IT201900025840A1 - Composti isotiocianati e isoselencianati - Google Patents

Composti isotiocianati e isoselencianati

Info

Publication number
IT201900025840A1
IT201900025840A1 IT102019000025840A IT201900025840A IT201900025840A1 IT 201900025840 A1 IT201900025840 A1 IT 201900025840A1 IT 102019000025840 A IT102019000025840 A IT 102019000025840A IT 201900025840 A IT201900025840 A IT 201900025840A IT 201900025840 A1 IT201900025840 A1 IT 201900025840A1
Authority
IT
Italy
Prior art keywords
isothiocianates
isoselencianates
compounds
compounds isothiocianates
Prior art date
Application number
IT102019000025840A
Other languages
English (en)
Italian (it)
Inventor
Carmela Fimognari
Piero Sestili
Andrea Milelli
Original Assignee
Univ Bologna Alma Mater Studiorum
Univ Degli Studi Di Urbino Carlo Bo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Bologna Alma Mater Studiorum, Univ Degli Studi Di Urbino Carlo Bo filed Critical Univ Bologna Alma Mater Studiorum
Priority to IT102019000025840A priority Critical patent/IT201900025840A1/it
Priority to PCT/IB2020/062485 priority patent/WO2021137134A1/fr
Publication of IT201900025840A1 publication Critical patent/IT201900025840A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102019000025840A 2019-12-31 2019-12-31 Composti isotiocianati e isoselencianati IT201900025840A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102019000025840A IT201900025840A1 (it) 2019-12-31 2019-12-31 Composti isotiocianati e isoselencianati
PCT/IB2020/062485 WO2021137134A1 (fr) 2019-12-31 2020-12-28 Composés isothiocyanates et isosélénocyanates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000025840A IT201900025840A1 (it) 2019-12-31 2019-12-31 Composti isotiocianati e isoselencianati

Publications (1)

Publication Number Publication Date
IT201900025840A1 true IT201900025840A1 (it) 2021-07-01

Family

ID=70228650

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000025840A IT201900025840A1 (it) 2019-12-31 2019-12-31 Composti isotiocianati e isoselencianati

Country Status (2)

Country Link
IT (1) IT201900025840A1 (fr)
WO (1) WO2021137134A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304720A (en) * 1980-04-30 1981-12-08 Merck & Co., Inc. Fluorescein esters and ethers and the preparation thereof
WO2003059149A2 (fr) * 2001-12-21 2003-07-24 Threshold Pharmaceuticals, Inc. Procede d'imagerie du cancer
EP1961418A1 (fr) * 2005-11-15 2008-08-27 Cheng, Jingcai Utilisation de composes a base d'isothiocyanates dans le traitement de maladies prostatiques et du cancer de la peau
US20130079401A1 (en) * 2011-09-23 2013-03-28 Yu-Jen Chen Novel use of isothiocyanates for treating cancer

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4304720A (en) * 1980-04-30 1981-12-08 Merck & Co., Inc. Fluorescein esters and ethers and the preparation thereof
WO2003059149A2 (fr) * 2001-12-21 2003-07-24 Threshold Pharmaceuticals, Inc. Procede d'imagerie du cancer
EP1961418A1 (fr) * 2005-11-15 2008-08-27 Cheng, Jingcai Utilisation de composes a base d'isothiocyanates dans le traitement de maladies prostatiques et du cancer de la peau
US20130079401A1 (en) * 2011-09-23 2013-03-28 Yu-Jen Chen Novel use of isothiocyanates for treating cancer

Non-Patent Citations (27)

