ITRM20130223A1 - CODEINE DERIVATIVES AS INHIBITORS OF MORUCINE GLUCURONATION - Google Patents

CODEINE DERIVATIVES AS INHIBITORS OF MORUCINE GLUCURONATION

Info

Publication number
ITRM20130223A1
ITRM20130223A1 IT000223A ITRM20130223A ITRM20130223A1 IT RM20130223 A1 ITRM20130223 A1 IT RM20130223A1 IT 000223 A IT000223 A IT 000223A IT RM20130223 A ITRM20130223 A IT RM20130223A IT RM20130223 A1 ITRM20130223 A1 IT RM20130223A1
Authority
IT
Italy
Prior art keywords
morucine
glucuronation
inhibitors
codeine derivatives
codeine
Prior art date
Application number
IT000223A
Other languages
Italian (it)
Inventor
Letizia Antonilli
Armandodoriano Bianco
Laura Guarcini
Paolo Nencini
Rosario Nicoletti
Anna Rita Togna
Giuseppina Ines Togna
Alessandro Venditti
Original Assignee
Rosario Nicoletti
Univ Roma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosario Nicoletti, Univ Roma filed Critical Rosario Nicoletti
Priority to IT000223A priority Critical patent/ITRM20130223A1/en
Publication of ITRM20130223A1 publication Critical patent/ITRM20130223A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
IT000223A 2013-04-15 2013-04-15 CODEINE DERIVATIVES AS INHIBITORS OF MORUCINE GLUCURONATION ITRM20130223A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT000223A ITRM20130223A1 (en) 2013-04-15 2013-04-15 CODEINE DERIVATIVES AS INHIBITORS OF MORUCINE GLUCURONATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT000223A ITRM20130223A1 (en) 2013-04-15 2013-04-15 CODEINE DERIVATIVES AS INHIBITORS OF MORUCINE GLUCURONATION

Publications (1)

Publication Number Publication Date
ITRM20130223A1 true ITRM20130223A1 (en) 2014-10-16

Family

ID=48446520

Family Applications (1)

Application Number Title Priority Date Filing Date
IT000223A ITRM20130223A1 (en) 2013-04-15 2013-04-15 CODEINE DERIVATIVES AS INHIBITORS OF MORUCINE GLUCURONATION

Country Status (1)

Country Link
IT (1) ITRM20130223A1 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB751994A (en) * 1953-03-30 1956-07-04 Rech S Biolog Laborec Lab De New derivatives of alkaloids
US5977395A (en) * 1994-05-27 1999-11-02 Rhone-Poulenc Chimie Ester syntheses and transesterifiable xanthate reactants therefor
WO1999058545A1 (en) * 1998-05-13 1999-11-18 Cenes Limited Process for preparation of 4,5-epoxymorphinan-6-oxyglucuronides
WO2002016367A1 (en) * 2000-08-25 2002-02-28 Glaxo Wellcome Australia Ltd Chemical methods
WO2007120864A2 (en) * 2006-04-14 2007-10-25 Shire Llc Compositions and methods for enhancing analgesic potency of covalently bound compounds, attenuating its adverse side effects, and preventing their abuse
WO2011011543A1 (en) * 2009-07-21 2011-01-27 Nektar Therapeutics Oligomer-opioid agonist conjugates
WO2011088140A1 (en) * 2010-01-12 2011-07-21 Nektar Therapeutics Pegylated opioids with low potential for abuse and side effects

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB751994A (en) * 1953-03-30 1956-07-04 Rech S Biolog Laborec Lab De New derivatives of alkaloids
US5977395A (en) * 1994-05-27 1999-11-02 Rhone-Poulenc Chimie Ester syntheses and transesterifiable xanthate reactants therefor
WO1999058545A1 (en) * 1998-05-13 1999-11-18 Cenes Limited Process for preparation of 4,5-epoxymorphinan-6-oxyglucuronides
WO2002016367A1 (en) * 2000-08-25 2002-02-28 Glaxo Wellcome Australia Ltd Chemical methods
WO2007120864A2 (en) * 2006-04-14 2007-10-25 Shire Llc Compositions and methods for enhancing analgesic potency of covalently bound compounds, attenuating its adverse side effects, and preventing their abuse
WO2011011543A1 (en) * 2009-07-21 2011-01-27 Nektar Therapeutics Oligomer-opioid agonist conjugates
WO2011088140A1 (en) * 2010-01-12 2011-07-21 Nektar Therapeutics Pegylated opioids with low potential for abuse and side effects

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