IT202200006080A1 - Oral solid composition for the management of neuropathic, osteo-articular, gynecological, post-surgical pain and mitochondrial trophism - Google Patents
Oral solid composition for the management of neuropathic, osteo-articular, gynecological, post-surgical pain and mitochondrial trophism Download PDFInfo
- Publication number
- IT202200006080A1 IT202200006080A1 IT102022000006080A IT202200006080A IT202200006080A1 IT 202200006080 A1 IT202200006080 A1 IT 202200006080A1 IT 102022000006080 A IT102022000006080 A IT 102022000006080A IT 202200006080 A IT202200006080 A IT 202200006080A IT 202200006080 A1 IT202200006080 A1 IT 202200006080A1
- Authority
- IT
- Italy
- Prior art keywords
- trophism
- osteo
- gynecological
- neuropathic
- articular
- Prior art date
Links
- 208000004550 Postoperative Pain Diseases 0.000 title 1
- 230000002438 mitochondrial effect Effects 0.000 title 1
- 230000002981 neuropathic effect Effects 0.000 title 1
- 239000008247 solid mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nutrition Science (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102022000006080A IT202200006080A1 (en) | 2022-03-28 | 2022-03-28 | Oral solid composition for the management of neuropathic, osteo-articular, gynecological, post-surgical pain and mitochondrial trophism |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT102022000006080A IT202200006080A1 (en) | 2022-03-28 | 2022-03-28 | Oral solid composition for the management of neuropathic, osteo-articular, gynecological, post-surgical pain and mitochondrial trophism |
Publications (1)
Publication Number | Publication Date |
---|---|
IT202200006080A1 true IT202200006080A1 (en) | 2023-09-28 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IT102022000006080A IT202200006080A1 (en) | 2022-03-28 | 2022-03-28 | Oral solid composition for the management of neuropathic, osteo-articular, gynecological, post-surgical pain and mitochondrial trophism |
Country Status (1)
Country | Link |
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IT (1) | IT202200006080A1 (en) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103169695B (en) * | 2013-02-05 | 2014-07-23 | 西安交通大学 | Application of alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10 and hydroxytyrosol composition for preventing and treating amyotrophy |
RU2701720C1 (en) * | 2018-04-12 | 2019-10-01 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Combinations of palmitoylethanolamide for treating chronic pain |
-
2022
- 2022-03-28 IT IT102022000006080A patent/IT202200006080A1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103169695B (en) * | 2013-02-05 | 2014-07-23 | 西安交通大学 | Application of alpha-lipoic acid, acetyl-L-carnitine, coenzyme Q10 and hydroxytyrosol composition for preventing and treating amyotrophy |
RU2701720C1 (en) * | 2018-04-12 | 2019-10-01 | Общество С Ограниченной Ответственностью "Валента - Интеллект" | Combinations of palmitoylethanolamide for treating chronic pain |
Non-Patent Citations (21)
Title |
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ALESSANDRA PACINI ET AL.: "Comparative Assessment of the Activity of Racemic and Dextrorotatory Forms of Thioctic (Alpha-Lipoic) acid in Low Back pain: Clinical results and Clinical outcomes from an Open Randomized Trial", FRONT PHARMACOL., vol. 12, 24 February 2021 (2021-02-24), pages 607772 |
AMIT D KANDHARE ET AL.: "Polishing of molecular mechanism involved in neuroprotective effect of Coenzyme Q10 in alcohol-induced neuropathic pain", FUNDAM CLIN PHARMACOL., vol. 27, no. 6, 2 October 2012 (2012-10-02), pages 603 - 22 |
BEKIR BERKER ARTUKOGLU ET AL.: "Efficacy of Palmitoylethanolamide for pain: A Meta-Analysis", PAIN PHYSICIAN., vol. 20, no. 5, July 2017 (2017-07-01), pages 353 - 362 |
CHRISTIANE SCHULZUTE C OBERMU!!ER-JEVICOLIVER HASSELWANDERJURGEN BERNHARDTHANS K BIESALSKI: "Comparison of the relative bioavailability of different coenzyme Q10 formulations with a novel solubilized (sulu Q10", INT J FOOD SCI NUTR, vol. 57, no. 7-8, November 2006 (2006-11-01), pages 546 - 55 |
