IT201900024622A1 - INNOVATIVE PEGILATION OF THE KILLER TNF-APOPTOSIS INDUCED LIGAND (KILLER-TRAIL) - Google Patents

INNOVATIVE PEGILATION OF THE KILLER TNF-APOPTOSIS INDUCED LIGAND (KILLER-TRAIL)

Info

Publication number
IT201900024622A1
IT201900024622A1 IT102019000024622A IT201900024622A IT201900024622A1 IT 201900024622 A1 IT201900024622 A1 IT 201900024622A1 IT 102019000024622 A IT102019000024622 A IT 102019000024622A IT 201900024622 A IT201900024622 A IT 201900024622A IT 201900024622 A1 IT201900024622 A1 IT 201900024622A1
Authority
IT
Italy
Prior art keywords
killer
pegilation
trail
tnf
innovative
Prior art date
Application number
IT102019000024622A
Other languages
Italian (it)
Inventor
Christian Celia
Felisa Cilurzo
Donato Cosco
Massimo Fresta
Donatella Paolino
Giuseppe Sammarco
Gianfranco Pasut
Original Assignee
Univ Degli Studi G Dannunzio Chieti Pescara
Univ Degli Studi Magna Graecia Di Catanzaro
Univ Degli Studi Padova
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi G Dannunzio Chieti Pescara, Univ Degli Studi Magna Graecia Di Catanzaro, Univ Degli Studi Padova filed Critical Univ Degli Studi G Dannunzio Chieti Pescara
Priority to IT102019000024622A priority Critical patent/IT201900024622A1/en
Priority to PCT/IB2020/062211 priority patent/WO2021124266A1/en
Publication of IT201900024622A1 publication Critical patent/IT201900024622A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
IT102019000024622A 2019-12-18 2019-12-18 INNOVATIVE PEGILATION OF THE KILLER TNF-APOPTOSIS INDUCED LIGAND (KILLER-TRAIL) IT201900024622A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102019000024622A IT201900024622A1 (en) 2019-12-18 2019-12-18 INNOVATIVE PEGILATION OF THE KILLER TNF-APOPTOSIS INDUCED LIGAND (KILLER-TRAIL)
PCT/IB2020/062211 WO2021124266A1 (en) 2019-12-18 2020-12-18 Pegylation of a trail ligand

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000024622A IT201900024622A1 (en) 2019-12-18 2019-12-18 INNOVATIVE PEGILATION OF THE KILLER TNF-APOPTOSIS INDUCED LIGAND (KILLER-TRAIL)

Publications (1)

Publication Number Publication Date
IT201900024622A1 true IT201900024622A1 (en) 2021-06-18

Family

ID=70155149

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000024622A IT201900024622A1 (en) 2019-12-18 2019-12-18 INNOVATIVE PEGILATION OF THE KILLER TNF-APOPTOSIS INDUCED LIGAND (KILLER-TRAIL)

Country Status (2)

Country Link
IT (1) IT201900024622A1 (en)
WO (1) WO2021124266A1 (en)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004001009A2 (en) 2002-06-24 2003-12-31 Genentech, Inc. Apo-2 ligand/trail variants and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004001009A2 (en) 2002-06-24 2003-12-31 Genentech, Inc. Apo-2 ligand/trail variants and uses thereof

Non-Patent Citations (23)

* Cited by examiner, † Cited by third party
Title
ALMASAN AASHKENAZI A, CYTOKINE GROWTH FACTOR REV., vol. 14, no. 3-4, 2003, pages 337 - 48
ANONYMOUS: "PRODUCT DATA SHEET - KillerTrailTM Protein (soluble) (human), (recombinant)", 5 May 2020 (2020-05-05), XP055720979, Retrieved from the Internet <URL:https://www.enzolifesciences.com/fileadmin/reports/Datasheet-ALX-201-073.pdf> [retrieved on 20200807] *
ASHKENAZI A ET AL., J. CLIN. INVEST., vol. 104, no. 2, 1999, pages 155 - 62
BIOCHEM. PHARMACOL., vol. 81, no. 7, 2011, pages 838 - 47
BODMER ET AL., J. BIOL. CHEM., vol. 275, no. 27, 2000, pages 20632 - 7
BODMER JL ET AL., J. BIOL. CHE., vol. 275, no. 27, 2000, pages 20632 - 7
BUCKMANN AF ET AL., MACROMOL. CHEM. PHYS., vol. 182, no. 5, 1981, pages 1379 - 84
CHINNAIYAN AM ET AL., PROC. NATI. CAD. SKIING. USA, vol. 97, no. 4, 2000, pages 1754 - 9
DA SILVA FREITAS D ET AL., BIOCONJUG CHEM., vol. 24, no. 3, 2013, pages 456 - 63
DA-SILVA-FREITAS D. ET AL., PROTEIN PEPT. LETTER, vol. 22, no. 12, 2015, pages 1133 - 9
DUIKER EW ET AL., BR. J. PHARMACOL., vol. 165, no. 7, 2012, pages 2203 - 12
HYMOWITZ SG ET AL., BIOCHEMISTRY, vol. 39, no. 4, 2000, pages 633 - 40
HYMOWITZ SG ET AL., MOLEC. CELL, vol. 4, no. 4, 1999, pages 563 - 71
JO M ET AL., NAT. MED., vol. 6, no. 1, 2000, pages 564 - 7
LE BLANC HNASHKENAZI A, CELI. DEATH DIFFER., vol. 10, no. 1, 2003, pages 66 - 75
PAN LQ ET AL., SCI. REP., vol. 5, 2015, pages 14872
PASUT G.VERONESE FM., DRUGS TODAY (BARC, vol. 45, no. 9, 2009, pages 687 - 95
PASUT G.VERONESE FM., J. CONTROL. RELEASE, vol. 161, no. 2, 2012, pages 461 - 72
PITTI RM ET AL., J. BIOL. CHEM., vol. 271, no. 22, 1996, pages 12687 - 90
WANG XG ET AL., THER. JOURNAL OF CLINICAL ONLOMOLOGY, vol. 5, no. 2, 2013, pages 969 - 6
WILEY SR ET AL., IMMUNITY, vol. 3, no. 6, 1995, pages 673 - 82
XIANG H ET AL., DRUG METAB-DISPOS, vol. 32, no. 11, 2004, pages 1230 - 8
XIANG H. ET AL., DRUG METAB. DISPOS., vol. 32, no. 11, 2004, pages 1230 - 8

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Publication number Publication date
WO2021124266A1 (en) 2021-06-24

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