> 1..937
<223> /organism="Enterococcus faecalis 0G1RF"
/mol_type="unassigned DNA"
<400> 72
gcgaatcaat tagccacacc gtatactttg gatgcagaag ctatggaaaa attgatccaa 60
aaagttgaag atgctggtat cagcgtggtc gatgaaaatg gagacccaag tgaacatagc 120
ttgaaaaaag atgaaaaaga agcggaaaag gcccaagcag aagacttatc tgcgccaaca 180
ggtgttaaaa ttaatgatcc cgtgcgtatg tacctaaaag aaattgggcg cgttcaatta 240
ttaactgccg cagaagaagt tgaattggca cttaaaattg aagaaggcga tcaagaagca 300
aaacaacgtt tagcagaagc taacttacgt ttggttgttt caattgccaa acgatatgta 360
ggtcgtggta tgcaattctt ggatttaatt caagaaggta atatgggctt aatgaaagct 420
gttgaaaaat ttgactaccg taaaggattc aaattctcta cgtatgctac ttggtggatt 480
cgtcaagcga ttacgcgggc aattgcggat caagctagaa cgattcgaat tcctgttcac 540
atggttgaaa caatcaataa attgattcgg attcaacgcc aactattgca agatttaggt 600
agagaaccaa cgccagaaga aattggtgcg gaaatggatt taccaacaga aaaagttcgt 660
gaaatcctaa aaatcgcaca agagccagtc tctttagaaa caccaattgg tgaagaagat 720
gattcacatt taggtgattt cattgaagac caagatgcta ccagtcctgc tgaacatgca 780
gcttacgaat tgttaaaaga acaactagaa gatgttctgg atactttaac agaccgtgaa 840
gaaaatgttt tacgtttacg ttttggttta gatgatggtc ggacacgtac gctagaagaa 900
gtcggaaaag ttttcggtgt cactcgcgaa cgtattc 937
<210> 73
<211> 1014
<212> DNA
<213> Enterococcus faecalis V583
<220>
<221> source
<222> 1..1014
<223> /organism="Enterococcus faecalis V583"
/mol_type="unassigned DNA"
<400> 73
ttgggttgtt ttccttcctg tactattttg cacgaacgtt tacagactgg caacgatata 60
aatctcgaat cgttgcgtat tttactactt ctcttttagc tggtggagca tccatgatta 120
tggtcttacc tgctgtctta gatttacgaa ccaatggtga aactctttct gaaattacaa 180
cctttaaaac agaagcgact gcctttttag atattattat gaaaaatatg attggcgttt 240
acgatacaac caaatatggg tccattcctt ttatttacat tgggttgttg cctttgattt 300
tttgtctctt ctatttcgtt acgaaagaag ttccattgaa aaacaaacta ctttttggca 360
gtttgtttgt cctattgatt gctagctttt acatcacgcc cttaaattta ttctggcacg 420
gtatgcatgc gccgaacatg tttcttttcc gctatagttt cctcttttca ttcttagtta 480
ttttgcttgc aggttatggt tgggagaaat ttgaaaagga tgatctcggt gtcttaagcg 540
gcttgatttt gattctttta gcaatttttg ctcttgcaat gggcacaaaa ggtgctacta 600
gttatacgta tgtgacttta acctctttcg tattaacggc aactttttta ctattatact 660
ttttcgggat tgctttttat caattgaaaa aagcgcctat gcaatactta gtgattttgt 720
tattgctgct cgtttctggt gaagcaatca ttaacacacg ggcgatggtc actggtattt 780
tagatgattg gaactacgca tcacgcagct tgtattctga gccttatcct gacttaaaaa 840
atctagtcga tcaaacaaaa aaagaaaatg atacctttta ccgcttggaa aatttaaatg 900
gtgtttcggc caatgacggc attaactatg gctacagtgg cattagcatg ttttcttccg 960
tacggaaccg acattcttca acatacctaa acgccttagg tttccgctca cgag 1014
<210> 74
<211> 1184
<212> DNA
<213> Enterococcus faecalis V583
<220>
<221> source
<222> 1..1184
<223> /organism="Enterococcus faecalis V583"
/mol_type="unassigned DNA"
<400> 74
aaaacagtga gtccgcaggt agtcaaagcg ccgctaaaag attagaagcc attcaaatta 60
aattagtgaa gaagggcgaa gcggcacctg aaggaaatgg aaaagccttt ttaattggaa 120
atgaagcaaa acgtccagat gaaatcaaac caactgtcaa ttatcaaaca cacgtgcaaa 180
atattggttg gcaaggggtt gtcaagaatg gcgaaatagc tggtacaagt gggaaaaatt 240
tacaactgga agcaatcaaa atcaacctga gtgatgctgc tctagctgga aacatagaat 300
actctacgca catccaaaat atcggatggc aagattataa agccaatggg gcattatctg 360
gcacaactgg aaaaaattta caattagaag ccattaaaat taaactgtcc ggtgatgttt 420
caagatatta tgatgtctat taccgtgtcc atatccaaga taaaggttgg ttaaattggg 480
cagctaatgg cgccccagct ggaagtcaag ctgcatctaa acatttagaa gccatccaaa 540
tcaaagtagt tagaaagggc gaaactgctc ctaaaggaaa tggaaaatcc tttttagttg 600
gaaatgaagc aaaacgtcca gatgaaatca aaccaaatgt caactatcaa acacacgtgc 660
aaaatattgg ttggcaaggg gttgtcaaga atggtgaaat agctggtaca agtgggaaaa 720
atttacaact ggaagcaatc aaaatcaacc tgagtgatgc tgctctagct ggaaatatag 780
aatactctac gcacatccaa aatatcggat ggcaagctta taaagctaat ggggcattgt 840
ctggcacaac tggaaaaaat ttacaattag aagccattaa aattaaactg gccggtgatg 900
tttcaagata ttatgatgtc tattaccgtg tccatatcca agataaaggt tggttgaatt 960
gggcagctaa tggtgcctca gctggaagtc aagctgcctc taaacatttg gaagctattc 1020
aaatcaaaat agttagaaaa ggtgaaactg ctcctaaagg atctggaaaa gcctttttag 1080
ttggcgatga agctcgcaca ccagcagaga tagcaaacag attacgtgca gaaagattaa 1140
agaaaaaacc ttattattat tctcaacgtg acccacaatg gatt 1184
<210> 75
<211> 1039
<212> DNA
<213> Enterococcus faecalis V583
<220>
<221> source
<222> 1..1039
<223> /organism="Enterococcus faecalis V583"
/mol_type="unassigned DNA"
<400> 75
gcggtgtttg ccttgtttat ttgttggttt ggacaagtaa aaacaattga tggtaaaacg 60
caaaatgggg caattttttt gattagttcg gttagtgaga tgacaaaaca agtacaaggc 120
aagtttactt ctaatgtaaa ctttggaggg gatacaagcc aagaagtaga cgatggaaag 180
aaaaaagtgt atcaaagccc aatgtttgac gcaacggttt tacagacgtt taactatgtc 240
aatagtggct cgattgatgg caaaatggca aatgggaaga agcttgatta tgataaacta 300
ttagaaaagc ctaacctgaa tgataaagag aaaaaggatt ttagagaaaa aagaaatgct 360
tatattgaac agcaggagaa agacaatcct tatttttcgc aagatacctt aaaaactatg 420
gaaaaaagtt ttgcggtatg gacgggtgca acaaatttat ttattctagc aattcctgtg 480
ttatatatta atttaatgtt gtcgttgata cagctgttag ttgtcttttt aattcttata 540
tttccagttg ttttgttggc ttcctttttt ccacggtgtc aaatgttact attcaagttc 600
tttcaaggtt taattggtgc gttattcacg ccaattattt atggtatttt tttatcggtg 660
ctgttttgga ttaacaaact gattgatggg gcatttttag gtgtcgcaaa aaaagtcagt 720
ggcagcttgc ttgaattgat ttcaggtagt acggtttata tgatcgtttt atttgtagca 780
gtggtagtga agattgtagt tttacgaaaa gtttggaaaa ataaatatgc cattcttgct 840
tacttttcaa atgggcaagt gtcacagcct gtgtttgaac aaaaagtgga acagttgtct 900
gaacgaacga aagaagtagc aactggtgga gcgcaagttg ccctaggtgc ttatacaggc 960
aatctgggca tggtcgcaaa cggtgcaggt aatattctac cgaatcaaga taaagccatt 1020
gaaatgggcc aagaacatt 1039
<210> 76
<211> 1000
<212> DNA
<213> Enterococcus faecalis V583
<220>
<221> source
<222> 1..1000
<223> /organism="Enterococcus faecalis V583"
/mol_type="unassigned DNA"
<400> 76
tttttaggaa tccttggctt gtttagcttt ttgtttttat tgcctttttt gttatttttg 60
ggcaccatgt caacagaaat tggaaacaat acacaatttc aagcaacaac gccacaagaa 120
aaagtagcgc tagaggtatc caattttgtt accaaaaatg gtggatcgtt acaatttgcc 180
tctgcatggc taggaaatat ggaacatgag agcggattaa atcctgctag aatacaaagt 240
gatttaacgt ttaattcagc gtgggcgttt aatccttcga ccaatggtta tgcgttaggt 300
ttagcaatga tggacggtga gcgccgtgta aacttgttaa attttgccaa agaacaaaag 360
aaagattggc aggctgtccc agtacaactc gagtatatgt ggaatcatga cggctcagac 420
agtgccttgc tgaaacgtat gtcgaaaagc tctgatgtga atcaattagc tgtagatatt 480
ttggtacatt gggaacgtgc aggcactaaa aatgatccca acgaacaaat caaacgaaaa 540
acaagtgcga ataattggta taagagactg tctacaggtt ctatgggggc aggttcagcc 600
aatattggtg gtggcaaaat tgatgtgtta gaacaaatgt tagggcaaac agtcaatgga 660
ggtcagtgtt atggggggac ttcttattat gttgaaaaga tgggctttca atctttaatg 720
aatacagggc atatgtttgc cagtgaaatt ggcaatgatt atgcgtggga acaatctggc 780
tggcaggtaa tcaaaaatcc aaactattct gatgtcaaag caggtgatgt gattaatttc 840
gcaatgggcg gttatgcgac cagcgtttac ggtcatactg gaattgtagc tagtgttgaa 900
ggtaatggaa agcttgtttt atatgaacag aacgctgaaa aaggacaaat aattgctaaa 960
tattttcgac aatggggagc agaatatcct aacgtgacaa 1000
<210> 77
<211> 1014
<212> DNA
<213> Enterococcus faecalis OG1RF
<220>
<221> source
<222> 1..1014
<223> /organism="Enterococcus faecalis OG1RF"
/mol_type="unassigned DNA"
<400> 77
gttcccgact tgcaacaaat ttatattaac ggtgtcatcc aaccggaaca aatggaagcc 60
tttgcgcgtg atcaaaaaat aacaaaggat ccagagatta aggtgaaaaa cggcgatgtc 120
gtagatgcag gcacagaatt atttacttat gaagatgagg cggtcacaaa agaaattgag 180
gcacaacaaa atagcttagc caaattagaa acgaagcggg cgaatatcta taataagtgg 240
aatcgggcca ttgataaatt taataaaact aaagaagaag accgcacgat gtctggtgat 300
gatttaaatg aacaatatca aacagaagtc gatgcagtag atgaagagat taccttcacc 360
aatgaaacct tagcggattt aggagcgaag caatatattt ccacaaaggc taatttcaaa 420
ggtcgtgtat caattccaga agtaaaagat gccaattcac cgattttacg gttaacttca 480
gaagatcttt atttagctgg aaaagtgaat gaaaaggact tgactaaaat tagtgttggg 540
caaaaagcta aactaacttc tgtttccaac aatgtggttg tggatggctc aatttcttac 600
atcgatgata atcctcctga aggcaacagc gatgccgcga gtggcaatcc agagggcggc 660
acaacgatgt ctagttatag cgtcaaaatt gcgttggcca atttagacaa agtcaaaaat 720
ggctaccata tgcaagcaac cattgattta ggcgatttag gggcgattga gttaccgaaa 780
aaagcgattc aaaaagaggg tgaacaggcc tacgttttag tgaatgattt tggaaccatc 840
attcgtcgtg atgtccaagt cgggcaagaa aatggcgaca aaatggcgat tgaatctggc 900
ttagaatcag ccgaccgagt ggttatttct tcaaaaaaac cagtaaaagt cggtgatatt 960
gttgaatcag atgcagcgat tgcttctgat gaatcagcaa ccaacgaatc aatg 1014
<210> 78
<211> 1590
<212> DNA
<213> Enterococcus faecium FAIR-E 345
<220>
<221> source
<222> 1..1590
<223> /organism="Enterococcus faecium FAIR-E 345 "
/mol_type="unassigned DNA"
<400> 78
tgcagtctga cgactcaaaa atgagtcgta taaatcaatt atagtaataa gtcattgatt 60
tctttaaatt ctttatcaag ttctttttca tcatattttt catatttatc agcttcatga 120
agaacttttt taatttcatg aatagccttt cgttcaacta accatttttt taggttatgt 180
tttttttctg gattttcaga taacgtatca agttcgtcta actctttatc cagtttattg 240
acaacagaaa caattttgtt tacaactttt tcttctttgt tttctaaatt tgacatttat 300
cttcacgtcc tttttatttg ataatttaag tatagaactt tgatatagtt tatacaaata 360
aaaacgcttc tttgtgtatt ctgtgctttt cttttggaat gaggaaaact ttggagtaat 420
atgaacgtgg acagaaaaat atttaggagg aataaactat gtgtacgtct attacttatg 480
taacaagtga tcattatttt ggaaggaatt ttgattatga aatatcttac aatgaagtag 540
tcactattac tccaagaaat tataagttga attttcgaaa ggtaaatgat ttggatactc 600
attatgcaat gattggtatt gccgctggta tagctgacta ccctctttat tacgatgcga 660
caaatgaaaa aggattgagt atggctggac taaatttttc tgggtatgct gattataaag 720
aaatacaaga agggaaagac aatgtatctc cttttgaatt tattccttgg attttaggac 780
aatgctcaac agtaggagaa gctaaaaaat tgttaaaaaa tatcaattta gcaaatataa 840
attatagtga cgaacttcct ttatcccctt tacattggct attagctgat aaagaaaaat 900
caattgtcat tgaaagtatg aaagatggac ttcatatata tgataaccct gtgggcgttc 960
ttaccaataa tccttcattt gactatcaat tatttaattt aaacaattat cgtgtcttat 1020
cgagtgaaac tcctaaaaat aatttttcaa atcaaataag tttgaatgcc tatagccgcg 1080
gtatgggagg gataggcttg cctggagatt tatcctcagt atctcgtttt gttaaagcga 1140
cttttacgaa gctgaattct gtatctggag attcagagtc agaaagtatt agtcaatttt 1200
tccatatctt aggttcagta gaacaacaaa aaggtttgtg tgatgttggt gatggaaaat 1260
atgaatatac aatttattct tcttgttgca atgttgataa aggaatctat tattatcgaa 1320
catatgaaga cagtcaaatt actgcaattg atatgaataa agaagactta gatagtcata 1380
agttaattag ttatccaatt atagaaaaac aacaaattaa atatataaat tagttagtgt 1440
gttgtgattg attatttaat atagatataa tacaaaaagg caaagatatt ttcaaaacat 1500
tttttcttga tgtgatatcc ttgtcttttt tgtaatgttt ttaacttatt gcttttgcaa 1560
aatttattta cctgttttct ggatcaacga 1590
<210> 79
<211> 1571
<212> DNA
<213> Enterococcus faecium Aus0004
<220>
<221> source
<222> 1..1571
<223> /organism="Enterococcus faecium Aus0004"
/mol_type="unassigned DNA"
<400> 79
gaaatattcg cggtgaagga ttccaaaaag aaatcccatt aatgattgaa aataaaaatg 60
ttggaacttt aacggtcaga aaagattctg cgcaggttgt gtttaatgaa aatattaaaa 120
acctagactc agtagaaggt tgggggcaat ttgagataca ggccagaaac gtaaccgata 180
ccggtgaaga aaatacggga ccattcaccg tgacgagcgg tgataaaaca gctactgtaa 240
atgtgacaaa gccagcttct ggttcttctt ctagcgtttt ttattataaa acaggagaca 300
tgctacctga agatactaag cacattcgat ggtttttgaa tattaacaat aacggcactt 360
atgttgaaca accagttaaa atcagtgatg aaatccaaag tggacaaaga ttagatccaa 420
gtacgtttga aattaatcaa atacacttag gtgaacagaa ggtttataga ggagaagagg 480
gaatccaaca atttttacaa gatttcccca gcgctacatt taatttttca gtaactgata 540
attacattga aataactata ccaaaaaact ttgtcaatct taggaaaata atggtgagtt 600
ataagacgat catagaaaac ccagaacaaa taaattttga gaatcattcg gaagcttggt 660
ttaaagaatt taataaacct gctgttgatg gagaaagttt caatcataca gttaaaaata 720
tttcagcttc tggtggagtc aacggtacag ttagaggcga attgaagatt ttcaaatata 780
tcaatgacac agagattggt atcccaaatg tgactttcga attaagacga gcagatgaac 840
agcctattca aggacagtct agtatcctgt tgacttcgaa tgaacaggga gaagctagta 900
tcaaaggcct gcaagtagga gactatgttg taaaagaaaa agaagcaccc aattggattg 960
attttgatcc actaagttca aatgaactca aattctccat aaacgaaaat gatacagagg 1020
gagtcagttt acctatttat aacaagaaaa aggttacgaa catcacagca actaaaattt 1080
ggaacggtgg aaccactcca agaccgagta tttattttaa attattcaga gcaagtacaa 1140
acaattggga accagttcct gatgcagaaa caaaacgatt agacaatgga ataacttcag 1200
tgacttggga agatatccaa cagtatgatg atagtggaaa cgaatatacg tttaaagtgc 1260
aagaagtaga tcaaaacgga aatgattatg tcccttcagg ttatcaaaaa attgaaaacg 1320
ggctagtcgt tacaaatgag aataaagaag tcatttcagt ctcaggacaa aaaacatggg 1380
aagacaatga gaaccaagac ggcaaacgac cgacgacgat cacagtaaat ctattagccg 1440
acggtcaacc gatccaacac aaagaagtaa gtgaaaaaga tgattggcgc tatcgtttca 1500
caaatctgcc aaaatacaga gacgggcaag aaatcatcta tactgtaacg gaagacaacg 1560
tgcccgaata c 1571
<210> 80
<211> 1477
<212> DNA
<213> Enterococcus faecium DO plasmici 3
<220>
<221> source
<222> 1..1477
<223> /organism="Enterococcus faecium DO plasmici 3" /mol_type="unassigned DNA"
<400> 80
gtctggaaac cggtaacgaa tttccaatca tgtcctgtac agctcataaa tgatccaaaa 60
gaaacatacg atttatgtat aacacacctt tataaccagc atttgaaaaa tgacggattt 120
tatttaaagg ttactaatga caatcaactt acgattgaat cagcaaacct tcgagggttt 180
caatatgcta tggaagcctt attagagagt tttttttcgg taggagatca attattatta 240
ccggaattga ttctgaaaca tgaaccatca gtgaaaattc gaggaatcat tgaagggttt 300
tatggtatcc cctggacaca tgaaatgcgc ctctctcttt tttcatatat gaaagataac 360
caattgaata cttttatgta tgcccctaaa gatgatgaat tattacgtaa aaaatggcgt 420
gaactctacg atgcgcaaga attagacaaa tttaaggagc ttttatctgc tgctgaggct 480
agcaatatcg atttttggta cttaattagt cctggaaatg atattgatat tacgtgtgaa 540
gaagacattc aagttcttct gaaaaagtta gaacaactga ttgagcttgg cgtatttcaa 600
tttggtctat taatggatga tattgactat caattaaaag gtgctgctaa acgccgtttt 660
cgagagccag cattcgctca tgcctattta gtgaatcgag tagaggaata tcttagcact 720
cggttgtcca atcatgaatt agtcatttgt cctacagaat atgataatcg tcatggttct 780
cgctatttag caacgttaag tcaagaaata ccagaacaat taccgttctt ttggactggc 840
ccaagcacgt tagcggcgtc aatttctaca gaagagctgc aggaaatggc ttctgtctat 900
caacggccga tgctgatttg ggataatatt ccggtaaatg attatttaga ggataaagaa 960
ctattgttca tgagtccata tgagaatcga acaccgaatc tttctaagga gagataccag 1020
gttacaggag tagtttcgaa tccaatggct caattagaag cttcaaagtt tacgatcaat 1080
agtatggcta attacttatg gaactgtgag cgttttgatc ctttggaaac ttggacgtca 1140
gtcgttgaaa aagtagttgg aagtaaacta caaccagctt atcttacctt aaccaatgct 1200
tttccaaatc attacacaag cagtctgctt tcagatgaag aattactgct agccaaagac 1260
ccagaatggg tcacaaaaga aatggctgct ttagtccaag cagtaaaatg gatccagcaa 1320
gaacaacata catctagatt gagaacagaa ttggagcctt ggttacaagc aatcacagaa 1380
agttggactt tctggcaaga atggcaatta aaaaaagatc caaaagaagc agaagaatgg 1440
ttggctaaga aaaaaacaca ccgcatagga cgtgatt 1477
<210> 81
<211> 1061
<212> DNA
<213> Enterococcus faecium DO
<220>
<221> source
<222> 1..1061
<223> /organism="Enterococcus faecium DO"
/mol_type="unassigned DNA"
<400> 81
agcaggagga gcaatcgtaa caacaacttc tgttcaagca ttcaatccaa gcgaacattt 60
attagattac gcagcaacaa aagcttcaat cgctaacttt acgatcggtt tagcaaaaca 120
gcttgcacct aaaggaatcc gtgtaaatgg tgtagcacct ggtccaatct ggacaccatt 180
acaactagac gaaggacaac cttctgattc gatccctgaa tttggtcagc aaagtttact 240
agaacgtgca ggtcagccag gagaattagc accagtttat gttttcttag catcgaataa 300
agcaagttat gttacagccc aaatttacgg agtaactggt ggagaagcga tcaacttata 360
agaagttgat cgtttcaccc ctatgaggag gtgcgaaaat gaataaaggt gtaaaaacga 420
tcggagtgat cggaacatta cttttgctat ctgtgctttt gtttgcgata ctattaagtg 480
caacctatcc attgcctttt cagctagaga agtttcgatt cttttccatc actaattcat 540
acgtgcaaca atatgtattt tggcttgccg ttgcatttgc tattttgaca attatcacgt 600
tacttgtttt cctgttttat ccaaaaacaa tcggaaactt tctactgaaa catggtgatg 660
gggagttgac gttggataaa aaagcaattg aaggaatggt tcgttctcac ttgcatgaag 720
atgaattcat ccattcacca aaagtaaatg tcaaagcaac gaaaaacaag atcgccgtca 780
atgtaaaagg ggagttgaaa cgaacttcag cactcattgg taaaacagga acattgatga 840
aagaaatcga aaatgaagta caacacatat tgggaacaaa agagccagtg aaagtatcgg 900
tgaaatacac aggctttgaa gaaccagcta aacgaagcaa tgaccgcaaa cgagtagaat 960
agggggggac caaaaatgaa agaactattt tcgacataca agctccctat catctttggg 1020
gtacttggat tgatattagc cgttttatgg atcaccgtgg g 1061
<210> 82
<211> 1024
<212> DNA
<213> Enterococcus faecium DO
<220>
<221> source
<222> 1..1024
<223> /organism="Enterococcus faecium DO"
/mol_type="unassigned DNA"
<400> 82
ccaatcaaat ggtgtgaacg atgaaaagaa caaaacagca ccagtatctg cacatccaga 60
tccagtagtc cctaacgttc aacaaggagt agaagagaag aaacatgatg cagaaaagca 120
tgcacctcat catccaggaa ctccagaatc taaagttcca gaacaacatg atgcaatcga 180
tccttctaaa cctgtggaag agcaaaaaca tccttctgac catgcgaaag cacaagaaaa 240
acttagttct gaccacacaa acggacaagg aaaacttggt tctgatcata caaataacca 300
aggaaagcat gattctgaac aggaagattc aatgcgcggt gaattgaatt atgaagataa 360
agttgtgcaa aaaatcatcg gttatgcatt gaaagatgta gatggtctat tgacattaga 420
tggcggattt ttctcaaata tggctgaaaa attagtcaac acagataatg taacagcagg 480
tatcgaaaca gaagtcggta aaaaacaagt agcagttgat atggatgtca ttgtggaata 540
tggcaaagat atcgaaaaaa tctttgaaga aatgcaagaa gtaatcggca aagaagtaaa 600
aaatatgaca catttagaag tgatcgaagt caacgctaac gtagtggaca tcaaaacaaa 660
agaagaattt gaaaaagatc aagaaacggt gcaagacaaa gtaactgacg cagcgaaaaa 720
aaccggtgaa tttgcttcga atcaaacaga taaagtaaaa tcagcagctg gaagcggcgc 780
acaaaaagta aaagaaaata cagaaccacg ggttcagtaa taaggaagta aaacattagg 840
aggaacgaaa catgggattt atttggtcac ttatcgtcgg aggaattatc ggagcaattg 900
caggagcaat cacgaataaa ggttcttcga tggggattat tgcaaatgtc gtagcaggtt 960
tagttggatc agcacttggt caagcattat taggttcttg gggaccaagt attgcaggaa 1020
tggc
1024
<210> 83
<211> 1120
<212> DNA
<213> Enterococcus faecium Aus0004
<220>
<221> source
<222> 1..1120
<223> /organism="Enterococcus faecium Aus0004"
/mol_type="unassigned DNA"
<400> 83
tctttggagc cactgctttt gggatgctaa cagcagcagt gattggtttc gtgactcagc 60
ggagccgatt gaaaaatgat acagcgattg gaattgtctt tagctccttt tttgcattag 120
ggattatctt gatttcatat gcccagagtg cgacagattt gtatcatatt ttatttggga 180
atgtcttagc tgttagggaa agcgatttgt tgctgacagc actcgttagt ggaatcgtct 240
tgatatttgt ctttttcttt tataaagaat tgaagatcac atcattcgat ccgacaatgg 300
caaaagctta tgggctgaac acatcgctga tccattatct tttgatgttc tttttgacat 360
tagtggctgt agtcagttta cagacagtag gaacaatctt ggtgattgcc atgttgatca 420
caccagccgc cacggcttac ttgctaacga accatttact gaaaatgatc attacagctg 480
caggaatcgg tatgctaagt gcagttgtcg gtgtgttttt cagttatagt tacaattggc 540
catcaggagc tacgatcgtg ttagcatgta ccgcattttt tatccttgct tttttatttt 600
ctccaacaaa aggaatttta tttcagaaag gaagcagata gatgaaaaca aaaaaatcac 660
tctttttaat cttggcagtt agtttcttgg tattagccgg ttgcggaaag caggcttctg 720
accaagcgga tgaaggaagt aaagaaaagt tgtcagtcgt ggctaccaat tcgatcttgg 780
cggacatggc aaaagaggtc ggaacagatc aaatagatat ccacagtatc gtaccagtcg 840
gaacagatcc gcatgaatat gaagtactac cagaagacat caaaaaggca agcgatgcag 900
atgttatttt atacaacggt ttgaatcttg aaacaggtaa cagctggttc gataacttga 960
tggaaacggc taaaaaagaa gaaggaaaag attattttgc agttagcaaa aatgtagaac 1020
ctctttattt aactagcggt gaagaacata caaaagcaga tccccatgct tggctagacc 1080
tatctaacgg aataaaatat gtggaggaaa tcgcacgtat 1120
<210> 84
<211> 1082
<212> DNA
<213> Enterococcus faecium Aus0004
<220>
<221> source
<222> 1..1082
<223> /organism="Enterococcus faecium Aus0004"
/mol_type="unassigned DNA"
<400> 84
ccccagtaac gacatcgact gacggtggtg tttgatcatt tgtatgcccg ttatcgacat 60
ttgcttggtt agaaaatcct ttggttggat ctgctttttc gttcaaatgc atatagtaaa 120
cgaatttcaa tgtaccgcca ggagttaatg aaggaatata attcggatca actgaaaccg 180
tgaatccgtc tgtttgctca gtgacagaat aatttactgg gtcgatttct ttatttccat 240
catataaggc ataagcatac gttcctgaag aatcattatc aaatgttaaa gcagcgtcat 300
gagtatcgat aagtttgaat gttgtgtact tgttttgcgt tccttcttta tcagcgatac 360
ctaatgggat attgacagaa atctcatatt gaattttttc accgattgcg acatcttttc 420
cattcaattg aggtgttgtt ttatcaactt tagacgtatc atttttgatg gtcttttcta 480
ctggtgtttg gctatttgcc aggatctcaa aaggcgtgat tgtttgcttt tcaatcattt 540
ccgcattatc aggagctttt acttcttcta aattatattt tccaacttct aaatgattaa 600
cgatcaactg gcctttttca atagatgcct cggcaaagtc attgttgccg atgtcataag 660
aatgaccagt aatgaaatgt ttggctttgg tttgatcagt tgtccaagtg tacaatccat 720
ctgtgacact ttggatgtat tttttgacgc ttggtgttcc ttcttcttta gaaataataa 780
attctgctcc atttagtgct tcgttttcgg cagtaccgat ttttgtaact ttcaacgttc 840
catcattacc gactgtattt ttagggtaga gatggatagt atctagttct tctgtcccgt 900
atttataaga gccatctgct tgtttgatca tctcatatac agggaaagct aaaaccatgt 960
ttgcggcagc tgacactccg tcttttggtt cttctttgat cgtgtagact gcatctttcc 1020
cattttgttt tttaggtaaa gataaagtga catttccatc agcatctgtc gttcctgaag 1080
ca
1082
<210> 85
<211> 1145
<212> DNA
<213> Enterococcus faecium DO plasmici 3
<22 0>
<221> source
<222> 1. .1145
<223> /organism="Enterococcus faecium DO plasmici 3" /mol_type="unassigned DNA"
<4 00> 85
tgctgctatc tgacgtttgg attgtttgtt ctgtgctatc cgtgctttct tgtctgtctg 60