DANIELA IMPELLIZZERI ET AL.: "Micronized/ultramicronized palmitoylethanolamide diplays outweighs or orai efficiency compared to non-micronized palmitoylethanolamide in a rat model of inflammatory pain", J NEUROINFLAMMATION., vol. 11, 28 August 2014 (2014-08-28), pages 136 |
ELIZABETH STEELSRUCHITHA VENKATESHELEANOR STEELSGEMMA VITETTALUIS VITETTA: "A double-blind randomized placebo-controlled study assessing safety, tolerability and efficacy of palmitoylethanolamide for symptoms of knee osteoarthritis", INFLAMMOPHARMACOLOGY, vol. 27, no. 3, 29 March 2019 (2019-03-29), pages 475 - 485, XP036801007, DOI: 10.1007/s10787-019-00582-9 |
EVANGELOS AGATHOS ET AL.: "Effect of a-lipoic acid on symptoms and quality of life in patients with pain diabetic neuropathy", J INT MEAN RES, vol. 46, no. 5, May 2018 (2018-05-01), pages 1779 - 1790 |
GUILLERMO LOPEZ-LLUCHJESUS DEL POZO-CRUZANA SACHEZ-CUESTAANA BELENCORTES-RODRIGUEZPLACIDO NAVAS: "Bioavailability of coenzyme Q10 supplements depends on carrier lipids and solubilization", NUTRITION, vol. 57, pages 133 - 140, XP085536397, DOI: 10.1016/j.nut.2018.05.020 |
HEMMI N BAGNAVARAJ K CHOPRO: "Plasma coenzyme Q10 response to orai ingestion of coenzyme Q10 formulations", MITOCHONDRION, vol. 7, June 2007 (2007-06-01), pages S78 - 88, XP022072331, DOI: 10.1016/j.mito.2007.03.003 |
HEMMI N BHAGAVANRAJ K CHOPRO: "Coenzyme Q10: absorption, tissue uptake, metabolism and pharmacokinetics", FREE RADICAL RES, vol. 40, no. 5, May 2006 (2006-05-01), pages 445 - 53, XP009102744, DOI: 10.1080/10715760600617843 |
HUA QU ET AL.: "The effect of statin treatment on circulating coenzyme Q10 concentrations: An updated meta-analysis of randomized controlled trials", EUR J MED RES., vol. 23, 2018, pages 57 |
LINDA GABRIELSSONSOFIA MATTSSONCHRISTOPHER J FOWLER: "Palmitoylethanolamide for the treatment of pain: Pharmacokinetics, safety and efficacy", BR J CLIN PHARMACOL., vol. 82, no. 4, October 2016 (2016-10-01), pages 932 - 42, XP055452245, DOI: 10.1111/bcp.13020 |
LINDA RANKINCHRISTOPHER J FOWLER: "The Basai Pharmacology of Palmitoylethanolamide", INT J MOL SCI., vol. 21, no. 21, 26 October 2020 (2020-10-26), pages 7942 |
LUE ROCHETTESTELIANA GHIBUCAROLE RICHARDMARIANNE ZELLERYVES COTTINCATHERINE VERGHELY: "Direct and indirect antioxidizing properties of a-lipoic acid and therapeutic potential", MOL NUTR FOOD RES, vol. 57, no. 1, January 2013 (2013-01-01), pages 114 - 25 |
M PILAR VALDECENTOS ET AL.: "Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of syrtuin 1 and syrtuin 3", OBESITY (SILVER SPRING)., vol. 20, no. 10, 1 February 2012 (2012-02-01), pages 1974 - 83 |
MARIA LAVINIA BARTOLUCCI ET AL.: "Micronized palmitoylethanolamide reduces joint pain and glial celi activation", INFLAMM RES., vol. 67, no. 10, 18 August 2018 (2018-08-18), pages 891 - 901, XP036581605, DOI: 10.1007/s00011-018-1179-y |
MARIO BRUFANI, ROCCO FIGLIOLA.: "(R)-a-lipoic acid liquid formulation:Pharmacokinetic parameters and therapeutic efficiency.", ACTA BIOMED, vol. 85, no. 2, 20 August 2014 (2014-08-20), pages 108 - 15 |
NASRIN SADEGHIYAN GALESHKALAMI ET AL.: "Alpha-lipoic acid and coenzyme Q10 combination ameliorates experimental diabetic neuropathy by modulating oxidative stress and apoptosis", LIFE SCIENCES., vol. 216, 1 January 2019 (2019-01-01), pages 101 - 11 |
PATEL SP, SULLIVAN PG, LYTTLE TS, RABCHEVSKY AG: "Acetyl-L-carnitines ameliorates mitochondrial function following contusion spinous cord injury", J NEUROCHEM., vol. 114, no. 1, 2010, pages 291 - 301 |
YAN PING ZHANG ET AL., ANESTHESIOLOGY, vol. 118, April 2013 (2013-04-01), pages 945 - 954 |
ZHENG-XIAN LIU , DEAR ARTMANN: "Relative bioavailability comparisonof different coenzyme Q10 formulated ons with a novel delivery system.", ALTERN THER HEALTH MED, vol. 15, no. 2, May 2009 (2009-05-01), pages 42 - 6 |
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