IT201900021090A1 - Nanoparticelle per applicazioni mediche e diagnostiche - Google Patents

Nanoparticelle per applicazioni mediche e diagnostiche

Info

Publication number
IT201900021090A1
IT201900021090A1 IT102019000021090A IT201900021090A IT201900021090A1 IT 201900021090 A1 IT201900021090 A1 IT 201900021090A1 IT 102019000021090 A IT102019000021090 A IT 102019000021090A IT 201900021090 A IT201900021090 A IT 201900021090A IT 201900021090 A1 IT201900021090 A1 IT 201900021090A1
Authority
IT
Italy
Prior art keywords
nanoparticles
medical
diagnostic applications
diagnostic
applications
Prior art date
Application number
IT102019000021090A
Other languages
English (en)
Inventor
Roberto Palomba
Paolo Decuzzi
Original Assignee
Fondazione St Italiano Tecnologia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fondazione St Italiano Tecnologia filed Critical Fondazione St Italiano Tecnologia
Priority to IT102019000021090A priority Critical patent/IT201900021090A1/it
Priority to PCT/IB2020/060519 priority patent/WO2021094893A1/en
Priority to US17/776,481 priority patent/US20230000784A1/en
Priority to EP20804690.4A priority patent/EP4057997B1/en
Publication of IT201900021090A1 publication Critical patent/IT201900021090A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y40/00—Manufacture or treatment of nanostructures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
IT102019000021090A 2019-11-13 2019-11-13 Nanoparticelle per applicazioni mediche e diagnostiche IT201900021090A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT102019000021090A IT201900021090A1 (it) 2019-11-13 2019-11-13 Nanoparticelle per applicazioni mediche e diagnostiche
PCT/IB2020/060519 WO2021094893A1 (en) 2019-11-13 2020-11-09 Nanoparticles for medical and diagnostic applications
US17/776,481 US20230000784A1 (en) 2019-11-13 2020-11-09 Nanoparticles for medical and diagnositc applications
EP20804690.4A EP4057997B1 (en) 2019-11-13 2020-11-09 Nanoparticles for medical and diagnostic applications

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000021090A IT201900021090A1 (it) 2019-11-13 2019-11-13 Nanoparticelle per applicazioni mediche e diagnostiche

Publications (1)

Publication Number Publication Date
IT201900021090A1 true IT201900021090A1 (it) 2021-05-13

Family

ID=69743870

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000021090A IT201900021090A1 (it) 2019-11-13 2019-11-13 Nanoparticelle per applicazioni mediche e diagnostiche

Country Status (4)

Country Link
US (1) US20230000784A1 (it)
EP (1) EP4057997B1 (it)
IT (1) IT201900021090A1 (it)
WO (1) WO2021094893A1 (it)

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
ADHYATMIKE ET AL.: "The elusive Antifibrotic Macrophage", FRONTIERS IN MEDICINE, vol. 2, 2015
ASHLEIGH ET AL.: "Targeting Macrophages in Cancer: From Bench to Bedside", FRONTIERS IN ONCOLOGY, vol. 8, 2018
CAI P ET AL: "Methyl palmitate: Inhibitor of phagocytosis in primary rat Kupffer cells", TOXICOLOGY, LIMERICK, IR, vol. 210, no. 2-3, 1 June 2005 (2005-06-01), pages 197 - 204, XP027602885, ISSN: 0300-483X, [retrieved on 20050601] *
EMAN M MANTAWY ET AL: "Insights antifibrotic mechanism of methyl palmitate: Impact on nuclear factor kappa B and proinflammatory cytokines", TOXICOLOGY AND APPLIED PHARMACOLOGY, ACADEMIC PRESS, AMSTERDAM, NL, vol. 258, no. 1, 25 October 2011 (2011-10-25), pages 134 - 144, XP028435720, ISSN: 0041-008X, [retrieved on 20111104], DOI: 10.1016/J.TAAP.2011.10.016 *
FEI-FEI AN ET AL: "Strategies for Preparing Albumin-based Nanoparticles for Multifunctional Bioimaging and Drug Delivery", THERANOSTICS, vol. 7, no. 15, 1 January 2017 (2017-01-01), AU, pages 3667 - 3689, XP055708600, ISSN: 1838-7640, DOI: 10.7150/thno.19365 *
JIIANG ET AL.: "Macrophages in solid organ transplantation", VASCULAR CELL, vol. 6, 2014, pages 5, XP021180143, DOI: 10.1186/2045-824X-6-5
LIU ET AL.: "Macrophages as Effectors of Acute and Chronic Allograft Injury", CURR TRANSPLANT REP, 2016, pages 303 - 312
MOKOS ET AL.: "Current Therapeutic Approach to Hypertrophic Scars", FRONTIERS IN MEDICINE, vol. 4, 2017
MOORE ET AL.: "Macrophages in atherosclerosis: a dynamic balance", NATURE REVIEWS, vol. 13, 2013, pages 709 - 721
OISHI ET AL.: "Macrophages in inflammation, repair and regeneration", INTERNATIONAL IMMUNOLOGY, vol. 30, no. 11, 2018, pages 511 - 528
PERVIN ET AL.: "Transient effects of empty liposomes on hepatic macrophage populations in rats", J TOXICOL PATHOL, 2016, pages 139 - 144
SALEHI ET AL.: "The Divergent Roles of Macrophages in Solid Organ Transplantation", CURR OPIN ORGAN TRANSPLANT, 2015, pages 446 - 453
SUN ET AL.: "Improved tumor uptake by optimizing liposome based RES blockade strategy", THERANOSTICS, 2017, pages 319 - 328

Also Published As

Publication number Publication date
US20230000784A1 (en) 2023-01-05
EP4057997B1 (en) 2024-04-17
WO2021094893A1 (en) 2021-05-20
EP4057997C0 (en) 2024-04-17
EP4057997A1 (en) 2022-09-21

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