caaacgtcaa ctgtgtgtag gcagtgaaag aaaaaagagc ggctgcacaa acaaatagcc 120
attttctatt tctcatgttg gttaccctcc tttatttttt ctttttataa acaaatagcg 180
aaccaatgat catgactgaa agaaaaacag tacttcctaa aagccatttc caagataatt 240
tttgtttctt attttcttca tcttttaatt ctgattttgt aaaggttact cgcttcccat 300
acactagaaa acggtgtgtg ttgatcccct taggcgtaca tgtcattagc gttactcgat 360
cttcattggg atttgattct aagtaagtga caaagtttct ttgtagttcg tctttttgca 420
cttcctcaat ccgatcgatt tgataagcgt gctgctcacc atcaactttg atataaaact 480
tttctccctt ttttactgaa ggtaaatcat caaaaagatt atctttataa agtccactat 540
gacctgcgat taaaggattt ttaccgtttc ctcctgtaat atcaccagtt ccttccgtaa 600
tacctacacc attttctaaa attttgtcgg acgttccgtc ataaattggt agttttaaag 660
aaatacttag aattgtaaga ataccaacag gatcgcctaa ctcaatctta gcaacatcca 720
aagaagaatc cgtttctgct gccgttcctg ttcgatcgat tgcggcaatc tgctgatttt 780
gttggtattt cgccacactc gcttcagcag gcatcaaaag taagacacct acagctgaaa 840
gtaaccagaa agcaatgatc catttaccca tgattcgctt tttcttaggc ttcctgataa 900
tcattggttt tgatccttct aggctttctt cttaaagtaa acaactgcag aaagtgcccc 960
tgctcctagc aacaagcaag agattaatac atacgtttga aaaccgttgc taccggtcat 1020
tggtacggaa gctttttgat tgtttttgat cgtgattcgg ttttcttctt tgtatgaatc 1080
tttgtctact ttgaaagaga tctctttcgt taatttttga tagttttcag gcgcttttgt 1140
ttctt
1145
<210> 86
<211> 1090
<212> DNA
<213> Enterococcus faecium Aus0004 plasmiciAUS0004_pl
<220>
<221> source
<222> 1..1090
<223> /organism="Enterococcus faecium Aus0004 plasmici AUS0004_pl "
/mol_type="unassigned DNA"
<400> 86
aacgatttcg tccactttcg cgttggttag atcagaatct tcagtcggta atacttgatc 60
cgtaatattt cctaacgtaa actcaacatc accataatct gccttgttgt atttcgttac 120
acctgtagga tattgatcgt gcgtataacc atcatttttg attccgtcaa tatcaacgtt 180
caattgcgta ctttgatcgt acattaattt atgaaccgtg atattgaccc tttctggtgg 240
cgttttttgc gtgacatctt ctgcataagc tcgatacccc tgaaagcagc ctgcaatgat 300
tcctaacatt ccaacaatca ttccagcttt ttttacatac cgatttattg ccatttttta 360
ctctcctcat ttcatatttc aacgactcgc gttgattaaa ttcttgttat tgtagctctc 420
cctgtaccac gtatctttct tttccttgtg acgtataaac acaagtaaac aacgttaata 480
agggtttctc tcctttcttt ggtaaagaca agaaagagtt ctcttcagga acgccatcga 540
ttaatttaaa gtactcaggt acgataaatt tacgcgttac cttgtaacga tagacgccat 600
cgttactaac taagtccatc acctccccta atgacaactt ttgaatatca gaaaataaaa 660
cacctggcat ttccatgtta tgacctgcta ggacatagtt tcctttaccc atttcggcat 720
cttcataaaa ataagtagcc gctccaagac tcaaagtgta ttgatttgcc cctttaaaaa 780
ttggcaatgc taaaccaagt gcaggaatct gaatttgtgc aaatacttgt ttattgacgc 840
ccatttcgat tgcttctttt tgtatggaca acatttgccc caaagacata tcattattga 900
cgttcgttgc atcctcctta taactctttg cgtgtgcatt gatttgatct acgggcatct 960
ttttttctat attttgctta aacacctctc cttcatgttt ttggtagcta acatagccaa 1020
acacactgca aacgacgatt aaagcgactc ctaaaaaacc aaataaccat tttttcatcc 1080
atctgcctcc
1090
<2 10> 87
<2 11> 865
<2 12> DNA
<213> Enterococcus faecium plasmici pZB18
<22 0>
<221> source
<222> 1..865
<223> /organism="Enterococcus faecium plasmici pZB18" /mol_type="unassigned DNA"
<400> 87
gaggagcatg acgtatcggt aaaatctgca atagagatag ccgctaacat taataaagaa 60
aaatacgagc cgttatacat tggaattacg aaatctggtg tatggaaaat gtgcgaaaaa 120
ccttgcgcgg aatgggaaaa cgacaattgc tattcagctg tactctcgcc ggataaaaaa 180
atgcacggat tacttgttaa aaagaaccat gaatatgaaa tcaaccatgt tgatgtagca 240
ttttcagctt tgcatggcaa gtcaggtgaa gatggatcca tacaaggtct gtttgaattg 300
tccggtatcc cttttgtagg ctgcgatatt caaagctcag caatttgtat ggacaaatcg 360
ttgacataca tcgttgcgaa aaatgctggg atagctactc ccgccttttg ggttattaat 420
aaagatgata ggccggtggc agctacgttt acctatcctg tttttgttaa gccggcgcgt 480
tcaggctcat ccttcggtgt gaaaaaagtc aatagcgcgg acgaattgga ctacgcaatt 540
gaatcggcaa gacaatatga cagcaaaatc ttaattgagc aggctgtttc gggctgtgag 600
gtcggttgtg cggtattggg aaacagtgcc gcgttagttg ttggcgaggt ggaccaaatc 660
aggctgcagt acggaatctt tcgtattcat caggaagtcg agccggaaaa aggctctgaa 720
aacgcagtta taaccgttcc cgcagacctt tcagcagagg agcgaggacg gatacaggaa 780
acggcaaaaa aaatatataa agcgctcggc tgtagaggtc tagcccgtgt ggatatgttt 840
ttacaagata acggccgcat tgtac 865
<2 10> 88
<2 11> 535
<2 12> DNA
<213> Enterococcus faecium plasmici transposon Tnl546
<22 0>
<22 1> source
<222> 1. .535
<223> /organism="Enterococcus faecium plasmid transposon Tnl54 6 "
/mol_type="unassigned DNA"
<4 00> 88
tggcaagtca ggtgaagatg gatccataca aggtctgttt gaattgtccg gtatcccttt 60
tgtaggctgc gatattcaaa gctcagcaat ttgtatggac aaatcgttga catacatcgt 120
tgcgaaaaat gctgggatag ctactcccgc cttttgggtt attaataaag atgataggcc 180
ggtggcagct acgtttacct atcctgtttt tgttaagccg gcgcgttcag gctcatcctt 240
cggtgtgaaa aaagtcaata gcgcggacga attggactac gcaattgaat cggcaagaca 300
atatgacagc aaaatcttaa ttgagcaggc tgtttcgggc tgtgaggtcg gttgtgcggt 360
attgggaaac agtgccgcgt tagttgttgg cgaggtggac caaatcaggc tgcagtacgg 420
aatctttcgt attcatcagg aagtcgagcc ggaaaaaggc tctgaaaacg cagttataac 480
cgttcccgca gacctttcag cagaggagcg aggacggata caggaaacgg caaaa 535
<210> 89
<211> 502
<212> DNA
<213> Enterococcus faecium Aus0004
<220>
<221> source
<222> 1..502
<223> /organism="Enterococcus faecium Aus0004"
/mol_type="unassigned DNA"
<400> 89
tgaaagaaag cgaatacgaa acacggcgta ttgatgtggc tttcccggtt ttgcatggca 60
aatgcgggga ggatggtgcg atacaggggc tgtttgtatt gtctggtatc ccctatgtgg 120
gctgtgatat tcaaagctcc gcagcttgca tggacaaatc actggcctac attcttacaa 180
aaaatgcggg catcgccgtt cccgaatttc aaattattga taaaggtgac aagccggagg 240
cgggtgcgct tacctaccct gtctttgtga agccggcacg gtcaggttcg tcctttggcg 300
taaccaaagt aaacggtacg gaagaactta acgctgcgat agaagcggca ggacaatatg 360
atggaaaaat cttaattgag caagcgattt cgggctgtga ggtcgggtgt gcggtcatgg 420
ggaacgagga tgatttgatt gtcggcgaag tggatcaaat ccggctgagc cacggtatct 480
tccgcatcca tcaggaaaac ga 502
<210> 90
<211> 1450
<212> DNA
<213> Escherichia coli Xuzhou21
<220>
<221> source
<222> 1..1450
<223> /organism="Escherichia coli Xuzhou21"
/mol_type="unassigned DNA"
<400> 90
tgcaagtcga acggtaacag gaagaagctt gcttctttgc tgacgagtgg cggacgggtg 60
agtaatgtct gggaaactgc ctgatggaga gggataacta ctggaaacgg tagctaatac 120
cgcataacgt cgcaagacca aagaggggga ccttcgggcc tcttgccatc ggatgtgccc 180
agatgggatt agctagtagg tggggtaacg gctcacctag gcgacgatcc ctagctggtc 240
tgagaggatg accagccaca ctggaactga gacacggtcc agactcctac gggaggcagc 300
agtggggaat attgcacaat gggcgcaagc ctgatgcagc catgccgcgt gtatgaagaa 360
ggccttcggg ttgtaaagta ctttcagcgg ggaggaaggg agtaaagtta atacctttgc 420
tcattgacgt tacccgcaga agaagcaccg gctaactccg tgccagcagc cgcggtaata 480
cggagggtgc aagcgttaat cggaattact gggcgtaaag cgcacgcagg cggtttgtta 540
agtcagatgt gaaatccccg ggctcaacct gggaactgca tctgatactg gcaagcttga 600
gtctcgtaga ggggggtaga attccaggtg tagcggtgaa atgcgtagag atctggagga 660
ataccggtgg cgaaggcggc cccctggacg aagactgacg ctcaggtgcg aaagcgtggg 720
gagcaaacag gattagatac cctggtagtc cacgccgtaa acgatgtcga cttggaggtt 780
gtgcccttga ggcgtggctt ccggagctaa cgcgttaagt cgaccgcctg gggagtacgg 840
ccgcaaggtt aaaactcaaa tgaattgacg ggggcccgca caagcggtgg agcatgtggt 900
ttaattcgat gcaacgcgaa gaaccttacc tggtcttgac atccacagaa ctttccagag 960
atggattggt gccttcggga actgtgagac aggtgctgca tggctgtcgt cagctcgtgt 1020
tgtgaaatgt tgggttaagt cccgcaacga gcgcaaccct tatcctttgt tgccagcggt 1080
ccggccggga actcaaagga gactgccagt gataaactgg aggaaggtgg ggatgacgtc 1140
aagtcatcat ggcccttacg accagggcta cacacgtgct acaatggcgc atacaaagag 1200
aagcgacctc gcgagagcaa gcggacctca taaagtgcgt cgtagtccgg attggagtct 1260
gcaactcgac tccatgaagt cggaatcgct agtaatcgtg gatcagaatg ccacggtgaa 1320
tacgttcccg ggccttgtac acaccgcccg tcacaccatg ggagtgggtt gcaaaagaag 1380
taggtagctt aaccttcggg agggcgctta ccactttgtg attcatgact ggggtgaagt 1440
cgtaacaagg
1450
<210> 91
<211> 1492
<212> DNA
<213> Escherichia coli W
<220>
<221> source
<222> 1..1492
<223> /organism="Escherichia coli W"
/mol_type="unassigned DNA"
<400> 91
gcactcgggc acgacaacca atttatcgaa ccacttcatt taatgagcgc cctgctgaat 60
caggaagggg gttcggttag tcctttatta acatccgctg gcataaatgc tggccagttg 120
cgcacagata tcaatcaggc attaaatcgt ttaccgcagg ttgaaggtac tggtggtgat 180
gtccagccat cacaggatct ggtgcgcgtt cttaatcttt gcgacaagct ggcgcaaaaa 240
cgtggtgata actttatctc gtcagaactg ttcgttctgg cggcacttga gtctcgcggc 300
acgctggccg acatcctgaa agcagcaggg gcgaccaccg ccaacattac tcaagcgatt 360
gaacaaatgc gtggaggtga aagcgtgaac gatcaaggtg ctgaagacca acgtcaggct 420
ttgaaaaaat ataccatcga ccttaccgaa cgagccgaac agggcaaact cgatccggtg 480
attggtcgtg atgaagaaat tcgccgtacc attcaggtgc tgcaacgtcg tactaaaaat 540
aacccggtac tgattggtga acccggcgtc ggtaaaactg ccatcgttga aggtctggcg 600
cagcgtatta tcaacggcga agtgccggaa ggattgaaag gccgccgcgt actggcgctg 660
gatatgggcg cgctggtggc tggggcgaaa tatcgcggtg agtttgaaga acgtttaaaa 720
ggcgtgctta acgatcttgc caaacaggaa ggcaacgtca tcctgtttat cgacgaatta 780
cataccatgg tcggcgcggg taaagccgat ggcgcaatgg acgccggaaa catgctgaaa 840
ccggcgctgg cgcgtggtga attgcactgc gtaggtgcca cgacgcttga cgaatatcgc 900
cagtacatcg aaaaagatgc tgcgctggaa cgtcgtttcc agaaagtgtt tgttgccgag 960
ccttctgttg aagataccat tgcgattctg cgtggcctga aagaacgtta cgaattgcac 1020
caccatgtgc aaattactga cccggcaatt gttgcagcgg cgacgttgtc tcatcgctac 1080
attgctgacc gtcagctgcc ggataaagcc atcgacctga tcgatgaagc agcatccagc 1140
attcgtatgc agattgactc aaaaccagaa gaactcgacc gactcgatcg tcgtatcatc 1200
cagctcaaac tggaacaaca ggcgttaatg aaagagtctg atgaagccag taaaaaacgc 1260
ctggatatgc tcaacgaaga actgagcgac aaagaacgtc agtactccga gttagaagaa 1320
gagtggaaag cagagaaggc atcgctttct ggtacgcaga ccattaaagc ggaactggaa 1380
caggcgaaaa tcgctattga acaggctcgc cgtgtggggg acctggcgcg gatgtctgaa 1440
ctgcaatacg gcaaaatccc ggaactggaa aagcaactgg aagccgcaac gc 1492
<210> 92
<211> 1454
<212> DNA
<213> Escherichia coli Xuzhou21
<220>
<221> source
<222> 1..1454
<223> /organism="Escherichia coli Xuzhou21"
/mol_type="unassigned DNA"
<400> 92
cgcctggtga aaggcgcgta ctgggatagt gaaatcaagc gcgcgcagat ggacggcctt 60
gaaggttatc cggtttatac ccgcaaggta tataccgacg tttcttatct cgcctgtgcg 120
aaaaagctgc tggcggtgcc gaatctaatc tacccgcagt tcgcaacgca caacgcccac 180
acgctggcgg cgatttatca actggcaggt cagaactact atccgggtca gtacgagttc 240
cagtgcctgc atggtatggg cgagccgctg tatgagcagg tcaccgggaa agttgccgac 300
ggcaaactta accgtccgtg tcgtatttat gccccggtcg gcacacatga aacgctgctg 360
gcgtatctgg tgcgccgcct gctggaaaac ggtgctaaca cctcgtttgt taaccgtatt 420
gccgatacct ctttgccact ggatgaactg gtcgccgatc cggtcactgc tgtagaaaaa 480
ctggcacaac aggaagggca aactggatta ccgcatccga aaattcccct gccgcgcgat 540
ctttacggtc acgggcgcga caactcggca gggctggatc tcgctaacga acaccgtctg 600
gcatccctct cttctgccct gctcaatagt gcactgcaaa aatggcaggc cttgccaatg 660
ctggaacaac cggtagcggc aggtgagatg tcgcccgtta ttaacccggc ggaaccgaaa 720
gatattgtgg gctatgtacg tgaagccacg ccgcgtgaag tagagcaggc gctggaaagt 780
gcggttaata acgcgccaat ctggtttgcc actcctccgg ctgaacgcgc ggcgattttg 840
catcgcgctg ccgtgctgat ggaaagccag atgcagcaac tgattggtat tctggtgcgt 900
gaagccggaa aaaccttcag taacgccatt gccgaagtgc gtgaagcggt cgattttctc 960
cactactacg ccggacaggt gcgggatgat ttcgctaacg aaacccatcg tccattaggg 1020
cctgtggtat gtatcagccc gtggaacttc ccgctggcga ttttcaccgg gcagatcgct 1080
gccgcactgg cggcaggtaa cagcgtactg gcaaaaccgg cagaacaaac gccactgatt 1140
gccgcgcaag ggatcgccat tttgctggaa gcgggcgtac cgccaggcgt ggtgcaattg 1200
ctgccaggtc ggggtgaaac cgtgggcgcg caactgacgg gtgatgatcg cgtacgcggg 1260
gtgatgttta ccggttcaac cgaagtcgct acgttactgc agcgcaatat cgccagccgc 1320
ctcgacgctc agggtcgccc tattccgctc atcgctgaaa ccggcggcat gaacgcgatg 1380
attgtcgatt cttcagcact gaccgaacaa gtcgtaatag atgtgctggc ctcggcgttc 1440
gacagtgcgg gtca 1454
<210> 93
<211> 1192
<212> DNA
<213> Escherichia coli W
<220>
<221> source
<222> 1..1192
<223> /organism="Escherichia coli W"
/mol_type="unassigned DNA"
<400> 93
tggcatcctg cgcatctccg gcttcaaagc ccgtgaagtt gccgaaaccg tgctgggtaa 60
actgcctaag ccgcgctacg ccgattatct tccgtttaaa gacgccgacg gcagcgtgct 120
cgatcagggg attgcgctat ggttccctgg cccgaactcg ttcaccggcg aagatgtgct 180
ggaactgcag ggtcatggcg gtccagtgat cctcgacctg ctgttaaaac gcattctgac 240
cattcccggc ctgcggattg ctcgcccagg tgagttttcc gaacgtgctt ttcttaacga 300
taaactcgac ttagcccagg ccgaggcgat tgcggatctt atcgacgcca gttcggaaca 360
ggcggcccgt tcggcactta actcgctgca aggcgcattc tccgcacggg tcaaccatct 420
ggtggaagcc ctcacccact tgcgcattta cgtcgaagcg gcaattgatt tccctgatga 480
agagatcgat ttcctctccg acggcaaaat tgaagcccag ctcaatgacg tgattgccga 540
tcttgatgca gtgcgtgctg aagcgcgtca gggtagtttg ttgcgcgaag ggatgaaggt 600
ggtgattgcc ggacgtccta acgccggtaa atcgagcctg ttaaacgcgc tggcgggccg 660
tgaagcagca atcgtaactg atatcgccgg aaccacacgt gacgtgctgc gtgagcatat 720
ccacattgac ggaatgccgc tgcatatcat cgataccgct gggctacgtg aagccagtga 780
cgaagtggaa cgtattggta tcgagcgcgc gtggcaggaa attgaacagg ccgaccgcgt 840
gctgtttatg gtcgatggca ccacaacaga cgccgtggat ccggcagaga tctggccgga 900
atttatcgcc cgtctgccag cgaaactgcc gatcaccgtg gtgcgcaata aagccgatat 960
caccggcgaa acgctgggaa tgagtgaagt gaacggtcac gcgttaattc gtctctcggc 1020
aaggacaggt gaaggcgtgg aggtgctgcg taaccatctc aaacagagca tgggctttga 1080
caccaacatg gaaggcggct tcctggcgcg tcgtcgccac ctacaggcgc tggaacaggc 1140
agcggaacat ctacaacagg gcaaagcgca actgttggga gcctgggcag gt 1192
<210> 94
<211> 1588
<212> DNA
<213> Escherichia coli Xuzhou21
<220>
<221> source
<222> 1..1588
<223> /organism="Escherichia coli Xuzhou21"
/mol_type="unassigned DNA"
<400> 94
cggtggcgac ggcgattgat acccaccttg tgtcgaatga cttcagcgca ttaaggccac 60
aaattaccga attaatgatg tcggcagata tcgttcgtgt agacctgctc catggtgata 120
agcaggttta taccctggcc agaaatggta gttatcgtcc ggttggcacc agcgatctgt 180
ttcgtgaact gagcgttccg ttgataaagc atccggggat gtcgttgcgt ctggtttatc 240
aggatccgat gggcaactat ttccattcgt tgatgaccac cgcgccgctc acaggggcga 300
ttggctttat cattcttatg ctctttctgg cggtacgctg gttacaacgg caacttgccg 360
ggcaagaatt gctggaaacc cgggctactc gtatcttaaa cggtgagcgt ggctctaatg 420
tgttgggaac catctatgaa tggccgccca gaaccagcag tgcgctggat acgctgcttc 480
gtgaaattca gaacgcacgc gaacaacaca gccgtcttga tacgctgatc cgctcttatg 540
ccgcacagga cgtgaaaacc ggcctcaata accgactctt tttcgataat cagttagcaa 600
cgttactgga agatcaggag aaagtaggta cccacgggat cgtgatgatg attcgtctgc 660
cggatttcaa tatgttgagc gatacctggg ggcacagcca ggttgaagaa cagttcttca 720
ctctgacgaa tctgctgtcg acatttatga tgcgctaccc tggcgcactg ctggcgcgtt 780
accaccgcag tgattttgct gcgctgttac cgcaccggac gttaaaagag gcagagagca 840
tcgccggtca gttaatcaaa gccgtcgata ccttgccgaa caataaaatg ctcgatcgcg 900
acgatatgat ccacattggt atctgcgcct ggcgtagtgg tcaggatacc gagcaggtaa 960
tggaacatgc agagtctgcc acgcgtaatg cgggattgca gggcggcaat agctgggcta 1020
tttacgatga ctcgttgcct gaaaaaggac gcggtaatgt tcgctggcgt acgcttatcg 1080
agcaaatgct cagtcgcggc ggcccgcgcc tttatcaaaa accggcggtt actcgcgaag 1140
gtcaggttca tcatcgcgaa ctcatgtgcc gcatctttga tggtaatgaa gaggttagct 1200
cggcggagta tatgccgatg gtcttgcagt ttggcttatc ggaagagtat gaccgtctgc 1260
aaatcagccg tcttattcca ctattgcgtt actggccaga ggaaaatctg gcgattcagg 1320
ttaccgttga gtcgctgatt cgcccgcgtt ttcagcgttg gctgcgcgat acgttaatgc 1380
aatgtgaaaa atcacaacga aaacgcataa ttattgaact tgcagaggcc gatgtaggtc 1440
aacatatcag tcgtttacaa cctgttattc gtttagtgaa tgctttaggg gtacgggtag 1500
ccgtcaacca ggctggtttg acgctggtaa gcaccagttg gatcaaagaa cttaatgttg 1560
agttactcaa gctccatccg gggctggt 1588
<210> 95
<211> 1434
<212> DNA
<213> Escherichia coli Xuzhou21
<220>
<221> source
<222> 1..1434
<223> /organism="Escherichia coli Xuzhou21"
/mol_type="unassigned DNA"
<400> 95
ttacagataa ccagcgatcc gttattggca atattgtttc agtagtgagt agtgttctgc 60
ctgaatacgg taacggtaaa ctggacgccc cgtgacgcca taatggatac tggtgaacaa 120
gatgtggcag ttgaccagcc agataaggta tttacggcag gaaacacgcg aaatgttaac 180
ctcgttggct agctcgtcgg ttgaaaactc atagtcctga tgcgcgtcaa tccactggca 240
cagtgtgcgt aacgtctgcg gcgttaagcc ttttggcaag cgacgaggat cctgctcgtt 300
ggagctgctg ccgtggatta gctgatcaag ctcggcctgg tcataatact gatgtttttc 360
cagcgccatt ttcttttgcc gccagccggt gagcgcctct tcaaagcggg aagcctggaa 420
gggtttgatc aggtaatcca cgacaccgta atgcagcgaa tctttaatgg ttgccgcatc 480
ggctgcggag gagatgacaa tcacatcact tttgcaacgc gcgttatgca ggacaggcag 540
taaatcgagc ccgttctctt tttgcatata gatatcgagc aatatcaggt cgataggcgt 600
atcgctattg aagataatct ctttggcttt ctccagcgtc gaggctgttc cacagcattg 660
aaagcctggg atttgtgcta cgtatcggcg attcagctcc gcgaccattg cgtcgtcatc 720
gataattaat acattgatca tctgttcgac ctctccccgt cccagggtat ctggacaaaa 780
aattgtgtga aaatcccggg ttccgattcc acggcgatgc tgccgccgag attttctacc 840
tgttgtttga caagtgctaa accgacgcct cgctcgcttc cttttgtcga gacacctttg 900
tcaaaaatgt gatcgatttt gtcgggtgcg atccccggtc catcatcgtt aacttcgcag 960
tgcagccagc cgtgacggta gtgcaatgtt acgctaattt cgccaccggg ttccggccct 1020
aatgcttcca gcgcgttttc tatcagattt cccaatgtgg taatcagcgt cgcgacctgg 1080
tcctcactgc cgctgtctgg cagctggctt tcactgttta aaatcagcgt atggcctaaa 1140
tcggtcgcgc ggttaatctt gctgattaaa aaaccagcga taaccggaga tttgatctta 1200
cccagcagag agccaatctc ttcctgatag ttattggctg ttttgagaat gtaatcttcc 1260
aactgcttat aactcttcag atgcaataat ccgagaatca catgcaattt attcataaat 1320
tcgtgggatc gttcacgaag tgcatcagca tagttgacca gaccgtcgag tcgctgcatc 1380
agtttacgaa cttcagtttt gtccctgaag gttgaaatgg caccgatgat aacg 1434
<210> 96
<211> 1406
<212> DNA
<213> Escherichia coli Xuzhou21
<220>
<221> source
<222> 1..1406
<223> /organism="Escherichia coli Xuzhou21"
/mol_type="unassigned DNA"
<400> 96
ggatagcaaa ggagataacg atgggtaaaa cccagccctt gccaatatta attactggcg 60
gaggtcgtcg catcggcctc gccctcgcat ggcatttcat taatcaaaag caaccggtga 120
ttgtcagcta tcggacacac tatccagcca ttgatggact gattaatgca ggtgcgcagt 180
gtattcaggc tgatttttcg accaacgacg gtgtgatggc gtttgccgat gaagtactaa 240
aaagcaccca tggtctgcgt gctattttgc ataacgccag tgcgtggatg gcggaaaaac 300
cgggtgcgcc actggccgac gtactggctt gcatgatgca gatccacgtt aataccccat 360
acctgctcaa ccatgcgctg gaaagattac tgcgtgggca cggacacgcc gccagcgata 420
tcattcactt taccgattat gtggtggagc gcggtagcga caaacatatt gcgtatgctg 480
caagcaaagc ggcactggat aatatgaccc gctcgtttgc ccgcaagctg gcaccggaag 540
tgaaagtgaa ttctattgcg ccatcgctga tcctgtttaa tgaacatgat gatgccgaat 600
atcgacaaca ggcgctgaat aaatcattga tgaaaaccgc gcctggcgag aaagaagtga 660
tcgacctggt cgattactta cttaccagtt gctttgtcac cggacgcagt ttcccacttg 720
atggcggtcg tcatctgcgt taatgcagct ttatccagca tataatcaac acccatgcgc 780
ttatccccca acacgcaaca gaaccaacaa aagcggcggg caagcgcatc attccggtga 840
aataccacag cgacaccagg taaacaaaat agggaataat cgaccacata ctaaaaatga 900
tggttgcgcg taaggcttca atgccgcgtt cgctggcaac aatataatgc gcgataagcg 960
caaaggtcgg gaaaagtgga atcagcccgg cgatataata atttttcgtt tttgctaaaa 1020
caccaatcaa cagcactacc agcgcaccga gcgcggcttt gattaccagc cccatctttt 1080
taccttaaca cttccataac aagtcatcag tagaatacct gatgaaaact tgtttagaaa 1140
cgattgatag taagtaaaaa cagcgcggtg tattgtgacg tttttatatc taccgtgaat 1200
gttatgaaca ctatcgtatt tgtggaagat gatgcggaag tcggttcact gattgccgcg 1260
tacctggcaa aacatgatat acaggttacc gtagagccgc gcggcgacca ggccgaagaa 1320
accattttgc gagaaaatcc ggatttggtg ttactcgaca tcatgctacc aggcaaggac 1380
ggcatgacca tttgtcgtga tttacg 1406
<210> 97
<211> 1407
<212> DNA
<213> Escherichia coli Xuzhou21
<220>
<221> source
<222> 1..1407
<223> /organism="Escherichia coli Xuzhou21"
/mol_type="unassigned DNA"
<400> 97
ttgaaacgtg catagccgta ccaggcttcg tcaaagtgca gacgatcgga ggttttttcc 60
agcagatcct gcgcttcttt agcgttataa cacacgccgt cataggtgca gttggtcacc 120
acgcagtaag acggtttttg cccggctttg tctttagtca gcgggctttc actgattttc 180
ttctgcaagg tttcaggttg catttcctgc ggatagattg gcccgataat gccgtagcgg 240
ttgcggcttg gcaccatgta gaccggtttc gcgcctgtca gcatcaaacc ttgttcgatg 300
gatttatggc agttacggtc aacgaccacg acatcgttat cggtcatgca agcctgcatg 360
atggtgcggt tagagccgga agtaccgacg actaccgacc aggagcgatc ggcaccaaat 420
acgcgtgcgg catatttttc gctttcgcca aatgcgccag tatggtcaag caaagaaccg 480
agggaagttc gttcgatgcc catgtcggtg cggaacagat tttcaccgta gtagtcatgg 540
tagaaacgtc cggcgggtgt tttggtaaaa ccaacgccgc cctggtggcc tggcgctgcc 600
caggaatatt catggatgtc gctatatttc atcagcgcgc tgaacagtgg cggcaacagc 660
tgctggcggt agcgggtcat cgcggcaacg gcgcgtccgg cgataaagtc ggcggtatct 720
tccagaatcc aggcgaattc atcgacaagc tccagcagat cccggtccat tgcggcgagg 780
gctttttccc gatcgcccaa caggaagacc ggcacgtttt gttggcgctc atgaagctta 840
ccgatcaatt gtctgacgtt ttgatgttcg tccggatgtt ccatttgata gctgaacatc 900
aggcagtcaa tggcttcgtt tgaagagaga atggcaaaac catcatcaaa ggaggtggat 960
ttaatcacgg taacattttg ctggcttaaa gcatctgcca gacgctcaac agcgttaccg 1020
acccaggtgt cttgatggag aaactcgctt tcaacaatta atactttcat cattgcttac 1080
ccggttatga aggaatcttc gttgcgggca agtatcttcc ggccttttcg ggctgtaaag 1140
cgcgtgaaaa acaaacattt ttgaaatatt tgtttttata aacaatatgt tatgtgatta 1200
ttttaaatta ttttcactgc ttattatcga cggctaaact atttttttgg ctgatactga 1260
