ITMI20012693A1 - SPRAY UNIT OF A SPRAY DRYER - Google Patents
SPRAY UNIT OF A SPRAY DRYER Download PDFInfo
- Publication number
- ITMI20012693A1 ITMI20012693A1 ITMI20012693A ITMI20012693A1 IT MI20012693 A1 ITMI20012693 A1 IT MI20012693A1 IT MI20012693 A ITMI20012693 A IT MI20012693A IT MI20012693 A1 ITMI20012693 A1 IT MI20012693A1
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- IT
- Italy
- Prior art keywords
- particles
- spray
- coating
- spray unit
- unit according
- Prior art date
Links
- 239000007921 spray Substances 0.000 title claims description 44
- 239000011248 coating agent Substances 0.000 claims description 28
- 238000000576 coating method Methods 0.000 claims description 27
- 239000002245 particle Substances 0.000 claims description 27
- 239000007788 liquid Substances 0.000 claims description 13
- 239000000725 suspension Substances 0.000 claims description 10
- 239000002904 solvent Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000003570 air Substances 0.000 description 10
- 238000000034 method Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 238000004891 communication Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 239000003094 microcapsule Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical class CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229920002678 cellulose Chemical class 0.000 description 1
- 239000001913 cellulose Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/14—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas designed for spraying particulate materials
- B05B7/1404—Arrangements for supplying particulate material
- B05B7/1431—Arrangements for supplying particulate material comprising means for supplying an additional liquid
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/20—Sprayers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying
- B01J13/043—Drying and spraying
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/04—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge
- B05B7/0416—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid
- B05B7/0441—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber
- B05B7/0475—Spray pistols; Apparatus for discharge with arrangements for mixing liquids or other fluent materials before discharge with arrangements for mixing one gas and one liquid with one inner conduit of liquid surrounded by an external conduit of gas upstream the mixing chamber with means for deflecting the peripheral gas flow towards the central liquid flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/12—Spray pistols; Apparatus for discharge designed to control volume of flow, e.g. with adjustable passages
- B05B7/1209—Spray pistols; Apparatus for discharge designed to control volume of flow, e.g. with adjustable passages the controlling means for each liquid or other fluent material being manual and interdependent
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B3/00—Drying solid materials or objects by processes involving the application of heat
- F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
- F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
- F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B7/00—Spraying apparatus for discharge of liquids or other fluent materials from two or more sources, e.g. of liquid and air, of powder and gas
- B05B7/02—Spray pistols; Apparatus for discharge
- B05B7/06—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane
- B05B7/062—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet
- B05B7/066—Spray pistols; Apparatus for discharge with at least one outlet orifice surrounding another approximately in the same plane with only one liquid outlet and at least one gas outlet with an inner liquid outlet surrounded by at least one annular gas outlet
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Microbiology (AREA)
- Medicinal Preparation (AREA)
- Glanulating (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Description
“Unità di spruzzo di uno spray dryer” "Spray unit of a spray dryer"
Descrizione Description
La presente invenzione riguarda un’unità di spruzzo per spray dryer utilizzato per la microincapsulazione di particelle solide. The present invention relates to a spray unit for a spray dryer used for the microencapsulation of solid particles.
La microincapsulazione mediante spray dryer impiega normalmente una sospensione delle particelle da rivestire nella soluzione o nella sospensione di rivestimento. Microencapsulation by spray dryer normally employs a suspension of the particles to be coated in the coating solution or suspension.
Questa tecnica è di limitata applicazione quando le particelle da rivestire sono solubili nella miscela di rivestimento oppure, per incompatibilità chimica, non possono rimanere a contatto per molto tempo con il liquido di rivestimento (per esempio proteine o sostanze sensibili all’azione dei solventi, ecc.). This technique is of limited application when the particles to be coated are soluble in the coating mixture or, due to chemical incompatibility, cannot remain in contact for a long time with the coating liquid (for example proteins or substances sensitive to the action of solvents, etc. .).
Inoltre problemi d’inquinamento ambientale e di pericolosità nell’utilizzo dei solventi organici, hanno portato sempre più all’ impiego di agenti di rivestimento formulati su base acquosa e questo rende praticamente impossibile l’utilizzo dello spray dryer nella miscroincapsulazione di particelle idrosolubili con la tecnica convenzionale. Furthermore, problems of environmental pollution and dangerousness in the use of organic solvents, have increasingly led to the use of coating agents formulated on a water basis and this makes it practically impossible to use the spray dryer in the miscroencapsulation of water-soluble particles with the technique. conventional.
