ITTO20110203A1 - COMBINED AND / OR ALTERNATE MANAGEMENT OF ELECTRONICS FOR ELECTROPORATION AND IONTOFORESIS TO OPTIMIZE TRANSDERMAL VEHICLE. - Google Patents

COMBINED AND / OR ALTERNATE MANAGEMENT OF ELECTRONICS FOR ELECTROPORATION AND IONTOFORESIS TO OPTIMIZE TRANSDERMAL VEHICLE. Download PDF

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Publication number
ITTO20110203A1
ITTO20110203A1 IT000203A ITTO20110203A ITTO20110203A1 IT TO20110203 A1 ITTO20110203 A1 IT TO20110203A1 IT 000203 A IT000203 A IT 000203A IT TO20110203 A ITTO20110203 A IT TO20110203A IT TO20110203 A1 ITTO20110203 A1 IT TO20110203A1
Authority
IT
Italy
Prior art keywords
electroporation
electronics
combined
iontoforesis
iontophoresis
Prior art date
Application number
IT000203A
Other languages
Italian (it)
Inventor
Cesare Quaranta
Original Assignee
Cesare Quarante Srl Unipersonale
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cesare Quarante Srl Unipersonale filed Critical Cesare Quarante Srl Unipersonale
Priority to IT000203A priority Critical patent/ITTO20110203A1/en
Publication of ITTO20110203A1 publication Critical patent/ITTO20110203A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation

Description

Gestione combinata e/o alternata di elettronica per eiettroporazione e iontoforesi per ottimizzare la veicolazione transdermica Combined and / or alternating management of electronics for ejection and iontophoresis to optimize transdermal delivery

La presente invenzione ha per ogetto la gestione combinata e/o alternata di elettronica per elettroporazione e iontoforesi per ottimizzare la veicolazione transdermica. Ad oggi, le elettroniche per l'elettroporazione e la iontoforesi vengono utilizzate singolarmente e separatamente. L’elettronica per l’elettroporazione genera impulsi di forme d’onda (sinusoidali, esponenziali o quadre) con tensione massima abbastanza elevata (Vhigh>= 10 V), ma di breve durata (T8hort~centina di ps) opportunatamente modulate (fm~Hz); ciò induce modifiche strutturali (formazione di canali acquosi) a livello della membrana dermica facendo passare facilmente le molecole. The present invention has as its object the combined and / or alternating management of electronics for electroporation and iontophoresis to optimize transdermal delivery. To date, electronics for electroporation and iontophoresis are used individually and separately. The electronics for electroporation generate pulses of waveforms (sinusoidal, exponential or square) with a fairly high maximum voltage (Vhigh> = 10 V), but of short duration (T8hort ~ hundred ps) suitably modulated (fm ~ Hz); this induces structural changes (formation of aqueous channels) at the level of the dermal membrane making the molecules pass easily.

A differenza, l’elettronica per la iontoforesi genera impulsi di forma d’onda quadra con tensione massima molto bassa (V|0W<= 5 V), ma di lunga durata (Tiong~centina di ms); ciò consente modifiche elettriche a livello di membrana e si favorisce il passaggio di ioni. In contrast, the electronics for iontophoresis generates square wave pulses with a very low maximum voltage (V | 0W <= 5 V), but with a long duration (Tiong ~ hundreds of ms); this allows electrical changes at the membrane level and favors the passage of ions.

In una soluzione da veicolare dove siano presenti sia molecole che ioni, o l'una o l’altra elettronica, pilotando gli opportuni impulsi, non possono veicolare tutti i componenti dei principi attivi contenuti in soluzione, una percentuale di essi sarebbe sprecata. In a solution to be conveyed where both molecules and ions are present, or one or the other electronics, by driving the appropriate pulses, they cannot convey all the components of the active ingredients contained in the solution, a percentage of them would be wasted.

L'invenzione in questione nasce per ovviare a questa problema, ovvero l’elettronica adottata gestisce con un ciclo con frequenza opportuna (f|00p) fasi alternate di elettroporazione e iontoforesi (ved. Schema in allegato) : si attua in primis l’elettroporazione favorendo il passaggio di molecole mediante i canali formatisi, segue la iontoforesi che induce il passaggio di ioni, sfruttando inoltre le vie preferenziali precedentemente create. Ovviamente l'apertura di questi canali è temporanea quindi si procede con una nuova modulazione di impulsi di elettroporazione. The invention in question was created to overcome this problem, that is the electronics adopted manages with a cycle with an appropriate frequency (f | 00p) alternating phases of electroporation and iontophoresis (see diagram in the annex): first of all the electroporation is carried out favoring the passage of molecules through the channels formed, iontophoresis follows which induces the passage of ions, also exploiting the previously created preferential pathways. Obviously, the opening of these channels is temporary so we proceed with a new modulation of electroporation pulses.