tatcgtcttt agccgggaaa cgtctggcgg cgctgttggc taagtttgcg gtattgttgc 1320
ggcgacatgc cgacatattt gccgaacgtg ctgtaaaaac gactacttga acgaaagcct 1380
gccgtcaggg caatatcgag aatactt 1407
<210> 98
<211> 1555
<212> DNA
<213> Human adenovirus 19
<220>
<221> source
<222> 1..1555
<223> /organism="Human adenovirus 19"
/mol_type="unassigned DNA"
<400> 98
ctcctctatc tcgcctggtg tacacagtta agaaggatta taaagaggaa tttgaaaatc 60
tttttgctga ctgctctggc ctgctagatt ctctgaatct tggccaccag tcccttttcc 120
aggaaagggt actccacagc cttgattttt ccagcccagg gcgcactaca gccggggttg 180
cttttgtggt ttttctggtt gacaaatgga gccaggacac ccaactgagc aggggctaca 240
tcctggactt cgcagccatg cacctgtgga gggcctggat caggcagcgg ggacagagaa 300
tcttgaacta ctggcttcta cagccagcag ctccgggtct tcttcgtcta cacagacaaa 360
catccatgtt ggaggaagaa atgaggcagg ccatggacga gaacccgagg agcggcctgg 420
accctccgtc ggaagaggag ctggattgaa tcaggtatcc agcctgtacc cagagcttag 480
caaggtgctg acatccatgg ccaggggagt gaagagggag aggagcgatg ggggtaatac 540
cgggatgatg accgagctga cggccagcct gatgaatcgg aagcgcccag agcgccttac 600
ctggtacgag ctacagcagg agtgcaggga tgagttgggc ctgatgcagg ataaatatgg 660
tctggagcag ataaaaaccc attggttgaa cccagatgag gattgggagg aggctattaa 720
gaagtatgcc aagatagccc tgcgcccaga ttgcaagtac atagtgacca agaccgtgaa 780
tatcagacat gcctgctaca tctcggggaa cggggcagag gtggtcatcg ataccctgga 840
caaggccgcc ttcaggtgtt gcatgatggg aatgagagca ggagtgatga atatgaattc 900
catgatcttc atgaacatga agttcaatgg agagaagttt aatggggtgc tgttcatggc 960
caacagccac atgaccctgc atggctgcag tttcttcggc ttcaacaata tgtgcgcaga 1020
ggtctggggc gcttccaaga tcaggggatg taagttttat ggctgctgga tgggcgtggt 1080
cggaagaccc aagagcgaga tgtctgtgaa gcagtgtgtg tttgagaaat gctacctggg 1140
agtctctacc gagggcaatg ctagagtgag acactgctct tccctggaga cgggctgctt 1200
ctgcctggtg aagggcacag cctctctgaa gcataatatg gtgaagggct gcacggatga 1260
gcgcatgtac aacatgctga cctgcgattc aggggtctgc catatcctga agaacatcca 1320
tgtgacctcc caccccagaa agaagtggcc agtgtttgag aataacctgc tgatcaagtg 1380
ccatatgcac ctgggagcca gaaggggcac cttccagccg taccagtgca actttagcca 1440
gaccaagctg ctgttggaga acgatgcctt ctccagggtg aacctaaacg gcatctttga 1500
catggatgtc tcggtgtaca agatcctgag atacgatgag accaagtcca gggtg 1555
<210> 99
<211> 1597
<212> DNA
<213> Human adenovirus 14 strain HAdV14-BJ430/CHN2010
<220>
<221> source
<222> 1..1597
<223> /organism="Human adenovirus 14 strain HAdV14-BJ430/CHN2010"
/mol_type="unassigned DNA"
<400> 99
agaaaatggc atggatgagc atcacagcgt tctggtggaa ttggagggcg ataatgccag 60
actcgcagta ctcaagcgaa gcgtcgaggt cacacacttt gcataccccg ctgtcaacct 120
gccccctaaa gtcatgacgg cggtcatgga ccagttactc attaagcgcg caagtcccct 180
ttcagaagac atgcatgacc cagacgcctg tgatgagggt aaaccagtgg tcagtgatga 240
gcagctaacc cgatggctgg gcaccgactc tccccgggat ttggaagagc gtcgcaagct 300
tatgatggcc gtagtgctgg ttaccgtaga actagagtgt ctccggcgtt tctttaccga 360
ttcagaaacc ttgcgcaaac tcgaagagaa tctgcactac acttttagac acggctttgt 420
gcggcaggcg tgcaagatat ctaacgtgga actcaccaac ctggtttcct acatgggtat 480
tctgcatgag aatcgtctag gacaaagcgt gctgcacagc acccttaagg gggaagcccg 540
ccgtgattac atccgcgatt gtgtctatct ctacctgtgc cacacgtggc aaaccggcat 600
gggtgtatgg cagcaatgtt tagaagaaca gaacttgaaa gagcttaaca agctcttaca 660
gaaatctctt aaggttctgt ggacagggtt cgacgagcgc accgtcgctt ccgacctggc 720
agacctcatc ttcccagagc gtcttagggt tactttgcga aacggactgc ctgactttat 780
gagccagagc atgcttaaca attttcgctc tttcatcctg gaacgctccg gtatcctgcc 840
cgccacctgc tgcgcactgc cctccgactt tgtgcctctc acctaccgcg agtgcccccc 900
gccgctatgg agtcactgct acctattccg tctggccaac tacctctcct accactcgga 960
tgtgatcgag gatgtgagcg gagacggctt gctggagtgt cactgccgct gcaatctgtg 1020
cacgccccac cggtccctag cttgcaaccc ccagttgatg agcgaaaccc agataatagg 1080
cacctttgaa ctgcaaggcc ccagcagcca aggcgatggg tcttctcctg ggcaaagttt 1140
aaaactgacc ccgggactgt ggacctctgc ctacttgcgc aagtttgccc cggaagatta 1200
ccacccctat gaaatcaagt tctatgagga ccaatcacag cctccaaagg ccgaactttc 1260
ggcctgcgtc atcacccagg gggcaatttt agcccaattg caagccatcc aaaaatcccg 1320
ccaagaattt ctactgaaaa agggtaaggg ggtctacctt gacccccaga ccggcgagga 1380
actcaacaca aggttccctc aggatgtccc aacgacgaga aagcaagaag ttgaaggtgc 1440
agccgccgcc cccagaagat atggaggaag attgggacag tcaggcagag gaagcggagg 1500
aggacagtct ggaggacagt ctggaggaag acagtttgga ggaggaaaac gaggaggcag 1560
aggaggtgga agaagtaacc gccgacaaac agttatc 1597
<210> 100
<211> 1574
<212> DNA
<213> Human adenovirus B strain ColoAdl
<220>
<221> source
<222> 1..1574
<223> /organism="Human adenovirus B strain ColoAdl" /mol_type="unassigned DNA"
<400> 100
gactctctgg gcgacagaac cagatacttt agcatgtgga atcaggctgt ggacagttat 60
gatcctgatg tacgtgttat tgaaaatcat ggtgtggaag atgaacttcc caactactgt 120
tttccactgg acggcatagg tgttccaaca accagttaca aatcaatagt tccaaatgga 180
gacaatgcgc ctaattggaa ggaacctgaa gtaaatggaa caagtgagat cggacagggt 240
aatttgtttg ccatggaaat taaccttcaa gccaatctat ggcgaagttt cctttattcc 300
aatgtggctc tatatctccc agactcgtac aaatacaccc cgtccaatgt cactcttcca 360
gaaaacaaaa acacctacga ctacatgaac gggcgggtgg tgccgccatc tctagtagac 420
acctatgtga acattggtgc caggtggtct ctggatgcca tggacaatgt caacccattc 480
aaccaccacc gtaacgctgg cttgcgttac cgatccatgc ttctgggtaa cggacgttat 540
gtgcctttcc acatacaagt gcctcaaaaa ttcttcgctg ttaaaaacct gctgcttctc 600
ccaggctcct acacttatga gtggaacttt aggaaggatg tgaacatggt tctacagagt 660
tccctcggta acgacctgcg ggtagatggc gccagcatca gtttcacgag catcaacctc 720
tatgctactt ttttccccat ggctcacaac accgcttcca cccttgaagc catgctgcgg 780
aatgacacca atgatcagtc attcaacgac tacctatctg cagctaacat gctctacccc 840
attcctgcca atgcaaccaa tattcccatt tccattcctt ctcgcaactg ggcggctttc 900
agaggctggt catttaccag actgaaaacc aaagaaactc cctctttggg gtctggattt 960
gacccctact ttgtctattc tggttctatt ccctacctgg atggtacctt ctacctgaac 1020
cacactttta agaaggtttc catcatgttt gactcttcag tgagctggcc tggaaatgac 1080
aggttactat ctcctaacga atttgaaata aagcgcactg tggatggcga aggctacaac 1140
gtagcccaat gcaacatgac caaagactgg ttcttggtac agatgctcgc caactacaac 1200
atcggctatc agggcttcta cattccagaa ggatacaaag atcgcatgta ttcatttttc 1260
agaaacttcc agcccatgag caggcaggtg gttgatgagg tcaattacaa agacttcaag 1320
gccgtcgcca taccctacca acacaacaac tctggctttg tgggttacat ggctccgacc 1380
atgcgccaag gtcaacccta tcccgctaac tatccctatc cactcattgg aacaactgcc 1440
gtaaatagtg ttacgcagaa aaagttcttg tgtgacagaa ccatgtggcg cataccgttc 1500
tcgagcaact tcatgtctat gggggccctt acagacttgg gacagaatat gctctatgcc 1560
aactcagctc atgc 1574
<210> 101
<211> 1466
<212> DNA
<213> Human adenovirus type 2
<220>
<221> source
<222> 1..1466
<223> /organism="Human adenovirus type 2"
/mol_type="unassigned DNA"
<400> 101
cctgattcgg gagtttacca agcgccccct gctagtggag cgggagcggg gtccctgtgt 60
tctgaccgtg gtttgcaact gtcctaaccc tggattacat caagatcttt gttgtcatct 120
ctgtgctgag tataataaat acagaaatta gaatctactg gggctcctgt cgccatcctg 180
tgaacgccac cgtttttacc cacccaaagc agaccaaagc aaacctcacc tccggtttgc 240
acaagcgggc caataagtac cttacctggt actttaacgg ctcttcattt gtaatttaca 300
acagtttcca gcgagacgaa gtaagtttgc cacacaacct tctcggcttc aactacaccg 360
tcaagaaaaa caccaccacc accaccctcc tcacctgccg ggaacgtacg agtgcgtcac 420
cggttgctgc gcccacacct acagcctgag cgtaaccaga cattactccc atttttccaa 480
aacaggaggt gagctcaact cccggaactc aggtcaaaaa agcattttgc ggggtgctgg 540
gattttttaa ttaagtatat gagcaattca agtaactcta caagcttgtc taatttttct 600
ggaattgggg tcggggttat ccttactctt gtaattctgt ttattcttat actagcactt 660
ctgtgcctta gggttgccgc ctgctgcacg cacgtttgta cctattgtca gctttttaaa 720
cgctgggggc aacatccaag atgaggtaca tgattttagg cttgctcgcc cttgcggcag 780
tctgcagcgc tgccaaaaag gttgagttta aggaaccagc ttgcaatgtt acatttaaat 840
cagaagctaa tgaatgcact actcttataa aatgcaccac agaacatgaa aagcttatta 900
ttcgccacaa agacaaaatt ggcaagtatg ctgtatatgc tatttggcag ccaggtgaca 960
ctaacgacta taatgtcaca gtcttccaag gtgaaaatcg taaaactttt atgtataaat 1020
ttccatttta tgaaatgtgc gatattacca tgtacatgag caaacagtac aagttgtggc 1080
ccccacaaaa gtgtttagag aacactggca ccttttgttc caccgctctg cttattacag 1140
cgcttgcttt ggtatgtacc ttactttatc tcaaatacaa aagcagacgc agttttattg 1200
atgaaaagaa aatgccttga ttttccgctt gcttgtattc ccctggacaa tttactctat 1260
gtgggatatg ctccaggcgg gcaagattat acccacaacc ttcaaatcaa actttcctgg 1320
acgttagcgc ctgatttctg ccagcgcctg cactgcaaat ttgatcaaac ccagcttcag 1380
cttgcctgct ccagagatga ccggctcaac catcgcgccc acaacggact atcgcaacac 1440
cactgctacc ggactaacat ctgccc 1466
<210> 102
<211> 1460
<212> DNA
<213> Klebsiella pneumoniae strain HUB-IV-033
<220>
<221> source
<222> 1..1460
<223> /organism="Klebsiella pneumoniae strain HUB-IV-033"
/mol_type="unassigned DNA"
<400> 102
atcatggctc agattgaacg ctggcggcag gcctaacaca tgcaagtcga gcggtagcac 60
agagagcttg ctctcgggtg acgagcggcg gacgggtgag taatgtctgg gaaactgcct 120
gatggagggg gataactact ggaaacggta gctaataccg cataacgtcg caagaccaaa 180
gtgggggacc ttcgggcctc atgccatcag atgtgcccag atgggattag ctggtaggtg 240
gggtaacggc tcacctaggc gacgatccct agctggtctg agaggatgac cagccacact 300
ggaactgaga cacggtccag actcctacgg gaggcagcag tggggaatat tgcacaatgg 360
gcgcaagcct gatgcagcca tgccgcgtgt gtgaagaagg ccttcgggtt gtaaagcact 420
ttcagcgggg aggaaggcga tgaggttaat aacctcatcg attgacgtta cccgcagaag 480
aagcaccggc taactccgtg ccagcagccg cggtaatacg gagggtgcaa gcgttaatcg 540
gaattactgg gcgtaaagcg cacgcaggcg gtctgtcaag tcggatgtga aatccccggg 600
ctcaacctgg gaactgcatt cgaaactggc aggctagagt cttgtagagg ggggtagaat 660
tccaggtgta gcggtgaaat gcgtagagat ctggaggaat accggtggcg aaggcggccc 720
cctggacaaa gactgacgct caggtgcgaa agcgtgggga gcaaacagga ttagataccc 780
tggtagtcca cgctgtaaac gatgtcgatt tggaggttgt gctcttgagg cgtggcttcc 840
ggagctaacg cgttaaatcg accgcctggg gagtacggcc gcaaggttaa aactcaaatg 900
aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgatgc aacgcgaaga 960
accttacctg gtcttgacat ccacagaact ttccagagat ggattggtgc cttcgggaac 1020
tgtgagacag gtgctgcatg gctgtcgtca gctcgtgttg tgaaatgttg ggttaagtcc 1080
cgcaacgagc gcaaccctta tcctttgttg ccagcggtta ggccgggaac tcaaaggaga 1140
ctgccagtga taaactggag gaaggtgggg atgacgtcaa gtcatcatgg cccttacgac 1200
cagggctaca cacgtgctac aatggcatat acaaagagaa gcgacctcgc gagagcaagc 1260
ggacctcata aagtatgtcg tagtccggat tggagtctgc agctcgactc catgaagtcg 1320
gaatcgctag taatcgtaga tcagaatgct acggtgaata cgttcccggg ccttgtacac 1380
accgcccgtc acaccatggg agtgggttgc aaaagaagta ggtagcttaa ccttcgggag 1440
ggcgcttacc actttgtgat 1460
<210> 103
<211> 1202
<212> DNA
<213> Klebsiella pneumoniae KCTC 2242
<220>
<221> source
<222> 1..1202
<223> /organism="Klebsiella pneumoniae KCTC 2242"
/mol_type="unassigned DNA"
<400> 103
cttgctccag cgcaaaacgc aaaaatagaa cgccgtgaaa tacggcgggc ggattacgga 60
ctttcatcca ttggtcatat gggcttcttt cgtacccgga atgcggagaa attatggccc 120
ctcgtcgcac aatggctgga gagacattgc ccggataaga ggcggacgac ctgagcaata 180
tttcaggaga cgccgcttcc ggcgcctcct gttcttcacc tcgcggctac tcctcgtacg 240
ccgcgtgatg gaaatcaatt tcccactgca gcacctcgcc gtaaagcgcc gataacgcct 300
gcttttcgtc ttcactcagc gccatggcgc agcggtcgag ttcgtttttt agccagagag 360
cctgctgata aaattcgtcc tccgcgtgca tttccaccca gcgtcgtaaa tcagcatcgc 420
tctgataatg ttcgctcgcc cgtcggcacc agaaatagta catccattcc gcaccgaaca 480
tcagggtcac gatctgctca tagctgccct cgcgggcggt ccgcagcata ccgtcgcgaa 540
agcgccgtac cccgggcaaa tcatccgggt actcagcggg atcgatctgc cgcgctgaca 600
acacctgttc aaaccacgcg atctgtatat caaccagggc attcagcacg ccaatcagcc 660
agcgctgctg ttgaataccc ggcgctttgc tgaccccgag ggcaaaaatc gcgattgccg 720
tcgcgacaaa gttgccctca aacaccagat agcggttgaa gacgactgtc ggcagacgat 780
cctgttcgat atcagtcaca aacgggtgct gctgcatcgc ctgccacgct ggttgatgtt 840
cgcgcagcag gcgttcgcta aacgcttcca ttaagcttcc tccagcgcgg cctgcgcgac 900
cgacataaaa tgtttcaccc gggccagctc aacatcgttc caccagacgc catcgacctt 960
cattgtactg gccacaatga ccccctgagt ccgcccgagg atctgcttca cgttagccgg 1020
tgtcaccccg gagcccacca ggagcggtag ttccgtcgcc gcgcggatct cgtcaatttc 1080
cgccatcgtg gcgctatcgc ccgtacgctg gccggtggcg atcaccgcgt cagcctcgaa 1140
gaaatcgaca tcgcgcgtca gttcctgaat cgaacgatcg gcgacaatgg catggctacc 1200
gt
1202
<2 10> 104
<2 11> 1223
<2 12> DNA
<213> Klebsiella pneumoniae subsp. pneumoniae HS11286
<22 0>
<22 1> source
<222> 1 ..1223
<223> /organism= "Klebsiella pneumoniae subsp . pneumoniae HS 11286"
/mol_type="unassigned DNA"
<4 00> 104
tgcgccccta caaagcattt ttcccacaaa tcggtcttcg cgtcatgatt gacgcatcca 60
gcgtcgtcat cggcgatgtc agaattgccg atgacgtcag cgtctggcct ctggtggcca 120
ttcgcggcga cgtcaactat gtatcgatag gtcaacgcag caatattcag gacggtagcg 180
ttctccatgt gacccataag tcctcttata agccggaggg aaatccgctg atcattggtg 240
aggatgtaac tgttggtcat aaagtgatgc tgcacggctg cactatcggc aaccgcgtac 300
tggttggcat gggttcgatc ttattagatg gtgtcgtcgt tggcgacgac gtcatgatag 360
gtgcgggaag tctggtaccg cagaacaaac agctggaaag cggctacctt tactttggca 420
atccggtcaa acagatccgc cccctgacag aggcggaacg ggaaggactc aagtattcag 480
caaataacta tgtgaaatgg aaaaatgagt acctggatca ggataaccag atccagccct 540
gagcatcttc ctgaccatcg cggatcaatg cttctgcctc ttcctctaga tcccaacgat 600
gttcctggaa ggcggccagc cactgcgctg gcccctctgc accgaaacgc tgctgcagga 660
tttgccctga aattgcgcag gttaattgca tcccattcac cagcgcggga aaaaccacgc 720
cctgccgttc ggcatcccat gattcccggt caggaaactg aatcgcctga ttcatgcatt 780
cagttcctgc tgcagcgttt caatgaccgg agcgatagcc ggcagaacgc cgtgccatag 840
cagaacagca tgggcggctt gcgccaccag cattcccagc ccatcggcac agtgaactgc 900
gccatattgc tggcaccagt gaagaaacgg tgtcggccct ttctggtaaa acatgtcata 960
gcaatatacg tcagcgttga caatagatgc cgggatagct ggtacatcac cgtctattcc 1020
actggacgtc gcattgacga tcagatcgaa tgtttccccg gataaggtat ccatctccct 1080
tgcgctaacg ctcccggtat gggcgaagag agtggctaac tcacgggcac gagaataggt 1140
gcgattcacg atcgtgacgg cgcatcccag cgacagaagc ggcaaaagaa caccgcgaga 1200
tgccccacca gcaccaacaa gca 1223
<210> 105
<211> 1568
<212> DNA
<213> Proteus mirabilis strain HI4320
<220>
<221> source
<222> 1..1568
<223> /organism="Proteus mirabilis strain HI4320" /mol_type="unassigned DNA"
<400> 105
tcaggctgat atctgggtcc gttaccaacg aatgcgcggc aaagaagttc atttcatctg 60
cgctgatgat gctcacggca cgcctattat gctgaaagct caacaattgg gtattacccc 120
agaagccatg attgaagaga tgagcaaaga gcatcaacag gattttgccg gttttaatat 180
cagctacgat aattatcact ccacacacag tgaagaaaat cgtcaattat cgacgaaaat 240
ttatctagcc ctgaaaaaaa atggtcatat taaaagtaaa acgatttctc aactttatga 300
tgaagaaaaa ggcatgttct tgcctgatcg ttttgttaaa gggacttgcc ctaagtgtaa 360
agcgcccgat caatatggtg ataactgtga agtatgtggg tcaacttata gcccgacaga 420
attaattaat cctcgctctg tggtatcggg ttcaacgccg gtaatgcgtg aaaccgaaca 480
ctatttcttt gatctcccag cctttagcaa tatgttgcaa gagtggatcc gctccggtgc 540
attgcaagag caagtagcca ataagatgca agagtggttt gacagcggtc tgcaacagtg 600
ggatatcacc cgtgacgccc cttatttcgg ttttgaaatc cctgatgcgc cgggtaaata 660
tttctatgtt tggttagacg cccctattgg ttatatgggc tcattcttaa acctatgtga 720
aaagcgtggt gatttaagct ttgatgagtt ctggaacaaa gagagcaaaa ctgacttata 780
ccattttatc ggtaaagata tcgtttattt ccacagctta ttctggccgg cagtgttaga 840
aggtagtgaa taccgtaaac caaccaacct atttgtgcat ggctatgtca ccgtcaatgg 900
tgcgaagatg tcaaaatctc gcggcacctt tattacggca cgagcctatc ttgatcactt 960
tgatgctgat tgcctacgct attactatgc agcaaaactt tcatcacgta ttgatgatat 1020
tgacctaaac ttagaagact ttgtacagcg tgtaaacagc gatatcgtca acaaggtggt 1080
taacctcgcg tcccgtactg cgggttttat cagtaaacgc tttgatggca aattagcggc 1140
aaaccttgat gatgcgaagt tatatcaaca tttcgtcgat atgcaagaaa gcatcgcaca 1200
atgttttgaa aaccgtgaat ttggtaaagc cattcgtgaa attatggcat tagcagacga 1260
agctaaccgc tatattgatg aaaaagcgcc ttgggtggtt gctaaacaag aaggtaaaga 1320
ggctgagttg caagctattt gtactatggg aattaactta ttccgtgtac tgatgactta 1380
tttaaaacca attctacctt ctttaacaga acgttcagaa gccttcttac aaactgaatt 1440
aacttggaat gctctgtcgc aaccgctgtt aaaccatgaa attactaaat ttaaagcatt 1500
gtttaatcgt attgaaatgg ataaagccaa tgcaatggta gaagcttcaa aaagtaccat 1560
tgcgccag
1568
<2 10> 106
<2 11> 1536
<2 12> DNA
<213> Proteus mirabilis strain HI4320
<22 0>
<221> source
<222> 1. .1536
<223> /organism="Proteus mirabilis strain HI4320"
/mol_type="unassigned DNA"
<4 00> 106
tcttcatatt ggccatgcaa aatcaatttg cttaaatttt ggtattgcac aagattatca 60
aggtaaatgt aatttacgtt ttgatgatac gaatccagta aaagaagatg ttgaatatat 120
caactcgatt caaaaagacg ttcagtggtt aggtttccaa tgggatggta acgttcatta 180
ctcctctgac tattttgatc aactgtatca atatgcgatt gagctgatta acaaaggctt 240
ggcttatgtt gatgagttga gtgctgaaga aattcgtgaa tatcgtggca cactcaaaga 300
gccaggaaaa aatagccctt atcgctctcg tagtgtagaa gaaaacttag cgctatttga 360
aaaaatgcgt gcgggtggct ttgaagaggg gaaagcgtgc ctacgtgcga aaattgacat 420
ggcatcacca tttattgtca tgcgtgatcc tgttctttac cggatcaaat tcgctgaaca 480
ccatcaaaca ggtaacaaat ggtgcattta tccaatgtat gattttaccc attgtatttc 540
tgatgcattg gaaaatatca cacattcttt atgtactttg gaattccaag ataaccgtcg 600
tttatatgat tgggtgttgg ataatatcac tattccttgc caccctcgtc aatatgagtt 660
ctcacgtctt aatcttgaat ataccgtcat gtctaagcgc aagctaaatc agcttgtgac 720
agaaaatatt gttgatggtt gggatgatcc gcgtatgccg acaatttctg gcttacgtcg 780
tcgtggttat acggctgagt caatccgcga attctgtcaa cgtattggtg tgaccaaaca 840
agataacaac gtggaaatgg catcattaga agcttgtatt cgtgatgatt taaacgaaaa 900
cgcacctcgt gcaatggctg ttatcgatcc ggtacgttta gtgattgaaa atatgccaga 960
aggtgaagag attttaactg cgccaaatca cccaaataaa ccagaaatgg gaactcgtga 1020
agtaccattt agccgtgaaa tttatattga tcgtgcagac tttaaagaag aagccaatcg 1080
tcaatataaa cgtctggtat taggtaaaga agtccgtctg cgtaatgctt atgtcattaa 1140
agcagaacga gttgaaaaag atgaacaagg tgaaataacc accatttatt gtacttacga 1200
tccacagacg ttaaataaag atccggctga tggtcgtaaa gtaaaagggg tgatccactg 1260
ggtcagcatt ccacatgcta ttccagcaga aattcgtctt tatgatcgtt tatttagcgt 1320
acctaatcct ggtgctgaag aggatttctt atcaaccatt aaccctgaat cattagtgat 1380
ccgtcaaggt tttgtggaag caagcttaaa agatgcggct attgaaaaag cgtatcaatt 1440
tgagcgtgaa ggttacttct gtgctgataa gctttcgaca gcggataaac tggtctttaa 1500
ccgtactgtt ggtttacgtg atacttgggc gaagat 1536
<210> 107
<211> 1514
<212> DNA
<213> Proteus mirabilis strain HI4320
<220>
<221> source
<222> 1..1514
<223> /organism="Proteus mirabilis strain HI4320"
/mol_type="unassigned DNA"
<400> 107
tgatgccgat gatctgatgt tggcagaaaa ttcaaatgac actgatgatg atgctgtcga 60
agccgctgct caggtacttt ctagtgtaga atctgaaatt ggccgtacaa ccgatcctgt 120
gcgtatgtat atgcgcgaaa tgggaaccgt tgaactgctc acccgggaag gtgaaattga 180
tatcgcaaaa cgtattgaag atggtattaa ccaagttcaa tgctcagttg ctgaatatcc 240
tgaagcaatc acttatcttc ttgaacaata tgatcgtgtt gaagccggtg aagcgcgtct 300
ttctgattta attactgcct ttattgaccc taatgccgaa gaagtggcag aaagtgatga 360
tgtcaattta ggcaaagacg acgatgaaat cgacaacagc gccgatgacg aagatgaaga 420
cgaagatgaa gatagcgaca cagacagcga tagcgatgat gataacagca tcgatcctga 480
acttgctcgc caaaaattca ccgagcttcg tgaacagtac gaaaaaacgc gtcaatctat 540
taaggccaaa ggtcgtaatc ataaagatac cgaactggaa attttacagt tatcagaaat 600
tttcaaacag ttccgcttag tgccaaaaca gtttgattat ctggttaaca acatgcgtga 660
aatgatggac agagtccgtg ctcaagagcg tcacatcatg cgtctttgtg ttgatcaggt 720
caaaatgcct aagaaaaact tcattactct gtttacagga aatgaaacta acgacacatg 780
gtttactgcc gctcgtgcga tgaataaacc ttggtctgaa aaactggcag gtattgaaga 840
agaagtacaa cgtagcttac aaaagttaca acaaattgaa gttgaaacag gactgacaat 900
cgaacaggtt aaagatatta accgtcgtat gtctatcggt gaagcaaaag cacgccgtgc 960
gaaaaaagag atggtcgaag cgaacttacg tttagttatc tctatcgcga aaaaatatac 1020
caaccgtggc ttacagttcc ttgacctgat ccaggaaggg aatattggtc taatgaaagc 1080
ggttgataaa tttgaatatc gtcgtggtta taagttctca acttatgcaa catggtggat 1140
ccgtcaggct attactcgtt caatcgccga tcaggcacgt accattcgta ttccggtaca 1200
tatgattgaa acgattaata agctaaaccg tatctcgcgc caaatgttgc aagagatggg 1260
acgtgagcct tcaccagaag agcttgcaga acgtatgctg atgcctgaag ataaaatccg 1320
taaggtacta aaaatcgcta aagagcctat ctccatggaa accccaattg gtgacgatga 1380
agattcacat ttaggtgatt ttatcgagga tactaccctc gaattacctc tggattcagc 1440
aacatcagaa agcttacgtt cagcgacaca cgaagtatta ggtggtttaa cactgcgtga 1500
agctaaagtc ctgc 1514
<210> 108
<211> 1518
<212> DNA
<213> Proteus mirabilis strain HI4320
<220>
<221> source
<222> 1..1518
<223> /organism="Proteus mirabilis strain HI4320"
/mol_type="unassigned DNA"
<400> 108
tactggcgtt gaagctgatg atgtgattgg cacattggca ttaaaagcag ccagtgatgg 60
tcgtaatgtg ttaatcagta ccggtgataa agatatggca cagctagtta cgcccaatat 120
cacacttatc aacacgatga cgaatgttat tttaggcccc gatgaagtta aagaaaaata 180
tggggtgcca ccggagttga ttatcgactt tctcgccctg atgggtgact catcagataa 240
tattcccggt gttccgggcg taggtgaaaa aacagcatta gggctattgc aaggacttgg 300
tagcttagag gatatttatc aacagcttga taaaatagcc acattgagtt tccgaggtgc 360
gaaaacactt ggcgctaaaa tggttgaaca tgagaaagtt gccaaacttt cttatcaatt 420
agcgacaatt aaaacagatg tagcgcttga taaaaccttt gatgacttag tggttaatga 480
acctaattta gataagttac ttgaaatgtt tacgcgttat gaatttaaac gctggataag 540
