IT202000021634A1 - DEVICE FOR THE ADMINISTRATION OF A SOLUTION WITH POVIDONE IODIUM FOR THE PREVENTION OF EYE INFECTIONS - Google Patents
DEVICE FOR THE ADMINISTRATION OF A SOLUTION WITH POVIDONE IODIUM FOR THE PREVENTION OF EYE INFECTIONS Download PDFInfo
- Publication number
- IT202000021634A1 IT202000021634A1 IT102020000021634A IT202000021634A IT202000021634A1 IT 202000021634 A1 IT202000021634 A1 IT 202000021634A1 IT 102020000021634 A IT102020000021634 A IT 102020000021634A IT 202000021634 A IT202000021634 A IT 202000021634A IT 202000021634 A1 IT202000021634 A1 IT 202000021634A1
- Authority
- IT
- Italy
- Prior art keywords
- povidone
- solution
- eye
- iodine
- administration
- Prior art date
Links
- 208000001860 Eye Infections Diseases 0.000 title claims description 3
- 208000011323 eye infectious disease Diseases 0.000 title claims description 3
- 230000002265 prevention Effects 0.000 title claims description 3
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 title description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 title description 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 title description 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 title description 2
- 229940069328 povidone Drugs 0.000 title description 2
- CPKVUHPKYQGHMW-UHFFFAOYSA-N 1-ethenylpyrrolidin-2-one;molecular iodine Chemical compound II.C=CN1CCCC1=O CPKVUHPKYQGHMW-UHFFFAOYSA-N 0.000 claims description 11
- 229920000153 Povidone-iodine Polymers 0.000 claims description 10
- 229960001621 povidone-iodine Drugs 0.000 claims description 10
- 239000000243 solution Substances 0.000 claims description 7
- 210000003128 head Anatomy 0.000 claims description 6
- 210000001508 eye Anatomy 0.000 claims description 5
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 4
- 229920002125 Sokalan® Polymers 0.000 claims description 4
- 229960001631 carbomer Drugs 0.000 claims description 4
- 239000003889 eye drop Substances 0.000 claims description 4
- 229940012356 eye drops Drugs 0.000 claims description 4
- 229920000742 Cotton Polymers 0.000 claims description 3
- 210000000795 conjunctiva Anatomy 0.000 claims description 3
- 239000000645 desinfectant Substances 0.000 claims description 3
- 239000000017 hydrogel Substances 0.000 claims description 3
- 238000004659 sterilization and disinfection Methods 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 229920003023 plastic Polymers 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 210000000720 eyelash Anatomy 0.000 claims 1
- 210000000744 eyelid Anatomy 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 3
- 229910052740 iodine Inorganic materials 0.000 description 3
- 239000011630 iodine Substances 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 230000003612 virological effect Effects 0.000 description 3
- 208000036142 Viral infection Diseases 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 230000003449 preventive effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 208000025721 COVID-19 Diseases 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 229940064804 betadine Drugs 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000006196 drop Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M35/00—Devices for applying media, e.g. remedies, on the human body
- A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Ophthalmology & Optometry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
Descrizione Description
Titolo: DISPOSITIVO PER LA SOMMINISTRAZIONE DI UNA SOLUZIONE CON IODIOPOVIDONE PER LA PREVENZIONE DELLE INFEZIONE DELL'OCCHIO Title: DEVICE FOR THE ADMINISTRATION OF A SOLUTION WITH POVIDONE IODIUM FOR THE PREVENTION OF EYE INFECTION
Ambito dell'invenzione Scope of the invention
La presente invenzione si riferisce ad un dispositivo per la somministrazione di una soluzione liquida a The present invention relates to a device for administering a liquid solution a
base di iodiopovidone in concentrazioni controllate sulla mucosa della congiuntiva. based on povidone iodine in controlled concentrations on the mucous membrane of the conjunctiva.
Stato della tecnica nota State of the prior art
Lo stato dell'arte suggerisce che lo iodiopovidone ? efficace nel trattamento preventivo, dei paziente non The state of the art suggests that povidone-iodine ? effective in preventive treatment, of patients not
solo affetti da Covid-19, ma per tutte le infezioni virali, micotiche e batteriche. Il dispositivo risulta only affected by Covid-19, but for all viral, fungal and bacterial infections. The device turns out
un'innovazione per la possibilit? di disinfezione delle mucose congiuntivali dato che allo stato dell'arte i an innovation for the possibility? of disinfection of the conjunctival mucous membranes since the state of the art i
dispositivi per la disinfezione dell'occhio prevedono sistemi a spray che nebulizzano il prodotto oppure eye disinfection devices provide spray systems that nebulize the product or
dispenser in gocce, mentre il dispositivo proposto dispone lo iodiopovidone in concentrazioni controllate dispenser in drops, while the proposed device has povidone iodine in controlled concentrations
sulla mucosa creando quindi uno strato protettivo sulla congiuntiva. L'Originalit? del dispositivo proposto on the mucosa thus creating a protective layer on the conjunctiva. The originality? of the proposed device
che lo distingue dagli altri dispositivi, consta non solo per il composto in cui si scioglie il prodotto ma anche which distinguishes it from other devices, consists not only of the compound in which the product is dissolved but also
per il tipo di supporto che contiene il preparato, non essendo un dispenser per collirio, ma prevedendo for the type of support that contains the preparation, not being a dispenser for eye drops, but foreseeing
un'applicabilit? del prodotto diretta all'occhio non del tipo spray. an applicability? of the product directed to the eye not of the spray type.