Oggetto della presente invenzione è un particolare tipo di unità di spruzzo che consente di ovviare ai problemi sopra citati e permette di usare apparecchiature di spray dryer anche per applicazioni che richiedono un ridotto tempo di contatto della soluzione o sospensione di rivestimento con le particelle da rivestire. The object of the present invention is a particular type of spray unit which allows to obviate the aforementioned problems and allows to use spray dryer equipment also for applications which require a reduced contact time of the coating solution or suspension with the particles to be coated.
Infatti, il contatto fra particelle e l’agente di rivestimento avviene solo nella fase finale del processo di spruzzo rendendo la dissoluzione o l’azione della componente liquida da evaporare dall’agente di rivestimento praticamente trascurabili. In fact, the contact between particles and the coating agent occurs only in the final phase of the spraying process, making the dissolution or the action of the liquid component to be evaporated by the coating agent practically negligible.
L’unità di spruzzo della presente invenzione può essere impiegata oltre che nei casi di microincapsulazione classica cioè quando la particella da rivestire è insolubile nel mezzo di rivestimento, anche nel caso di particelle solubili nel mezzo di rivestimento ed anche nel caso si desideri microincapsulare sostanze sensibili all’azione del solvente (per esempio peptidi, proteine e sostanze degradabili a causa del solvente stesso). The spray unit of the present invention can be used not only in the cases of classical microencapsulation, that is when the particle to be coated is insoluble in the coating medium, also in the case of soluble particles in the coating medium and also in the case of microencapsulation of sensitive substances. to the action of the solvent (for example peptides, proteins and degradable substances due to the solvent itself).
L’uso dell’unità di spruzzo secondo la presente invenzione permette l’applicazione della tecnica di spray dryer per rivestire particelle del diametro di 10-500 μm solubili nel liquido di rivestimento. The use of the spray unit according to the present invention allows the application of the spray dryer technique to coat particles with a diameter of 10-500 μm soluble in the coating liquid.
Una seconda applicazione è quella di rivestire particelle del diametro sopra riportato ed insolubili nel liquido di rivestimento. A second application is to coat particles of the above mentioned diameter which are insoluble in the coating liquid.
Un ulteriore applicazione è quella di rivestire particelle del diametro sopra riportato sensibili all’azione di solventi contenuti nel liquido di rivestimento. Mediante l’utilizzo di uno spray dryer munito dell’unità di spruzzo secondo la presente invenzione si possono ottenere microcapsule gastroresistenti, a rilascio prolungato, a rilascio ritardato e microcapsule taste-masking. A further application is to coat particles of the above mentioned diameter sensitive to the action of solvents contained in the coating liquid. By using a spray dryer equipped with the spray unit according to the present invention, it is possible to obtain gastro-resistant, prolonged-release, delayed-release microcapsules and taste-masking microcapsules.
Il liquido di rivestimento è la soluzione o sospensione della sostanza che farà da rivestimento delle particelle nel o nei solventi prescelti includendo tra questi anche l’acqua. The coating liquid is the solution or suspension of the substance that will coat the particles in the selected solvent or solvents, including water.
I rivestimenti utilizzabili per l’ottenimento di queste capsule possono essere derivati polimerici dell’acido metacrilico, derivati della cellulosa, lipidi e loro miscele. The coatings that can be used to obtain these capsules can be polymeric derivatives of methacrylic acid, cellulose derivatives, lipids and their mixtures.
L’unità di spruzzo dell’ invenzione viene costruita in acciaio (o altro materiale compatibile con i prodotti utilizzati) opportunamente forata e sagomata al fine di permettere il passaggio della particelle, della sospensione o soluzione di rivestimento e dell’aria, garantendo al tempo stesso il massimo isolamento con l’ambiente esterno e tra i canali. The spray unit of the invention is built in steel (or other material compatible with the products used) suitably perforated and shaped in order to allow the passage of particles, suspension or coating solution and air, while ensuring maximum isolation from the external environment and between the channels.