tgacttacaa aatggtggtt ggttagctca acgcagtagc cgtaaagcgc cagtccccta 600
tagtgcagaa gtcgcaacac ccaaagagca gccagctgca gacaatttcc cagttatctc 660
tcaagagaac tatgagtcta tattgactca tgaaagctta atgcgctggg ttgaggtact 720
gaaaaaagcg cccgcctttg cttttgatac tgaaacagat agcttgaata atattgatgc 780
acgtttaatc ggtctgtcat ttgcggtaga gcctggcaag gccgcttata ttccattgcg 840
tcatgattat ctagatgcac cagagcaatt acctgttgat gaggtactaa ctgctttaaa 900
accgatttta gaagataaaa ccatcttaaa aattgggcaa aacctgaaat tcgaccgcgg 960
cattatggaa aatgaaggca tcgaattaaa cggtatttat tttgatacca tgttggagtc 1020
ttatgtctta aatagtgtga gtagccgcca tgatatggat accttagcgg aaaagcattt 1080
aaatcataaa acgacgacat ttgaagagat tgctggtaaa ggtaaggggc aacttacctt 1140
taatcagatt gaggttgaac aagcgacctt atatgcagcg gaagatgctg atattacctt 1200
gttactgcat caagcgcttt atcctcaaat agaggcgatt gcaccgctaa aacacgttta 1260
tcacgatatt gagatgccat tagtccctgt gctttcacgc atggagcgta agggcgtatt 1320
gattgacgca caagtgcttg ccatgcaatc ccaagaaatc actcaacgtt tagctgagat 1380
tgaaaaagag acattcgcgt tagcagggca agaatttaat ctctcttcac ctaagcaatt 1440
acaagagatt ttatttgaaa aactcaatct tcctattatc aagaaaacgc caaaaggtgc 1500
cccttcaaca aatgaaga 1518
<210> 109
<211> 1010
<212> DNA
<213> Proteus mirabilis strain HI4320
<220>
<221> source
<222> 1..1010
<223> /organism="Proteus mirabilis strain HI4320"
/mol_type="unassigned DNA"
<400> 109
acattggtgg acagcacaaa gtggcgcatt aggcacaact tttactttct gggataaaga 60
aacaaaacaa tttttacaag cgacacaagc tcgccctaat caacttgata ccctatttaa 120
tcgctatagt gtttggcata gtttatcgtt atggaaacaa actgcagata agctcatgcg 180
ccgacctttc ttattacaag cgcctcgtat ttctgatgaa gggaaactag ctactattgg 240
cgatagcttt gcgcaaaatc aaaccgattt tcttgatgtc acagattatc atcaactaca 300
aacagaatta ggtattcata actggcaaga tttacccaat tattttacgg atcaaccaga 360
aggatttctt tcccctctgg ttttacatat caaaagctat aatcccttaa tttggcatga 420
agtagagcag tgtgttattt gggaagtggt agataataat ggaaattcgg cctttttgcg 480
cctttattgg gaaggcgaaa cgcaaaataa tttagaagaa ttacgttttc tcactaaacg 540
agaattagaa atcgttgcga tcaccgtgca acctgttcga cgtgatttca atatcgattt 600
attacccacc accatttgga tcaaaacaga gcaaggcatt gaaatgtttt atctcgattt 660
tgaccaattt ccacgtaaga aaaaacagtc tggttttatt agtcatattc aagaatatat 720
ggctaaacgt aagcgacaaa cggcaatgca tcacagcgaa cctacccttg cacaaaaatt 780
ttgtcgcccc attttatccg tattggaagc ccaagcatgt acagggcgag aacaactttc 840
tgcaatgcaa aaagagcaat tagagagaag caaacaaatt gctgacgatt taggtatgac 900
attaatagct aaccaattaa ctcgttatct cgctttaact gctcgtgact ctcaagcttt 960
attacagtta atttggctat gtgataatct gcaacaatta caaagcccgt 1010
<210> 110
<211> 1028
<212> DNA
<213> Proteus mirabilis strain HI4320
<220>
<221> source
<222> 1..1028
<223> /organism="Proteus mirabilis strain HI4320"
/mol_type="unassigned DNA"
<400> 110
agatgcgctt accgtctttg ctaatgccgg attattaaga cgcgcaagaa aagatgttga 60
taacgaaaaa gtctctgtta ctgatgcaaa tacagggcaa tttagcagtg atgggcaaaa 120
agtcgtttta catgaagcag gcattcagca agccagttgt gattgttccg cagcaggttg 180
ttgcaaacat attttagccg ctattttatg gttacaagcc aacaacaatt cgactgatga 240
tattaatact gataatccca ttgaaacatc agcagaaaaa attatagcgc ctgttgaaac 300
accgccttta ttaccctctt tatttacgct tgatcccgag ttactcatca aaaaagcagg 360
taaacccgcc tgtcggactg cgattaactt aattgaacaa tgggaagata aaactttagt 420
tctagaagac acaggaaccc agctaaaaat ccaactccct gatgttgatg aaccggtcat 480
tttcttacaa gcaagtggtt acgatggcat gttatcccct ttttctagct ctcagaaaaa 540
agcttttcat cttgcgattg tcgcgaaaat atttaagcaa aatacacagc cttggacgtg 600
gcctgaagat ttaattccct taaaatcttc acaacgccca ctgaatgatg aagaaattgc 660
ccttattaat actattgaac aatttattga tgatctatta cgtcaagggc tatcacacat 720
tagtttaagt agcgcaacgc aattacattt acttaatatg tctgctcgtg ccgagggttt 780
acctcgttta gcctcttatt tacgaacatt aagtactcaa gtcaagcggt tagctgaaag 840
acatttcact atggatgaaa gcaatgtctt acgtctatta gctcatatct cagcctatct 900
tttccagcta tcttatgcga cacctgaaca attaaaaaca ttacgagggc aacttcgccg 960
tcaatatgat gataaaaaaa ccagtctcgc gcttattcct attgatgcac attggtggac 1020
agcacaaa
1028
<210> 111
<211> 1176
<212> DNA
<213> Proteus mirabilis strain HI4320
<220>
<221> source
<222> 1..1176
<223> /organism="Proteus mirabilis strain HI4320"
/mol_type="unassigned DNA"
<400> 111
cttgcacgcc ttgactatga acctgaagta cttgcatctg aaggctcttc acaacgtgaa 60
gcacatatgc tcactcatat aaaaaccatc aaacagtacg agcctaatgc caaaatatta 120
atcgtcacag ggggagccca cacccttgcg ctaatcgaag gcttagcttc ttcacaaccc 180
aactctttcg ctatttctag ctcagaacaa aagcacttta ctaaaatgca aaaaatgggc 240
gaaaaagagc aagcttggct tattcgctat agctttgaca gattagatgc acttaatggc 300
tatgcatctg gtatgccatc tccggctttt taccaacaag cttggcaaag cttaatgcaa 360
caacatcatg ataaattaga aaacaatgag gcggcaaaac agccaacgca agtttatcgc 420
aataaaatgg gcatcgcctt tttaagctca gtggctcaga ctatcagaga acaacaattt 480
gataatccac ccagttattt aaccgtaaaa ctagcagccg agcagagttt acgcctcgct 540
ttactaagag agcacactgg tatggggcgt tatgatttgc ttgatgggtt acaaagcgcc 600
tttattaaag gcagtttaga tgacagtcaa aacgaattat gggacgaaat caaaacctgt 660
ttttcaggtt atctattagg acaaattcca ttaggtacag caacgccccc tttagtcaat 720
gaaacctatg aacgcgccaa agcatttcgc tttaaacttg atgatacatt agcaaaaact 780
acaaaatgtg atgtttatcg caacccccaa catcgcttaa gaagtcgttt tttacattta 840
ttggcatttt tagaaatcca ttttgcccac cgtgtcaatg gacctgattt tctttctggt 900
caccagttag atctattatt tgaagaatgg caatatgcat ggacccccaa tgttgaaggt 960
gaactgatct cattatcaga aaaaggctct caacttgaaa ctatcgcctt aaataaactg 1020
ttagcaatgg aaaaacagct tgcagaacaa ggacaaagcc gttcaagcca aagtgcggtc 1080
actttgttaa ttcaagcggc attaattggg ctccaccagc gtatccctac gctatttaaa 1140
ctgctagata gctatattca gcaagatttt cgcctt 1176
<210> 112
<211> 1060
<212> DNA
<213> Pseudomonas aeruginosa strain R13
<220>
<221> source
<222> 1..1060
<223> /organism="Pseudomonas aeruginosa strain R13" /mol_type="unassigned DNA"
<400> 112
ggacgggtga gtaatgccta cgaatctgcc tggtagtggg ggataacgtc cggaaacggg 60
cgctaatacc gcatacgtcc tgagggagaa agtgggggat cttcggacct cacgctatca 120
gatgagccta ggtcggatta gctagttggt ggggtaaagg cctaccaagg cgacgatccg 180
taactggtct gagaggatga tcagtcacac tggaactgag acacggtcca gactcctacg 240
ggaggcagca gtggggaata ttggacaatg ggcgaaagcc tgatccagcc atgccgcgtg 300
tgtgaagaag gtcttccgat tgtaaagcac tttaagttgg gaggaagggc agtaagttaa 360
taccttgctg ttttgacgtt accaacagaa taagcaccgg ctaacttcgt gccagcagcc 420
gcggtaatac gaagggtgca agcgttaatc ggaattactg ggcgtaaagc gcgcgtaggt 480
ggttcagcaa gttggatgtg aaatccccgg gctcaacctg ggaactgcat ccaaaactac 540
tgagctagag tacggtagag ggtggtggaa tttcctgtgt agcggtgaaa tgcgtagata 600
taggaaggaa caccagtggc gaaggcgacc acctggactg atactgacac tgaggtgcga 660
aagcgtgggg agcaaacagg attagatacc ctggtagtcc acgccgtaaa cgatgtcgac 720
tagccgttgg gatccttgag atcttagtgg cgcagctaac gcgataagtc gaccgcctgg 780
ggagtacggc cgcaaggtta aaactcaaat gaattgacgg gggcccgcac aagcggtgga 840
gcatgtggtt taattcgaag caacgcgaag aaccttacct ggccttgaca tgctgagaac 900
tttccagaga tggattggtg ccttcgggaa ctcagacaca ggtgctgcat ggctgtcgtc 960
agctcgtgtc gtgagatgtt gggttaagtc ccgtaacgag cgcaaccctt gtccttagtt 1020
accagcacct cgggtgggca ctctaaggag actgccggtg 1060
<210> 113
<211> 385
<212> DNA
<213> Pseudomonas aeruginosa UCBPP-PA14
<220>
<221> source
<222> 1..385
<223> /organism="Pseudomonas aeruginosa UCBPP-PA14" /mol_type="unassigned DNA"
<400> 113
aaggccggcg acatcagcaa caccacttgg tccctggcgg cagcctacac tctggatgcg 60
cacactttca ccttggccta ccagaaggtc catggcgatc agccgtttga ttatatcggc 120
ttcggcgaga acggttccgg cggcggcggt gactcgattt tcctcgccaa ctccgtgcag 180
tactccgact tcaacggccc cggcgagaaa tcctggcagg cccgctacga cctgaacctc 240
gcctcctatg gcgttcccgg cctgactttc atggtccgct atatcaatgg caaggacatc 300
gatggcacca agatgtctga caacaacgtc ggctataaga actacggcta cggcgaggac 360
ggcaagcacc acgagaccaa cctcg 385
<210> 114
<211> 420
<212> DNA
<213> Pseudomonas aeruginosa PAOl
<220>
<221> source
<222> 1..420
<223> /organism="Pseudomonas aeruginosa PAOl"
/mol_type="unassigned DNA"
<400> 114
ccacccttgc caatgcggga atcacgctgg gaggaacccg ggtcgttctg caggcgcctg 60
ccaaggaggc tgcaatcctg gtcaggaacc aggcttccaa tgacgtgatg attcaatcct 120
gggtagaggc tgataatggg gcagataaac gtgaggttcc gtttgtcatc acgcctgccc 180
tcagtcgttt gggaggcaat aagcagcaaa ccctgcgtat cctgtttcaa ggggaaggct 240
tgccgagcga cagggaatcc gtattccgcc tgaacgtcca ggaaattcca caaaaatctg 300
cgtcggctaa tacgttgcag atagctttgc gccagcgtat caaggtcttc taccgccctg 360
ataacttatc gggaacttcc gccgaagcgc ctggaaagtt gaactggcgt cttgtccggc 420
<210> 115
<211> 378
<212> DNA
<213> Pseudomonas aeruginosa PAOl
<220>
<221> source
<222> 1..378
<223> /organism="Pseudomonas aeruginosa PAOl"
/mol_type="unassigned DNA"
<400> 115
cggctcgaag aaggcaggca aaatacttac attcataggt gtttgtaaac gtccgaaagc 60
ctcgcgtgaa aacacctgaa acgttttagc tcgatggccg gttatccacc cggcgccatg 120
gcccatattc agaacctgaa acaaggttga taaggtcaac taaaataagc aaaatagttg 180
actggatcaa ccacatttac attaggttta ctcggccaaa ccaatgaact accccgtgaa 240
tcccgacctg atgcccgcgc tgatggcggt cttccagcat gtgcggacgc gcatccagag 300
cgagctcgat tgccagcgac tcgacctgac cccgcccgac gtccatgtat tgaagcttat 360
cgacgaacaa cgcgggct <210> 116
<211> 1513
<212> DNA
<213> Serratia marcescens strain MG1
<220>
<221> source
<222> 1..1513
<223> /organism="Serratia marcescens strain MG1"
/mol_type="unassigned DNA"
<400> 116
atagatgcgc cagccgggac agaatttaac gttcaacttt taactcagct cgaagcaatt 60
gttaatttac aaaaagattt tactgttgaa gagcagggca aagatacggg gatgcttacc 120
ctggctatga caggggacga ccctcaatta atcgggaaga tattagaaag cattagtcgg 180
aattatttgc agcaaaatat tgatcgccag gcagctcaag actcaaaaag tcttgatttc 240
ctagatcaga aaatccctaa ggtacgttct gagctctatt tagctgagga caaactaaat 300
tcttatcgac gtcagaaaga ttctgttgat ttaaatttgg aagctcagtc tgtattaaat 360
cgcatagtca atgtagataa ccagttaaat gaactgacat ttaaagaagc agagatctct 420
caactttata caaaggatca cccgacatat aatgcactaa tgcagaaaag ggaaacgtta 480
cagcaagaga agtccaagct taacaagcaa atctctgcaa tgcctgcaac tcaacaagaa 540
gtattgagac tcagtagaga tgttgagtct ggaagagctg tctatatgca actcttgaac 600
aggcagcaag agttgaatat tgctaagtcg agtgctattg gtaatgttcg aatcattgat 660
aatgcgatca ctgaacctaa accggtaaag ccaaagaaag cattgatagt tattatcggt 720
attttcttgg gtggttttat ttctatcggt gttgtgctga ttaacgtctt cttgcgcaga 780
ggcattgagt ctccagaaca actggaagag caaggaatta atgtttatgc cagcattccg 840
gtttcagaat ggctgcaaaa gaacacattg agcaaggcaa aaagcaaacg gctgacggtt 900
agtcagagaa gaataaatga atcaggtgca ttcctcgccg ttgagaatcc agcagactta 960
gctattgaag ctattcgtgg tcttcggaca agtttacatt ttgcaatgat ggaatcacca 1020
aataatgcag ttatgatttc aggtgcgagt ccaagtgcag gtaaaacttt tgtcagtacg 1080
aacttagctt cggtgattgc tcaaagtcat cagaaagtat tgctaatcga tgccgatatg 1140
agaaaggggt atgtacacaa attattcaat gtaaataacg ataacggttt atctgactat 1200
cttgtaggga aagctaagtt agaagatgct atcaagcctg taacaagtgc tggcttcgat 1260
ttcatttcaa gaggacaggt accgccaaat ccagctgaac tattaatgca tgatcgcttt 1320
aaagagttgc tggagtgggc tacaaaaaca tatgatttgg tcatgatcga tacgccaact 1380
attttggccg taacagatgc cgctattata ggtcgatatg caggaaccac cttgcttgtt 1440
gcacgctttg aaaataatac agtcaaggaa attgatgtca gtataaagcg ttttgagcaa 1500
agcggcgtcc cag 1513
<210> 117
<211> 1000
<212> DNA
<213> Serratia marcescens subsp. marcescens
<220>
<221> source
<222> 1..1000
<223> /organism="Serratia marcescens subsp. marcescens "
/mol_type="unassigned DNA"
<400> 117
aatatttttc gttaatagcc ggtaaaacat tccaatctac ggccaaacca gaatggtaaa 60
aataaaacaa gccgacaaga agggttattt ccaattgcgt tattagtctc tcattttgtc 120
ggtgaaatac gctcaactta caacattatt tcagtcagga gtgacttatg aacaaaactt 180
cccgtaccct gctctctctg ggcctgctga gcgcggccat gttcggcgtt tcgcaacagg 240
cgaatgctca cggttatgtc gagtcgccag ccagccgcgc ctaccagtgc aaactgcagc 300
tcaacacgca gtgcggcagc gtgcagtacg aaccgcagag cgtcgaaggc ctgaaaggct 360
tcccacaggc cggcccggct gacggccaca tcgccagcgc cgacaagtcc accttcttcg 420
aactggatca gcaaacgccg acgcgctgga acaagctcaa cctgaaaacc ggcccgaact 480
cctttacctg gaagctgacc gcccgtcaca gcaccaccag ctggcgctat ttcatcacca 540
agccgaactg ggacgcttcg cagccgctga cccgcgcttc ctttgacctg acgccgttct 600
gccagttcaa cgacggcggc gccatccctg ccgcacaggt cacccaccag tgcaacatac 660
cggcagatcg cagcggttcg cacgtgatcc ttgccgtgtg ggacatagcc gacaccgcca 720
acgccttcta tcaggcgatc gacgtcaacc tgagcaaata atcggtcaaa tgaggagatc 780
gttaagggtt cagcctggcg ctgaaccctt ttttttgcag gtgccgctat tgcgacatgt 840
tgaggatagt gcgcacattg agcgcgctgg tggcgataat gtcgatggcg ccggtgcgca 900
aagcgcccaa aatcgccaac gccttggtat tctcggaagc aatggcgatc acgcaaggga 960
ttttgcgcag ctcatcaatg ctcagcccga tcactctgtc 1000
<210> 118
<211> 1063
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1063
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 118
cggcaattac ggtagcactt gaaaaaagtc taaatcatat cttagcagaa gatattgtag 60
ctacttatga tataccaagg tttgataaat caccttatga tggttttgca attcgcagtg 120
ttgattcaca aggggcaagt ggtcagaatc gcattgagtt taaagtgatt gatcatattg 180
gtgcaggttc agtttctgat aaattagttg gggatcacga agcggtgcgt attatgactg 240
gagcacaaat accaaatggc gcagatgctg ttgttatgtt tgaacaaacg attgaactag 300
aagatacatt tacaattcgt aaaccatttt caaaaaatga aaatatatct ttaaaaggtg 360
aagaaacaaa gacaggcgat gttgttctaa aaaaaggaca agtaattaac ccaggggcta 420
tcgcggtcct tgcaacatat ggctatgcag aggttaaagt tattaagcaa ccgagtgtcg 480
ctgttattgc aacaggaagc gaattattag atgttaatga tgtattagaa gatggaaaaa 540
ttcgtaactc taatggccca atgattcgtg ccttagcaga aaaattaggt cttgaagttg 600
gtatttacaa aacacaaaaa gatgatttag atagtggcat ccaagtcgtt aaagaagcta 660
tggaaaaaca cgatatcgtt attacaacgg gtggagtttc tgttggagac tttgactatt 720
tacctgagat ttataaggct gtaaaggcgg aagtgttatt taataaagta gcaatgcgtc 780
ctggtagcgt aacaacggtt gcatttgcag atggaaagta tttgtttgga ttatctggaa 840
atccatcagc ttgttttaca ggatttgaac tatttgtgaa accagctgtt aaacatatgt 900
gtggcgcact agaagtcttc ccgcaaataa ttaaagcaac attaatggaa gattttacca 960
aggcaaaccc attcacacga tttatacgtg ctaaagcaac gttaacaagt gctggagcta 1020
ctgtagtacc ttcaggattc aataaatcag gtgcggttgt agc 1063
<210> 119
<211> 1146
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1146
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 119
tgccggtgtg aatgtttcta tagctgactt tatcacatta ctaatattag tttatttact 60
gtttttcgct aaccatttat taaaggcaaa tcatttttta cagtttttca ttattttgta 120
tacatatcgt atgattatta cgctttgttt gctatttttt gatgatttga tatttattac 180
ggttaaggaa gttcttgcat ctacagttaa atatgcattt gtagtcattt atttctattt 240
agggatgatc atctttaagt taggtaatag caaaaaagtg atcgttacct cttatattat 300
aagcagtgtg actataggtc tattttgtat tatagctggt ttgaacaagt cccctttact 360
aatgaaattg ttatattttg atgaaatacg ttcaaaagga ttaatgaatg accctaacta 420
tttcgcgatg acacagatta ttacattggt acttgcttac aagtatattc ataattacat 480
attcaaggtc cttgcatgtg gtattttgct atggtcttta actacaacgg ggtctaagac 540
tgcgtttatc atattaatcg tcttagccat ttatttcttt attaaaaagt tatttagtag 600
aaatgcggta agtgttgtga gtatgttagt gattatgctg atattacttt gttttacctt 660
ttataatatc aactactatt tattccaatt aagcgacctt gatgccgtac cgtcattaga 720
tcgaatggcg tctatttttg aagagggctt tgcatcatta aatgatagtg ggtctgagcg 780
aagtgttgta tggataaatg ccattttagt aattaaatat acactaggtt ttggtgtcgg 840
attagtggat tatgtacata ttggctcgca aattaatggt attttacttg ttgcccataa 900
tacatatttg cagatctttg cggaatgggg cattttattc ggtgcattat ttatcatatt 960
tatgctttat ttactgtttg aattatttag atttaacatt tctgggaaaa atgtaacagc 1020
aattgttgta atgttgacga tgctgattta ctttttaaca gtatcattta ataactcaag 1080
atatgtcgct tttattttag gaattatcgt ctttattgtt caatatgaaa agatggaaag 1140
ggatcg
1146
<210> 120
<211> 1000
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1000
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 120
atcgcacgta ttactcccat ttatgtttgg tcctattatc gcatcaatca tttgtgtgaa 60
agttttcaaa cttgatatta aatggccatt cttacttagt gaattaggga ttgtactatt 120
aggggtgcaa atcggatcaa cgtttacgaa aaatgtcgtt atggatatta aaaacaattg 180
gctttcgatt attgttgtat ctatttcgat attattaatt gcaatagtaa tggcatttat 240
ttttaaaaaa attgcacgta ttaatacaga aacagctatt ttaagtgtta taccaggagc 300
actaacacaa atgctggtca tggctgaaca agacaaacgt gctaatttgt tagttgttag 360
cttaacgcaa acatcacgaa ttatatttgt tgttgtttta gtaccgttca tttcatattt 420
ttttcatgat ggtaacatgc atgcgaatgg aaagttaaca aaagtcttgc ctttatcaca 480
agtattaaac atagggcaaa tagttatttt agcgatagct atctttatag tttatctaat 540
tatgtctaaa ataaagtttc caacatttca attattagca ccactcattg tattaattgt 600
ttggaatttt tctacaggtt taacatttac actagatcat tggttgttga acatggcaca 660
actaatatat atgattagaa ttggagttca aattgcgcat ttattgtcag atttaaaagg 720
tagactagca atcgcaatta caattcaaaa tattatgttg ataattggtg cgctaatcat 780
ggtttatatc atacatttct ttgataataa tcctattaat gaattgtttc ttggtgcagc 840
accaggaggg gttaatcaga tagttttagt tgcattagct actggtgccg atgttgctat 900
gattacgagt tatcatattt tccgaatctt tttcatccta tttattattg caccaggaat 960
taattacttt ttaaaatatc gttcgaataa gcgtgaagat 1000
<210> 121
<211> 911
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..911
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 121
ccgaattata tatctggaca aagcattgcg gaatcactta atatttcacg cactgcagta 60
aaaaaggtga ttgaccaatt aaagttagag ggatgtaaaa ttgattcagt aaatcataaa 120
gggcatttat tacaacaact cccagatatt tggtatcagg gtataataga ccaatataca 180
aaaagttctg ctttgtttga ttttagtgaa gtatacgatt caatagattc tacacaactt 240
gctgcgaaaa agtcacttgt tggaaatcaa tcttcatttt ttatcttgag tgatgaacaa 300
acgaaaggtc gtgggcgatt taatagacat tggagttctt caaaagggca aggactttgg 360
atgtctgtcg tgttaagacc taacgttgca ttctcaatga tatctaaatt taatttattt 420
attgcattag ggataagaga tgcgattcaa cattttagtc aagatgaagt caaagtgaaa 480
tggccgaatg atatatatat tgataatggt aaagtgtgtg gtttcttaac tgaaatggtt 540
gctaataatg atggtataga agcaataata tgtggtatag gtattaattt gacgcaacaa 600
ctagaaaact ttgatgaaag tattagacat agagcaacaa gtatacaatt acatgataaa 660
aataaattag atagatatca atttttagag agattacttc aagaaattga aaaaagatat 720
aatcaatttt taacgttacc tttttctgaa attcgtgaag aatatattgc agcttctaat 780
atttggaata gaacgttgct atttacagaa aatgataaac agtttaaagg acaagcaatt 840
gatttagatt acgatggcta tctaattgtt agagatgaag cgggtgaatc acaccgttta 900
attagtgcag a 911
<210> 122
<211> 1059
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1059
<223> /organism="Staphylococcus aureus subsp. aureus Mu50
/mol_type="unassigned DNA"
<400> 122
tcggtcgctt aaatcggtag ggtatataga tagacagtat attgaagtag aaaataagag 60
atgtacgaac tatacatcta atgattattt aggattaggt caaatagcgt ttgataagga 120
tgatttcgaa agatttatgc ggaagtatag ttatcactta tcaagttcaa gattaattag 180
tggaagttcg acagcttatg aagaaattga aacaatgtta gcaggttggc tcggatatag 240
tgcatgtact atcttaaata gtggttatga tgctaatttg gcgttgttta atattttcaa 300
aaatacaaat tgtgtcgtgt tttcagatca agaaaatcat gcgagtatta ttgacggtat 360
taagttaagt ggtttagaaa aagtgatata taagcattta gatattgctg atttagaaaa 420
aaggttagag aaatacccta atcaaaatat accaaaaata atcatatctg atagtgtatt 480
ttcaacgaat ggcgacgttg tggatattgg tcaattagtc tcattaaagc ataaatataa 540
cgcaacactg atactcgatg tttcacatag ttttggaata gagaattact cgaattatca 600
aggtgtagat atactcactt ctagtttatc taaagcatgt ggtgcatacg ggggtgtgat 660
tttaagttca aatgatgtga aggatatgtt aattaatcac ggtagaccac tcatctactc 720
aagtagtttg ccaatttata atttgtattt tataaaaaga aacattgaaa agttaataaa 780
tgctgatgat agacgcacta aattaaatag tttgagtaaa tattttaacc aaaagttaaa 840
agcactcaat gttaattata atagttcaaa ctcgccgatt aagtttattg agtttgatga 900
catagaagcg gctgagaaca ttcatcaaac attattaaag catcatgtgt ttacaagtta 960
tttaaggtat ccaactgtga ctaagccaat gttaagaata tcattgtcgt attttcatac 1020
tgaacaagat atagataggt tgtttgaaat tttgcatca 1059
<210> 123
<211> 1352
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1352
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 123
acgcgctgaa attgcaacaa gcaatcaaga ccaagaaact aattcatcga aacgcgttca 60
cttaaaacgt tggcaattca tatcaatatt aattggcaca accctaataa cagctgtcat 120
cacagttgtt gcatatattt ttataaatca aaaaataagt ggtttaaaca aaactgatca 180
agcaaactta aataaaattg aaaatgtgta taaaatctta aatagtgatt attacaaaaa 240
acaggactct gacaagttaa gtaaagctgc aattgatggt atggtcaaag aattaaaaga 300
tccttattct gaatatttaa caaaagaaca aacgaaatcc tttaatgaag gtgtttcagg 360
tgattttgta ggtattggtg cagaaatgca aaagaaaaat gatcaaatta tggttactag 420
ccctatgaag ggttctccag cagaacgtgc tggcatccgt cctaaagatg tcattactaa 480
agtaaatgga aaatcaatta aaggaaaagc attagacgaa gttgtcaaag acgttcgtgg 540
taaagaaaac actgaagtaa ctttaactgt tcaacgaggc agtgaagaaa aagacgttaa 600
gattaaacgt gaaaaaattc atgttaaaag tgttgattat aagaaaaaag gtaaggttgg 660
agttattact attaataaat tccagaatga tacatcaggt gaattgaaag atgcagttct 720
taaagctcac aaagatggtt tgaaaaagat tgttttagat ttaagaaata atcctggtgg 780
actactagat gaagctgtta aaatggcaaa tatttttatc gataaaggaa aaactgttgt 840
taaactagaa aaaggtaaag atactgaagc aattcaaact tctaatgact cgttaaaaga 900
agcgaaagac atggatatat ccatcttagt gaatgaaggt tcagctagtg cttctgaagt 960
