IT202100003284A1 - PROCEDURE AND RELATED DEVICE BASED ON THE USE OF AN ELECTROMAGNETIC FIELD TO CONTRAST THE SPREAD OF "CORONA" TYPE VIRUSES INTO AN ORGANISM - Google Patents

Description

Description of the invention with TITLE:

Process and related device based on the use of an electromagnetic field aimed at countering the spread of ?Corona? in an organism.

SUMMARY

The new invention consists of a method and an apparatus able to produce with a particular modality Electromagnetic fields capable of hindering, using various mechanisms of action, specifically identified, the ability? of a Corona-type virus to bind to a cell through the S proteins of which the surface of the virus? surrounded. The action of this new invention ? completely new, being physical and non-pharmacological.

CONDITIONS ON WHICH THE NEW FOUND IS BASED

In order to understand the functioning of the new invention, some electrostatic and physical characteristics of the protein S, published and known to the community, are preliminarily summarized below. science, and some considerations relating to the electromagnetic field (from now on referred to as EMC).

A) Electrostatic and Electromagnetic Characteristics of protein S Said characteristics of protein S are extensively studied and characterized by the community? scientific. e.g. in the paper ?Modeling the Opening SARS-CoV-2 Spike: an Investigation of its Dynamic Electro-Geometric Properties? by Anna Kucherova, Selma Strango, Shahar Sukenik, Maxime Theillard (doi: https://doi.org/10.1101/2020.10.29.361261, October 29, 2020) , analyzing the electric potential of protein S with the non-differential equation method linear Poisson-Boltzmann, it is determined that the S1 and S2 regions of protein S have different potentials, functional to the connection with the ACE2 receptor (see fig 1, taken from the above mentioned article according to the CC 4.0 Int. license). With completely different method many other scientific articles, including e.g. we mention ?Electrostatic Characteristics of SARS-CoV-2 Spike and Human ACE2 Protein Variations Predict Mutable Binding Efficacy? by Scott P. Morton and Joshua L. Phillips (doi: https://doi.org/10.1101/2020.04.30.071175 May 09, 2020) underline the importance of the electrical potential expressed by protein S for coupling to the ACE2 receptor, arriving even to quantify the Force (in Newton) due to the electrostatic attraction attributable to the potential present in the S1 and S2 regions.

B) In protein S the S1 component ? mobile with respect to the component S2

The mechanism of infection includes the fact that the S1 component moves ?discover? the component S2, which ? then the one responsible for transmitting the virus. This also ? very well established and shared in the specialized scientific literature, see e.g.: ?Controlling the SARS-CoV-2 spike glycoprotein conformation? by Henderson, Acharya et al. (Nature Structural & Molecular Biology volume 27, pages 925?933 (2020) ).

In order to understand one of the mechanisms of action of this patent, it should be noted that a molecule with degrees of freedom? and electric charge exhibits a resonance frequency linked to its mass and electric charge, according to what is set out in formula 2) of the following point. An effective and clear graphical representation of mobility? ? depicted in fig. 2, taking it from the article cited in A), according to the CC 4.0 Int. license.

C) Decreased NAD+ levels in COVID patients

AND? Common notion that Nicotinamide Adenine Dinucleotide (NAD+) levels decrease with age? and in some patient groups (e.g., obese, diabetic, and hypertensive). According to statistics, elderly people and/or people with the aforementioned pathologies are also those who are at risk of experiencing more severe symptoms. severe than average in COVID infections. Thus NAD+ levels may play a relevant role in COVID infections (see e.g.:?NAD+ deficiency may predispose heaged, obese and type2 diabetics to mortality through its effect on SIRT1 activity? by Miller, Wentzela, Richards, (Med. Hypothesy, doi: 10.1016/j.mehy.2020.110044, Epub 2020 Jun 29). NAD+ is an ion with a resonance frequency linked to its mass and electric charge, according to what is exposed in formula 2) of the following point

D) Selective action of the EMF by excitation of resonance frequencies (Cyclotron like) of specific ions

An electric current whose time course is described by a periodic waveform f(t) of frequency w0 , if made to flow in a coil produces a variable EMF (Electromagnetic Field) that can? be represented with the well-known ?Fourier decomposition? , and that? as the sum of infinite sine and cosine functions with integer multiple frequency of w0 according to the relation:

where the terms an and bn represent the amplitude of the single components of the nth harmonic.

It has long been clear that the harmonic components of an EMF applied to a biological system are important for obtaining observable biological effects.

For example. in the 70s of the last century Basset C.A.L. (J. Cell. Biochem. 51:387?393, and references cited therein) and Chiabrera A. et al., (see among his many works, for example ?Interactions between Magnetic Fields and Cells?, London, Plenum Press, 1985) noted that in a biological system the harmonic richness of the E component induced by a variable EMF was fundamental for obtaining the therapeutic result.

