IT202000001732A1 - Composizione per uso nel trattamento della leucemia - Google Patents

Composizione per uso nel trattamento della leucemia

Info

Publication number
IT202000001732A1
IT202000001732A1 IT102020000001732A IT202000001732A IT202000001732A1 IT 202000001732 A1 IT202000001732 A1 IT 202000001732A1 IT 102020000001732 A IT102020000001732 A IT 102020000001732A IT 202000001732 A IT202000001732 A IT 202000001732A IT 202000001732 A1 IT202000001732 A1 IT 202000001732A1
Authority
IT
Italy
Prior art keywords
leukemia
treatment
composition
Prior art date
Application number
IT102020000001732A
Other languages
English (en)
Inventor
Francesco Fazi
Silvia Masciarelli
Original Assignee
Univ Degli Studi Roma La Sapienza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Roma La Sapienza filed Critical Univ Degli Studi Roma La Sapienza
Priority to IT102020000001732A priority Critical patent/IT202000001732A1/it
Priority to US17/759,546 priority patent/US20230073499A1/en
Priority to PCT/IB2021/050674 priority patent/WO2021152501A1/en
Publication of IT202000001732A1 publication Critical patent/IT202000001732A1/it

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203Retinoic acids ; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • A61K31/4045Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/69Boron compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/36Arsenic; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05Dipeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
IT102020000001732A 2020-01-29 2020-01-29 Composizione per uso nel trattamento della leucemia IT202000001732A1 (it)

Priority Applications (3)

Application Number Priority Date Filing Date Title
IT102020000001732A IT202000001732A1 (it) 2020-01-29 2020-01-29 Composizione per uso nel trattamento della leucemia
US17/759,546 US20230073499A1 (en) 2020-01-29 2021-01-28 Compounds for use in the treatment of leukemia
PCT/IB2021/050674 WO2021152501A1 (en) 2020-01-29 2021-01-28 Compounds for use in the treatment of leukemia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102020000001732A IT202000001732A1 (it) 2020-01-29 2020-01-29 Composizione per uso nel trattamento della leucemia

Publications (1)

Publication Number Publication Date
IT202000001732A1 true IT202000001732A1 (it) 2021-07-29

Family

ID=70480438

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102020000001732A IT202000001732A1 (it) 2020-01-29 2020-01-29 Composizione per uso nel trattamento della leucemia

Country Status (3)

Country Link
US (1) US20230073499A1 (it)
IT (1) IT202000001732A1 (it)
WO (1) WO2021152501A1 (it)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015101618A1 (en) * 2013-12-30 2015-07-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of an arsenic compound and at least one retinoid for treating acute myeloid leukemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015101618A1 (en) * 2013-12-30 2015-07-09 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of an arsenic compound and at least one retinoid for treating acute myeloid leukemia

Non-Patent Citations (29)