Essa può essere applicata su diversi tipi di apparecchiature spray drier con modifiche minime che risultano evidenti per il tecnico del ramo, quali la scelta della filettatura adatta per l’avvitamento sull’apparecchiatura, la lunghezza ed il diametro in funzione delle caratteristiche specifiche dell’apparecchiatura usata. I disegni e la descrizione degli aspetti tecnici sotto riportata si riferiscono in particolare ad una unità di spruzzo adatta ad uno spray dryer BUCHI B191. It can be applied on different types of spray drier equipment with minimal modifications that are evident for the skilled in the art, such as the choice of the thread suitable for screwing onto the equipment, the length and diameter according to the specific characteristics of the equipment. used. The drawings and the description of the technical aspects below refer in particular to a spray unit suitable for a BUCHI B191 spray dryer.
II diametro delle parti dell’unità di spruzzo può essere modificato in finizione della specifica operazione di microincapsulazione che si vuole eseguire con lo spray dryer. The diameter of the parts of the spray unit can be modified in order to finish the specific microencapsulation operation that you want to perform with the spray dryer.
I disegni e la loro descrizione che seguono si riferiscono in particolare alla miscroincapsulazione per l’ottenimento di forme farmaceutiche gastroresistenti. Tuttavia è ovvio che l’unità di spruzzo secondo la presente invenzione può essere usata senza sostanziali modifiche per altri tipi di applicazioni al di fuori del settore farmaceutico quali rivestimenti di granuli ad uso alimentare, dietetico, cosmetico e fitosanitario. The following drawings and their description refer in particular to the microencapsulation for obtaining gastro-resistant pharmaceutical forms. However, it is obvious that the spray unit according to the present invention can be used without substantial modifications for other types of applications outside the pharmaceutical sector such as coatings of granules for food, dietary, cosmetic and phytosanitary use.
L’unità di spruzzo oggetto dell’invenzione si compone di quattro parti fondamentali, che descriveremo qui di seguito, come indicato nella tavola 1 : testa superiore (A), nucleo (B), mantello (C), testa inferiore (D). The spray unit object of the invention consists of four basic parts, which we will describe below, as indicated in table 1: upper head (A), core (B), mantle (C), lower head (D).
Testa superiore (A) Upper head (A)
E’ la parte dell’unità di spruzzo dove viene introdotta l’aria e dalla quale vengono caricate le particelle e la soluzione o sospensione di rivestimento. It is the part of the spray unit where the air is introduced and from which the particles and the coating solution or suspension are loaded.
E’ dotata di 3 canali predisposti per inserimento di speciali connettori di allaccio indicati con A1=ana, A2=particelle e A3=soluzione o sospensione di rivestimento. It is equipped with 3 channels designed for the insertion of special connection connectors indicated with A1 = ana, A2 = particles and A3 = solution or suspension of coating.
Il caricamento delle polveri avviene tramite un sistema meccanico o pneumatico in grado di far passare le particelle entro il canale. The loading of the powders takes place through a mechanical or pneumatic system able to pass the particles into the channel.
La forma cilindrica illustrata nella tavola 1 con terminale a tronco di cono può essere modificata a seconda degli inserimenti e degli adattamenti necessari per le connessioni allo specifico spray dryer sul quale viene montato. The cylindrical shape illustrated in table 1 with a truncated cone terminal can be modified according to the insertions and adaptations necessary for the connections to the specific spray dryer on which it is mounted.
Nucleo (B) Core (B)
Il nucleo è la parte centrale e più interna dell’ugello che funge da supporto e da collegamento tra la testa superiore e quella inferiore. The core is the central and innermost part of the nozzle which acts as a support and connection between the upper and lower heads.
Il nucleo è di forma cilindrica ed è provvisto di un canale centrale (B2) per il trasporto delle particelle e di due canali laterali (B3) per il trasporto della soluzione o sospensione di rivestimento. Sia il canale B2 che B3 sono in diretta comunicazione con la parte sovrastante alloggiata nella testa e cioè A2 e A3 rispettivamente. The core is cylindrical in shape and is provided with a central channel (B2) for transporting the particles and two lateral channels (B3) for transporting the coating solution or suspension. Both channels B2 and B3 are in direct communication with the overlying part housed in the head, that is A2 and A3 respectively.
Mantello (C) Cloak (C)
Il mantello è costituito da un tubo di collegamento tra la testa inferiore (D) e quelle superiore (A) ed è posto concentricamente al nucleo. The mantle consists of a connecting tube between the lower head (D) and the upper one (A) and is placed concentrically to the core.
Lo spazio che rimane tra mantello e nucleo funge da canale di passaggio per l’aria (Cl). La tenuta è garantita da adatti anelli di gomma (O-rings). The space that remains between the mantle and the core acts as a passage channel for the air (Cl). The tightness is guaranteed by suitable rubber rings (O-rings).