Subsequently (1985, Prof. Liboff) yes ? discovered that an ion, subjected to a Static Magnetic Field (typically the Earth's Magnetic Field is used) of value B0, even if in a medium such as the biological one (and that is, in the presence of shocks is differently from the classic Cyclotron Frequency which is experienced in vacuum-), has a resonance frequency f0 (similar to that of the Cyclotron) which depends on the mass m of the ion itself, on its charge Zi and on the value B0 , according to the classic relation of the Cyclotron Frequency:

Experimentally yes? verified that the excitation of an ion by means of an EMF of frequency equal to that of relation 2), also called Cyclotronic Frequency, induces a resonance which makes it more? the ion itself is also reactive from a chemical and biochemical point of view, and therefore more capable of a biological action.

An example of how not only the frequency of a variable EMF can be important, but also its harmonic components, is provided by the same Prof. in US patent #5.160.591 (November 3, 1992), where the use of harmonic frequencies in such a way that the same variable EMF can excite a given ionic species with the fundamental frequency, and with another harmonic, typically a multiple or submultiple of the fundamental, an ionic species different from the first, and like the two (or more ?) excitation mechanisms occur simultaneously. On the other hand, on the contrary, the biological effect could be depressed by the stimulation of an ionic species of interest but at the same time as its antagonist.

Therefore, irradiating a biological system with an EMC, acting appropriately on the frequencies according to the test principles? mentioned we can select the target of our stimulation (in the specific case, the protein S) to favor/disadvantage appropriate reactions. The harmonic components present in the sent signal generated by a variable EMC and evaluable according to the Fourier decomposition (see relation 1 and relation 2) are extremely important. Therefore the EMF generated must have well controlled characteristics, among which we highlight frequency and harmonic content.

DESCRIPTION

A ?Corona? its surface is surrounded by protein protuberances (S proteins) which make it capable of binding to cells and subsequently infecting them. As ? known, a protein S ? divided into two components, called:

- S1, with capacity? to bind to the ACE2 receptor;

-S2, which allows the virus to enter the cell.

The classic approach to countering Corona virus infections? pharmacological: what are they looking for? molecules capable of interfering with the action of S proteins.

On the contrary, the new invention consists of a method and an apparatus able to produce with a particular modality Electromagnetic fields capable of hindering, using various actions, the ability? of a Corona-type virus to bind to a cell via S proteins.

The procedure consists in exposing the site where you want to interfere with the action of the Corona virus (for example the lungs, nose, etc.), to a variable level EMC such as to irradiate the tissues with an electrical component capable of actively interfere with the electrostatic forces relating to zones S1 and S2, taking care that the frequency radiated is such as to induce resonance of the S1 component and of the NAD+ molecule (fig.3).

The apparatus consists of a programmable generator (fig. 4) capable of generating an alternating current which, made to flow in one or more? radiating surfaces, generates the variable EMF with the necessary characteristics of amplitude, duration, frequency and harmonic content. Each radiating surface ? constituted by a set of conductors with a layout such as to allow, when crossed by current, the induction, in the biological site of interest, of an EMC of suitable intensity? and uniformity? (variation in intensity: /- 10%), see fig. 5.

MECHANISMS OF ACTION

- explanation of how the electrostatic charge is made to vary by the EMC:

the electric charges (ions, charged molecules and free electrons) are concentrated in the S1 and S2 components of the S protein; to each zone exhibiting a certain total charge corresponds a second with a total charge of opposite sign, forming a configuration similar to a capacitor. The two opposite charges are equal and tend to couple with each other, i.e. to position themselves opposite each other, so that the flux lines can go from the negative charge to the positive one, but, probably due to the configuration of the protein S , they are not canceled by directly entering into contact. The fact that this charge difference is maintained? detected by the measurement of a local electric potential difference, as illustrated by A. Kucherova et al. in the article cited in A). When these concentrations of charge positioned in an (almost) specular way are hit by an electromagnetic wave of suitable frequency and power (in any case very low) they are perturbed and this perturbation leads them to loosen their mutual contact at a distance: the energy transported by The incident electromagnetic wave tends to scatter the charges on a greater volume, moving them away from each other and decreasing the density? of flux lines between charges of opposite sign. This ? also explainable by the observations of Henderson et al. which showed that the two parts of the S protein, S1 and S2, are mutually mobile. This mobility, if guided by a suitable external electromagnetic wave which in practice injects energy into the two charge distributions, ends up weakening their mutual interaction. This interaction can be seen as the combined action of a sort of C-shaped capacitor which, when opened, brings its two poles to the surface of the cell, allowing the virus to hook up thanks to the flux lines joining the two poles of the capacitor. These flux lines can certainly, at the price of some attenuation, cross the ?pinched? cell substance? between the leaders of the C, anchoring cos? the virus. The electric potential between zones S1 and S2 can? have an abnormal value (up to 500 mV) for biological substances, according to simulations. Weakening the flux lines that run between S1 and S2 means in practice weakening the mechanism by which the virus attaches itself to the cell surface, ultimately reducing its ability to attack the cell surface. to introduce inside the cell to be able to reproduce and cos? infecting her. The undermining mechanism? based on the well-known ability? of electromagnetic waves to interact with distributions of electric charges, scattering them. The type of distribution conditions the type of response of the virus with respect to the incident electromagnetic wave and together with the total distribution of the charge volume of the joint charge system S1 and S2 determines in which frequency range an optimized interaction is obtained.

