IT8821678A0 - PROCEDURE FOR THE SYNTHESIS OF VINBLASTINE AND VINCRISTINE. - Google Patents
PROCEDURE FOR THE SYNTHESIS OF VINBLASTINE AND VINCRISTINE.Info
- Publication number
- IT8821678A0 IT8821678A0 IT8821678A IT2167888A IT8821678A0 IT 8821678 A0 IT8821678 A0 IT 8821678A0 IT 8821678 A IT8821678 A IT 8821678A IT 2167888 A IT2167888 A IT 2167888A IT 8821678 A0 IT8821678 A0 IT 8821678A0
- Authority
- IT
- Italy
- Prior art keywords
- vinblastine
- vincristine
- synthesis
- procedure
- Prior art date
Links
- JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical compound C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 title 1
- 229960003048 vinblastine Drugs 0.000 title 1
- 229960004528 vincristine Drugs 0.000 title 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 title 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA000543832A CA1341262C (en) | 1987-08-06 | 1987-08-06 | A new process of the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8821678A0 true IT8821678A0 (en) | 1988-08-05 |
| IT1227155B IT1227155B (en) | 1991-03-19 |
Family
ID=4136214
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT8821678A IT1227155B (en) | 1987-08-06 | 1988-08-05 | VINBLASTIN AND VINCRISTINE SYNTHESIS PROCEDURE. |
Country Status (12)
| Country | Link |
|---|---|
| JP (1) | JPH0613532B2 (en) |
| AU (1) | AU617342B2 (en) |
| BE (1) | BE1003228A4 (en) |
| CA (1) | CA1341262C (en) |
| CH (1) | CH676711A5 (en) |
| DE (1) | DE3826412A1 (en) |
| GB (1) | GB2215331B (en) |
| HU (1) | HU208829B (en) |
| IT (1) | IT1227155B (en) |
| NL (1) | NL8801966A (en) |
| SE (1) | SE467875B (en) |
| ZA (1) | ZA885765B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5047528A (en) * | 1987-01-22 | 1991-09-10 | University Of Bristish Columbia | Process of synthesis of vinblastine and vincristine |
| USRE37449E1 (en) | 1987-02-06 | 2001-11-13 | University Of British Columbia | Process of synthesis of 3′,4′-anhydrovinblastine, vinblastine and vincristine |
| US5432279A (en) * | 1989-03-04 | 1995-07-11 | Mitsui Petrochemical Industries, Inc. | Process for the preparation of binary indole alkaloids |
| CA2350854C (en) * | 1990-11-30 | 2005-01-04 | Ucb Japan Co., Ltd. | 1,4-dihydropyridine derivatives and methods of producing the same |
| JP3010151U (en) * | 1994-04-26 | 1995-04-25 | スミ子 片山 | A cylindrical tableware storage case with a notch. |
| FR2779146B1 (en) * | 1998-06-02 | 2002-01-18 | Roowin | NOVEL VINCA-ALKALOIDE DERIVATIVES AND PREPARATION METHODS |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4279817A (en) * | 1975-05-30 | 1981-07-21 | The United States Of America As Represented By The Department Of Health & Human Services | Method for producing dimer alkaloids |
| HU195513B (en) * | 1984-10-16 | 1988-05-30 | Richter Gedeon Vegyeszet | Process for producing stable solutions of alkaloides with bis-indole skeleton |
| EP0215058A1 (en) * | 1985-03-12 | 1987-03-25 | The University Of Vermont And State Agricultural College | Synthesis of vinblastine and vincristine type compounds |
| CA1341261C (en) * | 1987-01-22 | 2001-06-26 | James P. Kutney | Process for the synthesis of 3',4'-anhydrovinblastine, vinblastine and vincristine |
-
1987
- 1987-08-06 CA CA000543832A patent/CA1341262C/en not_active Expired - Fee Related
-
1988
- 1988-08-03 SE SE8802813A patent/SE467875B/en not_active IP Right Cessation
- 1988-08-03 DE DE3826412A patent/DE3826412A1/en not_active Ceased
- 1988-08-05 AU AU20512/88A patent/AU617342B2/en not_active Ceased
- 1988-08-05 IT IT8821678A patent/IT1227155B/en active
- 1988-08-05 BE BE8800908A patent/BE1003228A4/en not_active IP Right Cessation
- 1988-08-05 ZA ZA885765A patent/ZA885765B/en unknown
- 1988-08-05 CH CH2974/88A patent/CH676711A5/de not_active IP Right Cessation
- 1988-08-05 NL NL8801966A patent/NL8801966A/en not_active Application Discontinuation
- 1988-08-06 JP JP63196999A patent/JPH0613532B2/en not_active Expired - Lifetime
- 1988-08-08 HU HU884126A patent/HU208829B/en not_active IP Right Cessation
- 1988-08-08 GB GB8818765A patent/GB2215331B/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH0613532B2 (en) | 1994-02-23 |
| GB2215331A (en) | 1989-09-20 |
| NL8801966A (en) | 1989-03-01 |
| DE3826412A1 (en) | 1989-02-16 |
| BE1003228A4 (en) | 1992-02-04 |
| GB8818765D0 (en) | 1988-09-07 |
| GB2215331B (en) | 1992-01-02 |
| SE467875B (en) | 1992-09-28 |
| HUT50351A (en) | 1990-01-29 |
| AU617342B2 (en) | 1991-11-28 |
| CH676711A5 (en) | 1991-02-28 |
| AU2051288A (en) | 1989-02-09 |
| SE8802813D0 (en) | 1988-08-03 |
| ZA885765B (en) | 1989-09-27 |
| HU208829B (en) | 1994-01-28 |
| JPH01151590A (en) | 1989-06-14 |
| CA1341262C (en) | 2001-06-26 |
| SE8802813L (en) | 1989-02-07 |
| IT1227155B (en) | 1991-03-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19970829 |