gtttactggt gcgctaaagg actataataa agctaaagtt tatgggtcaa aaacattcgg 1020
caaaggtgtc gtacaaacta caagagagtt taaggatggt tcattgttaa aatatactga 1080
aatgaaatgg ttaacgccag atggtcatta tattcacggt aagggcatta aaccagacgt 1140
tactattgac acacctaaat atcaatcttt aaatgtcatt cctaatacga aaacatttaa 1200
agttggagac gatgataaaa atattaaaac tattaaaatt ggtttatcag ctttaggtta 1260
taaagttgat aatgaatcaa cgcaatttga tcaagcttta gaaaatcaag ttaaagcttt 1320
ccaacaagcg aataaactcg aggtaactgg tg 1352
<210> 124
<211> 1474
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1474
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 124
gcaatggtgg aaagaagcag tagcatatca agtatatcca agaagtttta atgatagtaa 60
tcacgatggt attggggatt tacctggaat gattgataaa ttggactact taaaagattt 120
aggtatcgat gtcatttggc tcagtccaat gtttaaatca cctaatgatg acaatggtta 180
tgatattagt gactatcaag aaattatgga tgaatttgga acgatggaag actttgattg 240
tttattaaaa ggtattcatg atagaggcat gaagcttatt ttagatttag ttgtaaatca 300
tacatctgat gaacatcctt ggtttataga atctaaatct agtaaagaca atcccaaacg 360
tgattggtat atttggcaag atccaaagca agatggctct gaacctaaca actgggaaag 420
tatctttaat ggatctacat gggaatatga tgctaatact gagcaatatt atttccattt 480
attcagtaaa aaacaacctg atttgaattg gggtaatcca gaagttagag atgctgtatt 540
tgaaatgatg aactggtggt ttgataaagg cattgatgga tttagagtag atgcaattac 600
gcatattaag aagacgtttg aagcgggtga cttacctgta cctgagggta aaacatatgc 660
cccagcattt gatgtagata tgaatcagcc aggtatacaa acttggttac aagagatgaa 720
agatcgctca ttaagtaagt atgacattat gactgtcggt gaagcgaatg gtgtaagccc 780
tgatgatgct gatgactggg tcggggaaga aaatggtaaa tttaatatga tattccaatt 840
tgaacatttg ggactgtgga atagtggtga ttctcacttt gatgtaaatt cgtataaatc 900
tgtattaaat agatggcaaa aacaacttga aaataaaggt tggaatgcgt tgtttattga 960
aaatcacgac caaccacgac gtgtatcgac gtggggtgac gatgacaagt attggtatga 1020
atcagcaaca agtcatgcag ctgtttattt cttgcaacaa ggtacgccat tcatttatca 1080
aggtcaagaa attggtatga cgaattatcc atttgaaagt attgaaacgt ttaacgatgt 1140
tgctgtaaaa aatgactatc aaatagtgaa agctcaaggt ggagatgtag acgctttact 1200
tgcgaaatat aaagatgaga accgagataa ttctcgcaca ccaatgcaat gggatgatac 1260
gttaaatgga ggatttacaa atggtgaacc gtggttccca gtgaatctga attataaaac 1320
tatcaatgtt gcacaacaat tagaagatga gcattcagta ttacaatttt ataaagattt 1380
aattcaatta agaaagtcta atgatgtata cgtatatggt caatttgatt tagtagatgc 1440
tgaaaattca caagtttttg cgtacacgag aaca 1474
<210> 125
<211> 1468
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1468
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 125
gtgcgcgtcg tggtgagcta gtgtcatgtt tcttattaga agtggatgac agcttaaatt 60
caattaactt tattgattca actgcaaaac aattaagtaa aattgggggc ggcgttgcaa 120
ttaacttatc taaattgcgt gcacgtggtg aagcaattaa aggaattaaa ggcgtagcga 180
aaggcgtttt acctattgct aagtcacttg aaggtggctt tagctatgca gatcaacttg 240
gtcaacgccc tggtgctggt gctgtgtact taaatatctt ccattatgat gtagaagaat 300
ttttagatac taaaaaagta aatgcggatg aagatttacg tttatctaca atatcaactg 360
gtttaattgt tccatctaaa ttcttcgatt tagctaaaga aggtaaggac ttttatatgt 420
ttgcacctca tacagttaaa gaagaatatg gtgtgacatt agacgatatc gatttagaaa 480
aatattatga tgacatggtt gcaaacccaa atgttgagaa aaagaaaaag aatgcgcgtg 540
aaatgttgaa tttaattgcg caaacacaat tacaatcagg ttatccatat ttaatgttta 600
aagataatgc taacagagtg catccgaatt caaacattgg acaaattaaa atgagtaact 660
tatgtacgga aattttccaa ctacaagaaa cttcaattat taatgactat ggtattgaag 720
acgaaattaa acgtgatatt tcttgtaact tgggctcatt aaatattgtt aatgtaatgg 780
aaagcggaaa attcagagat tcagttcact ctggtatgga cgcattaact gttgtgagtg 840
atgtagcaaa tattcaaaat gcaccaggag ttagaaaagc taacagtgaa ttacattcag 900
ttggtcttgg tgtgatgaat ttacacggtt acctagcaaa aaataaaatt ggttatgagt 960
cagaagaagc aaaagatttt gcaaatatct tctttatgat gatgaatttc tactcaatcg 1020
aacgttcaat ggaaatcgct aaagagcgtg gtatcaaata tcaagacttt gaaaagtctg 1080
attatgctaa tggcaaatat ttcgagttct atacaactca agaatttgaa cctcaattcg 1140
aaaaagtacg tgaattattc gatggtatgg ctattcctac ttctgaggat tggaagaaac 1200
tacaacaaga tgttgaacaa tatggtttat atcatgcata tagattagca attgctccaa 1260
cacaaagtat ttcttatgtt caaaatgcaa caagttctgt aatgccaatc gttgaccaaa 1320
ttgaacgtcg tacttatggt aatgcggaaa cattttaccc tatgccattc ttatcaccac 1380
aaacaatgtg gtactacaaa tcagcattca atactgatca gatgaaatta atcgatttaa 1440
ttgcgacaat tcaaacgcat attgacca 1468
<210> 126
<211> 1080
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1080
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 126
gtcgaagctt atgctactga aattggcata actttgaaaa gtatcaaaaa tgcccgtaag 60
gaacttaaaa actggactaa aacaaaaaat gtagacacac ctttatattt atttccaaca 120
aaaagctata tcaaaaaaga accttatgga acagttttga tcattgcacc atttaactat 180
ccttttcaac tagtattcga acctttaatc ggtgctattg cagcaggtaa tacagcaatt 240
attaaaccat ctgagttgac accaaatgtt gcacgagtga ttaaacgatt aatcaatgaa 300
acatttgatg caaattacat tgaagttatt gagggaggaa ttgaagaaac gcaaacgtta 360
attcacttac cttttgacta tgtcttcttt acaggaagtg aaaatgtagg caaaatcgtt 420
tatcaagctg ccagcgaaaa tttagttcct gtgacattag aaatgggtgg taaatctcca 480
gtcatcgttg atgaaacagc gaatattaaa gttgctagtg agcgcatttg ttttgggaaa 540
ttcactaatg ccggccaaac atgtgttgca ccagattaca ttttagtaca cgaatctgta 600
aaagatgatt taatcacagc cctatcaaaa acgttgcgtg aattttatgg tcaaaatata 660
caacaaagtc cagattatgg ccgcattgta aaccttaaac attatcatcg tctgacttca 720
ttacttaaca gtgcacaaat gaatattgta tttggtggtc atagtgatga ggatgaacgt 780
tatatagaac caacattgtt agatcacgtt acaagtgatt cagcaattat gcaagaagaa 840
atttttggtc ctatcttacc gattttaacg tatcagtcat tggatgaagc aatagccttt 900
attcaccaaa gaccaaaacc tttgagttta tatttattta gcgaagatga aaatgctaca 960
caacgtgtaa taaacgagtt atcatttggc ggcggcgcta ttaatgatac attgatgcac 1020
ctagcgaatc ctaaattacc atttggtggt gttggcgcct caggtatggg acgctatcat 1080
<210> 127
<211> 1498
<212> DNA
<213> Staphylococcus aureus subsp. aureus Mu50
<220>
<221> source
<222> 1..1498
<223> /organism="Staphylococcus aureus subsp. aureus Mu50 "
/mol_type="unassigned DNA"
<400> 127
tgcaatttct gatggtgcat tacctgccaa tgaaggtaga ggatatgtat tacgtcgatt 60
gttacgtcgt gccgttcgtt ttagtcaaac gttaggaatc aatgagccat ttatgtacaa 120
acttgttgat attgttgcag acattatgga accatattat ccaaatgtta aggaaaaagc 180
agatttcatt aagcgtgtta taaagtctga agaagaacga ttccatgaaa cattagaaga 240
tggtttagcg attttaaatg aattaattaa aaaagctaaa gcgacaacaa atgaaattaa 300
tgggaaagat gcatttaaat tgtatgatac gtacgggttc ccaattgaat taactgaaga 360
aatagcagtg caagcaggat tgaaagttga tatgacaaca tttgagtcag aaatgcaaca 420
acaacgtgat cgtgcacgtc aagcacgtca aaattctcaa tcaatgcaag ttcaaagtga 480
agtattgaaa aatattacat ctgcaagtac ttttgttggt tatgatactg cgacagctca 540
aacaacacta acacacttga tatataatgg tgaagaagtt tcacaagttg aagcgggtga 600
aacagtatac ttcatgttaa cggaaacacc attttatgca gtcagtggtg gacaagttgc 660
ggatacaggt attgtttata atgacaattt tgaaattgct gttagtgaag taaccaaagc 720
accaaatggt caaaacttgc ataaaggagt agtacaattt ggccaagtaa atgttggcgc 780
tacagtgtct gctgaagtga accaaaatga tcgacgtgac attcaaaaga accatagtgc 840
aacacattta ttacatgcag cgttgaaatc agtactgggt gatcatgtta accaagctgg 900
ttcactagta gaagcagatc gtttacgttt tgatttctct cattttggtc caatgactaa 960
tgatgaaatt gatcaagttg aacgcttagt aaatgaagaa atttggaaag gtattgacgt 1020
taacattcaa gaaatggata ttgcttcagc taaagaaatg ggcgcaatgg cattattcgg 1080
tgaaaaatat ggtgatgttg tgcgtgtagt aaatatggca ccattttcaa ttgaattatg 1140
tggtggtatt catgtccgca atacttctga aattggctta ttcaaaatag taagtgagtc 1200
aggtacagga gctggtgtgc gtcgtattga agcattaaca ggtaaagcag ctttcttata 1260
tttagaagat attcaagaga aatttaatac gatgaaatca cagatgaaag tgaaatctga 1320
tgatcaagta gtcgaaaagt taacacaatt acaagatgaa gaaaaagcat tattaaaaca 1380
attagagcaa cgtgacaaag aaatcacatc acttaaaatg ggtaatattg aagatcaagt 1440
tgaagaaatc aatggctata aagtattggt tactgaagtg gatgtaccaa atgcgaaa 1498
<210> 128
<211> 1572
<212> DNA
<213> Staphylococcus aureus subsp. aureus HO 50960412
<220>
<221> source
<222> 1..1572
<223> /organism="Staphylococcus aureus subsp. aureus HO 50960412"
/mol_type="unassigned DNA"
<400> 128
accgcatgtt ctactccacc gatatataaa tcaacaggta accaatgttt taatttttca 60
ggatctgcta acatattttc atttttagga tcgatgtaac gtaaataata ccaacaacta 120
cctgcccatt gtggcattgt atttgtttca cgacgtcctt tcatacctgt tttttcatct 180
acaacattta caaatgaatc aatattagct agtggagact caccagtccc tgatggcttg 240
atttcatctg tttcaggtaa caacaatggt agctcttctt caggaacagt tgtcattgtt 300
ccatcttccc aatgaatgac aggaattggt tcgccccaat aacgctgacg actgaataac 360
caatctctta atttgtaatt aactttcttt tcgccagcac ctttttgctc taataattga 420
atagctttag taattgccgc ttcattttct aaaccatcaa gttcaccaga attaatatgt 480
ttaccttcac cagtgtatgc tgcttcttca acatttccac cttcgatgac ttcaatgatt 540
ggcaaatcaa actttttagc aaattcataa tctctgtcat catgcgctgg tactgccata 600
attgctccag taccatatgt tgataataca taatcagcaa tccaaatttg tactttttca 660
ccagataaag gattaattgc atatgcacca gtaaacacac ctgatttatc ttttgctaaa 720
tctgtacgtt ctaaatctga ctttttagaa gcttctgttt gataagcttt tactttttct 780
ttatattcat cagtagtaat tgaattaact aatgcatgtt caggacttaa gactaagaat 840
gatgcaccat agattgtatc tggtctagtc gtaaatactt ctacttttcc ttccgtatta 900
tctacatcaa atgaaacttt ggccccttca gaacgtccaa tccaattgcg ctgcatatct 960
tttaaagact caggccaatc taaatcatct aaatctgcta ataattgatc tgcatattct 1020
gtgattttaa gtacccattg tttcatcggc ttacgataaa ctggatgtcc accacgttca 1080
gagacaccat caatcacttc ttcgttagat aaaacagtgc ctaatgctgg acaccagtta 1140
actgcaactt catcaacgta tgctaaacct ttgttatata actgtatgaa aatccactgt 1200
gtccatttat agtattctgg atctgttgta ttaacttcac gatcccaatc ataactgaac 1260
cctaattctt taatttgtcg tttaaaagtt tggatatttt tctttgtaaa ttcacgtggg 1320
tcgttgccag tgtctaaagc atattgctct gctggtaatc cgaatgcatc ccaccccatc 1380
ggatgtaata cattatatcc ttgcattctt ttatatcttg aaatgatatc tgttgctgta 1440
tagccctcag gatgtccaac atgtaaacca gcacctgatg gatatggaaa catgtctaaa 1500
gcataaaatt tcttttgacc taagttatca tttgttttaa atgttttatt ttcgtcccaa 1560
tagtcttgcc at 1572
<210> 129
<211> 1453
<212> DNA
<213> Staphylococcus aureus 13101
<220>
<221> source
<222> 1..1453
<223> /organism="Staphylococcus aureus 13101"
/note="mecRl and mecA"
/mol_type="unassigned DNA"
<400> 129
tccaggaatg cagaaagacc aaagcataca tattgaaaaa ttaaaatcaa aacgtggtaa 60
aattttagac cgaaacaatg tggaattggc caatacagga acagcatatg agataggcat 120
cgttccaaag aatgtatcta aaaaagatta taaagcaatc gctaaagaac taagtatttc 180
tgaagactat atcaaacaac aaatggatca aaagtgggta caagatgata ccttcgttcc 240
acttaaaacc gttaaaaaaa tggatgaata tttaagtgat ttcgcaaaaa aatttcatct 300
tacaactaat gaaacagaaa gtcgtaacta tcctctagaa aaagcgactt cacatctatt 360
aggttatgtt ggtcccatta actctgaaga attaaaacaa aaagaatata aaggctataa 420
agatgatgca gttattggta aaaagggact cgaaaaactt tacgataaaa agctccaaca 480
tgaagatggc tatcgtgtca caatcgttga cgataatagc aatacaatcg cacatacatt 540
aatagagaaa aagaaaaaag atggcaaaga tattcaacta actattgatg ctaaagttca 600
aaagagtatt tataacaaca tgaaaaatga ttatggctca ggtactgcta tcaaccctca 660
aacaggtgaa ttattagcac ttgtaagcac accttcatat gacgtctatc catttatgta 720
tggcatgagt aacgaagaat ataataaatt aaccgaagat aaaaaagaac ctctgctcaa 780
caagttccag attacaactt caccaggttc aactcaaaaa atattaacag caatgattgg 840
gttaaataac aaaacattag acgataaaac aagttataaa atcgatggta aaggttggca 900
aaaagataaa tcttggggtg gttacaacgt tacaagatat gaagtggtaa atggtaatat 960
cgacttaaaa caagcaatag aatcatcaga taacattttc tttgctagag tagcactcga 1020
attaggcagt aagaaatttg aaaaaggcat gaaaaaacta ggtgttggtg aagatatacc 1080
aagtgattat ccattttata atgctcaaat ttcaaacaaa aatttagata atgaaatatt 1140
attagctgat tcaggttacg gacaaggtga aatactgatt aacccagtac agatcctttc 1200
aatctatagc gcattagaaa ataatggcaa tattaacgca cctcacttat taaaagacac 1260
gaaaaacaaa gtttggaaga aaaatattat ttccaaagaa aatatcaatc tattaactga 1320
tggtatgcaa caagtcgtaa ataaaacaca taaagaagat atttatagat cttatgcaaa 1380
cttaattggc aaatccggta ctgcagaact caaaatgaaa caaggagaaa ctggcagaca 1440
aattgggtgg ttt 1453
<210> 130
<211> 740
<212> DNA
<213> Staphylococcus aureus 13101
<220>
<221> source
<222> 1..740
<223> /organism="Staphylococcus aureus 13101"
/note="mecRl and mecA"
/mol_type="unassigned DNA"
<4 00> 130
tctgacacga cttcttcggt tagtcatatg ttagatggtc aacaatcatc tgttacgaaa 60
gacttagcaa ttaatgttaa tcagtttgag acctcaaata taacgtatat gattcttttg 120
atatgggtat ttggtagttt gttgtgctta ttttatatga ttaaggcatt ccgacaaatt 180
gatgttatta aaagttcgtc attggaatcg tcatatctta atgaacgact taaagtatgt 240
caaagtaaga tgcagttcta caaaaagcat ataacaatta gttatagttc aaacattgat 300
aatccgatgg tatttggttt agtgaaatcc caaattgtac taccaactgt cgtagtcgaa 360
accatgaatg acaaagaaat tgaatatatt attctacatg aactatcaca tgtgaaaagt 420
catgacttaa tattcaacca gctttatgtt gtttttaaaa tgatattctg gtttaatcct 480
gcactatata taagtaaaac aatgatggac aatgactgtg aaaaagtatg tgatagaaac 540
gttttaaaaa ttttgaatcg ccatgaacat atacgttatg gtgaatcgat attaaaatgc 600
tctattttaa aatctcagca cataaataat gtggcagcac aatatttact aggttttaat 660
tcaaatatta aagaacgtgt taagtatatt gcactttatg attcaatgcc taaacctaat 720
cgaaacaagc gtattgttgc 740
<210> 131
<211> 1102
<212> DNA
<213> Staphylococcus aureus subsp. aureus 71193
<220>
<221> source
<222> 1..1102
<223> /organism="Staphylococcus aureus subsp. aureus 71193"
/mol_type="unassigned DNA"
<400> 131
gttatacatg cgtgcgtgct tttgttcatc attatctcta taggattagt ttttcatcga 60
ttacaaacga aaacgaactc tatagaacct atacataagg aaacaaaatt atcggataat 120
gcaaaatatt tggttgatcg taataaaggc aagggtgagc catcgaaatt aaaggaagta 180
tataatagta aagatcctaa gtataagaag attgacaagt atttacaaaa ttcattattt 240
aatggttcag tagcggtata tgaaaatggc aaattgaaaa tgagtaaggg ctatggttat 300
caagattttg aaaaaggaat taaaaataca ccaaatacga tgtttctaat tggttcagct 360
caaaaatttt caacaggatt actgttaaaa cagttagaag aagaacataa aattaatatt 420
aatgattcag taagcaaata tattccatgg tttaaaacat ctaagcctat tcctttaaaa 480
gacttgatgc tgcatcaaag tggattatat aaatataaat cttcaaaaga ctataagaac 540
ttagatcaag cagtgagagc aattcaaaaa cgtggcattg atcctaagaa atacaaaaag 600
catatgtata atgatggaaa ttatttagtg ctagctaaag ttatcgaaga agttaccggc 660
aaatcatatg ccgagaatta ctatactaaa ataggtgatc cattaaaact tcagcattcg 720
gcattttatg atgaaaaatc atttagaaaa tattttgcaa aaggttattc ttataatagt 780
acaggacttt ctttcttgaa gccaaatgtt ttagaacaat attatggtgc aggtaatata 840
tacatgacac caacagatat gggtaaatta attactcaga tacaacaata taaattattt 900
agtcctaaaa taaccaatcc attattacat gagtttggta cgaaacagta tccagatgaa 960
tatcgatatg gtttctatgt taagccaaca ttgaatagac ttaacggggg attctttgga 1020
caagtcttta ctgtttacta taatgataag tatgtagttg tacttgcatt aaatgtaaaa 1080
ggaaacaatg aagttcgaat ca 1102
<2 10> 132
<2 11> 1504
<2 12> DNA
<213> Staphylococcus epidermidis RP62A
<22 0>
<221> source
<222> 1. .1504
<223> /organism="Staphylococcus epidermidis RP62A"
/mol_type="unassigned DNA"
<4 00> 132
ggcgtacaaa agagtttgcc ttataccaac tgataggttt aacacgtgga aatattctaa 60
gaatgctcaa tatagaacaa ctagtatttt ttattgtaac aggaatttta ggcactttaa 120
ttggtatttt tggttcaaaa cttttacttg ttatcgcttc taaattaatg aagttaaaca 180
cacatatctc tattggcttt gaaccccaag ctatacttat tactatcgta atgttagctg 240
tcgctttttt attgataatg atacaaaatt acattttctt aaaaaaacac agcattttag 300
ctttgatgaa agacaattat accccggaag ctacccaaaa acggataact acgtttgaag 360
caatcggcgg cattttagga attataatga tagtatttgg atattatatg tctactgaaa 420
tgtttggtgt ttttaaagcc ttaacaactg ctttgattac accttttagc atactttttt 480
taactattgt tggtgctttc ttattcttta gaagttctgt atcacttatt tttaaaacac 540
taaaacatat taaacatggt cgtgtaaata tcacagacgt tgtctttaca tcatctatca 600
tgcacagaat gaagaaaaat gcgatgtctc tcacagttat tgctatcatt tcagctttca 660
cggttagtat tctttgcttc gcggcaatta cacaatctaa tactaataca actttagaaa 720
tgacctctcc agatgatttt aatataagcc agaataaaat agctgcgcaa tttaaacata 780
aactagatca aggaaattta aaatatcatc agcggactta tgaagtaatc aatccaaaaa 840
cattaagcga ccacgtcatg aagagtaaaa atggttctga tatgtctact aatacaacat 900
cactaatgat gaactcacat ctcaaaggtc atgaagctaa aataacgaat atacaatcat 960
caacaggatt aatagatatt catttaaatc ataagattac agttaaagga aaatctaaac 1020
aatctattat cgttaaagac aaagataact ctaaaatata tccatcccaa ttatcatttg 1080
gagctcctat agttgaggtg agtccggagg tatataacac attaaaaact gacaatattg 1140
ttaataagat gtacggtttt aatttcaaca ctcacaaaga tgtgaaaaaa gcagaaaaaa 1200
ttgcctcaaa agttaatcgt aatattgtat cgcacgatga atataagaaa tttataaacc 1260
aaagcaatgg catacttatc tttgtaacat cattcttagg aatagcattt ttaatggctg 1320
ctggttgtat tatttacatt aaacaaatgg atgaaactga ggatgaactt gataacttta 1380
agatattacg tcgtatagga tttacctaca ctgatatgtc taaaggttta ctattaaaaa 1440
ttgcatttaa ttttggatta ccgcttctta ttgctttatt acatgcatta tttgcagcac 1500
ttgc
1504
<210> 133
<211> 1376
<212> DNA
<213> Streptococcus agalactiae 2603V/R
<220>
<221> source
<222> 1..1376
<223> /organism="Streptococcus agalactiae 2603V/R"
/mol_type="unassigned DNA"
<400> 133
aattcgccga ttgaaagttg gagctgcatc tgtaatgatt gctagtggaa gcattgttgc 60
tttagggcaa tctcatattg tttcagcaga tgagatgtcc caacctaaaa caaccattac 120
agctccaaca gctaacactt ctacaaatgt agaaagtagt actgataagg cattatcaaa 180
agttactacg atggagacaa gttcagaaat gcctaaaatg caaaatatgg caaaagttga 240
aaaaacgagt gacaaaccta tgatggtggc tacctctgtt agaaaaatga tggcaacgcc 300
gacacctgta gcgatgacca aaacgactag tgtagatgag gtaaagaaat caactgatac 360
tgcttttaaa cagacagtag acgttccggc tcattatgtt aatgcagcaa aagggaatgg 420
cccatttcta gcaggtgtaa atcaaacgat tccatatgaa gcgtttggtg gagatggcat 480
gttaacgcgt ttaatcctta aatcttctga aggagcaaaa tggtcagata atggtgttga 540
taaaaatagt ccattattac cattgaaagg cttaactaaa ggtaaatatt tctatcaagt 600
ttctttaaat ggtaatacga caggtaaaga gggacaagct ctcttagatc aaattaaagc 660
taatgataaa catagctacc aagccacaat tagagtttat ggtgctaaag atggtaaagt 720
tgatttaaaa aacatgatta gcccaaaaat ggtaaccatt aacattcctc acattacaac 780
tgatatggaa gtaaaaaatt ctctaaagat ggcctttaaa gaaaaagtag acgtcccagc 840
aaaatatgtt agtgctgcaa aagctaaagg tccattttta gcaggtgtta acgaaacgat 900
tccatatgaa gcgtttggtg gggatggcat gttaacgcgt ttaatcctta aagcttcaga 960
gggagcaaaa tggtcagaca atggtgttga taaaaatagt ccattattac cgttaaaaga 1020
tttaactaag ggtaaatact tctaccaagt ctctcttaat ggcaatacag ccggtaaaaa 1080
aggccaagct ctcttagatc aaattaaggc aaatggaagc catacttatc aagcaactat 1140
cactatttat ggtacgaaag atggcaaagt tgatatgaat actattttag gacaaaagac 1200
agtgatgatt catattaatg tcgctaaaaa agatatgaat agcacatcaa tgatgatgaa 1260
aaaagataag atgacaatgc ctatgaagaa agaaatgact tcatctaaaa taaataccgg 1320
tatgatgatg tctaacaaca agatgtcagc taatatgcaa atgtcatcac aagcca 1376
<210> 134
<211> 1455
<212> DNA
<213> Streptococcus agalactiae 2603V/R
<220>
<221> source
<222> 1..1455
<223> /organism="Streptococcus agalactiae 2603V/R" /mol_type="unassigned DNA"
<400> 134
gctctgggtg aggagacaag tcaggaagat tttgaggttg actttactga agtggagcaa 60
ttaaaaacag aaatgttctc cgataatgat ttttattact ttgagatgtt gggtgataac 120
taccatgtag aagatttaat tgggatagct tggggaaata gcgatacaat ctacgctact 180
agtaatgtat cgttattgca agaagcttta tttaaaaaag ctttatcaaa acctatcaaa 240
acttatgatt ttaaaagaag taaggtcctt ttaaatcgtt ttaatattga tttaccagag 300
ccagcctttg atactagatt ggccaagtac cttttgtcta ctactgagga taatctagta 360
tcaacaattg ctaggttata tacaaatctg ccactggata ctgatgatgc tgtttatggg 420
aaaggtgcta aacgcgctat accagaaaaa acacgatttc ttgagcatct agctaaaaaa 480
gtaaaagttt tagtggattc tgaggctaat attatgcaac agcttaaagc taatgagcaa 540
gaagaattgc tgtttgaaat ggagcaacct ttagcgaatg ttttagctaa aatggaaatt 600
cgaggtatta aggttaagaa aaataccttg aatgaaatgg ccattgaaaa tcaaaaagtc 660
atcgaaacat taacacaaga aatctatgaa ttggctgggc aagagtttaa tattaattct 720
ccaaaacagt taggaaagtt gttgtttgaa acgttaggtc ttcctgtaga aatgactaaa 780
aaaacaaaaa caggttattc aactgcagta gatgtattag agcgcttagc tccgatttct 840
cctcttgtaa ctaaaatttt agagtaccgt caaatcacta aattgcaatc aacctatatt 900
attggtttac aagattatat tttagaagat ggtaaaattc atacacgtta tgttcaagat 960
ttgactcaga caggtcgtct ttcaagttct gacccaaacc ttcaaaatat accagttaga 1020
ctagagcaag gacggcttat ccgaaaagct tttgttccat cagaagacaa tgctgtttta 1080
ttgagttcag attattctca aatagaattg cgcgtgttag cacatatttc aaaagacgaa 1140
catttgatcg ctgcctttaa agagggagct gatattcata cttcaacagc tatgcgtgtt 1200
tttggtatcg aaaaacctga gaatgtcact cccaatgatc gtcgaaatgc taaggctgtt 1260
aattttggaa ttgtttatgg tatttcagat tttggtctat cgcataattt aggaatacct 1320
cgtaaactag cgaagcaata tattgacacc tattttgagc gttatcctgg aataaaaaac 1380
tatatggaaa cagttgttcg tgaagcaaaa gataagggtt acgttgaaac acttttccat 1440
cgtcgtcgtt catta 1455
<210> 135
<211> 1495
<212> DNA
<213> Streptococcus agalactiae A909
<220>
<221> source
<222> 1..1495
<223> /organism="Streptococcus agalactiae A909"
/mol_type="unassigned DNA"
<400> 135
ttgaaagagc gaggactggt gcgttttaca tatccgcctc tagtaacact gacgtatgtg 60
tcctcttcga taattaaact tgcagtatcg atttcaatag tttcagctaa ttcttgaagt 120
tcagaacgtc tagtattggc aaatttcttt ttgacctcac gtaactcacg tttcattacg 180
ttatacatcg tacgttcatc actaataatt gccttaagca ttgtgatttg ttgacgaagt 240
