ITRM940840A1 - "PATCH FOR TRANSCUTANEOUS ABSORPTION WITH CONTROLLED RELEASE OF POSSIBLY ENRICHED PHYTO0 ASSOCIATION" - Google Patents
"PATCH FOR TRANSCUTANEOUS ABSORPTION WITH CONTROLLED RELEASE OF POSSIBLY ENRICHED PHYTO0 ASSOCIATION" Download PDFInfo
- Publication number
- ITRM940840A1 ITRM940840A1 IT94RM000840A ITRM940840A ITRM940840A1 IT RM940840 A1 ITRM940840 A1 IT RM940840A1 IT 94RM000840 A IT94RM000840 A IT 94RM000840A IT RM940840 A ITRM940840 A IT RM940840A IT RM940840 A1 ITRM940840 A1 IT RM940840A1
- Authority
- IT
- Italy
- Prior art keywords
- adhesive
- patch
- transcutaneous absorption
- controlled
- layer
- Prior art date
Links
- 238000010521 absorption reaction Methods 0.000 title claims abstract description 17
- 238000013270 controlled release Methods 0.000 title claims abstract description 12
- 239000000853 adhesive Substances 0.000 claims abstract description 13
- 230000001070 adhesive effect Effects 0.000 claims abstract description 13
- 239000012790 adhesive layer Substances 0.000 claims abstract description 10
- 241000490050 Eleutherococcus Species 0.000 claims abstract description 9
- 235000008434 ginseng Nutrition 0.000 claims abstract description 9
- 241000208340 Araliaceae Species 0.000 claims abstract description 8
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 8
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 8
- 239000004480 active ingredient Substances 0.000 claims abstract description 7
- 239000000399 hydroalcoholic extract Substances 0.000 claims abstract description 7
- 239000010410 layer Substances 0.000 claims abstract description 6
- 239000011241 protective layer Substances 0.000 claims abstract description 6
- 239000000463 material Substances 0.000 claims abstract description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 4
- 230000002940 repellent Effects 0.000 claims abstract description 4
- 239000005871 repellent Substances 0.000 claims abstract description 4
- 239000003292 glue Substances 0.000 claims description 6
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 239000003814 drug Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 5
- 229940038481 bee pollen Drugs 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000002481 ethanol extraction Methods 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000001632 homeopathic effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000002789 Panax ginseng Nutrition 0.000 description 1
- 241001483078 Phyto Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000000908 ammonium hydroxide Substances 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- WQLVFSAGQJTQCK-UHFFFAOYSA-N diosgenin Natural products CC1C(C2(CCC3C4(C)CCC(O)CC4=CCC3C2C2)C)C2OC11CCC(C)CO1 WQLVFSAGQJTQCK-UHFFFAOYSA-N 0.000 description 1
- 229930190029 eleutheroside Natural products 0.000 description 1
- 239000008769 eleutheroside Substances 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 229940107131 ginseng root Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 208000000509 infertility Diseases 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 231100000535 infertility Toxicity 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229950008754 pyricarbate Drugs 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 229940109850 royal jelly Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- NWMIYTWHUDFRPL-UHFFFAOYSA-N sapogenin Natural products COC(=O)C1(CO)C(O)CCC2(C)C1CCC3(C)C2CC=C4C5C(C)(O)C(C)CCC5(CCC34C)C(=O)O NWMIYTWHUDFRPL-UHFFFAOYSA-N 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Cerotto per assorbimento transcutaneo a rilascio controllato, caratterizzato dal fatto di comprendere in combinazione le seguenti parti:- uno strato adesivo puro di collante;- uno strato di estratto idroalcolico, contenente almeno due principi attivi - scelti dal gruppo comprendente Eleuterococco, Ginseng e Polline d'Api - ed eccipiente, reso adesivo dalla presenza di un collante; e - un supporto sottile, flessibile, non repellente nei confronti del materiale adesivo, essendo eventualmente presente sullo strato adesivo puro uno strato protettivo asportabile, eventualmente dotato di una rima pretagliata centrale (onde facilitarne l'asportazione).Controlled-release transcutaneous absorption patch, characterized in that it comprises the following parts in combination: - a pure adhesive layer of adhesive; - a hydroalcoholic extract layer, containing at least two active ingredients - chosen from the group including Eleutherococcus, Ginseng and Pollen d 'Api - and excipient, made adhesive by the presence of an adhesive; and - a thin, flexible, non-repellent support towards the adhesive material, possibly having a removable protective layer on the pure adhesive layer, possibly equipped with a central pre-cut rim (in order to facilitate its removal).