* Cited by examiner, † Cited by third party
Title
ANDREW G. BOSANSQUETPHILIP B.: "Ex vivotherapeutic index by drug sensitivity assay using fresh human normal and tumor cells", BELL., vol. 4, no. 2, 2004, pages 145 - 154
ASAKO MURATA; SHIN-ICHI SATO; YOSHINORI KAWAZOE; AND MOTONARI UESUGI: "Small-molecule fluorescent probes for specific RNA targets", CHEMICAL COMMUNICATIONS, vol. 47, 17 March 2011 (2011-03-17), pages 4712 - 4714, XP055716402, DOI: 10.1039/c1cc10393h *
BOSANQUET, J EXP THER ONCOL, vol. 4, 2004, pages 145
C. FIMOGNARIF. BERTIR. LORIG. CANTELLI-FORTIP. HRELIA: "Micronucleus form-tion and induction of apoptosis by different isothiocyanates and a mixtureof isothiocyanates in human lymphocyte cultures", MUTAT. RES., vol. 582, 2005, pages 1 - 10
CANTONI, O.SESTILI, P.CATTABENI, F.: "randomly distributed DNA single strand breaks are not lethal for mammary cells", XENOBIOTIC, vol. 18, no. 12, 1988, pages 1481 - 1487
CANTONI, O.SESTILI, P.GUIDARELLI, A.GIACOMONI, P.U.CATTABENI, F.: "effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured malian cells", MOLECULAR PHARMACOLOGY, vol. 41, no. 5, 1992, pages 969 - 974
CANTONS, O.CATTABENI, F.STOCCHI, V.MEYN, R.E.CERUTTI, P.MURRAY, D.: "Hydrogen peroxide insulin in cultured mallens: Reliationstips between DNA single-strand breakage, poly(ADP-ribose) metabolism and celi killing", BIOCHIM BIOPHYS ACTA, vol. 1014, no. 1, 1989, pages 1 - 7
CANTONS, O.CATTABENI, F.STOCCHI, V.MEYN, R.E.CERUTTI, P.MURRAY, D.: "hydrogen peroxide island in cultured mammary cells: Relationships between single-strand DNA breakage, poly(ADP-ribose) metabolism and cell killing", BIOCHIM BIOPHYS ACTA, vol. 1014, no. 1, 1989, pages 1 - 7
CANTONS, O.SESTILI, P.GUIDARELLI, A.GIACOMONI, P.U.CATTABENI, F.: "effects of L-histidine on hydrogen peroxide-induced DNA damage and cytotoxicity in cultured mammary cells", MOLECULAR PHARMACOLOGY, vol. 41, no. 5, 1992, pages 969 - 974
CHOI, W. Y.CHOI, B.T.LEE, W. H.CHOI, Y. H.: "Sulforaphane generates reacti ve oxygen species leading to mitochondrial perturbation for apoptosis in human leukemia U937cells", BIOMED PHARMACOTHER, vol. 62, no. 9, 2008, pages 637 - 44, XP025572000, DOI: 10.1016/j.biopha.2008.01.001
COLEMAN, J.B.GILFOR, D.FARBER, J.L.: "Dissociation of the accumulation of single-strand breaks in DNA from the killing of cultured hepatocytes by an oxidative stress", MOL PHARMACOL, vol. 36, no. 1, 1989, pages 193 - 200
HOSOYA, N.MIYAGAWA, K.: "Targeting DNA damage response in cancer therapy", CANCER SKIING, vol. 105, no. 4, 2014, pages 370 - 88
KOPPENOL, W.H.HIDER, R. H.: "Iron and redox cycling. Do's and don't'ts", FREE RADICAL BIOL MED, 2018
LARROSA-GARCIA, M.BAER, M.R.: "FLT3 inhibitors in Acute Myeloid Leukemia: Current Status and future Directions", MOL CANCER THER, 2017, pages 991 - 1001
LEICK, M.B.LEVIS, M.J.: "The future of Targeting FLT3 Activation in AML", CURR HEMATOL MALIG REP, vol. 12, 2017, pages 153 - 167, XP036248968, DOI: 10.1007/s11899-017-0381-2
MEINIG J ET AL., INT. ANNEW. CHEM., vol. 54, 2015, pages 9696 - 9699
MOTTRAM L ET AL., ORG. LETTER, vol. 9, no. 19, 2007, pages 3741 - 3744
SESTILI PFIMOGNARI C.: "Cytotoxic and antitumor Activity of Sulforaphane: The role of reactive Oxygen species", BIOMED RES INT, vol. 2015, 2015, pages 402386
SESTILI, P.PAOLILLO, M.LENZI, M.COLOMBO, E.VALLORANI, L.CASADEI, L.MARTINELLI, C.FIMOGNARI, C.: "Sulforaphane induced DNA single strand breaks in cultured human cells", MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, vol. 689, no. 1, 2010, pages 65 - 73, XP027101647
SESTILI, P.PAOLILLO, M.LENZI, M.COLOMBO, E.VALLORANI, L.CASADEI, L.MARTINELLI, C.FIMOGNARI, C.: "Sulforaphane induces DNA single strand breaks in cultured human cells", MUTATION RESEARCH/FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, vol. 689, no. 1, 2010, pages 65 - 73, XP027101647
SESTILI, P.PIEDIMONTE, G.CATTABENI, F.CANTONI, O.: "Induction of DNA breakdown and suppression of DNA synthesis by the OH radical generated in a Fenton-like reaction", BIOCHEMISTRY INTERNATIONAL, vol. 12, no. 3, 1986, pages 493 - 501
SINGH, S.V.SRIVASTAVA, S.K.CHOI, S.LEW, K.L.ANTHOSIEWICZ, J.XIAO, D.ZENG, Y.WATKINS, S.C.JOHNSON, C.S.TRUMP, D.L.: "Sulforaphane-cell induced by humiostatic cell", J BIOL CHEM, vol. 280, no. 20, 2005, pages 19911 - 24
SNOW A.W. ET AL., SYNTHESIS, no. 4, 2003, pages 509 - 512
TEETER, M.E.BAGINSKY, M.L.HATEFI, Y.: "Ectopic inhibition of the complements of the electron transport system by rotenone, piericidin A, demerol and antimycin A", BIOCHIM BIOPHYS ACTA, vol. 172, no. 2, 1969, pages 331 - 3
XIAO, D.POWOLNY, A.A.ANTOSIEWICZ, J.HAHM, E.R.BOMMAREDDY, A.ZENG, Y.DESAI, D.AMIN, S.HERMAN-ANTOSIEWICZ, A.SINGH, S.V.: "Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species", PHARM RES, vol. 26, no. 7, 2009, pages 1729 - 38, XP019686219, DOI: 10.1007/s11095-009-9883-5
YONGBIN SONG; YIHUI YANG; JUN YOU; BO LIU; LIJUN WU; YUNLONG HOU; WENJI WANG; AND JIUXIN ZHU: "Design, Synthesis and Anticancer Activity of N3,N11-Bis(2-hydroxyethyl)-14-aryl-14H-dibenzo[a,j]xanthenes-3,11-dicarboxamide", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 61, no. 2, February 2013 (2013-02-01), pages 167 - 175, XP055716663 *
ZAKRZEWSKI J. ET AL., SYNTHESIS, vol. 48, 2016, pages 85 - 96

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Publication number Publication date
WO2021137134A1 (fr) 2021-07-08

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