Sintesi dell?invenzione Summary of the invention
Il dispositivo consiste in un tampone di plastica rigida e autoclavabile che garantisce un prodotto sterilizzato all'uso; la testa del tampone presenta una estremit? in fibra di cotone e/o ovatta ricoperta da Idrogel e/o Carbomer 341 come da disegno lettera A, questo permette l'assorbimento della soluzione a base di iodiopovidone e il suo successivo rilascio sulla mucosa, senza recare danni da graffiamento sui tessuti oculari. La lunghezza totale del tamponcino ? tra 4-10 cm come da disegno lettera B; la testa ha diametro complessivo compreso di rivestimento idrogel e/o carbomer 341 tra 3mm e 5mm come da disegno lettera A, mentre lo spessore del corpo del tampone ? di 2 mm riferimento al disegno lettera C. Il dispositivo ? monouso per garantire l'uso sterile del dispositivo. La soluzione all'interno del dispositivo ? un mix tra carbossi-metilcellulosa tra 0,2-0, 8% e iodiopovidone tra 0,3- 1%. Lo iodiopovidone viene gi? ampiamente adoperato come sostanza disinfettante in ambito chirurgico col nome di Betadine con una concentrazione al 10%, ma questa preparazione permette l'utilizzo della sostanze in concentrazioni minori con un'effetto di lunga durata e un'applicabilit? migliore del prodotto. The device consists of a rigid and autoclavable plastic pad which guarantees a sterilized product for use; the head of the swab has an end? in cotton fiber and/or wadding covered with Hydrogel and/or Carbomer 341 as per drawing letter A, this allows the absorption of the povidone-iodine-based solution and its subsequent release on the mucous membrane, without causing damage from scratching the ocular tissues. The total length of the pad? between 4-10cm as per drawing letter B; the head has an overall diameter including hydrogel coating and/or carbomer 341 between 3mm and 5mm as per drawing letter A, while the thickness of the body of the pad ? of 2 mm, referring to the letter C drawing. The device? disposable to ensure sterile use of the device. The solution inside the device? a mix of carboxy-methylcellulose between 0.2-0.8% and povidone-iodine between 0.3-1%. The povidone-iodine comes already? widely used as a disinfectant substance in the surgical field with the name of Betadine with a 10% concentration, but this preparation allows the use of substances in lower concentrations with a long-lasting effect and an applicability? better than the product.
I vantaggi di questi complessi rispetto allo iodio libero sono i seguenti: The advantages of these complexes over free iodine are as follows:
? aumento della solubilit? dello iodio in acqua; ? increase in solubility? iodine in water;
? liberazione graduale dello Iodio con diminuzione degli effetti indesiderati derivati dalle alte concentrazioni di questo elemento quali: irritazione e colorazione dei tessuti, corrosione di superfici metalliche, tossicit?; ? gradual release of iodine with reduction of undesirable effects deriving from high concentrations of this element such as: irritation and coloration of tissues, corrosion of metal surfaces, toxicity;
? propriet? tensioattive con conseguente migliore penetrazione nei substrati organici. ? property? surfactants resulting in better penetration into organic substrates.
Il loro meccanismo di azione si esplica con una inibizione della sintesi proteica, mediante ossidazione dei gruppi sulfidrilici, formazione di N-iododerivati e probabile inattivazione di altri gruppi fondamentali. Their mechanism of action is expressed with an inhibition of protein synthesis, through oxidation of the sulfhydryl groups, formation of N-iodo derivatives and probable inactivation of other fundamental groups.
Questa molecola ? usata per malattie virali interessanti gli occhi, come dimostrano vari colliri presenti sul mercato. This molecule? used for viral diseases affecting the eyes, as demonstrated by various eye drops on the market.
