ITRM20130588A1 - Derivati di chinossalina, metodi per la loro produzione e loro uso come agenti antitumorali. - Google Patents

Derivati di chinossalina, metodi per la loro produzione e loro uso come agenti antitumorali.

Info

Publication number
ITRM20130588A1
ITRM20130588A1 ITRM20130588A ITRM20130588A1 IT RM20130588 A1 ITRM20130588 A1 IT RM20130588A1 IT RM20130588 A ITRM20130588 A IT RM20130588A IT RM20130588 A1 ITRM20130588 A1 IT RM20130588A1
Authority
IT
Italy
Prior art keywords
chinosalalin
derivatives
production
methods
human agents
Prior art date
Application number
Other languages
English (en)
Inventor
Anna Carbone
Girolamo Cirrincione
Patrizia Diana
Barbara Parrino
Original Assignee
Univ Palermo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Palermo filed Critical Univ Palermo
Priority to ITRM20130588 priority Critical patent/ITRM20130588A1/it
Publication of ITRM20130588A1 publication Critical patent/ITRM20130588A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
ITRM20130588 2013-10-25 2013-10-25 Derivati di chinossalina, metodi per la loro produzione e loro uso come agenti antitumorali. ITRM20130588A1 (it)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ITRM20130588 ITRM20130588A1 (it) 2013-10-25 2013-10-25 Derivati di chinossalina, metodi per la loro produzione e loro uso come agenti antitumorali.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM20130588 ITRM20130588A1 (it) 2013-10-25 2013-10-25 Derivati di chinossalina, metodi per la loro produzione e loro uso come agenti antitumorali.

Publications (1)

Publication Number Publication Date
ITRM20130588A1 true ITRM20130588A1 (it) 2015-04-26

Family

ID=49640064

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM20130588 ITRM20130588A1 (it) 2013-10-25 2013-10-25 Derivati di chinossalina, metodi per la loro produzione e loro uso come agenti antitumorali.

Country Status (1)

Country Link
IT (1) ITRM20130588A1 (it)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008041264A1 (en) * 2006-10-02 2008-04-10 Universita' Degli Studi Di Palermo Isoindolo-quinoxaline derivatives having antitumor activity, process for their production and their use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008041264A1 (en) * 2006-10-02 2008-04-10 Universita' Degli Studi Di Palermo Isoindolo-quinoxaline derivatives having antitumor activity, process for their production and their use

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CIRRINCIONE G ET AL: "POLYCONDENSED NITROGEN HETEROCYCLES. PART 27. INDOLO not 3,2-C 3/4 CINNOLINE. SYNTHESIS AND ANTILEUKEMIC ACTIVITY", IL FARMACO, ELSEVIER FRANCE * EDITIONS SCIENTIFIQUES ET MEDICALES, IT, vol. 50, no. 12, 1 January 1995 (1995-01-01), pages 849 - 852, XP000984099, ISSN: 0014-827X *
PATRIZIA DIANA ET AL: "Isoindolo[2,1- a ]quinoxaline Derivatives, Novel Potent Antitumor Agents with Dual Inhibition of Tubulin Polymerization and Topoisomerase I", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 8, 1 April 2008 (2008-04-01), pages 2387 - 2399, XP055103389, ISSN: 0022-2623, DOI: 10.1021/jm070834t *
PLESHAKOV V G ET AL: "Formation of 9-methylisoindolo[1,2-c]quinoxaline in the catalytic dehydrocyclization of 2-(2,4-dimethylphenyl)quinoxaline", CAPLUS, 5 March 2008 (2008-03-05), XP002471568 *

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