Description
Descrizione dell'invenzione industriale dal titolo: Description of the industrial invention entitled:
"CEROTTO PER ASSORBIMENTO TRANSCUTANEO A RILASCIO CONTROLLATO DI FITOASSOCIAZIONE EVENTUALMENTE ARRICCHITA" "PATCH FOR TRANSCUTANEOUS ABSORPTION WITH CONTROLLED RELEASE OF POSSIBLY ENRICHED PHYTO ASSOCIATION"
DESCRIZIONE DESCRIPTION
La presente invenzione ha per oggetto un cerotto per l'assorbimento transcutaneo di estratto idroalcolico di Eleuterococco, Ginseng e Polline d'api. The present invention relates to a patch for the transcutaneous absorption of hydroalcoholic extract of Eleutherococcus, Ginseng and bee pollen.
Come è noto, l'Eleuterococco (Eleuterococcus Senticosus), arbusto appartenente alla famigla delle arailacee con il Ginseng, è diffusissimo nel Nord della Cina e in Mogolia. E' stato molto studiato anche in Russia dove veniva diffusametne somministrato agli anziani per ritardare gli effetti dell'invecchiamento. Aumenta la resistenza agli sforzi ed è assolutamente privo di tossicità. Il suo effetto è farmacologicamente attribuibile ai vari ginsenosidi ed eleuterosidi in esso contenuti. L'estratto fluido di Eleuterococco viene abitualmente assunto per via orale al dosaggio di circa 2-3 g prò die. Il Ginseng (Panax Ginseng) gode fama di preziosissimo farmaco in tutto l'Est asiatico dove è tenuto in grandissima considerazione come ricostituente sovrano. La sua azione farmacologica sembra dovuta a saponina, sapogenina, emiterpene, acido panaico, fitosterolo, glicoside e sostanze neurotoniche non identificate. Viene solitamente assunto per via orale alla dose di circa 1 g prò die. Il Polline d'api contiene gli stessi amminoacidi della Pappa Reale oltre a vitamine, oligoelementi e sali minerali. La sua pregiata composizione amminoacidica lo rende insostituibile dal punto di vista nutrìzionistico. L'anginina si oppone alla sterilità, alla frigidità e all'impotenza. Si assume solitamente per via orale alla dose di circa 2-3 g prò die. As is known, Eleutherococcus (Eleuterococcus Senticosus), a shrub belonging to the Arailaceae family with Ginseng, is widespread in Northern China and Mogolia. It has also been studied extensively in Russia where it was widely administered to the elderly to delay the effects of aging. It increases resistance to efforts and is absolutely free of toxicity. Its effect is pharmacologically attributable to the various ginsenosides and eleutherosides it contains. The fluid extract of Eleutherococcus is usually taken orally at a dosage of about 2-3 g per day. Ginseng (Panax Ginseng) enjoys a reputation as a very precious drug throughout East Asia where it is held in great esteem as a sovereign tonic. Its pharmacological action appears to be due to saponin, sapogenin, hemiterpene, panaic acid, phytosterol, glycoside and unidentified neurotonic substances. It is usually taken orally at a dose of approximately 1 g per day. Bee pollen contains the same amino acids as Royal Jelly as well as vitamins, trace elements and mineral salts. Its valuable amino acid composition makes it irreplaceable from a nutritional point of view. Anginine is opposed to infertility, frigidity and impotence. It is usually taken orally at a dose of about 2-3 g per day.