I parametri di esecuzione gestiti a cicli alternati sono' The execution parameters managed in alternating cycles are '

Elettroporazione Electroporation

Vhigh = Tensione elevata Vhigh = High voltage

Tshort = periodo impulso, dC=50% {nel caso specifico è costante, ma potrebbe essere variabile) Tshort = pulse period, dC = 50% (in the specific case it is constant, but it could be variable)

fpe = frequenza onda portante fpe = carrier wave frequency

Tm= periodo onda modulata (nel caso specifico è costante, ma potrebbe essere variabile) Tm = modulated wave period (in the specific case it is constant, but it could be variable)

n = numero impulsi nell’onda modulata n = number of pulses in the modulated wave

Ttot_ep = Tempo totale elettroporazione Ttot_ep = Total electroporation time

Z = numero onde modulate Z = number of modulated waves

lontoforesi fartophoresis

Viow = Tensione bassa Viow = Low voltage

Tiong = periodo impulso, dC=50% (nel caso specifico è costante, ma potrebbe essere variabile) Tiong = pulse period, dC = 50% (in the specific case it is constant, but it could be variable)

fpi= frequenza onda portante fpi = carrier wave frequency

Ttotj= Tempo totale iontoforesi Ttotj = Total iontophoresis time

F = numero onde portanti F = number of carrier waves

Gestione combinata e alternata di cicli di elettroporazione e iontoforesi Combined and alternating management of electroporation and iontophoresis cycles

fioop= frequenza ciclo fioop = cycle frequency

x_ 1 x_ 1

T,00p= durata ciclo 'loop - 1 — T, 00p = 'loop duration - 1 -

'loop 'loop

Tveicolazione= durata veicolazione Tveiculation = duration of vehiculation

N=numero cicli elettroporazione e iontoforesi N = number of electroporation and iontophoresis cycles

I parametri di esecuzione sono essenziali nell’ambito del dominio di brevetto d'invenzione. The execution parameters are essential within the domain of the invention patent.

Claims (1)

Rivendicazioni 1 -Gestione di cicli alternati di elettroporazione e iontoforesi per una determinata durata 2- Rivendicazione del punto 1, uscente da un unico outputClaims 1 - Management of alternating cycles of electroporation and iontophoresis for a given duration 2- Claim of point 1, coming from a single output
IT000203A 2011-03-08 2011-03-08 COMBINED AND / OR ALTERNATE MANAGEMENT OF ELECTRONICS FOR ELECTROPORATION AND IONTOFORESIS TO OPTIMIZE TRANSDERMAL VEHICLE. ITTO20110203A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT000203A ITTO20110203A1 (en) 2011-03-08 2011-03-08 COMBINED AND / OR ALTERNATE MANAGEMENT OF ELECTRONICS FOR ELECTROPORATION AND IONTOFORESIS TO OPTIMIZE TRANSDERMAL VEHICLE.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000203A ITTO20110203A1 (en) 2011-03-08 2011-03-08 COMBINED AND / OR ALTERNATE MANAGEMENT OF ELECTRONICS FOR ELECTROPORATION AND IONTOFORESIS TO OPTIMIZE TRANSDERMAL VEHICLE.

Publications (1)

Publication Number Publication Date
ITTO20110203A1 true ITTO20110203A1 (en) 2012-09-09

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IT000203A ITTO20110203A1 (en) 2011-03-08 2011-03-08 COMBINED AND / OR ALTERNATE MANAGEMENT OF ELECTRONICS FOR ELECTROPORATION AND IONTOFORESIS TO OPTIMIZE TRANSDERMAL VEHICLE.

Country Status (1)

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IT (1) ITTO20110203A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019805A1 (en) * 1994-01-21 1995-07-27 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
WO2000035533A1 (en) * 1998-12-17 2000-06-22 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US20020010414A1 (en) * 1999-08-25 2002-01-24 Coston Anthony F. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
US20020183686A1 (en) * 1999-06-04 2002-12-05 Nissim Darvish Drug delivery device
EP2087923A1 (en) * 2008-02-11 2009-08-12 Juan Carlos Font I Mas Electrotherapy machine

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995019805A1 (en) * 1994-01-21 1995-07-27 Genetronics, Inc. Electroporation and iontophoresis apparatus and method for insertion of drugs and genes into cells
WO2000035533A1 (en) * 1998-12-17 2000-06-22 Genetronics, Inc. Method and apparatus for a combination of electroporation and iontophoresis for the delivery of drugs and genes
US20020183686A1 (en) * 1999-06-04 2002-12-05 Nissim Darvish Drug delivery device
US20020010414A1 (en) * 1999-08-25 2002-01-24 Coston Anthony F. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
EP2087923A1 (en) * 2008-02-11 2009-08-12 Juan Carlos Font I Mas Electrotherapy machine

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