tcttcttctt cttctctcaa cgtcacaata tcagtatttg tgagacgata taattgcaat 300
gtgacgatag cctctgcttg ggcttctgaa aactcatagc tgaccttcaa attctctttc 360
gcatcagctt tattctcaga agcacgaatt aatgcaatca cttcatccaa aatagaaaga 420
accctaatca gtccctcaac aatatggaga cgtttttcgg ctttttcttt atcaaatttt 480
gaacgagcaa taataatttc tcttcggtga gcgatatagc tagttaatat tcttgataga 540
cccacctgct taggggtgta gtcatcaata gcaaccatat tgaaattata attcacttgt 600
aggtctgtat atttaaaaag ataatttaag acaattgttt catcggcttc ttttttgagc 660
tcaatagcga tacgaagacc atctctatca gactcatcac gcacctctgc tattcctgga 720
actttattat taacacgaac atcatcgatt cgttttacta aaactgactt attaacttca 780
taaggaattt cagtaacaat aatttgtttc ttaccacctt ttaaggtttc aatagcagtt 840
cgcgagcgaa ccgctactct ccccttacca gtctcatatg ccttacgaat ttcatctttt 900
ccttgaatga tagcgccagt tggaaaatct ggaccaggta gaaattccat taatttatct 960
aatttagctt tagggtgatc aatcatgtac acgacagcat caatgacttc tgctaaatta 1020
tgtggtggaa tatctgttgc atagcctgca gatattcctg ttgctccgtt gactaaaaga 1080
ttgggaaagg cagctggtaa aacagttggt tctttctctg tatcatcgaa attccaggca 1140
aagggtacgg tattcttatc aatatcttga agaagataac cagcaatttc tgatagacgg 1200
gcttccgtat aacgcatagc cgccgcagga tctccatcca tagaaccatt atttccgtgc 1260
atttcaatca atgtctcacg atttttccaa tcttgagaca tacgaaccat cgcgtcatag 1320
atagaggaat ccccatgagg atggaaattc cccataacat taccgactga ttttgcagat 1380
ttgcgaaatc ccttttcaaa agtattacca tctttattca ttgaataaag gattcgacgt 1440
tgaacaggtt ttaagccatc acgaatatcc ggcaacgccc gttcttgaat gatat 1495
<210> 136
<211> 1004
<212> DNA
<213> Streptococcus agalactiae A909
<220>
<221> source
<222> 1..1004
<223> /organism="Streptococcus agalactiae A909"
/mol_type="unassigned DNA"
<400> 136
gggcaatttg gtgaggacta tagtttttta cttaattttg cttacaatat tccattttca 60
tcggattttt ataatgagtt atttttagaa cacattatag agggtgatat agatattcga 120
ttggttatct cgttgattgt tgatggttct gttgatgata ttgctaaaga gtggtacttt 180
gagaaggaag acctaaatca acttatttct ttagagtccg atattagtgg tagccttgca 240
gttaaacttt ttgctaaggg aaagggtatc attaagttag gtccattgca ccgtcgtaat 300
ggtagaggag gattgggcac atttctacta ggaggagaac gtcacataga tgctataggt 360
catgaattta tgacttattt tgatccagta gatttcaaac cacctctaac tgtttatttt 420
tcgggatttc gttcagctga aggctttgag ggattctgga tgatgaagag tatgaagact 480
ccattcatgt taatttgtga tccacgatta caaggtggtg ccttttatat aggaagcaaa 540
gaatatgaac aaaaaatagt tgatgctatt caagaaaaac tggccttttt aaattttagt 600
tctgatcagt taattttatc cggactttca atggggactt atggtgctac ttaccatggt 660
gctaagctaa atcctcatgc tattattatt ggtaaaccaa tatttaattt aggaacagtt 720
gctcaacgtg aaagattaga gagaccagat ggatttgcta cttcattaga tattcaacta 780
ctcaatcaag gtgacttgac cagttcctct tctgagaagt taaataacca tttttggaaa 840
tctatagaag aaggagattt ttcaaatacg acttttgcct tagcctatat gaaaaacgat 900
gactatgatg cgactgcctt ttctgattta ttgcaatatt ttagaggaaa gaagcataag 960
atattaggca gaggttggga tggccgacat ggtgattgtt ctgc 1004
<2 10> 137
<2 11> 1024
<2 12> DNA
<213> Streptococcus agalactiae 2603V/R
<22 0>
<221> source
<222> 1. .1024
<223> /organism="Streptococcus agalactiae 2603V/R"
/mol_type="unassigned DNA"
<4 00> 137
gccgactaat gtcggttttg atgatactat caaccaaatg aagatgtttg attatgctgg 60
aaaagagagt agattagttg tcttaaacta tatgcccaat ttacgttatt atttacatcg 120
ctatgacttg ttagaatcag gttattattc agtttttgat gatattcaag aaattgggaa 180
tgtaagacag caaatgattg acttccgaca actcaattgg cctgaagggg tggactttac 240
ctatactccg tttatagttt tggtaaaaaa gtcaggagat ttaattgcta aggttcaatt 300
tggtgaagaa ggaaatttaa cgcatattga ttattttgca aatgaacaaa tagctaagaa 360
atacctcttt gatgatagag gatttctatc tagtattctc tattatgata atggtggtga 420
agcctatcaa gattatttag caccatcagg ggaaaggatc atgagagaat acctaagaga 480
aggtgaccac catgttgaaa ttaatcctaa gaaagctatt cattttttaa agttatctta 540
ctccgatatt gaagagttga ttagagagaa atatctgacc tatctccata aagaagttag 600
taaatcagat actatcattg ttagctttaa tcaagttcat aacgcattta ttgttgggaa 660
cactagtaaa ggaaatttaa tattatctgt tttctcggag aggaataatg ctcacaatgt 720
attggaggat tactcttcct tatctcgagc agacgctatt atttgtgata gactagatat 780
tgctgcacaa ttgaaagaaa aaatagataa accagttgtt catgtttctc cctttgatac 840
gcgtttagct ttgggaaaaa gtaatcaagt tagagattta gaaatatatt ttgtcgtaga 900
tagactttcc cataaagaat tgcaaaagtc tttaacatcc ttatataagg ttatgctcaa 960
aaataatgat ataaaagtaa catttgtcag ctacgaacga gaatttgaaa gtcggcaatt 1020
gaca
1024
<210> 138
<211> 1019
<212> DNA
<213> Streptococcus agalactiae 2603V/R
<220>
<221> source
<222> 1..1019
<223> /organism="Streptococcus agalactiae 2603V/R"
/mol_type="unassigned DNA"
<400> 138
gtctccagaa cgtgcgattt ctgttgtaga aaacatccgt aataaatttg tcaaagctta 60
tccaaaagat gcagcttcat ttaacaaaaa tgcagatgct tacattgcaa aattaaaaga 120
gcttgacaaa gaatacaaaa atggtttgtc aaatgctaaa caaaagagtt ttgtgactca 180
acacgcagcg tttggttaca tggcgcttga ttacggttta aatcaagttc caattgctgg 240
tcttactcca gatgcagaac cttcatcaaa acgtttaggc gaattagcta aatacatcaa 300
gaaatataac atcaactaca tttattttga agaaaatgct tcaaataaag ttgctaaaac 360
tttagcagat gaagttggcg tgaaaacagc tgtgcttagt ccacttgaag gactttctaa 420
aaaagaaatg gcagctggcg aagattactt ctcagttatg agacgtaatt tgaaagttct 480
taaaaagaca acagatgttg caggtaaaga agtagctcct gaagaagata aaactaaaac 540
agttgaaaca ggttacttta aaactaaaga tgttaaagac cgtaaattga cagattactc 600
tggtaattgg caatcagtat atcctcttct tcaagatggg acacttgatc cagtttggga 660
ttacaaagct aaatctaaaa aagatatgac tgctgcagag tacaaaaaat attatacagc 720
aggttacaag actgacgtag aatcaatcaa gattgatggt aaaaaacatc aaatgacctt 780
tgtacgtaat ggtaaatcac aaacatttac atacaaatat gcaggttaca aaatcttaac 840
ttataaaaaa ggtaatcgtg gagtacgtta tctctttgaa gctaaagaaa aagatgctgg 900
tcaattcaaa tatatccaat ttagtgacca tggtattaaa ccgaataaag ctgaacactt 960
ccatatcttc tggggttcag aaagccaaga aaaattattt gaggaaatgg aaaactggc 1019
<210> 139
<211> 831
<212> DNA
<213> Streptococcus agalactiae 2603V/R
<220>
<221> source
<222> 1..831
<223> /organism="Streptococcus agalactiae 2603V/R"
/mol_type="unassigned DNA"
<400> 139
tgggatgatt tttcaaggtt ttcttataat tttggaacaa aattacaatt tttaggaaaa 60
tcagtatgct ttgaaaatcc attagctcct tctagcacaa acttgtatac atggagctcc 120
cagactaatt atcagtcaaa aagaatttct cctaacttac ctttactaag aaagggaact 180
cgttatagct tgtcattaaa tgcagaactc gatttagtta gctctctttt tgttcgcatt 240
gaattttaca atcgctttaa tgagtctgtt ggttttgaac tgttaaaaaa agatagtatt 300
atttttatct atcctaaaga ggcttatacc tataccatta gtttgattaa tgcaggttgt 360
agcgatttta cttttcatta tttgaaactt gaggaagtta cagatagcgt tattcaggag 420
aaaaatctat cgacagagtt tactattgaa gaacatcaag acgttttaaa tcttcttttg 480
gtcgagaaaa aagatagtgt atatattaat aaaatagaaa gcatttctca attgcaacag 540
aaagtcgagt tggtcagcaa tccctcatta aattctgata gtttgatatt acctgagttg 600
gaaaaggggt tagaagatgc attaaaagtt tttcctaaca ttaagattaa tgtcattgcg 660
tatggaacac aaggtaattt tgctgcttta tattatgcta aaaaatttcc cagaataact 720
gcctatatta atgattgttt tgctcctttc ggaattttac ttaaatcctt accacacttg 780
actgccaaac aacaaatatt tcttagagaa gtctgggata cgagagagac g 831
<210> 140
<211> 862
<212> DNA
<213> Streptococcus agalactiae 2603V/R
<220>
<221> source
<222> 1..862
<223> /organism="Streptococcus agalactiae 2603V/R"
/mol_type="unassigned DNA"
<400> 140
ccgggaaagg gacagtattt ttgtccaact tgttgttcag ctgtaaggtt aaaggcaggt 60
cgaatcatga gaagacactt tgcacatatt agtctaaaaa attgtcagtt ttatcatgaa 120
aatgagtcta atgagcactt gcaattaaaa gcaaagttat atatgagttt aagtagagag 180
aatgaaacta tgctcgagca tcatttgcca gaaattaatc agattgcaga tttatttgtg 240
aatgagacat tggctttaga agttcagtgt agccgactat cagagcagcg actcagggag 300
cgaacaaaag catatctaca ggcagacttt caagtgagat ggttactagg ggaaaaactc 360
tggttaaagc atcgtttaac aaatctacat aaacaatttt tacaattttc tcaaagtatc 420
ggatttcata tttgggagtt agatttgagg ttagaagtac tgagactaaa atatttgatt 480
tacgaagatt tacgcggaca tgtctattac ttaagtaaaa cttgccctct tagtggagac 540
gttctagcat ttttgaagtg gccataccaa tcaaaaaatc taaattttta taaggttaaa 600
caagacagaa atatcagaga ttatgtgcgt cagcagttac gctatggcaa tcaattttgg 660
ttacgaaaac aagaaaaggc ctacctttct ggtcagaatc tattgaccca agagctaatg 720
atgttttttc ctcaaataca gccaccacgt gtagatactg atttttgtca aataacaaat 780
tctctaacat cgttttatca gaattttaca aattattatc aaaaaaataa gaataactta 840
gaccaaacac tttatccccc tg 862
<2 10> 141
<2 11> 822
<2 12> DNA
<213> Streptococcus agalactiae 2603V/R
<22 0>
<221> source
<222> 1. .822
<223> /organism="Streptococcus agalactiae 2603V/R"
/mol_type="unassigned DNA"
<4 00> 141
tggaggacag ggtaatgttc agtcaaaaca cctttgtcaa ctagttaaaa ctccaaaagg 60
tgaaattctt ttttcaaagt tacaagcaac tgatttagaa tcatatcagt taatgatgga 120
tgtcattaac cacaaggtaa gtttagacaa tgttcatgcg tctatgttag caaatttttt 180
atataatgat tggctaacaa acgatgaaaa aatagtatct gggataggat tttcagctca 240
tagcgccggt attttcaatg tgttatatgc tagtggtagt actagttttg aaaacattat 300
tcactttatt aaacgtcgtg cccaacttat agaaaattgt catgtgtctg aagagctttg 360
gcttttgatg gttgaaaaca ttgatatgtt tagtaaggat gttttaaaag aacagtctga 420
gaaagtaaaa ttagctatta ttactgatga tagagctggt gtaattgcta tggatcaagt 480
caaccgttct ttctttgatg acgtgatgac taacaaaggt tatttttata aattaaagca 540
gttaggcgta aaagcaccat atcatactga ttttttaaat gaatctaaag agcagtataa 600
acaattgatt gaaagcctag atatttcgca aaatgatgac tatgactata tttttcattg 660
tgatcaattg gtagatgaaa ttttatatca gtggaccaat ctctttaact ggcgtgcgat 720
taaggaaact atcatagaaa aggatgcgga gattattgat atttctccta ataggtttat 780
ttctagtcag ttgcaaaaaa tgaaaaagag ggggaggaaa ca 822
<210> 142
<211> 665
<212> DNA
<213> Streptococcus agalactiae 2603V/R
<220>
<221> source
<222> 1..665
<223> /organism="Streptococcus agalactiae 2603V/R"
/mol_type="unassigned DNA"
<400> 142
atggaacttc atggtgatcg ccagttcgca gatgacaaat caattatagg aggtttgggg 60
tacttggcag ggcgtcctgt gacgattgtc ggtattcaaa aaggtaagaa ccttcaagat 120
aatttagacc gtcattttgg tcaaccacat cctgaaggtt atcgtaaggc tttacgttta 180
atgaaacaag ctgagaagtt tggaagacct gttataacct tcatcaatac tgctggagca 240
tatcctgggg taggtgctga ggagcgaggt cagggtgaag caattgctag aaacctctta 300
gaaatgagtg atttaaaagt ccctattata gctattatta ttggtgaagg gggttctgga 360
ggagcattag ctttagctgt tgccgataag gtttggatgt tggaacatac tgtttattct 420
attttaagtc ctgagggctt tgcctctatt ttatggaaag atggtacaag aacaacagaa 480
gcagcacaat taatgaagat gactgctgga gaactttacc atatggaagt tgtagacaaa 540
gtaatccctg aacatggtta tttttcaagt gagattgtcg atatgattaa gacaagttta 600
atttcagagt tagaagtgct ctcacaatta tctcttgagg atttattgga acaacgttac 660
caacg
665
<210> 143
<211> 1582
<212> DNA
<213> Streptococcus bovis fba gene for class-II aldolase
<220>
<221> source
<222> 1..1582
<223> /organism="Streptococcus bovis fba gene for class-II aldolase "
/mol_type="unassigned DNA"
<400> 143
attcttcgtg gctgctcaat atcacccaga acttcaaagc cgtccaaacc gtccagaaga 60
gctttacaca gcatttgtga ctgcggcaat tgaaaataaa aacagtaaat aatagtagaa 120
atacgtgaaa aaaagcacct ttttaagcct ttctagggtt tagaaggtgt ttttttatgt 180
aatggtattg ttacatagga agtcttcaca ttttgataaa aaatagtata atagtgagca 240
tgataaaaat gataataagg aaacgtagta ttttgttatg gatgattgct ctagtgttta 300
tagcaagtgt cggggcaagt ttttatttct ttcatgttgc ccaggttcgt gaagataaat 360
cgtttattaa caataaacca cgtcccaaag atagtagttt atatgcctat gaacaaagtt 420
ttgatcagtt aagtaaagaa acacgttgga tgactaatca aggccttaag caggacgctt 480
ggtatgttcc tgcagcggct gaaacaaata aaacagctat cgttgttcac ggttttacaa 540
gtgaaaaaga agacatgaag ccttatgctt ggatgttcca tgaacttgga tataatgttc 600
tgatgccaga taacatgtct catggtgata gtcagggaca aattattggt tatggttgga 660
atgatcgcct aaacatcgta aaatgggctc aactattagc agaagaaaat tcggattgtc 720
aaatcacctt atttggtgtt tcgatgggtg gagctactgt catgatggct tcatgtgaag 780
agacactacc aaaacaagtg gttaatatta ttgaagattg tggttatagc agcgtttggg 840
atgaattaaa atatcaagcc aaagctatgt ataacttacc agctttcccg attctttatg 900
aagtgtctgc agtatcaaaa gttcgagcag gtttctctta cggacaagcc agctgtgtga 960
aacaattaaa aaacaatacg cgcccaattc tttttatcca tggtagcgaa gataagttcg 1020
ttccaacaag tatggtttat aaaaattatc gtgcaaccaa tagtgagaaa gacctttata 1080
tagccaaagg tgcagcgcat gccaaatctt ttgaaagtga tccttaaaac atacattgaa 1140
aaaatttcag cttttttgca aaaaaattga aaaatagtgt tgacagaaat gtgaatggct 1200
gatataatta tttatgttgt taaggaacag cggaaatggc ggaattggca gacgcgcagg 1260
actaaggatc ctgtgatcgc tttagatcgt gagggttcaa gtccctcttt ccgcagagtg 1320
acaagccaga gagtgcttgt ctttttttgt gctcagagga cattgagtga aaacagaaat 1380
gaaagcagtg agaaagtttg aaaagacttt cttatttaca ctgctttttt cacagaaaat 1440
taatcaaatt gtaagtaacg ctagcaatct tatttatttt gtgatagaat gtacatataa 1500
aaagggtata tcccaaaaaa taaataggag gcctatataa tggcaatcgt ttcagcggaa 1560
aaatttatca aagctgcccg tg 1582
<210> 144
<211> 1044
<212> DNA
<213> Streptococcus bovis
<220>
<221> source
<222> 1..1044
<223> /organism="Streptococcus bovis"
/mol_type="unassigned DNA"
<400> 144
aatcggcatg gtggaagtag agcgtatccc gaacgcaaaa caatttaatg gaaaatgggt 60
gacttttcaa cattttcaaa tcaaaaaata attttagttt taaaattttt accacattcc 120
cgattaaatt atcaaaaaat tgtcattatt tgtttgcgtt ttcataaaaa tgtgttatac 180
ttttattgaa tatgcaaccg attgcaaaat aaaaagagtg tttaggagga cagcttatac 240
gttaatcata atagcagtgt tattttagaa ttagcagaat agtatgtgat tgattgggca 300
ggtttcgcac atcgttctgg cttatttttt tacagttcaa cgaaaacggt tgcgtatttt 360
aatttatctt tttaggagat tatccatgac atttcagaat aaagtaaatt tgaaaaagaa 420
gatgaaaaaa agtctaggtt cattgcttat tttaacagct attggtgctg gcggattagt 480
tcaagttaaa gtcgttaatg cagatgaaca agtgtcaatg aaagatggta cgatacttca 540
tgcgtggtgc tggtctttca ataccattaa agataatatg caagccatta aagacgcagg 600
ttacacaagt gttcaaacgt ccccaatcaa cactgttgta gctggcgaag gcggaaataa 660
gagtttaaaa aattggtact atcaatatca accaactatt tataaaatcg gtaactatca 720
attaggtact gaagaagagt ttaaagaaat gaatcgtgtg gctgatcaat acggtattaa 780
aattattgtg gatgccgtct taaaccacac aacttcagat tacaatcaaa tcagtcaaga 840
aatcaaaaac atccctaact ggacacacgg aaacactctc atttctgatt ggcataatcg 900
ctacgatgtt actcaaaatg cacttcttac actttatgat tggaatactc aaaatgaata 960
tgtccaacaa tatttgttga gttatttgaa acaagcagta gctgatggtg cggacggttt 1020
ccgctatgat gccgcaaaac acat 1044
<210> 145
<211> 1036
<212> DNA
<213> Streptococcus bovis
<220>
<221> source
<222> 1..1036
<223> /organism="Streptococcus bovis "
/mol_type="unassigned DNA"
<400> 145
cgttgttctt ctcacgtcca gtcggtggtg gtaatggcac acgattccca ggtcaatcac 60
aaattggtga tgcaggtagc aatctttaca aagacgcgac agtgactgct gttaataaat 120
tccataatgc catggttgga gaatcagaat accttcgtaa tcctggtggt gatgaacaag 180
ttgcaatgat tgaacgtggc acaaaaggtg ctgttattgt gaaccttgtt gacggcgaca 240
aacaaattaa ttctgaaact aatttggctg atggtacata cactgacaag gtttctggtc 300
gacaatttaa tgtttcaaat ggtcgtatta caggtagcgt tccatcacgc tcagccgttg 360
ttttgtatga tgaccaagct agccaagcag ctcaagtttc agttgatggt tacaaagaag 420
gcgacaatag catttctaaa gccacagaag taacattgaa agctaaaaat gctgactctg 480
cgacttacaa acttggtaat ggtcaagagg tagcttataa agacggtgat aaagtcactg 540
ttggtgaagg gcttgaagct ggtcaatcaa ctactctaac attgactgca acaggagctg 600
acggtcaatc aacaacgaag acatacactt tcacaatgaa agacccaagt gctgagacta 660
acatttactt ccaaaaccca gataattggt cagaagtgta tgcttacatg tattcagcaa 720
aagataataa acttcttggc gcatggcctg gaactaagat gactaaagaa gcatcaggtc 780
gttattcaat cacagttcct gcttcatatg ctgaagaagg tgtgaaagta atcttcacaa 840
ataatcaagg ctcacaatat ccacaaaatg aaggatttga tttcaaagca gaaggcttgt 900
actcaaaagc tggtttgatg cctgatgtgc cagcaggaaa aactcgtgta acctttgata 960
accctggcgg ttgggatagt gcgaatgctt acctctacta cggaaatcct gttcaatacc 1020
ctctaggtgt gtggcc 1036
<210> 146
<211> 1133
<212> DNA
<213> Streptococcus bovis adhE
<220>
<221> source
<222> 1..1133
<223> /organism="Streptococcus bovis adhE"
/mol_type="unassigned DNA"
<400> 146
acaaccagga tttgcctttg tcatttacgc tgttatcagt ttgattattt gcttaggttt 60
gattgtaaaa acacgttttt caaagaaaaa ttaatttgtg ttaaagtctt gttaaattaa 120
gggaaaacct ttgacaaaac tagatttaat ctgctacaat aaggactgtc gtaagacaag 180
taacttcttc ttggtcgtag gatccgccaa aaacctacca ctcggatgaa gcaatataaa 240
ggagaaaaat tatggcaatc tcaaaagaga aaaaaaatga aatcatcgct caatacgcac 300
gtcacgaagg tgacacaggt tcagttgaag ttcaagtagc tgttcttact tgggaaatca 360
accaccttaa cgaacacatc aaacaacaca aaaaagacca cgcaacttac cgtggtttga 420
tgaaaaaaat cggtcaccgt cgtaacttgt tggcatacct tcgccgcaca gacgttaacc 480
gttaccgcga attgatcgca tcacttggtc ttcgtcgtta atctgacgca aaaccaaaga 540
aaaacttctt ggaatttcca agaagttttt ttgttttctt tgaaaatatt tttaatgaaa 600
atgagctttt gaataatgtg aaaatataaa agtgataaaa acattagttt aaaaggaaaa 660
cgaccgcttt tacttgtatc cccttacatt gcttttgtaa caaaaatgaa aaagcttaca 720
aaaaatactt gacttttttt gaaaaaggtt taatatagtt ggtgaagaat atcacaatga 780
tatgatgatt aaagaattta acttttgatt ttgtgtagtt tatgtaagga agaagacctc 840
aaataatgac gttgagtttt ggaatttcag actatacagt cgtgttttta tttaagtatc 900
aatcattaat atagttcttc ttaaaaaatg aggcacttat ttaagggtac ttataaggag 960
gttttcttaa tggctaaagc aacaaatgca gatgtaaaga ataacgagtt gagcgcagaa 1020
gaattggctc aacagtacac aggagctctt gtcgaaaaag ctcttgaagc tgaacgtgtt 1080
tatgcaactt attcacaaga acaagttgat aacattgtcg cagctatggc tct 1133
<210> 147
<211> 1171
<212> DNA
<213> Streptococcus bovis
<220>
<221> source
<222> 1..1171
<223> /organism="Streptococcus bovis "
/mol_type="unassigned DNA"
<400> 147
cttaccgcat tgccttgatt tatactgtgg ttaacaatct tggcaagctt tgcctggagt 60
gtatatctta atattccact ttcaccattc aatatcgttt tgccacttgt ctttttgggg 120
ctttatgctt atgtgtacaa caaagcagcg cagctattag acaaagaaga cgatgagact 180
gattctgaaa gtgttaatca ataactttta agaaatcaaa taccgtctca gaacttgagc 240
taagacggta ttttaatttt taaaagagat ttaacggacg aatattatct tctaatcccg 300
tgatagtaac ccccagaaga cgcacaccag attttgattc ttctaagctg tcaaatatcg 360
catgagcagc ttggtcaatc acctcaaaat cattggtgac atcatctagt gttttacgct 420
tggttaaagt cgaaaaatcc gcgtatcgaa ccttcaaaac gacaatgcga ccaactttat 480
tatttcgcat taagctgtcc acaactcgac gtgtattttt tgaaatctct gacttaatat 540
cagcatcctc gtacagtaat ttactgtagg tacgttcact cccaatagat tttcgaatac 600
gattgggtct gacttgtgaa tttgaaatac ctcgcgcttt acggtacaaa tcataaccaa 660
agcgcccgaa atgatcaatc aaggtcatct ctggtatttc taataaatcc gctcccgtaa 720
aaacacccat ttgatgtagt ttttcaactg attttttacc aacaccatga aatttttcaa 780
ttggtaattt tttcaaaaaa tcctgcgcat cttctggcaa tactaaggtt aaacctttcg 840
gtttatcata atccgaagct agtttagcta gaaattgtgt tataagagac accggctgaa 900
caagtcaagt gaacttcttg ccaaatatca tattgaatca ttttagcgat tttaatcgct 960
gacttgatgc cgcgtttatt ttcagtcnca tnnnagtaag cctcatcaat cgacatgggc 1020
tcaacaagat cggtgtaacg tctgaaaatc tcacgaattt gcattccaat ttctcggtat 1080
ttctgataat ttccagaaat aaaaatagcc tgtggacaac gttcgtaagc ttcttttgaa 1140
gacatggccg aatgaacgcc aaattttctg g 1171
<210> 148
<211> 1508
<212> DNA
<213> Streptococcus pneumoniae ST556
<220>
<221> source
<222> 1..1508
<223> /organism="Streptococcus pneumoniae ST556"
/mol_type="unassigned DNA"
<400> 148
tagcacgtta caaacgcctg atgggctacg atgtatttta tctgacaggt cttgatgaac 60
atggtcagaa aatccagcag aaagcggaag aagctggtat tacacctcaa gcctatgttg 120
atggaatggc ggttggagtt aaagaactct ggcaattact agatatctca tacgataaat 180
ttatccgtac aactgatgac taccatgaaa aagttgttgc acaggtcttt gaacgcttac 240
ttgctcaaga tgatatctac ttgggtgaat actctggttg gtattcagta tcagacgaag 300
aattctttac agaaagccag ctggcagaag ttttccgtga tgaagctgga aatgtgactg 360
gtggtattgc tccatcaggt catgaggttg aatgggtttc tgaagaatca tacttccttc 420
gccttagcaa ataccaagac cgtttggtcg aatttttcaa agctcatcct gaatttatca 480
cgccagatgg tcgccttaat gaaatgctac gcaacttcat cgagccaggt ttggaagatt 540
tggcggtatc tcgtacaacc tttacatggg gagtgcctgt cccatcaaat ccaaaacacg 600
ttgtctacgt ttggattgat gcccttctta actatgcgac agctcttggc tacgctcaag 660
acgaacatgg taactttgac aagttctgga atggaacagt cttccatatg gtaggaaaag 720
atatccttcg cttccactct atctactggc caatccttct tatgatgttg gatgttaaat 780
tacctgatcg tttgattgcc catggttggt ttgtcatgaa agacggaaaa atgtctaagt 840
caaaagggaa tgtcgtttac cctgaaatgt tggtagagcg ttatggacta gatccacttc 900
gttactacct catgcgtaac cttccagttg gttcagacgg aacctttact cctgaagact 960
atgtcggccg tatcaactat gaattggcta atgaccttgg gaacctcctt aaccgtacgg 1020
tttccatgat taataagtac tttgatggac aaatccctgc ctatgtagaa ggtgtgactg 1080
aatttgatca tgttcttgct gaggttgcag aacaatcaat cgcagacttc catacacaca 1140
tggaagcagt tgactatcca cgtgcgcttg aagcagtctg gactctgatc tctcgtacca 1200
ataaatacat cgatgagact gcaccatggg tcttggacaa ggatgaagct cttcgtgacc 1260
aattggcaag tgtcatgagc cacttggcag ccagcattcg tgtagttgct cacttgattg 1320
aaccatttat gatggaaact agtcgtgcag ttttgactca acttggtttg gaagaagttt 1380
ctagtcttga aaacttgagt ttggctgact tcccagcaga tgtgactgta gttgccaaag 1440
gaacacctat ctttccacgt ctaaatatgg aagaagaaat cgcctatatc aaggaacaaa 1500
tggaaggc
1508
<210> 149
<211> 1580
<212> DNA
<213> Streptococcus pneumoniae ST556
<220>
<221> source
<222> 1..1580
<223> /organism="Streptococcus pneumoniae ST556"
/mol_type="unassigned DNA"
<400> 149
cctgatgagt ttcgtgagca atttcctttc attcgtgagt tgctggatca tatggggatt 60
