ITRM20100047A1 - Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche. - Google Patents

Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche.

Info

Publication number
ITRM20100047A1
ITRM20100047A1 IT000047A ITRM20100047A ITRM20100047A1 IT RM20100047 A1 ITRM20100047 A1 IT RM20100047A1 IT 000047 A IT000047 A IT 000047A IT RM20100047 A ITRM20100047 A IT RM20100047A IT RM20100047 A1 ITRM20100047 A1 IT RM20100047A1
Authority
IT
Italy
Prior art keywords
chemoresistance
kit
prevention
monitoring
leukemic
Prior art date
Application number
IT000047A
Other languages
English (en)
Inventor
Annarosa Arcangeli
Andrea Becchetti
Lorenzo Emanuele De
Marika Masselli
Serena Pillozzi
Original Assignee
Noi Per Voi Onlus
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Noi Per Voi Onlus filed Critical Noi Per Voi Onlus
Priority to ITRM2010A000047A priority Critical patent/IT1398375B1/it
Priority to PCT/IB2010/055113 priority patent/WO2011058509A1/en
Publication of ITRM20100047A1 publication Critical patent/ITRM20100047A1/it
Application granted granted Critical
Publication of IT1398375B1 publication Critical patent/IT1398375B1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57426—Specifically defined cancers leukemia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ITRM2010A000047A 2009-11-10 2010-02-09 Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche. IT1398375B1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITRM2010A000047A IT1398375B1 (it) 2009-11-10 2010-02-09 Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche.
PCT/IB2010/055113 WO2011058509A1 (en) 2009-11-10 2010-11-10 Method and kit for the prevention and/or the monitoring of chemioresistance of leukaemia forms

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000578A ITRM20090578A1 (it) 2009-11-10 2009-11-10 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000047A IT1398375B1 (it) 2009-11-10 2010-02-09 Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche.

Publications (2)

Publication Number Publication Date
ITRM20100047A1 true ITRM20100047A1 (it) 2011-05-11
IT1398375B1 IT1398375B1 (it) 2013-02-22

Family

ID=42236559

Family Applications (3)

Application Number Title Priority Date Filing Date
IT000578A ITRM20090578A1 (it) 2009-11-10 2009-11-10 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000048A IT1398376B1 (it) 2009-11-10 2010-02-09 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000047A IT1398375B1 (it) 2009-11-10 2010-02-09 Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IT000578A ITRM20090578A1 (it) 2009-11-10 2009-11-10 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.
ITRM2010A000048A IT1398376B1 (it) 2009-11-10 2010-02-09 Nuove composizioni per il trattamento di leucemie chemioresistenti e/o di leucemie potenzialmente chemioresistenti.

Country Status (4)

Country Link
US (1) US20120309704A1 (it)
EP (1) EP2498773B1 (it)
IT (3) ITRM20090578A1 (it)
WO (2) WO2011058508A2 (it)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201318659D0 (en) * 2013-10-22 2013-12-04 Ucl Business Plc Beta-catenin
EP3177647B1 (en) * 2014-08-08 2018-10-10 Universita' Degli Studi di Firenze Anti-herg1 antibodies
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
US11071739B1 (en) 2020-09-29 2021-07-27 Genus Lifesciences Inc. Oral liquid compositions including chlorpromazine

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH681780A5 (en) * 1991-02-25 1993-05-28 Patrinove Anticancer compsns. - consists of a cytotoxic agent with a agent to prevent multi:drug resistance, e.g. in liposome(s)
ITMI992711A1 (it) * 1999-12-27 2001-06-27 Novartis Ag Composti organici
WO2004006842A2 (en) * 2002-07-11 2004-01-22 Combinatorx, Incorporated Combinations of drugs for the treatment of neoplasms
US20070009534A1 (en) * 2005-07-06 2007-01-11 Branimir Sikic Treatment of cancer patients exhibiting activation of the P-glycoprotein efflux pump mechanism
US20090208493A1 (en) * 2007-11-27 2009-08-20 Stc. Unm Compounds and methods for the selective inhibition of ABCB1, ABCC1 and ABCG2 transporters and the treatment of cancers, especially drug resistant cancers and high throughput flow cytometry assay to detect selective inhibitors
WO2010121141A1 (en) * 2009-04-17 2010-10-21 Biogen Idec Ma Inc. Compositions and methods to treat acute myelogenous leukemia

Also Published As

Publication number Publication date
WO2011058508A2 (en) 2011-05-19
EP2498773A2 (en) 2012-09-19
ITRM20090578A1 (it) 2011-05-11
ITRM20100048A1 (it) 2011-05-11
EP2498773B1 (en) 2015-07-29
IT1398376B1 (it) 2013-02-22
WO2011058508A3 (en) 2011-10-06
US20120309704A1 (en) 2012-12-06
WO2011058509A1 (en) 2011-05-19
IT1398375B1 (it) 2013-02-22

Similar Documents

Publication Publication Date Title
NL301192I2 (nl) Finerenon en zijn zouten, solvaten en solvaten van de zouten daarvan
SMP200900085B (it) 3-imidazolil-indoli per il trattamento di malattieproliferative.
DE602006007167D1 (de) Lagerzustandsüberwachung
BRPI1011129A2 (pt) métodos e compostos inibidores de janus cinase
NO20085322L (no) Fremgangsmate for raskere ansiktsdeteksjon
BRPI0813569A2 (pt) Método de inspeção.
FI20061090A (fi) Kunnonvalvontamenetelmä
BRPI0923837A2 (pt) Sistema de abandono sem sonda
BRPI0920146A2 (pt) agente de solubilização para íons de metal
IT1398375B1 (it) Metodo e kit per la prevenzione e/o monitoraggio della chemioresistenza di forme leucemiche.
IT1394096B1 (it) Metodo per la rivelazione di allergeni.
BRPI0919100A2 (pt) Inibição de corrosão.
ZA200904558B (en) Detection of analytes
BRPI0820295A2 (pt) Perfil de metal
IT1403092B1 (it) Metodo per la diagnosi e/o il monitoraggio della mucormicosi.
WO2009098451A3 (en) Biomarkers of aminopeptidase inhibition
ITRM20080037A1 (it) Procedimento per la ultrapurificazione di alginati.
IT1391285B1 (it) Macchina per la concia di pelli, e relativo procedimento.
IT1396169B1 (it) Metodo e apparecchiatura per la discriminazione di viti senza fine rumorose.
IT1399834B1 (it) Dispositivo e metodo per l'applicazione di inserti, particolarmente su stoffe, pelli, o altre strutture di base.
ITMI20080888A1 (it) Procedimento per la preparazione di zileuton
FI20051155A (fi) Kunnonvalvontamenetelmä
FI20061110A0 (fi) Kunnonvalvontamenetelmä
IT1397763B1 (it) Metodo per il monitoraggio della cancellazione di domini internet e successiva registrazione.
ES1070490Y (es) Equipo para la evacuacion de aguas en sotanos, garajes y similares.