Testa inferiore (D) Lower head (D)
La testa inferiore è la parte di unità di spruzzo che funge da supporto per i vari gruppi di ugelli. The lower head is the part of the spray unit that acts as a support for the various groups of nozzles.
E’ costituita da una canale centrale (D2) per il passaggio delle polveri direttamente comunicante con il sovrastante canale (B2), da diversi canali per il passaggio della soluzione o sospensione di rivestimento (D3) e da diversi canali per il passaggio deH’aria (DI). It consists of a central channel (D2) for the passage of powders directly communicating with the overlying channel (B2), of several channels for the passage of the coating solution or suspension (D3) and of different channels for the passage of air. (FROM).
Questi ultimi due tipi di canali (quello per il liquido di rivestimento e quello per l’aria) sono disposti circolarmente al canale centrale ed il loro numero varia da 1 a 250 in funzione delle dimensioni dell’unità di spruzzo e della quantità di fluido da trasportare. These last two types of channels (the one for the coating liquid and the one for the air) are arranged circularly to the central channel and their number varies from 1 to 250 depending on the size of the spray unit and the quantity of fluid to be to carry.
La parte inferiore D dell’unità di spruzzo è inoltre illustrata nella tavola 2. The lower part D of the spray unit is also shown in table 2.
Essa si compone di tre particolari calotte L, M e N che inserite nella testa inferiore (Tavola 2) provvedono a convogliare in un unico punto (E) le particelle provenienti dal canale D2, il liquido di rivestimento proveniente dal canale D3 e l’aria proveniente dal canale DI. It consists of three particular caps L, M and N which, inserted in the lower head (Table 2), convey the particles coming from channel D2, the coating liquid coming from channel D3 and the air to a single point (E) coming from the DI channel.
Tutti questi canali sono in diretta comunicazione con i sovrastanti canali C2, C3 e CI rispettivamente. All these channels are in direct communication with the overlying channels C2, C3 and CI respectively.
Le lunghezze delle calotte nel punto d’uscita possono essere modificate ad esempio mediante un sistema a vite meccanica, in funzione del tipo di processo e delle variabili operative strumentali. Per esempio la posizione dell’ugello della calotta N può essere portato sino ed oltre i limiti dell’ugello della calotta L indicata come punto K nella Tavola 2. The lengths of the caps at the exit point can be modified, for example, by means of a mechanical screw system, depending on the type of process and instrumental operating variables. For example, the position of the nozzle of the cap N can be brought up to and beyond the limits of the nozzle of the cap L indicated as point K in Table 2.
I diametri dei canali per il trasporto delle particelle, dei liquidi e dell’aria sono compresi tra 1 e 500 mm in funzione del tipo di lavorazione da effettuare. The diameters of the channels for the transport of particles, liquids and air are between 1 and 500 mm depending on the type of processing to be carried out.
I diametri degli ugelli sono compresi tra 1 e 400 mm in funzione delle lavorazioni da effettuare. The diameters of the nozzles are between 1 and 400 mm depending on the work to be carried out.
L’unità di spruzzo secondo la presente invenzione può essere modificata per adattarla a spray dryers divers dal BUCHI B191 a cui si fa riferimento nelle tavole. The spray unit according to the present invention can be modified to adapt it to spray dryers other than BUCHI B191 referred to in the tables.
Così, ad esempio, il tecnico del ramo potrà modificare la forma della testa superiore (A) per adattarla ad altri spray dryers, potrà aumentare il numero di canali B3 ed eventualmente renderli nell’insieme concentrici su B2. Thus, for example, the skilled in the art will be able to modify the shape of the upper head (A) to adapt it to other spray dryers, will be able to increase the number of B3 channels and possibly make them as a whole concentric on B2.
La lunghezza dell’intera unità di spruzzo può variare in funzione del tipo di spray dryer sul quale viene applicato. The length of the entire spray unit may vary depending on the type of spray dryer on which it is applied.
Anche la lunghezza dei canali ed il diametro del mantello che di per sè non sono critiche per quanto riguarda il processo di microincapsulazione, possono variare in funzione del tipo di spray dryer sul quale l’ugello viene applicato. The length of the channels and the diameter of the mantle, which in themselves are not critical as regards the microencapsulation process, may also vary depending on the type of spray dryer on which the nozzle is applied.