* Cited by examiner, † Cited by third party
Title
ABAZA YKANTARJIAN HGARCIA-MANERO G ET AL.: "Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab", BLOOD, vol. 129, no. 10, 2017, pages 1275 - 1283
ALEXANDER E. PERL GMJORGE E. CORTESANDREAS NEUBAUERELLIN BERMANSTEFANIA PAOLINIPAU MONTESINOSMARIA R. BAERRICHARD A. LARSONCELALET: "Proceedings of the American Association for Cancer Research Annual Meeting 2019", 29 March 2019, AACR, article "Abstract CT184: Gilteritinib significantly prolongs overall survival in patients with FLT3-mutated (FLT3mut+) related/refractory (R/R) Acute myeloid leukemia (AML): Results from the phase III ADMIRAL trial"
AU WYFONG BMTAM SKWONG YL: "Feasibility of oral arsenic trioxide treatment for acute promyelocytic leukemia during hemodialysis", ANN HEMATOL., vol. 92, no. 3, 2013, pages 417 - 418
AUNER HWCENCI S: "Recent advances and future directions in targeting the secretory apparatus in multiple myeloma", BR JHAEMATOL., vol. 168, no. 1, 2015, pages 14 - 25
CANCER RES, vol. 79, 2019
CENCI SMEZGHRANI ACASCIO P ET AL.: "Progressive impared protein storage during terminal plasma cells differentiation", EMBOJ., vol. 25, no. 5, 2006, pages 1104 - 1113
CORTES JEKHALED SMARTINELLI G ET AL.: "Quizartinib versus salvage chemotherapy in relapsed or refractory FLT3-ITD Acute myeloid leukaemia (Quantum-R): A multicenter, randomized, controlled, open-label, phase 3 trial", LANCET ONCOL., vol. 20, no. 7, 2019, pages 984 - 997
FIRKIN FRONCOLATE FHO WK: "Dose adjusted arsenic trioxide for acute promyelocytic leukaemia in chronic renai failure", EUR JHAEMATOL., vol. 95, no. 4, 2015, pages 331 - 335
GREGORY MAD'ALESSANDRO AALVAREZ-CALDERON F ET AL.: "ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia", PROC NATIACAD SCI USA, vol. 113, no. 43, 2016, pages E6669 - E6678
ILAND HJCOLLINS MBRADSTOCK K ET AL.: "Use of arsenic trioxide in remission induction and consolidation therapy for acute promyelocytic leukaemia in the Australasian leukaemia and Lymphoma Group (ALLG) APML4 study: A non-randomized phase 2 trial", LANCET HAEMATOL., vol. 2, no. 9, 2015, pages e357 - 366
KINDLER TLIPKA DBFISCHER T: "FLT3 as a therapeutic target in AML: Challenging styles after all these years", BLOOD, vol. 116, no. 24, 2010, pages 5089 - 5102
LARRUE CSALAND EBOUTZEN H ET AL.: "Proteome inhibitors induces FLT3-ITD degradation through autophagy in AML cells", BLOOD, vol. 127, no. 7, 2016, pages 882 - 892
LO-COCO FDI DONATO LGIMEMA, SCHLENK RF: "German-Austrian Acute Myeloid Leukemia Study G, Study Alliance L. Targeted Therapy alone for acute promyelocytic leukemia", NENGLJMED., vol. 374, no. 12, 2016, pages 1197 - 1198
LO-COCO FNOTIFIED GVIGNETTI M ET AL.: "Retinoic acid and arsenic trioxide for acute promyelocytic leukemia", NENGLJMED, vol. 369, no. 2, 2013, pages 111 - 121
MA HSGREENBLATT SMSHIRLEY CM ET AL.: "All-trans retinoic acid symptoms with FLT3 inhibition to eliminated FLT3/ITD+ leukemia stem cells in vitro and in vivo", BLOOD, vol. 127, no. 23, 2016, pages 2867 - 2878
MASCIARELLI SCAPUANO EOTTONE T ET AL.: "Retinoic acid and arsenic trioxide sensitize acute promyelocytic leukemia cells to ER stress", LEUKEMIA., vol. 32, no. 2, 2018, pages 285 - 294
MASCIARELLI SCAPUANO EOTTONE T ET AL.: "Retinoic acid symptoms with the unfolded protein response and oxidative stress to induce death celi in FLT3-ITD+ AML", BLOODADV, vol. 3, no. 24, 2019, pages 4155 - 4160
MCMAHON CMFEMG TCANAANI J ET AL.: "Clonai Selection with RAS pathway Activation median Secondary Clinical resistance to Selective FLT3 inhibitor in Acute Myeloid Leukemia", CANCERDISCOV, vol. 9, no. 8, 2019, pages 1050 - 1063
MOUJALLEED DMPOMILIO GGHIURAU C ET AL.: "Combining BH3-mimetics to target both BCL-2 and MCL1 has potential activity in pre-clinical models of acute myeloid leukemia", LEUKEMIA, vol. 33, no. 4, 2019, pages 905 - 917
MUINDI JRFRANKEL SRHUSELTON C ET AL.: "Clinical pharmacology of oral all-trans retinoic acid in patients with acute promyelocytic leukemia", CANCER RES., vol. 52, no. 8, 1992, pages 2138 - 2142
OSMAN AEGANDERSON JCHURPEK JE ET AL.: "Treatment of acute promyelocytic leukemia in Adults", J ONCOLPRACT., vol. 14, no. 11, 2018, pages 649 - 657
PERL AE: "he role of targeted therapy in the management of patients with AML", BLOOD ADV., vol. 1, no. 24, 2017, pages 2281 - 2294
PERL AEALTMAN JKCORTES J ET AL.: "Selective inhibition of FLT3 by gilteritinib in collapsed or refractory acute myeloid leukaemia: A multicenter, first-in-human, open-label, phase 1-2 study", LANCET ONCOL., vol. 18, no. 8, 2017, pages 1061 - 1075
SANZ MAMONTESINOS P: "How we prevent and treat differentiation syndrome in patients with acute promyelocytic leukemia", BLOOD, vol. 123, no. 18, 2014, pages 2777 - 2782
SCHMIDT-ARRAS DEBOHMER AMARKOVA BCHOUDHARY CSERVES HBOHMER FD: "Tyrosinine phosphorylation regulates maturation of receptor tyrosinine kinases", MOL CELIBIOL., vol. 25, no. 9, 2005, pages 3690 - 3703
SILVIA MASCIARELLI ET AL: "Retinoic acid synergizes with the unfolded protein response and oxidative stress to induce cell death in FLT3-ITD+ AML", BLOOD ADVANCES, vol. 3, no. 24, 23 December 2019 (2019-12-23), pages 4155 - 4160, XP055754520, ISSN: 2473-9529, DOI: 10.1182/bloodadvances.2019000540 *
STONE RMMANDREKAR SJSANFORD BL ET AL.: "Midostaurin plus chemotherapy for Acute Myeloid Leukemia with a FLT3 mutation", N ENGL J MEAN., vol. 377, no. 5, 2017, pages 454 - 464
TSITSIPATIS DJAYAVELU AKMULLER JP ET AL.: "Synergistic killing of FLT31TD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation", ONCOTARGET, vol. 8, no. 16, 2017, pages 26613 - 26624
WANG LNTANG YLZHANG YC ET AL.: "Arsenal trioxide and all-trans-retinoic acid selectively exert synergistic cytotoxicity against FLT3-ITD AML cells via co-inhibition of FLT3 signaling pathways", LEUK LYMPHOMA, vol. 58, no. 10, 2017, pages 2426 - 2438