- explanation of how the unfolding or rotation of S1 is disturbed by resonance at very low frequencies:

the S1 subpart of the S protein is not ? completely free to move, but has at least two degrees of freedom: rotate on itself and move in space, probably oscillating around an equilibrium position. AND? therefore sufficient to introduce into the biological system by irradiation small quantities? of electricity to induce rotational movements triggered on the principle of action propaedeutically exposed in D).

Furthermore, an abnormal concentration of charge is detected in area S1, together with area S2, the electrostatic potential (up to 500 mVolt) of which the scientific works cited above speak is generated from these two concentrations of charge. This concentration of charge pu? be attributed to two factors: an active mechanism that traps ions and/or electrons in the aforementioned areas, or an alignment and consequent orientation of the intrinsic electric dipole moments of the ions/atoms/molecules present. Many ions/atoms/molecules present in biological tissues are endowed with a high intrinsic dipole moment, deriving from a different or very different spatial charge distribution from a sphere.

These two effects can certainly coexist, the second? less expensive in terms of energy, also why? the lowest energy state for a set of dipoles is reached when they are aligned with each other. The dipoles also act as antennas (with good efficiency) and have a capacity? frequency-dependent receptivity. Whenever ions/atoms/molecules/dipoles are hit by electromagnetic waves, they absorb a fraction of their energy and tend to become misaligned and react in two ways: by rotating (which involves consuming less energy) and by moving in space. These rotations of ions/atoms/dipolar molecules are also described by the principle explained in point D) and can exhibit resonant behaviors. The difference between considering a dipole or a single ion without dipole moment involves only a correction in the resonance frequency value but the dipole has a greater interaction efficiency with the radiated electromagnetic radiation. For ?heavy? molecules (whether they are dipolar or not) the reaction times are rather slow, due to their intrinsic inertia to electromagnetic radiation, and these times are measurable by observing the relaxation times associated with an electromagnetic perturbation induced on a suitable sample in the laboratory. Many molecules, whether electrically charged or not, present in cellular tissues are to be considered ?heavy?. This suggests the use of low or very low frequencies to optimize the desired effects.

Not ? easy to calculate the mass and the electric charge of said subpart S1: the mass ? however considerable, and this leads, by comparison with other molecules, to hypothesize a very low resonance frequency (in the order of a few hundredths of Hz/micro Tesla), and, on the basis of previous experiences, it is believed that providing an EMF of very low (from tenths of Hz to a few Hz), it is possible to induce a sort of Resonance or at least a Parametric Resonance, and that, thanks to a frequency sweep, it is possible to obtain the necessary stress at the exact frequency of resonance of S1.

- explanation of how it is possible to remedy insufficient levels of NAD+: as propaedeutically explained in C) do the levels of Nicotinamide Adenine Dinucleotide (NAD+) decrease with age? and in some patient groups. Using the very well known and practiced technique of Cyclotron Ion Resonance described in D), ? possible to make more biologically activates the NAD+ still present in the body, mitigating the effects of its impoverishment. Said NAD+ molecule? made up of 2 nucleotides joined together by a phosphoanhydride bond. Basically: ? a heavy molecule, whose calculated resonance frequency is of a few hundredths of Hz/microTesla, falling again in the previous case.

CONCLUSION

given that the energy associated with the single photon of electromagnetic radiation ? roughly always the same, by varying the frequency in the field of interest (from 0.1 to 10 Hz), you can? to say that the variation, induced by EMF, of the electrostatic charge expressed by the protein S pu? be assumed to be independent of frequency.

This consideration explains how it is possible to combine the three different effects described above, adopting frequencies capable of stimulating, parametrically, the resonance of NAD+ and of the S1 component of protein S.