L'Originalit? del dispositivo proposto che lo distingue dagli altri dispositivi, consta non solo per il composto in cui si scioglie il prodotto ma anche per il tipo di supporto che contiene il preparato, non essendo un dispenser per collirio, ma prevedendo un'applicabilit? del prodotto diretta all'occhio non del tipo spray. Ha, inoltre, una azione non solo curativa, ma anche preventiva per le malattie da infezioni virali e non. The originality? of the proposed device that distinguishes it from other devices, consists not only of the compound in which the product is dissolved but also of the type of support that contains the preparation, not being a dispenser for eye drops, but providing an applicability? of the product directed to the eye not of the spray type. Furthermore, it has not only a curative action, but also a preventive one for diseases caused by viral and non-viral infections.
Esempi di utilizzo Usage examples
Il dispositivo dispone sulla mucosa una pellicola di iodiopovidone in concentrazioni controllate, o di The device places a film of povidone iodine in controlled concentrations on the mucosa, or of
qualsiasi altra soluzione assorbibile dal cappuccio in Carbomer 341 in cui ? intinto la testa del dispositivo. any other absorbable solution from the cap in Carbomer 341 in which ? dipped the head of the device.
L'applicazione del prodotto avviene per apposizione e lieve sfregamento della testa del dispositivo, imbibita The application of the product takes place by application and slight rubbing of the head of the device, soaked
della soluzione di iodiopovidone, creando quindi uno strato protettivo disinfettante. of the povidone-iodine solution, thus creating a protective disinfectant layer.
Claims (3)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102020000021634A IT202000021634A1 (en) | 2020-09-16 | 2020-09-16 | DEVICE FOR THE ADMINISTRATION OF A SOLUTION WITH POVIDONE IODIUM FOR THE PREVENTION OF EYE INFECTIONS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102020000021634A IT202000021634A1 (en) | 2020-09-16 | 2020-09-16 | DEVICE FOR THE ADMINISTRATION OF A SOLUTION WITH POVIDONE IODIUM FOR THE PREVENTION OF EYE INFECTIONS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IT202000021634A1 true IT202000021634A1 (en) | 2020-12-16 |
Family
ID=75111645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT102020000021634A IT202000021634A1 (en) | 2020-09-16 | 2020-09-16 | DEVICE FOR THE ADMINISTRATION OF A SOLUTION WITH POVIDONE IODIUM FOR THE PREVENTION OF EYE INFECTIONS |
Country Status (1)
| Country | Link |
|---|---|
| IT (1) | IT202000021634A1 (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4036230A (en) * | 1976-08-18 | 1977-07-19 | Kenneth Waldock Adams | Medicinal insert instrument |
| CN202620473U (en) * | 2012-06-14 | 2012-12-26 | 杭州普瑞美克生物科技有限公司 | Disposable compound iodine medical big disinfection cotton swab |
| EP2745818A1 (en) * | 2012-12-19 | 2014-06-25 | Lucie Palasova | Device for removal of undesirable substances |
| US9788994B2 (en) * | 2010-12-29 | 2017-10-17 | Louis D. Nichamin | Eye treatment |
| EP3310443A1 (en) * | 2015-06-19 | 2018-04-25 | Avadim Technologies, Inc. | Method for improving health outcomes |
-
2020
- 2020-09-16 IT IT102020000021634A patent/IT202000021634A1/en unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4036230A (en) * | 1976-08-18 | 1977-07-19 | Kenneth Waldock Adams | Medicinal insert instrument |
| US9788994B2 (en) * | 2010-12-29 | 2017-10-17 | Louis D. Nichamin | Eye treatment |
| CN202620473U (en) * | 2012-06-14 | 2012-12-26 | 杭州普瑞美克生物科技有限公司 | Disposable compound iodine medical big disinfection cotton swab |
| EP2745818A1 (en) * | 2012-12-19 | 2014-06-25 | Lucie Palasova | Device for removal of undesirable substances |
| EP3310443A1 (en) * | 2015-06-19 | 2018-04-25 | Avadim Technologies, Inc. | Method for improving health outcomes |
Non-Patent Citations (3)
| Title |
|---|
| CORTELYOU PR: "Use of peroxide of hydrogen in diseases of the throat and nose. J MedAssoc.", vol. 57, September 1968, WORLD HEALTH ORGANIZATION, article "Global Guidelines lor the Prevention of Surgical Site infection; Urban MV1, Rath T2, Radtke C2. Hydrogenperoxide (H202): A review of its used in surgery. Wien MedWochenschr. 1-2", pages: 449 - 50 |
| KAMPF GTODT DPFAENDER SSTEINMANN E: "Persistence of corona viruses on inanimate surfaces and theirinactivation with biocidal agents", JOURNAL OF HOSPITAL INECTION, vol. 104, 2020, pages 246 - 251 |
| LAI CCSHIH TPKO WCTANG HJHSUEH PR: "Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) and corona virus disease-2019 (COVID- 19): The epidemics and the challenges", INTJ ANTIMICROBIAL AGENTS, vol. 17, February 2020 (2020-02-01), pages 105924 |
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