Also Published As

Publication number Publication date
US20230073499A1 (en) 2023-03-09
WO2021152501A1 (en) 2021-08-05

Similar Documents

Publication Publication Date Title
CO2019002975A2 (es) Compuestos de tetraciclina y métodos de uso de los mismos
NI201500072A (es) Inhibidores de bmi-1 de pirimidina inversa sustituida
CL2021001027A1 (es) Inhibidores selectivos de rgmc y el uso de los mismos
IT202000001732A1 (it) Composizione per uso nel trattamento della leucemia
CL2016000024A1 (es) Volasertib en combinación con decitabina para el tratamiento de leucemia mieloide aguda y síndrome mielodisplásico.
CO2019011980A2 (es) Formas cristalinas de (s)-afoxolaner
JP1726601S (ja) テーブル付きベンチ
JP1712664S (ja) テーブル
JP1718811S (ja) テーブル
JP1716905S (ja) テーブル
JP1714825S (ja) テーブル
JP1708776S (ja) テーブル
JP1708778S (ja) テーブル
JP1713255S (ja) テーブル
JP1708811S (ja) テーブル
JP1708779S (ja) テーブル
JP1708784S (ja) テーブル
JP1713302S (ja) テーブル
JP1708810S (ja) テーブル
JP1708770S (ja) テーブル
JP1710172S (ja) テーブル
JP1708755S (ja) テーブル
JP1708753S (ja) テーブル
JP1709584S (ja) テーブル
JP1709582S (ja) テーブル