SYNTHETIC DESCRIPTION OF THE FIGURES

Fig. 1 : representation of the properties? of various areas of the protein S. In particular, in the upper part (100) the flux lines of the Electrostatic Field are depicted with the S1 and S2 regions of the protein S closed, while in the lower part (101) the flux lines with S1 and S2 separated: it can be seen how in the latter case they are more? open and stretched.

Fig. 2 : represents the mobility? of the S1 subpart of the S protein compared to the S2 subpart. At the top left (102) the S1 and S2 regions of protein S are shown side by side, at the top right (103) the S1 and S2 regions are separated. Below a quantification of the movement, graphing the elongation of the distance of 4 points, respectively with the protein ?closed? (104) and ?open? (105).

Fig. 3 : example of the application of the CEM. The EMF is delivered and applied through radiators applied to two of the sites often affected by the multiplication of the corona virus: nose (106) and lung (107). The radiators are powered by the generator (108).

Fig. 4 : typical configuration of the generator. The generator (108) consists of an interface with the outside world (109), necessary for the entry of the operating parameters, a memory (110), a unit? processor (111) and a power interface (112) which generates the current i which feeds the radiators.

Fig. 5 : typical conformation of a radiator. A radiator? simply constituted by a winding (113) in which flows the alternating current i coming from the? power interface (112), with the necessary parameters. Alternating current generates the desired EMC. The shape of the radiator? such as to generate the? intensity? desired on the anatomical part, with maximum uniformity? possible (+/- 10%).

EXPERIMENTAL TESTS

Pending the emergency situation caused by the 2020 pandemic, the authorities regulatory authorities have at times been inclined to allow the experimental use of drugs or other health aids without double-blind clinical trials being available and without the procedures normally necessary for the approval of medical devices being undertaken (intended both as diagnostic devices, than as therapeutic aids). A small set of devices implementing this invention ? been tested, with positive results, both on some intubated patients (the doctors who used the devices were not aware of the delivery/production method of the EMF: they knew that it was simply an ?Electromagnetic Field?), and on one of the authors of this patent, who became quite seriously ill .

PREFERRED IMPLEMENTATIONS

- a preferred implementation ? the one with which an EMF with a pure sine wave of a level of 150 micro Tesla is generated with a radiator positioned under the lungs, (said level supplied is well below the 1000 micro Tesla envisaged by current legislation for occupational exposures), with frequency of 2 Hz, for 6 hours a day;

- a further preferred implementation ? the one in which, on equal terms? in the other conditions, the frequency is generated by operating a sweep from 0.1 to 5 Hz, in steps of 0.1 Hz, each lasting 10 minutes;

- a third preferred implementation ? the one in which, maintaining the conditions of the previous point, the evolution of the current i made to flow in the application is not ? more? sinusoidal, but with high-low levels with pseudo-udorandomic evolution, so as to generate an EMF with harmonic content at least up to the octave within 10 dB.

Claims (6)

1) device for contrasting the spread of ?Corona? in the human body composed of a radiator winding (113) capable of generating a variable electromagnetic field, in which the current generated by a unit circulates? of power (112), said current having the time pattern of a repetitive wavelet generated by a unit? central (111). Said wavelet being generated on the basis of data set by a unit? interface (109) and a memory (110) and such as to produce by means of the radiator (113) an electromagnetic field with a frequency between 0.1 and 10 Hz and intensity? between 100 micro Tesla and 500 micro Tesla; 2) device like 1), where the wavelet is constituted by a pseudo random sequence of two or more? analog values, such that the variable electromagnetic field produced by? radiator winding (113) has a harmonic content in which the? amplitude of the first 8 multiples of the fundamental is not less than 10 dB with respect to the fundamental itself; 3) device such as 1) where the wavelet consists of a sequence of analog values of amplitude and duty cycle regulated in such a way that the variable electromagnetic field produced by the? radiator winding (113) is characterized by a harmonic content in which the? amplitude of the first 8 multiples of the fundamental is not less than 10 dB with respect to the fundamental itself; 4) device like 1), 2) or 3), where the frequency of the fundamental component of the electromagnetic field does not have a constant value, but sweeps between the minimum value of 0.1 Hz and the maximum value of 10 Hz; 5) device such as 1), 2) or 3), where the frequency of the fundamental component of the electromagnetic field does not have a constant value, but sweeps with a span of +/- 2 Hz around the calculated parametric resonance frequency of a component of the protein S of the virus under consideration; 6) device like 1), 2) or 3), where the frequency of the fundamental component of the electromagnetic field does not have a constant value, but sweeps with a span of /- 2 Hz around the calculated resonance frequency ICR of the NAD+ molecule .