Il ricorso alla somministrazione orale urta tuttavia contro tutta una serie di inconvenienti. I più importanti sono i seguenti. Innanzitutto, la ripetizione delle somministrazioni è poco gradita da parte del pubblico. Inoltre, le concentrazioni piasmatiche dei prodotti non sono costanti a causa dell'assorbimento discontinuo. Infine, a causa del metabolismo del farmaco nel tratto gastrointestinale e nel fegato, è necessario ricorrere ad un sovradosaggio per ottenere effetti farmacologicamente soddisfacenti, con conseguenze negative anche sul piano economico. However, recourse to oral administration runs up against a whole series of drawbacks. The most important are the following. First of all, the repetition of the administrations is unwelcome by the public. Furthermore, the piasmatic concentrations of the products are not constant due to discontinuous absorption. Finally, due to the metabolism of the drug in the gastrointestinal tract and in the liver, it is necessary to resort to an overdose to obtain pharmacologically satisfactory effects, with negative consequences also on the economic level.
Esiste quindi nello specifico settore l'esigenza di una riduzione della dose totale impiegata dei suddetti principi attivi, di una loro somministrazione più gradita al pubblico, e di effetti farmacologici più potenti e prolungati. There is therefore in the specific sector the need for a reduction in the total dose used of the aforesaid active ingredients, for their administration more pleasing to the public, and for more potent and prolonged pharmacological effects.
L'adozione della presente invenzione consente di soddisfare tutte queste esigenze, offrendo inoltre altri vantaggi la cui importanza verrà chiarita nel seguito. The adoption of the present invention makes it possible to satisfy all these needs, while also offering other advantages the importance of which will be clarified below.
E' oggetto della presente invenzione un cerotto per assorbimento transcutaneo a rilascio controllato, caratterizzato dal fatto di comprendere la combinazione delle seguenti parti: uno strato adesivo puro di collante; uno strato di estratto idroalcolico, contenente almeno due principi attivi- scelti dal gruppo comprendente Eleuterococco, Ginseng e Polline d'api- ed eccipiente, reso adesivo dalla presenza di un collante; e un supporto sottile, flessibile, non repellente nei confronti del materiale adesivo, essendo eventualmente presente sullo strato adesivo puro uno strato protettivo asportabile, eventualmente dotato di una rima pretagliata centrale (onde facilitarne l'asportazione). The subject of the present invention is a patch for transcutaneous absorption with controlled release, characterized in that it comprises the combination of the following parts: a pure adhesive layer of glue; a layer of hydroalcoholic extract, containing at least two active ingredients - selected from the group comprising Eleutherococcus, Ginseng and Bee Pollen - and excipient, made adhesive by the presence of an adhesive; and a thin, flexible support that does not repel the adhesive material, possibly being present on the pure adhesive layer a removable protective layer, possibly provided with a central pre-cut rim (to facilitate its removal).
Il collante presente negli strati adesivi può consistere preferibilmente di acido acrilico. The glue present in the adhesive layers can preferably consist of acrylic acid.
Lo strato adesivo di estratto idroalcolico nel collante può contenere almeno due componenti scelti dal gruppo comprendente da 0,5 a 50 mg di Eleuterococco, da 0,5 a 50 mg di Ginseng e da 0,5 a 50 mg di Polline d'api. La dose molto bassa dei principi attivi, pari a circa un millesimo della dose abitualmente assunta per via orale, e l'assorbimento continuato rendono la modalità di azione simile a quella descritta come percolazione omeopatica . The adhesive layer of hydroalcoholic extract in the glue can contain at least two components selected from the group comprising from 0.5 to 50 mg of Eleutherococcus, from 0.5 to 50 mg of Ginseng and from 0.5 to 50 mg of Bee pollen. The very low dose of the active ingredients, equal to about one thousandth of the dose usually taken orally, and the continued absorption make the mode of action similar to that described as homeopathic percolation.
Il supporto sottile, flessibile, non repellente nei confronti del materiale adesivo può consistere preferibilmente di poliuretano. Lo strato protettivo asportabile può consistere di carta. The thin, flexible, non-repellent substrate against the adhesive material may preferably consist of polyurethane. The removable protective layer may consist of paper.