cgtcactatg agctggctca gtatgaggcg gatgacatca ttgggacgct ggataagcta 120
gcagagcagg atggttttga tattaccatt gtcagtgggg acaaggattt gattcagctg 180
acggatgagc atacggtggt tgaaatttcc aagaaaggtg tggctgagtt tgaggccttt 240
acgccagatt acctcatgga agaaatgggc ctcacaccag ctcagtttat cgatctcaag 300
gcgctcatgg gtgataagtc ggataatatc cctggggtga ccaaagtcgg tgaaaagacg 360
ggtattaagc tcttgctgga gcatggttcg cttgagggga tttatgaaaa tattgatgga 420
atgaagactt ctaagatgaa ggaaaatctc atcaatgaca aggaacaggc ctttttatct 480
aaaacactag cgaccattga taccaaggca ccgattgcga ttggtttaga ggacttggtc 540
tatagtggtc cagatgttga aaatcttggg aaattctacg atgagatggg cttcaaacag 600
ctaaagcagg ctttaaatgt gtcgtcagct gatgtgtctg agagtttgga ttttactatt 660
gttgaccaaa tcagtcaaga tatgctgagt gaagagtcta tcttccactt tgagcttttt 720
ggtgagaatt accatacgga taatttggtt ggatttgcct ggtcttgtgg ggataagctc 780
tatgccacag acaagcttga gctgttgcaa gacccgattt tcaaggattt cttagaaaaa 840
acatctctga gagtttatga ctttaagaag gttaaagttc ttttgcaacg ttttggtgtg 900
gatttgcagg cgcctgcttt tgacatccgt ttggctaaat acctcctttc gactgtggag 960
gacaatgaaa ttgcgaccat cgctagtctt tatggtcaga cttacttggt tgatgatgaa 1020
actttctacg gtaagggtgt taaaaaggcc attcctgaac gtgagaaatt cttggaacac 1080
ttagcttgta aacttgctgt tttggtagaa acagagccta ttttacttga aaaactcagc 1140
gaaaatgggc aattagagct tctttatgat atggagcaac ctctggcttt tgtccttgcc 1200
aagatggaaa ttgctgggat tatggtcaag aaagagacct tgcttgagat gcaggctgaa 1260
aatgagcttg tcattgaaaa actgactcaa gagatttacg agctggctgg tgaggagttt 1320
aatgtcaact cgcctaagca gttgggcgtg cttctctttg agaaattggg acttcctcta 1380
gaatacacta agaaaaccaa gacaggttat tcgacagcag tggatgtgtt ggagcgtctc 1440
gctcctattg ctccgattgt taagaaaatc ctggattacc gtcaaattgc taagattcaa 1500
tctacttatg taattggctt gcaggactgg attttggctg atggaaagat tcatactcgc 1560
tatgtgcagg atttgaccca 1580
<210> 150
<211> 1000
<212> DNA
<213> Streptococcus pneumoniae ST556
<220>
<221> source
<222> 1..1000
<223> /organism="Streptococcus pneumoniae ST556" /mol_type="unassigned DNA"
<400> 150
aaaattattg gaatggtgct agctttactt tctgtaactg tagtaggagt aggtgttttt 60
gcttatacta tttatcaaca agggacagaa accttagcta aaacctataa aaaaatcggc 120
gaagaaacca aggttattga agcgactgaa cctctaacca ttctgttaat gggagtggac 180
accggaaatg ctgaacgaac tgaaacttgg gtcggtagaa gtgatagcat gatcttgatg 240
acagtgaatc ctaaaacgaa aaaaacaaca atgatgagtt tagagcggga tattctgacg 300
cgcattgaat cagggaatgg tcaggctcat gaagcgaaac tgaactcagc atatgcagat 360
ggtggagcag agcttgctat agaaaccatt caaaaaatga tgaatatcca tattgatcgc 420
tatgtgatgg tcaatatgag agggttgcaa aaactagtgg atgcagtagg aggtattaca 480
gtcaataata tcctaggttt cccaatttct atcagtgacc aagaagaatt taatactatt 540
tctatcggtg ttggggagca acatattggg ggagaagaag ccctagtcta tgcacgaatg 600
cgttaccaag atcctgaggg ggattatggt cgtcaaaaac gtcaacgtga agttattcaa 660
aaagtcatgg aaaaagctct cagtttaaat agcgttggtc attatcaaga gattctaaaa 720
gctttgagtg acaatatgca gaccaatatt gatttgtctg caaaaagtat ccctaacttg 780
ctaggctata aagattcatt taaaaccatt gaaactcagc agttgcaggg tgaaggagag 840
atacttcaag gtgtttctta ccagattgtt tcgagagcac gtatgttgga aatgcaaaat 900
atactccgac gttctttggg acaagaagaa gttactcagc ttgaaaccaa tgcggtttta 960
tttgaagatt tatttggcag agcacctgtt ggtgatgaag 1000
<210> 151
<211> 1098
<212> DNA
<213> Streptococcus pneumoniae ST556
<220>
<221> source
<222> 1..1098
<223> /organism="Streptococcus pneumoniae ST556"
/mol_type="unassigned DNA"
<400> 151
gagacaggtg agcctgatcc aaaaggtatt gctttctaca atgccatcat tgaagaagct 60
aaaaagaacc agatggatct tgtgatgaat ttacatcatt ttgatttacc agtggaactt 120
cttcaaaaat acggtggttg ggaaagcaaa catgtagtgg agttattcgt gaagtttgcc 180
aagactgctt tcacatgctt tggagataag gttcattact ggacaacttt caatgagcca 240
atggtcattc cagaagcagg atacttatat gctttccatt atccaaatct aaaaggaaag 300
ggaaaagagg ccgtacaagt catctataat ctaaaccttg ctagtgcaaa agtgattcaa 360
ctatatcgct cattagaact tgatggaaag attgggatta ttttaaactt gacacctgct 420
tatccaagaa gtaattctcc agaagactta gaagcaagtc gatttacaga tgacttcttt 480
aacaaagtct tcttgaatcc agctgttaaa ggaactttcc cagaaagatt ggtaaaacag 540
ctagagagag atggcgtgtt atggagtcat accgaaaaag agcttcaact gatgaaatca 600
aatacggttg attttcttgg agtaaactac taccatccaa aacgtgttca agcacaagca 660
aatcctgagg aatatcagac gccctggatg ccagaccaat acttcaaaga gtatgaatgg 720
ccggagcgtc gcatgaatcc atatcgtggt tgggaaattt ttccgaaatc catttatgat 780
attgctatga ttgtgaagga agaatatggt aatatcccat ggtttatcag tgaaaacgga 840
atgggtgttg aaaacgaagc acggtttatc gatgaaaatg gagttatcga tgacgtgtat 900
cgtattgaat tttatgaaga acatttaaga tggctacata aagccattga agagggaagt 960
cactgttttg gataccacgc ttggaccgca tttgattgct ggtcttggaa taatgcatat 1020
aagaatcgtt acggatttat ctccgttgat ttagaaacgc aaaagagaac catcaagagc 1080
tcaggaagat ggtatcgc 1098
<210> 152
<211> 1034
<212> DNA
<213> Streptococcus pneumoniae 670-6B
<220>
<221> source
<222> 1..1034
<223> /organism="Streptococcus pneumoniae 670-6B"
/mol_type="unassigned DNA"
<400> 152
tgggatatgg agccttgttc aaaaatccat caaaaccagc cgatggtatg ggatcaagta 60
tttgaagatg atccagaatg ggcttatatg ctcaatcgac aagaatatct cttgcagttt 120
atgatagggt atgtggtaga aggagataag gactatattc aaaagtgcaa gttctttcta 180
tttgattgga ttgagcaggt gagagaattt tctcctcaat ccttgatgac tagaaccttg 240
gatacgggta ttcgttcctt tacttggttg aaactactct tgcttctctt gaaatttgac 300
ttgctagagg agaaagaact agagaaaatt ttggtcagtc tagaaaagca gattgacttt 360
atgaaaagct actatcgcgc caagtacacc cttagtaact gggggatttt acaaacaatt 420
ccgatgcttg ctatctatca tttcttttca gataagatgg acctagaaga agcttaccat 480
tttgcttcag aggagttgaa acagcaaatt gagacacaga ttttaggaga tggaagccag 540
tttgaacagt cgattctcta tcatgtagag gtttataaag ccttgctgga tttgtgtctc 600
ttgcttccag acttgcaaga tagttaccaa gagttgctgg aaaagatggc gacctatatt 660
caaatgatga caggcttaga tggacggact ttggcttttg gtgatagcga ttctacagaa 720
acgacagaaa tgttgagcct gtctgctgtg gttttgaaca aggaagacct tcttaacggt 780
ctggatgtta aagttgattt gcttagcctc ttgttcctgg ggcgagaaaa ggtcaagcga 840
ctgcaggaat ttgaaaggag agcttggcag cctaagtcca tgatctttga agactctgga 900
catgtctgca ttaaggatga acatcgttat ctatttttca aaaatggtcc gctaggaagt 960
gcccatagcc atagtgacga gaatagtttt tgcttacagt atcaaggcca acctattttc 1020
atagatgctg ggcg 1034
<210> 153
<211> 1004
<212> DNA
<213> Streptococcus pneumoniae AP200
<220>
<221> source
<222> 1..1004
<223> /organism="Streptococcus pneumoniae AP200"
/mol_type="unassigned DNA"
<400> 153
tgttgaaagt cttctcgtat ccattgtaat cagtgcatac aatgaagaaa aatatctgcc 60
tggtctaatt gaagacttaa aaaatcaaac ttatcctaaa gagaatattg aaattctatt 120
tataaatgct atgtccacag atgggaccac agctatcatt cagcaattta taaaggaaga 180
tacagagttt aactcaatta gattgtataa caatcctaag aaaaatcaag ctagtggttt 240
taacctggga gttaaacatt ctgtagggga ccttatttta aaaattgatg ctcattcaaa 300
agttactgag agttttgtaa tgaacaatgt ggctattatt caacaaggtg aatttgtctg 360
tggggggcct agaccgacga ttgtcgaagg aaaaggaaaa tgggcagaga ccttgcatct 420
tgttgaggaa aatatgtttg gcagtagtat tgccaattat cgaaatagtt ccgaggatag 480
atatgtttct tctatttttc atgggatgta taaacgagag gttttccaga aggttggttt 540
agtaaatgag caacttggcc gaactgaaga taatgatatt cattatagaa ttcgagaaca 600
tggttataaa atccgctata gcccaagtat tctatcttat cagtatattc gaccaacatt 660
caagaaaatg ctgcatcaaa agtattcaaa tggtttgtgg attggcttga caagtcatgt 720
tcagtttaag tgtttatcat tatttcacta tgttccttgt ttatttgttt tgagtcttgt 780
gtttagtcta gcattgttac cgatcacatt cgtattcata actttactat taggtgccta 840
ttttctactt ttgtcactac tcactttgct gactttatta aaacataaaa atggatttct 900
aattgtgatg ccctttcttt tattttccat tcactttgct tatggccttg ggacgattgt 960
aggtttaatt agaggattta aatggaagaa ggagtacaag ggaa 1004
<210> 154
<211> 1527
<212> DNA
<213> Streptococcus pneumoniae 670-6B
<220>
<221> source
<222> 1..1527
<223> /organism="Streptococcus pneumoniae 670-6B"
/mol_type="unassigned DNA"
<400> 154
aggctcctag cctatccgag agtaaactag ttgcaacaac ttctagtaaa atctacgaca 60
ataaaaatca actcattgct gacttgggtt ctgaacgccg cgtcaatgcc caagctaatg 120
atattcccac agatttggtt aaggcaatcg tttctatcga agaccatcgc ttcttcgacc 180
acagggggat tgattccatc cgtatcctgg gagctttctt gcgcaatctg caaagtaatt 240
ccctccaagg tggatcaact ctcacccaac agttgattaa gttgacttac ttttcaacct 300
cgacttccga ccagactatt tctcgtaagg ctcaggaagc ttggttagcg attcagttag 360
aacaaaaagc aaccaaacag gaaatcttga cctactatat aaataaggtc tacatgtcta 420
atggcaacta tggaatgcag acagcagctc aaaactacta tggtaaagac ctcaataatt 480
taagtttacc tcagttagcc ttgctggctg gaatgcctca ggcaccaaac caatatgacc 540
cctattcaca tccagaagca gcccaagacc gccgaaactt ggtcttatct gaaatgaaaa 600
atcaaggtta catctctgct gaacagtatg agaaagcagt caatacacca attactgatg 660
gactacaaag tctcaaatca gcaagtaatt accctgctta catggataat tacctcaagg 720
aggtcatcaa tcaagtagaa caagaaactg gctataacct tctaactact gggatggatg 780
tttacacaaa tgtagaccaa gaagctcaaa aacatctgtg ggatatctac aactccgatc 840
aatacgtctc ttaccctgac gatgatttgc aagtcgcatc tacggtcgta gatgtttcaa 900
atggtaaagt catcgcccaa cttggagctc gtcaccaagc aagtaacgtt tcatttggta 960
ccaaccaagc tgtggaaacc aatcgtgact ggggttctgc tatgaaacca atcaccgatt 1020
atgcacctgc catagaatac ggtgtttatg attccactgc aactatggtt aatgatattc 1080
cttataacta tccgggaaca agcacacctg tctacaactg ggatagagca tatttcggta 1140
atattactct gcaatatgct cttcaacaat cacgaaatgt cacagccgtt gagactttga 1200
ataaggtcgg tctagataga gctaaaacct tccttaatgg tcttggtatc gactatccaa 1260
gcatgcatta tgcaaacgcc atttcaagta atacaacaga atctaataaa caatacggag 1320
caagtagtga aaaaatggct gctgcttatg ctgcctttgc caacggtgga atttaccaca 1380
aacccatgta tatcaataag gtcgtcttca gtgacggtag taaaaaagaa ttttcagatg 1440
taggtacacg agctatgaaa gaaacaactg cttacatgat gaccgaaatg atgaaaactg 1500
tcttggcata cggaactggt cgtggag 1527
<210> 155
<211> 1523
<212> DNA
<213> Streptococcus pneumoniae 670-6B
<220>
<221> source
<222> 1..1523
<223> /organism="Streptococcus pneumoniae 670-6B"
/mol_type="unassigned DNA"
<400> 155
gcaccaaacc aatatgaccc ctattcacat ccagaagcag cccaagaccg ccgaaacttg 60
gtcttatctg aaatgaaaaa tcaaggttac atctctgctg aacagtatga gaaagcagtc 120
aatacaccaa ttactgatgg actacaaagt ctcaaatcag caagtaatta ccctgcttac 180
atggataatt acctcaagga ggtcatcaat caagtagaac aagaaactgg ctataacctt 240
ctaactactg ggatggatgt ttacacaaat gtagaccaag aagctcaaaa acatctgtgg 300
gatatctaca actccgatca atacgtctct taccctgacg atgatttgca agtcgcatct 360
acggtcgtag atgtttcaaa tggtaaagtc atcgcccaac ttggagctcg tcaccaagca 420
agtaacgttt catttggtac caaccaagct gtggaaacca atcgtgactg gggttctgct 480
atgaaaccaa tcaccgatta tgcacctgcc atagaatacg gtgtttatga ttccactgca 540
actatggtta atgatattcc ttataactat ccgggaacaa gcacacctgt ctacaactgg 600
gatagagcat atttcggtaa tattactctg caatatgctc ttcaacaatc acgaaatgtc 660
acagccgttg agactttgaa taaggtcggt ctagatagag ctaaaacctt ccttaatggt 720
cttggtatcg actatccaag catgcattat gcaaacgcca tttcaagtaa tacaacagaa 780
tctaataaac aatacggagc aagtagtgaa aaaatggctg ctgcttatgc tgcctttgcc 840
aacggtggaa tttaccacaa acccatgtat atcaataagg tcgtcttcag tgacggtagt 900
aaaaaagaat tttcagatgt aggtacacga gctatgaaag aaacaactgc ttacatgatg 960
accgaaatga tgaaaactgt cttggcatac ggaactggtc gtggagccta tctcccatgg 1020
ttagcgcaag ctggtaagac aggtacttct aactacacag atgatgaaat tgaaaaacac 1080
atcaagaaca ctggctatgt agctccagat gaaatgtttg ttggttatac tcgtaagtat 1140
tctatggctg tatggacagg ttattcgaat cgtttaactc ctatcgttgg agatggtttc 1200
ctagttgcag ctaaagttta tcgctcaatg ataacgtatc tatcagaaga tactcatcca 1260
gaagactgga cgatgccaga cggacttttc agaaacgggg aatttgtatt caaaaatgga 1320
gctcgttcta cgtggaactc acctgctcca caacaacccc catcaactga aagttcaagc 1380
tcatcatcag atagttcaac ttcacagtct agctcaacca ctccaagcac aaataatagt 1440
acgactaccg atcctaacaa taatacgcaa caatcaaata caacccctga tcaacaaaat 1500
cagaatcctc aaccagcaca acc 1523
<210> 156
<211> 1555
<212> DNA
<213> Streptococcus pneumoniae 670-6B
<220>
<221> source
<222> 1..1555
<223> /organism="Streptococcus pneumoniae 670-6B"
/mol_type="unassigned DNA"
<400> 156
ttaacagcca ttcgattccg attcggctta atttattgtt ttcaatcgtc attttactct 60
ttatgaccat tattggtcgt ttgttgtata tgcaggtttt gaacaaggat ttttacgaaa 120
aaaagctagc ctcagctagt cagaccaaga ttacaagcag ttcagcccgt ggggaaattt 180
atgatgctag tggaaaacct ttggtagaaa atacgttaaa gcaggttgtt tcctttacgc 240
gtagcaataa aatgacggct acagacttaa aagaaacagc taaaaagtta ctgacttatg 300
tgagcatcag ttctccaaat ttgacagaac gccagctggc ggattactat ttggctgatc 360
ctgaaatcta taaaaaaaca gtggaagctc tcccaagtga gaaacgcttg gattcagatg 420
gcaatcgtct atccgaatca gaactgtata acaatgcggt cgatagtgtc caaacaagtc 480
aactaaacta tacagaggat gaaaagaaag aaatctatct ttttagtcag ttaaatgctg 540
ttggaaactt tgcgacagga accattgcta cagatcctct aaatgattct caggtggctg 600
ttattgcctc tatttcaaag gagatgcctg gcattagtat ttctacttct tgggatagaa 660
aggttttgga aacttccctt tcttctatag ttgggagtgt atccagtgaa aaagctggtc 720
tcccagcgga agaagcagaa gcctatctta aaaaaggcta ttctctaaat gatcgtgtag 780
gaacctccta tttggaaaag caatatgaag agaccttaca aggaaaacgc tcggtaaaag 840
aaatccatct ggataaatat ggcaatatgg aaagcgtgga tacaattgag gaaggtagta 900
agggaaacaa tatcaaactg accattgatt tggctttcca agatagcgtg gatgctttac 960
tgaaaagtta tttcaattcc gagctagaaa atggtggagc caagtattct gaaggtgtct 1020
atgcagtcgc ccttaaccca aaaacaggtg ctgttttgtc tatgtcaggg attaaacatg 1080
acttgaaaac gggagattta acacctgatt ccttgggaac agtaaccaat gtctttgtcc 1140
cgggttctgt tgtcaaggcg gcgaccatca gctctggttg ggagaatgga gtcttatcag 1200
gaaatcagac cttgacagac caaccgattg tcttccaagg ttcagctccg attaattctt 1260
ggtacactca ggcttacgat tcatttccga ttacagcggt ggaagccttg gagtattctt 1320
ctaatgccta tatggtccaa acagctctag gtcttatggg gcagacctac caacccaata 1380
tgtttgtcgg caccagcaat ctagagtctg ctatggggaa attgcgttca acctttggtg 1440
aatatggctt gggctctgcg actgggattg acctaccaga tgaatctact ggatttgttc 1500
ccaaagagta tagctttgct aattacatta ctaatgcctt tgggcagttt gataa 1555
<210> 157
<211> 1585
<212> DNA
<213> Streptococcus pneumoniae 670-6B
<220>
<221> source
<222> 1..1585
<223> /organism="Streptococcus pneumoniae 670-6B"
/mol_type="unassigned DNA"
<400> 157
tgcaggtttt gaacaaggat ttttacgaaa aaaagctagc ctcagctagt cagaccaaga 60
ttacaagcag ttcagcccgt ggggaaattt atgatgctag tggaaaacct ttggtagaaa 120
atacgttaaa gcaggttgtt tcctttacgc gtagcaataa aatgacggct acagacttaa 180
aagaaacagc taaaaagtta ctgacttatg tgagcatcag ttctccaaat ttgacagaac 240
gccagctggc ggattactat ttggctgatc ctgaaatcta taaaaaaaca gtggaagctc 300
tcccaagtga gaaacgcttg gattcagatg gcaatcgtct atccgaatca gaactgtata 360
acaatgcggt cgatagtgtc caaacaagtc aactaaacta tacagaggat gaaaagaaag 420
aaatctatct ttttagtcag ttaaatgctg ttggaaactt tgcgacagga accattgcta 480
cagatcctct aaatgattct caggtggctg ttattgcctc tatttcaaag gagatgcctg 540
gcattagtat ttctacttct tgggatagaa aggttttgga aacttccctt tcttctatag 600
ttgggagtgt atccagtgaa aaagctggtc tcccagcgga agaagcagaa gcctatctta 660
aaaaaggcta ttctctaaat gatcgtgtag gaacctccta tttggaaaag caatatgaag 720
agaccttaca aggaaaacgc tcggtaaaag aaatccatct ggataaatat ggcaatatgg 780
aaagcgtgga tacaattgag gaaggtagta agggaaacaa tatcaaactg accattgatt 840
tggctttcca agatagcgtg gatgctttac tgaaaagtta tttcaattcc gagctagaaa 900
atggtggagc caagtattct gaaggtgtct atgcagtcgc ccttaaccca aaaacaggtg 960
ctgttttgtc tatgtcaggg attaaacatg acttgaaaac gggagattta acacctgatt 1020
ccttgggaac agtaaccaat gtctttgtcc cgggttctgt tgtcaaggcg gcgaccatca 1080
gctctggttg ggagaatgga gtcttatcag gaaatcagac cttgacagac caaccgattg 1140
tcttccaagg ttcagctccg attaattctt ggtacactca ggcttacgat tcatttccga 1200
ttacagcggt ggaagccttg gagtattctt ctaatgccta tatggtccaa acagctctag 1260
gtcttatggg gcagacctac caacccaata tgtttgtcgg caccagcaat ctagagtctg 1320
ctatggggaa attgcgttca acctttggtg aatatggctt gggctctgcg actgggattg 1380
acctaccaga tgaatctact ggatttgttc ccaaagagta tagctttgct aattacatta 1440
ctaatgcctt tgggcagttt gataactata cgccgatgca gttggctcag tatgtagcaa 1500
ctattgcaaa tgatggtgtt cgtgtggctc ctcgtattgt ggaaggcatt tatggcaata 1560
atgataaggg aggactgggt gactt 1585
<210> 158
<211> 500
<212> DNA
<213> Streptococcus pneumoniae strain K13-108
<220>
<221> source
<222> 1..500
<223> /organism="Streptococcus pneumoniae strain K13-108 "
/mol_type="unassigned DNA"
<400> 158
attattggga caggcactcg ctttggaaca gatttagcga aggaagctaa gaaggttcat 60
caaaccaccc gtacagttcc tgccaaacgt gggactattt atgaccgaaa tggagtcccg 120
attgctgagg atgcaacctc ctataatgtc tatgcggtca ttgatgagaa ctataagtca 180
gcaacgggta agattcttta cgtagaaaaa acacaattta acaaggttgc agaggtcttt 240
cataagtatc tggacatgga agaatcctat gtaagagagc aactctcgca acctaatctc 300
aagcaagttt cctttggttc gaagggcaat gggattacct atgccaatat gatgtctatc 360
aaaaaagaat tggaaactgc agaggtcaag gggattgatt ttacaaccag tcccaatcgt 420
agttatccaa acggacaatt tgcttctagt tttatcggac tagctcagct ccatgaaaat 480
gaagatggca gcaagagctt 500
<210> 159
<211> 506
<212> DNA
<213> Streptococcus pneumoniae strain Kor74
<220>
<221> source
<222> 1..506
<223> /organism="Streptococcus pneumoniae strain Kor74
/mol_type="unassigned DNA"
<400> 159
ccgttatgcg accaaaaatc ggaaatcgcc ggctgaaaac agacgcagag ttggaaaaag 60
tctgagttta ttatctgtct ttgtttttgc cattttttta gtcaattttg cggtcattat 120
tgggacaggc actcgctttg gaacagattt agcgaaggaa gctaagaagg ttcatcaaac 180
cacccgtaca gttcctgcca aacgtgggac tatttatgac cgaaatggag tcccgattgc 240
tgaggatgca acctcctata atgtctatgc ggtcattgat gagaactata agtcagcaac 300
gggtaagatt ctttacgtag aaaaaacaca atttaacaag gttgcagagg tctttcataa 360
gtatctggac atggaagaat cctatgtaag agagcaactc tcgcaaccta atctcaagca 420
agtttccttt ggagcaaagg gcaatgggat tacctatgcc aatatgatgt ctatcaaaaa 480
agagttggaa actgcagagg tcaagg 506
<210> 160
<211> 1484
<212> DNA
<213> Streptococcus pyogenes Alab49
<220>
<221> source
<222> 1..1484
<223> /organism="Streptococcus pyogenes Alab49"
/mol_type="unassigned DNA"
<400> 160
gagcaaccaa agccagaaag tagtgagcta actactgaaa aagcaggtca gaaaacggat 60
gatatgctta actctaacga tatgattaag cttgctccca aagaaatgcc actagaatct 120
gcagaaaaag aagaaaaaaa gtcagaagac aaaaaaaaga gcgaagaaga tcacactgaa 180
gaaatcaatg acaagattta ttcactaaat tataatgagc ttgaagtact tgctaaaaat 240
ggtgaaacca ttgaaaattt tgttcctaaa gaaggcgtta agaaagctga taaatttatt 300
gtcattgaaa gaaagaaaaa aaatatcaac actacaccag tcgatatttc cattattgac 360
tctgtcactg ataggaccta tccagcagcc cttcagctgg ctaataaagg ttttaccgaa 420
aacaaaccag acgcggtagt caccaagcga aacccacaaa aaatccatat tgatttacca 480
ggtatgggag acaaagcaac ggttgaggtc aatgacccta cctatgccaa tgtttcaaca 540
gctattgata atcttgttaa ccaatggcat gataattatt ctggtggtaa tacgcttcct 600
gccagaacac aatatactga atcaatggta tattctaaat cacagattga agcagctcta 660
aatgttaata gcaaaatctt agatggtact ttaggcattg atttcaagtc gatttcaaaa 720
ggtgaaaaga aggtgatgat tgcagcatac aagcaaattt tttacaccgt atcagcaaac 780
cttcctaata atcctgcgga tgtgtttgat aaatcagtga cctttaaaga gttgcaacga 840
aaaggtgtca gcaatgaagc tccgccactc tttgtgagta acgtagctta tggtagaact 900
gtttttgtca aactagaaac aagttctaaa agtaatgatg ttgaagcggc ctttagtgca 960
gctctaaaag gaacagatgt taaaacgaat ggaaaatact ctgatatctt agaaaatagc 1020
tcatttacag ctgtcgtttt aggaggagat gctgcagagc acaataaggt agtcacaaaa 1080
gactttgatg ttattagaaa cgttatcaag gacaatgcta ccttcagtag aaaaaaccca 1140
gcttatccta tttcatacac cagtgttttc cttaaaaata ataaaattgc gggtgtcaat 1200
aacagaactg aatacgttga aacaacatct accgagtaca ctagtggaaa aattaacctg 1260
tctcaccaag gcgcgtatgt tgctcaatat gaaatcctct gggatgaaat caattatgat 1320
gacaaaggaa aagaagtgat tacaaaacga cgctgggaca acaactggta tagtaagaca 1380
tcaccattta gcacagttat cccactagga gctaattcac gaaatatccg tatcatggct 1440
agagagtgca ccggcttagc ttgggaatgg tggcgaaaag tgat 1484
<210> 161
<211> 1458
<212> DNA
<213> Streptococcus pyogenes MGAS1882
<220>
<221> source
<222> 1..1458
<223> /organism="Streptococcus pyogenes MGAS1882" /mol_type="unassigned DNA"
<400> 161
cggcttacct catggaaaaa atgggcttga cgccaaacca gtttattgac ctcaaagcct 60
tgatgggaga taaatcggat aacattcctg gagtgacaaa aattggagaa aaaacaggcc 120
ttaagctcct tcatgaattt ggtagtttgg aaggcattta cgagcatatt gatggattca 180
aggcctcaaa aatgaaagaa aacttgatca atgaccgtga ccaagctttc ctatctaaaa 240
cgctcgccac tatcaataca gcatctccta tcacaattgg cttagatgat attgtctaca 300
atggtccaga tgttgctagc ctctctcaat tttacgatga gatggatttt gtgcaactca 360
agaaaggtct tgctagccag atgcctcaag agccagtagc tgccatttcc tatcaagaag 420
tgaccaatgt gtctgctgat ttgtttagcg cagaagacat cttctacttt gaaacgcttc 480
gggataatta ccatcgtgag gccatcattg gttttgcttg gggacatggt gagcagattt 540
acgtatccac tgaccttagc ctattagcga cggatagttt taagcaggtc tttcaaaaac 600
ccattgccac ttatgatttt aaacgtagca aggtcttgtt gagccactta ggaattgagt 660
tggtagcacc tagctatgat gctagattag ctaattacct tctgtcaact gtagaagaca 720
atgagcttag caccattgcc cgcattttta ctgacatctc tttggaagaa gacgatacag 780
tctatggtaa aggtgctaaa cgggctgttc ctgataaaga cgttttacta gaacacttag 840
ctcgtaaggt caaagtatta ttagatagca agtctcaaat gctagacaag ctcactgccc 900
atgagcaact agacctctat cagaatattg aattgccttt ggctaatgtc cttgctaaaa 960
