ITMI912222A1 - 13-DIHYDRO-3 '- (2-alkoxy-4-morpholinyl) ANTHRACYCLINES - Google Patents

13-DIHYDRO-3 '- (2-alkoxy-4-morpholinyl) ANTHRACYCLINES

Info

Publication number
ITMI912222A1
ITMI912222A1 IT002222A ITMI912222A ITMI912222A1 IT MI912222 A1 ITMI912222 A1 IT MI912222A1 IT 002222 A IT002222 A IT 002222A IT MI912222 A ITMI912222 A IT MI912222A IT MI912222 A1 ITMI912222 A1 IT MI912222A1
Authority
IT
Italy
Prior art keywords
anthracyclines
morpholinyl
dihydro
alkoxy
Prior art date
Application number
IT002222A
Other languages
Italian (it)
Inventor
Alberto Bargiotti
Daniela Faiardi
Antonino Suarato
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of ITMI912222A0 publication Critical patent/ITMI912222A0/en
Publication of ITMI912222A1 publication Critical patent/ITMI912222A1/en
Application granted granted Critical
Publication of IT1251158B publication Critical patent/IT1251158B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
ITMI912222A 1990-09-12 1991-08-07 13-DIHYDRO-3 '- (2-alkoxy-4-morpholinyl) ANTHRACYCLINES IT1251158B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909019933A GB9019933D0 (en) 1990-09-12 1990-09-12 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines

Publications (3)

Publication Number Publication Date
ITMI912222A0 ITMI912222A0 (en) 1991-08-07
ITMI912222A1 true ITMI912222A1 (en) 1992-03-13
IT1251158B IT1251158B (en) 1995-05-04

Family

ID=10682082

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912222A IT1251158B (en) 1990-09-12 1991-08-07 13-DIHYDRO-3 '- (2-alkoxy-4-morpholinyl) ANTHRACYCLINES

Country Status (4)

Country Link
JP (1) JP3068258B2 (en)
DE (1) DE4126475B4 (en)
GB (2) GB9019933D0 (en)
IT (1) IT1251158B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009099741A1 (en) 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
EP2303332B1 (en) 2008-07-15 2014-12-31 Genentech, Inc. Anthracycline conjugates, process for their preparation and their use as antitumor compounds
EP2646456B1 (en) 2010-12-02 2015-01-21 Nerviano Medical Sciences S.r.l. Process for the preparation of morpholinyl anthracycline derivatives
DK2991993T3 (en) * 2013-04-29 2018-07-30 Nerviano Medical Sciences Srl NEW MORPHOLINYLANTHRACYCLINE DERIVATIVES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
JPS59212499A (en) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 4-demethoxy-3'-deamino-3'(4-morpholinyl) derivative
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
GB8905668D0 (en) * 1989-03-13 1989-04-26 Erba Carlo Spa New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives

Also Published As

Publication number Publication date
GB2247885B (en) 1994-02-09
GB9117175D0 (en) 1991-09-25
DE4126475B4 (en) 2005-09-15
ITMI912222A0 (en) 1991-08-07
DE4126475A1 (en) 1992-03-19
JPH04247096A (en) 1992-09-03
IT1251158B (en) 1995-05-04
GB2247885A (en) 1992-03-18
GB9019933D0 (en) 1990-10-24
JP3068258B2 (en) 2000-07-24

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970728