L'impiego di una medicazione occlusiva e di un sistema a rilascio controllato, insieme all'effetto sinergico ottenuto grazie al potenziamento reciproco dei diversi principi attivi, consente l'uso di dosi molto basse {come già detto, fino ad un millesimo di quelle convenzionali; dosi assimilabili a quelle impiegate nella medicina omeopatica) assicurandone peraltro un assorbimento continuo in tempi di circa 12-16 ore. Questo preparato viene preferibilmente utilizzato come coadiuvante dietetico, ad assorbimento transcutaneo, con effetti sistemici di aumento delle capacità mnemoniche e di concentrazione. The use of an occlusive dressing and a controlled release system, together with the synergistic effect obtained thanks to the mutual enhancement of the different active ingredients, allows the use of very low doses (as already mentioned, up to one thousandth of conventional ones ; doses similar to those used in homeopathic medicine), however, ensuring continuous absorption in about 12-16 hours. This preparation is preferably used as a dietary adjuvant, with transcutaneous absorption, with systemic effects of increasing memory and concentration capabilities.
Con l'aiuto del seguente esempio, verrà ora data una descrizione più dettagliata di una forma di realizzazione dell'invenzione, finalizzata a farne meglio comprendere scopi, caratteristiche, vantaggi e modalità di applicazione. With the help of the following example, a more detailed description of an embodiment of the invention will now be given, aimed at making it better understood the purposes, characteristics, advantages and methods of application.
ESEMPIO EXAMPLE
Un cerotto per assorbimento transcutaneo secondo l'invenzione, viene preparato come segue. Sul lato interno di un supporto plastico in poliuretano- di forma quadrangolare con angoli arrotondati e di dimensioni 3x3 cm - viene disteso uno strato di estratti idroalcolici di radice di Eleuterococco (solvente di estrazione etanolo a 35° in acqua con rapporto droga/solvente di 1 : 1) alla dose di 2 mg; di radice di Ginseng (solvente di estrazione etanolo a 35°; rapporto droga/solvente 1:1) alla dose di 2 mg; di granelli di Polline d'api millefiori (solvente di estrazione etanolo a 50°; rapporto droga/solvente 1:1) alla dose di 1 mg, miscelati con idrossido di ammonio come eccipiente e con acido acrilico come collante (in percentuale del 25 % in peso). Sopra di questo vengono distesi uno strato di acido acrilico e uno di carta asportabile con rima pretagliata centrale. A transcutaneous absorption patch according to the invention is prepared as follows. A layer of hydroalcoholic extracts of Eleutherococcus root (ethanol extraction solvent at 35 ° in water with a drug / solvent ratio of 1 : 1) at the dose of 2 mg; of Ginseng root (ethanol extraction solvent at 35 °; drug / solvent ratio 1: 1) at a dose of 2 mg; of wildflower bee pollen grains (ethanol extraction solvent at 50 °; drug / solvent ratio 1: 1) at a dose of 1 mg, mixed with ammonium hydroxide as excipient and with acrylic acid as glue (in percentage of 25% by weight). On top of this, a layer of acrylic acid and a layer of removable paper with a central pre-cut rhyme are spread.
Claims (7)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM940840A IT1274799B (en) | 1994-12-23 | 1994-12-23 | Sticking plaster for controlled-release transcutaneous absorption of a herbal association which may be enriched |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM940840A IT1274799B (en) | 1994-12-23 | 1994-12-23 | Sticking plaster for controlled-release transcutaneous absorption of a herbal association which may be enriched |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM940840A0 ITRM940840A0 (en) | 1994-12-23 |
| ITRM940840A1 true ITRM940840A1 (en) | 1996-06-23 |
| IT1274799B IT1274799B (en) | 1997-07-24 |
Family
ID=11402881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM940840A IT1274799B (en) | 1994-12-23 | 1994-12-23 | Sticking plaster for controlled-release transcutaneous absorption of a herbal association which may be enriched |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT1274799B (en) |
-
1994
- 1994-12-23 IT ITRM940840A patent/IT1274799B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| IT1274799B (en) | 1997-07-24 |
| ITRM940840A0 (en) | 1994-12-23 |
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| 0001 | Granted |