tggaaattga agggatcaag gttaataggg cgactttgca agatatggca gagcaaaaca 1020
aggtcattat tgaagcgctc acccaagaga tttacgatat ggctggtcaa gaatttaaca 1080
ttaattcgcc taaacagctg ggcagtatct tgtttgagaa gatgcagtta cctcttgaga 1140
tgactaagaa gaccaaaaca ggttattcta cagcagtgga tgttttggaa cgtttggcac 1200
cgattgctcc aattgtggct aaaattttgg attaccgcca gattactaaa ttgcaatcca 1260
cttatgtgat tggtttacag gattatattc tggctgatgg caagattcat acccgctatg 1320
tgcaggattt cacccagaca gggcgtttgt ctagtgtgga ccctaatctt caaaacattc 1380
ctattcgttt ggaacagggg cgtttgattc gtaaggcctt taccccatct catgaagatg 1440
ccgtcttgtt gagttcag 1458
<210> 162
<211> 1477
<212> DNA
<213> Streptococcus pyogenes MGAS1882
<220>
<221> source
<222> 1..1477
<223> /organism="Streptococcus pyogenes MGAS1882"
/mol_type="unassigned DNA"
<400> 162
gcgtcaatga ttttcacggc gctcttgata ataccggaac agcttacaca ccaagtggta 60
aaataccaaa tgctgggacg gctgctcaat taggtgctta tatggatgac gctgagatag 120
acttcaagca agcaaatcaa gacagaacaa gtatacgtgt tcaagctgga gatatggtcg 180
gagccagtcc tgctaactct gcacttttac aagatgagcc tactgtaaag gtctttaaca 240
aaatgaaatt tgaatatggc actcttggta atcatgaatt tgacgaagga ctagatgaat 300
ttaaccgtat catgacaggt caagcgcctg atcctgaatc aacaattaat gatatcacca 360
aacaatatga gcacgaagct tcgcatcaaa ccatcgtcat tgctaatgtt attgataaaa 420
aaaccaatga tatcccctat ggttggaaac cttatgctat aaaagacata gccattaatg 480
acaaaatcgt taagattggc ttcattggtg ttgtgactac agagattcca aatctcgttt 540
taaagcaaaa ctatgaacac tatcaatttt tagatgtagc tgaaaccatt gccaaatatg 600
ctaaagaact acaagaacaa catgttcatg ctattgtggt tttagctcat gttcctgcaa 660
caagtaaaga tggtgttgtt gatcatgaaa tggctacggt tatggaaaaa gtgaaccaaa 720
tctatcccga acatagcatt gatattattt ttgcaggaca taatcatcaa tacactaatg 780
gaactatcgg taaaacacgt atcgttcaag ccctctctca aggaaaagct tatgcagatg 840
tccgtggaac gctagatact gataccaatg attttatgac aactccatca gcaaatgttg 900
ttactgtagc accaggtatc aaaacaaaaa attcagatat caaagctata ataaatcatg 960
ctaatgatat tgttaaaaca gttactgaac gaaaaatcgg aactgcaact aattcttcaa 1020
ctatttctaa aacagaaaat attgataaag aatctcctgt cggtaactta gtaacaacag 1080
ctcagcttac tattgctaag aaaacttttc caactgttga ctttgctatg accaataatg 1140
gtggtattcg aagtgaccta gttgtcaaaa atgaccggac catcacctgg ggagctgcac 1200
aggctgtaca accatttggt aatatccttc aagtcattca aatgactggt caacacattt 1260
acgatgtcct aaatcagcaa tacgatgaaa accagaccta ttttcttcaa atgtcaggtt 1320
taacttacac ttatacagat aatgatccta agaactctga tacccccttc aagatagtta 1380
aggtttataa agacaatggt gaagaaatta acttaacaac tacttacacc gttgttgtca 1440
acgactttct ttatggtggt ggtgatggct tttcagc 1477
<210> 163
<211> 1147
<212> DNA
<213> Streptococcus pyogenes MGAS1882
<220>
<221> source
<222> 1..1147
<223> /organism="Streptococcus pyogenes MGAS1882"
/mol_type="unassigned DNA"
<400> 163
accgtgaccc ttatttggaa cgggtttatc tgactggtca agtgtccaat tttcgaaaac 60
gaccaactca tcaatatttt tccttaaaag atgaaagtgc tgtgattcaa gccaccatgt 120
gggcaggagt ctataaaaaa ctaggattcg acctagaaga aggcatgaaa attaatgtaa 180
ttgggcgagt ccaactttat gaacctagtg gctcttactc tatcgtgatt gaaaaggcag 240
agccagatgg tataggtgcc ttggctttgc agtttgaaca attaaagaaa aaattaacgg 300
cagaaggtta ttttgagcaa aaacacaagc agcccttgcc acagtttgta tcaaaaattg 360
gggtcattac aagtcctagt ggtgctgtga ttcgagatat tatcacaacc gtttcacggc 420
gttttccagg ggttgagatt ttattattcc caactaaagt acaaggtgat ggagccgccc 480
aagaagtagt ggctaatatt cgaagagcca atcaaagaga ggatttggac ttgctcattg 540
tcggccgtgg aggtggctcg atagaagacc tttgggcctt caacgaggaa atagtggttc 600
aggctatctt tgaatcgcaa cttccagtga tttcgagtgt gggtcatgaa acagacacga 660
ctttagcgga ttttgtggca gatcgcagag cagccacacc aacagcagca gcagagttag 720
caacgcctat tacaaaaaca gatcttatgt cttggatagt agagcggcaa aatcgttcct 780
atcaggcctg cttgaggcgg attaagcaac ggcaagagtg ggtggataaa ctctcgcaat 840
ctgttatttt taggcaacca gaacgattat atgatgccta cctgcaaaaa attgatcgcc 900
ttagcatgac cctgatgaat acgatgaaag atcgtctgag ttccgccaaa gaaaacaagg 960
ttcagttgga ccattccttg gccaatagtc aattacagac aaaaatcgag cgataccaag 1020
accgtgttgc taccgctaag cgtttactga tggctaatat ggctagtcaa tatgatagtc 1080
agctggctcg ctttgaaaaa gcacaggatg ctttgctatc actggatgcc agccgaatta 1140
tcgcccg
1147
<210> 164
<211> 1002
<212> DNA
<213> Streptococcus pyogenes MGAS1882
<220>
<221> source
<222> 1..1002
<223> /organism="Streptococcus pyogenes MGAS1882"
/mol_type="unassigned DNA"
<400> 164
ccagtttgga aacaactaac gattttggct ttagccctat ttttcaatca gttcccgtat 60
ttgtcgccat tgctaattga tcctctatta tttttagttg ttttaaggca agaaaccaag 120
caattatttt ctttgaaagc tctttttttg gctgttgcac ctagtgtttt ggtggatttg 180
ctatctcgat ttatgggtac aatcgttatc ccctatcttt ttttgtcgag tggtatttat 240
ctgggtcata ttatctttga cttgcttgct tatctgctga tttttccaag ttttgctatt 300
attaattata tgattggaaa agattacaag atgatatgcc aatccggata ttcgaaacga 360
tcgcataatt tttatcaaac attgctgatt tttgttttgg tttattatgt ggacattttt 420
gtcattttag gatttacgga ccccttttta cattttcatc attctctttt tgttcccaca 480
ccttataagt tattgttttt gatgtttata cttcttttag tttatcttct atcttatttt 540
aatcatagtt ctaaagaata ccttaaaaat gagttgagaa gagaacaaca agcttatatg 600
actaacttag agacttatgg gaaacatctt gagaaactct atcgagatgt aagagctttt 660
caaagtgatt acctgagccg tatagagcgt ttaggtcaag ccattaagag tgaatccatt 720
actcagattc aagatattta tgcccaaacg gttcatgaag ctaacgacta ctgggatgat 780
aaacactata atatctcgaa gcttaggaaa attaatatct catcgattaa gagcttattg 840
tcagctaaaa ttatcagtgc ggaaaaatca ggtattaatt tgaatgtgga agtgccagat 900
aatataaaag agacttacat tcctgagttg gacttactat tgttgatgtc tattttttgt 960
gataacgcca ttgaggcagc tcttgaagca cagcaacctc at 1002
<2 10> 165
<2 11> 1010
<2 12> DNA
<213> Streptococcus pyogenes MGAS1882
<22 0>
<221> source
<222> 1. .1010
<223> /organism="Streptococcus pyogenes MGAS1882"
/mol_type="unassigned DNA"
<4 00> 165
cgagccaata aaatccttcg tgaatgccga caagctatcg ctagaaactt gggggcaagt 60
gaacagcaaa ttatagtaac gtccggtgga actgaaagca ataatatggc cataaaaggc 120
tatgctttag ctcatcaagc aaagggcaaa catctcatca caactactat tgagcaccac 180
tctgtgcttc ataccatggc ctatctcgaa gagcgatttg gttttgaggt cacttatttg 240
ccttgtcaaa atggacaaat aaatttatct gacttaaaac aagccttgag agatgacacc 300
attttggtaa gcataatgta tgccaataac gaaacaggtg acctgttacc tattaaggac 360
attgggaatc tgctcaaaga ccatcaagct gcttttcatg ttgatgccgt tcaagctgtt 420
ggcaaactca agattattcc tagcgaactt gggattgact ttttatctgc ttctgctcac 480
aaatttcatg gtcctaaagg atgcggcttt ttatacagta acggacaacc aatcgaccct 540
cttcttcacg ggggtgatca agaaggaaag cgacgcgcaa gtactgaaaa tatgttaggt 600
attattggta tggcacaagc tttgactgat gctatgactt gtcttgacca atcaactgat 660
cacattatta gtttacgtca tcacttgatt agcctcctag aaggactacc ctactatatt 720
aatcaaggta ctcattatct tcctcatgtt ctcaatattg gatttttagg ctaccaaaat 780
actattttac taacacaact tgacttagca ggcattgcag tatcaactgg ttctgcttgt 840
actgctggag ctgttaatcc aagtcatgtt ttagctgcgt actatgggga tgactcttct 900
cgtttaaaag aatcaattcg tatcagtttt tcagatcaaa atagcattga agatgttaat 960
caattagctc aaacattaaa aaatatttta ggaggaacag atggcttttg 1010
<210> 166
<211> 1085
<212> DNA
<213> Streptococcus pyogenes MGAS1882
<220>
<221> source
<222> 1..1085
<223> /organism="Streptococcus pyogenes MGAS1882"
/mol_type="unassigned DNA"
<400> 166
cgcctttgcc tattcttttg ctaatatgat ggtagttgtt ggactttttc aggttcgtaa 60
ttatcaagca acagatatta atgaaaaata ttcctttagt cagtacttag tggcaagact 120
gatgacttgt ttattaatgt tagccataac agtaatttat ttaacgttaa ctaagacaga 180
tagctacaag agtacaattg tctttctagt ctgtttctat agatcgacag atgctttttc 240
ggatttatat cagggaatgt tccaacaaca tgaacggctg gatattgcag gtaaatcgct 300
agcctacaga aatactctta tttttatggt gtacacagca ataatattat attccaaaaa 360
tcttacttta gcattagtag ctgtctgtat agtttcatta gtttttataa tgtattatga 420
cattggttat tcgaaaaaat ttcaaaagtt gatgtttagt gaattattaa gtaatatttc 480
atttcaaaac agtttaaagt tattaaaaga aagttttcca ctttttctaa acggtttttt 540
gattatctat atttatactc aaccaaaata cgctattgaa ctaatgacga ctttaggtga 600
aattgctttg ggctctcaaa caatttttaa tattttattt atgccagcct ttgttatgaa 660
tttgctaatt ttatttttta gaccttatat tacacagatg gctattgctt taatcagagg 720
tcaaataaaa gagtttaata agatacaagt tcaattgttt gcttatttag gagttttttc 780
actgatagcg ttagttggaa gtggtttgtt tggtattccc tttttatcaa tgctatatgg 840
tactaacctt acggattatt gggtagactt tatgttgatt atgctaggag gctcgattgg 900
tagttttgcg acagttatcg ataatatctt aaccgctatg agaaaacagc aacttcttct 960
tattccatat acaggaggat ttttgatttc gttattaatt accaatcttt ttgttatgaa 1020
atatcacatt ttaggagctg ctttgagctt tttaataaca atgttggttt ggttgggatt 1080
atcca
1085
<210> 167
<211> 861
<212> DNA
<213> Streptococcus pyogenes MGAS1882
<220>
<221> source
<222> 1..861
<223> /organism="Streptococcus pyogenes MGAS1882"
/mol_type="unassigned DNA"
<400> 167
ggcgacagtc gtgaccttat cagcttgtca atcatcacac aacaacacca aactcgtctc 60
gatgaaagga gacaccatca ctgtcagtga cttctacaat gagaccaaaa acacagaact 120
cgcacaaaaa gccatgttaa gcttggtgat tagccgcgtt tttgagacac aatatgccaa 180
caaagtctct gacaaagagg ttgaaaaagc ctataaacaa accgcagacc aatacggtac 240
ctcctttaag acagtcctag cacaatcagg cttaacgcca gaaacctata aaaaacaaat 300
tcgcctcaca aaattagtcg aatatgccgt caaagaacaa gccaaaaacg aaaccatctc 360
aaaaaaagac taccgtcagg cctatgacgc ttatacccca accatgaccg cagaaatcat 420
gcagtttgaa aaagaagagg atgccaaagc agcccttgaa gccgtcaaag ctgaaggggc 480
agactttgca gctattgcca aagaaaaaac cattgcagcc gataaaaaaa caacctacac 540
gtttgactca ggcgaaacaa ccctaccagc agaagtagtt agagctgcat caggcctcaa 600
agaagggaac agatcagaaa tcatcacagc gcttgatcca gccacctcaa aacgcaccta 660
ccatatcatc aaagtcacca aaaaagcaac taaaaaagca gactggaaag cgtaccaaaa 720
acgcttgaaa gacatcattg tgactggcaa attaaaagac cctgacttcc aaaacaaagt 780
catcgctaaa gctcttgata aagcaaatgt caaaatcaaa gacaaagcat ttgccaatat 840
cttagcccag tttgcaaaac c 861
<210> 168
<211> 802
<212> DNA
<213> Streptococcus pyogenes MGAS2096
<220>
<221> source
<222> 1..802
<223> /organism="Streptococcus pyogenes MGAS2096"
/mol_type="unassigned DNA"
<400> 168
ccctagtggt catcgcctta ttttttgcag caagcactgt tagcggtgaa gagtattcgg 60
taactgctaa gcatgcgatt gccgttgacc ttgaaagtgg caaagtttta tacgaaaaag 120
atgctaaaga ggttgtccca gtcgcctcag tcagtaagct cttgacaacc tatctggttt 180
acaaagaagt ttctaagggc aagctaaatt gggatagtcc tgtaactatt tctaactacc 240
cttatgaact cactacaaac tatactatta gtaacgttcc tcttgataag agaaaatata 300
ccgttaaaga acttttaagt gcgttagttg ttaataacgc caatagcccc gctattgctt 360
tagctgaaaa aataggcgga accgaaccca aatttgttga caaaatgaaa aaacaattaa 420
gacaatgggg catttccgat gcaaaggtcg tcaattcaac tggcttaact aaccattttt 480
taggagctaa tacttatcct aatacagaac cagatgatga aaattgtttt tgcgccactg 540
atttagctat tattgccagg catctcttat tagaatttcc agaagtactg aaattatcta 600
gcaaatcctc cactattttt gctggacaaa ccatttacag ttataattac atgcttaaag 660
gcatgccttg ttatcgagaa ggcgtggatg gtctttttgt tggttattct aaaaaagccg 720
gtgcttcttt tgtagctact agtgtcgaaa atcaaatgag ggttattaca gtagttttaa 780
atgctgatca aagcacgagg at 802
<210> 169
<211> 1197
<212> DNA
<213> Streptococcus pyogenes MGAS1882
<220>
<221> source
<222> 1..1197
<223> /organism="Streptococcus pyogenes MGAS1882" /mol_type="unassigned DNA"
<400> 169
gagctctttc tccagcttgc ttggatagtc aagacagtgg ttatttgctt aaaatgattg 60
gagaagatat tgaggcatta gaagtttttt ttgcccacac aatcgcgcct atttgtacag 120
caatattgtc tgcaagttta atgttctggt acttttgtca aagtagttgg cagttagcct 180
tattagcttt ggcaacctat gcttgtttag ccattgttat acccatttat tttgctaata 240
ttttacaggt tttactaaaa agccaaaatg aaggtcgaaa agattacctg tcttattttt 300
tagagagttt acgatcagtc aaagatcttt tgcaatttca ggtattagac gagcaatttg 360
aacgattaat aaaaaaaagt aatcatgtaa atgctcttga tcgtaacgta gcgcaagctc 420
aatttttgca aatggcattg acttttttct ggcttggctt aatgatctta gcattttctt 480
atatggtttt tgatgggata tgccatgaca gcttatcatt tgataaaggc ttattaactt 540
ttattgcttt cactgcttcg ttttctcctt ttttagaact aggacgtttg ccattaggct 600
ttaagcgtgc tatgaatgcg gctcgaaata tttttgacct tctagacgaa aatgtcatag 660
tagacgaagg cacaaaacag atagatcgtt taaggagtgt ttcttttgag gacctcagtt 720
ttgcttatcc aaagcgccaa gagctggttt ttaaggattt atcagttacc tttcaagaaa 780
aggggattat tggcattaaa ggcgaatcag gatctggtaa atcaactttg gtgaaattaa 840
ttatgaaatg gtataattgg aagacaggag atatttttct taatgatagg aatagttgct 900
tactaaatgc tgctaaatta caagatacta ttgcttatgt gccacaaaca gcgcagcttt 960
tccaacagtc tatccgtgaa aatcttacct ttggccgtca agatatttca gatgagtcca 1020
tttggaattt agctgaggct tgtggtatga aagacagact gttagcttgt aaggaaggtt 1080
tggatacgat tatcaagagt ccttctgact tttcagctgg agaaggtcaa cgtttagagt 1140
tgatgcgagc tttattgaaa gatgcgagtt gctatatttt tgatgaaccc acgtcaa 1197
Claims (14)
- RIVENDICAZIONI 1. Metodo per disegnare una pluralità di sequenze nucleotidiche sonda specifiche per una corrispondente pluralità di specie microbiche comprendente le fasi di: (a) fornire una pluralità di sequenze genomiche appartenenti a diversi ceppi della pluralità di specie microbiche; (b) per ciascuna specie microbica, allineare la pluralità di sequenze genomiche; (c) per ciascuna specie microbica, identificare porzioni conservate di sequenza genomica in base all'allineamento di fase (b); (d) per ciascuna specie microbica, selezionare almeno cinque diverse sequenze nucleotidiche sonda appartenenti a porzioni conservate di sequenza genomica e aventi una lunghezza da 300 a 2000 nucleotidi; (e) per ciascuna sequenza nucleotidica sonda selezionata in fase (d), disegnare una coppia di primer per amplificare detta sequenza nucleotidica sonda mediante PCR, in cui ciascun primer: - abbia temperatura di melting (Tm) da 55°C a 65°C; - abbia una lunghezza da 15 a 30 nucleotidi; (f) selezionare le sequenze nucleotidiche sonda con una percentuale di identità inferiore al 40% con ciascuna altra sequenza nucleotidica sonda; (g) selezionare le sequenze nucleotidiche sonda con una percentuale di identità inferiore al 10% con il DNA genomico umano.
- 2. Metodo secondo la rivendicazione 1, in cui ciascuna sequenza nucleotidica sonda non contiene sequenze di più di tre G consecutive.
- 3. Metodo secondo la rivendicazione 1 o 2, in cui ciascuna sequenza nucleotidica sonda contiene una percentuale di basi G e/o C dal 10% al 50%.
- 4. Metodo secondo una qualsiasi delle rivendicazioni da 1 a 3, in cui in fase (f) le sequenze nucleotidiche sonda sono selezionate con una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda .
- 5. Metodo secondo una qualsiasi delle rivendicazioni da 1 a 4, in cui in fase (g) le sequenze nucleotidiche sonda sono selezionate con una percentuale di identità inferiore all'1% con il DNA genomico umano.
- 6. Microarray per la rivelazione di una pluralità di specie microbiche comprendente almeno una sequenza nucleotidica sonda per almeno quattro diverse specie microbiche selezionate dal gruppo costituito da Acinetobacter baumannii, Enterobacter aerogenes, Enterobacter cloacae, Enterococcus faecalis, Enterococcus faecium, Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus , Staphylococcus epidermidis , Streptococcus agalactiae, Streptococcus bovis, Streptococcus pneumoniae e Streptococcus piogenes, in cui ciascuna sequenza nucleotidica sonda ha una lunghezza da 300 a 2000 nucleotidi e ha una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda.
- 7. Microarray secondo la rivendicazione 6, comprendente inoltre almeno una sequenza nucleotidica sonda per almeno una specie microbica selezionata dal gruppo costituito da Aspergillus fumigatus, Candida albicans, Candida glabrata, Candida parapsilosis e Candida tropicalis, in cui detta almeno una sequenza nucleotidica sonda ha una lunghezza da 300 a 2000 nucleotidi e ha una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda.
- 8. Microarray secondo la rivendicazione 6 o 7, comprendente inoltre almeno una sequenza nucleotidica sonda per almeno un adenovirus umano, in cui detta almeno una sequenza nucleotidica sonda ha una lunghezza da 300 a 2000 nucleotidi e ha una percentuale di identità inferiore al 20% con ciascuna altra sequenza nucleotidica sonda.
- 9. Microarray secondo la rivendicazione 8, in cui 1'adenovirus umano è human adenovirus D, human adenovirus B oppure human adenovirus C.
- 10. Microarray secondo una qualsiasi delle rivendicazioni da 6 a 9, in cui l'almeno una sequenza nucleotidica sonda per Acinetobacter baumannii è SEQ ID NO:1-14, e/o 1'almeno una sequenza nucleotidica sonda per Enterobacter aerogenes è SEQ ID NO:46-59, e/o 1'almeno una sequenza nucleotidica sonda per Enterobacter cloacae è SEQ ID NO:60-70, e/o 1'almeno una sequenza nucleotidica sonda per Enterococcus faecalis è SEQ ID NO:71-77, e/o 1'almeno una sequenza nucleotidica sonda per Enterococcus faecium è SEQ ID NO:78-89, e/o 1'almeno una sequenza nucleotidica sonda per Escherichia coli è SEQ ID NO:90-97, e/o 1'almeno una sequenza nucleotidica sonda per Klebsiella pneumoniae è SEQ ID NO:102-104, e/o 1'almeno una sequenza nucleotidica sonda per Proteus mirabilis è SEQ ID NO:105-111, e/o 1'almeno una sequenza nucleotidica sonda per Pseudomonas aeruginosa è SEQ ID NO:112-115, e/o 1'almeno una sequenza nucleotidica sonda per Serratia marcescens è SEQ ID NO:116-117, e/o 1'almeno una sequenza nucleotidica sonda per Staphylococcus aureus è SEQ ID NO:118-131, e/o 1'almeno una sequenza nucleotidica sonda per Staphylococcus epidermidis è SEQ ID NO:132, e/o 1'almeno una sequenza nucleotidica sonda per Streptococcus agalactiae è SEQ ID NO:133-142, e/o 1'almeno una sequenza nucleotidica sonda per Streptococcus bovis è SEQ ID NO:143-147, e/o 1'almeno una sequenza nucleotidica sonda per Streptococcus pneumoniae è SEQ ID NO:148-159, e/o 1'almeno una sequenza nucleotidica sonda per Streptococcus piogenes è SEQ ID NO:161-169.
- 11. Microarray secondo una qualsiasi delle rivendicazioni da 7 a 10, in cui l'almeno una sequenza nucleotidica sonda per Aspergillus fumigatus è SEQ ID NO:14-20, e/o 1'almeno una sequenza nucleotidica sonda per Candida albicans è SEQ ID NO:21-29, e/o 1'almeno una sequenza nucleotidica sonda per Candida glabrata è SEQ ID NO:30-35, e/o 1'almeno una sequenza nucleotidica sonda per Candida parapsilosis è SEQ ID NO: 36-40 e/o 1'almeno una sequenza nucleotidica sonda per Candida tropicalis è SEQ ID NO: 41-45.
- 12. Microarray secondo una qualsiasi delle rivendicazioni 8 a 11, in cui 1'almeno una sequenza nucleotidica sonda per human adenovirus D è SEQ ID NO:98, e/o 1'almeno una sequenza nucleotidica sonda per human adenovirus B è SEQ ID NO:99-100 e/o 1'almeno una sequenza nucleotidica sonda per human adenovirus C è SEQ ID NO:101.
- 13. Microarray secondo una qualsiasi delle rivendicazioni da 6 a 12 per uso nella diagnosi di batteriemia e/o sepsi.
- 14. Microarray secondo una qualsiasi delle rivendicazioni da 6 a 12 per uso secondo la rivendicazione 13 in cui il tempo necessario per 1'ibridizzazione tra il DNA di un campione da analizzare e le sequenze nucleotidiche sonda comprese nel microarray è minore di 2 ore.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001023604A2 (en) * | 1999-09-28 | 2001-04-05 | Infectio Diagnostic (I.D.I.) Inc. | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| FR2860801A1 (fr) * | 2003-10-10 | 2005-04-15 | Bertin Technologies Sa | Methode de detection rapide de micro-organismes sur puces a adn |
| US20100267012A1 (en) * | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
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2012
- 2012-10-02 IT IT000861A patent/ITTO20120861A1/it unknown
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100267012A1 (en) * | 1997-11-04 | 2010-10-21 | Bergeron Michel G | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| WO2001023604A2 (en) * | 1999-09-28 | 2001-04-05 | Infectio Diagnostic (I.D.I.) Inc. | Highly conserved genes and their use to generate probes and primers for detection of microorganisms |
| FR2860801A1 (fr) * | 2003-10-10 | 2005-04-15 | Bertin Technologies Sa | Methode de detection rapide de micro-organismes sur puces a adn |
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| Title |
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| B. E. E. CLEVEN ET AL: "Identification and Characterization of Bacterial Pathogens Causing Bloodstream Infections by DNA Microarray", JOURNAL OF CLINICAL MICROBIOLOGY, vol. 44, no. 7, 1 July 2006 (2006-07-01), pages 2389 - 2397, XP055056452, ISSN: 0095-1137, DOI: 10.1128/JCM.02291-05 * |
| YOO S M ET AL: "DNA microarray-based identification of bacterial and fungal pathogens in bloodstream infections", MOLECULAR AND CELLULAR PROBES, ACADEMIC PRESS, LONDON, GB, vol. 24, no. 1, 1 February 2010 (2010-02-01), pages 44 - 52, XP026832166, ISSN: 0890-8508, [retrieved on 20091007] * |
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