Ovviamente, queste modifiche non si discostano dallo spirito della presente invenzione che è quello di permettere l’uso di spray dryers anche in condizioni non precedentemente possibili. Obviously, these modifications do not depart from the spirit of the present invention which is to allow the use of spray dryers even in conditions not previously possible.
Riportiamo qui di seguito a titolo d’esempio la descrizione dell’applicazione pratica dell’unità di spruzzo oggetto dell’invenzione. Below is an example of the description of the practical application of the spray unit object of the invention.
Le particelle solide entrano nell’unità di spruzzo dal raccordo A2 percorrendo il canale B2 e D2 sino a giungere nella zona di miscelazione E. The solid particles enter the spray unit from connection A2 along the channel B2 and D2 until reaching the mixing area E.
Il liquido di rivestimento arriva dal raccordo A3, percorre il canale B3 e D3 giungendo alla zona di miscelazione E. The coating liquid arrives from fitting A3, goes through channel B3 and D3 reaching the mixing zone E.
L’aria viene introdotta dal raccordo A1, percorrre i condotti C1 e D1 arrivando alla zona di miscelazione E. The air is introduced from connection A1, along the pipes C1 and D1 reaching the mixing area E.
Le particelle solide, il liquido e l’aria si incontrano in E da cui parte il fenomeno di spruzzo nella corrente di aria calda. Solid particles, liquid and air meet in E from which the spray phenomenon in the hot air stream starts.
Claims (5)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20012693 ITMI20012693A1 (en) | 2001-12-19 | 2001-12-19 | SPRAY UNIT OF A SPRAY DRYER |
| PCT/EP2002/014465 WO2003051505A1 (en) | 2001-12-19 | 2002-12-18 | Spray unit of a spray dryer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI20012693 ITMI20012693A1 (en) | 2001-12-19 | 2001-12-19 | SPRAY UNIT OF A SPRAY DRYER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20012693A1 true ITMI20012693A1 (en) | 2003-06-19 |
Family
ID=11448711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITMI20012693 ITMI20012693A1 (en) | 2001-12-19 | 2001-12-19 | SPRAY UNIT OF A SPRAY DRYER |
Country Status (2)
| Country | Link |
|---|---|
| IT (1) | ITMI20012693A1 (en) |
| WO (1) | WO2003051505A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2268434T3 (en) | 2002-12-20 | 2007-03-16 | Lifecycle Pharma A/S | A SELF CLEANING ASPERSORA NOZZLE. |
| CN104997634A (en) | 2010-04-09 | 2015-10-28 | 帕西拉制药有限公司 | Method for formulating large diameter synthetic membrane vesicles |
| KR102445447B1 (en) * | 2022-03-04 | 2022-09-20 | 대성기계공업 주식회사 | cathode material integrated processing device |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2121066C3 (en) * | 1971-04-29 | 1974-05-30 | Knapsack Ag, 5033 Huerth-Knapsack | Atomizing nozzle for an atomizing dryer |
| US3949094A (en) * | 1974-07-31 | 1976-04-06 | Scm Corporation | Condiment-treating process and product |
| US3949096A (en) * | 1974-07-31 | 1976-04-06 | Scm Corporation | Spray drying process for encapsulation of condiment particles |
| US4033512A (en) * | 1975-09-05 | 1977-07-05 | Louis Beck | Nozzle assemblies for atomizing and mixing different fluids and combining the mixture with solids and the like |
| DE2746489C2 (en) * | 1977-10-15 | 1982-12-30 | Hans Dr. 3300 Braunschweig Junginger | Process for the production of microcapsules with liquid and / or with solid fillings by spray drying using a triple nozzle |
| DE3865906D1 (en) * | 1987-07-03 | 1991-12-05 | Ciba Geigy Ag | SPRAY DRYER FOR THE PRODUCTION OF POWDERS, AGGLOMERATES OR THE LIKE. |
| DE4329205C2 (en) * | 1993-08-31 | 1996-05-23 | Degussa | Process for the production of granular sodium percarbonate |
| DE19927537A1 (en) * | 1999-06-16 | 2000-12-21 | Merck Patent Gmbh | Spray drying plant and method of using it |
-
2001
- 2001-12-19 IT ITMI20012693 patent/ITMI20012693A1/en unknown
-
2002
- 2002-12-18 WO PCT/EP2002/014465 patent/WO2003051505A1/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003051505A1 (en) | 2003-06-26 |
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