IT201900018632A1 - COMPOSITION TO TREAT THE VOICE CHORDS OF A SUBJECT - Google Patents
COMPOSITION TO TREAT THE VOICE CHORDS OF A SUBJECT Download PDFInfo
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- IT201900018632A1 IT201900018632A1 IT102019000018632A IT201900018632A IT201900018632A1 IT 201900018632 A1 IT201900018632 A1 IT 201900018632A1 IT 102019000018632 A IT102019000018632 A IT 102019000018632A IT 201900018632 A IT201900018632 A IT 201900018632A IT 201900018632 A1 IT201900018632 A1 IT 201900018632A1
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- 239000000203 mixture Substances 0.000 title claims description 55
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 26
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 20
- 235000011187 glycerol Nutrition 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 13
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 235000011399 aloe vera Nutrition 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 244000144927 Aloe barbadensis Species 0.000 claims description 8
- 235000002961 Aloe barbadensis Nutrition 0.000 claims description 8
- 240000002129 Malva sylvestris Species 0.000 claims description 8
- 235000006770 Malva sylvestris Nutrition 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- 229940098465 tincture Drugs 0.000 claims description 8
- 210000001260 vocal cord Anatomy 0.000 claims description 8
- 210000000056 organ Anatomy 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 3
- 240000000560 Citrus x paradisi Species 0.000 claims description 2
- 235000014104 aloe vera supplement Nutrition 0.000 claims description 2
- 229940055390 glycerin / propylene glycol Drugs 0.000 claims description 2
- 230000000887 hydrating effect Effects 0.000 claims description 2
- 235000013311 vegetables Nutrition 0.000 claims description 2
- 239000003571 electronic cigarette Substances 0.000 description 11
- 230000000694 effects Effects 0.000 description 9
- 239000004480 active ingredient Substances 0.000 description 8
- 239000000443 aerosol Substances 0.000 description 8
- 230000002035 prolonged effect Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 230000001755 vocal effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 238000011282 treatment Methods 0.000 description 3
- 206010013952 Dysphonia Diseases 0.000 description 2
- 208000010473 Hoarseness Diseases 0.000 description 2
- 230000000386 athletic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000000867 larynx Anatomy 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 238000002803 maceration Methods 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000002604 ultrasonography Methods 0.000 description 2
- 239000006200 vaporizer Substances 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 241001116389 Aloe Species 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 208000027534 Emotional disease Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000014509 gene expression Effects 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000002475 laxative effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000008450 motivation Effects 0.000 description 1
- 238000002663 nebulization Methods 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 238000013021 overheating Methods 0.000 description 1
- 238000005325 percolation Methods 0.000 description 1
- 238000011458 pharmacological treatment Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
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- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
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Description
Descrizione dell’invenzione industriale dal titolo: “COMPOSIZIONE PER TRATTARE LE CORDE VOCALI DI UN SOGGETTO”, Description of the industrial invention entitled: "COMPOSITION TO TREAT THE VOICE CHORDS OF A SUBJECT",
DESCRIZIONE DESCRIPTION
Ambito dell’invenzione Scope of the invention
[0001] La presente invenzione si riferisce a una composizione per trattare di alcune condizioni degli organi deputati alla fonazione di un soggetto, tipicamente per trattare idratare e/o sfiammare le corde vocali e la porzione di laringe ad essa circostante. [0001] The present invention relates to a composition for treating some conditions of the organs responsible for phonation of a subject, typically for treating, hydrating and / or inflaming the vocal cords and the portion of the larynx surrounding it.
Tecnica anteriore - Problemi tecnici Prior art - Technical problems
[0002] Vi sono numerose situazioni in cui un soggetto ha necessità fare uso intensivo e prolungato della propria voce per ragioni professionali e/o artistiche. È questo il caso di cantanti, giornalisti radiotelevisivi, oratori e conferenzieri di vario tipo, i quali non possono permettersi pause prolungate a un dato momento della propria prestazione per favorire un naturale recupero vocale, o per mettere in atto tecniche di recupero come gargarismi, o anche utilizzare dispositivi attualmente disponibili per questo scopo. [0002] There are numerous situations in which a subject needs to make intensive and prolonged use of his voice for professional and / or artistic reasons. This is the case of singers, radio and television journalists, speakers and lecturers of various kinds, who cannot afford prolonged pauses at a given moment of their performance to favor a natural vocal recovery, or to implement recovery techniques such as gargling, or also use devices currently available for this purpose.
[0003] Sono infatti noti dispositivi come aerosol a compressione d’aria e a ultrasuoni che permettono di depositare sostanze benefiche sugli organi di fonazione utilizzando il vapore come veicolo, cioè rendono disponibile sotto forma di vapore la soluzione contenente i principi attivi. [0003] In fact, devices such as air compression aerosols and ultrasounds are known which allow to deposit beneficial substances on the speech organs using steam as a vehicle, that is, they make the solution containing the active ingredients available in the form of vapor.
[0004] Tuttavia, gli aerosol, in particolare quelli a compressione, hanno l’inconveniente di prevedere dispositivi ingombranti, e di richiedere in ogni caso tempi di trattamento relativamente lunghi, cioè dell’ordine dei 15 minuti al minimo. Pertanto, questi dispostivi non possono essere utilizzati in modo estemporaneo e frequente durante una prestazione vocale al pubblico, per esempio durante un’esecuzione canora, una performance recitativa, una lezione scolastica o universitaria, un’attività arbitrale in una competizione sportiva, una cronaca radiotelevisiva di un’attività a forte densità di eventi, un discorso al pubblico in genere, atre attività di rappresentanza e in specifici contesti sociali. In tali circostanze non sono ammesse pause prolungate quali quelle necessarie per una seduta di aerosol, inoltre l’uso delle specifiche apparecchiature ha un notevole impatto visivo ed è alquanto scomodo. [0004] However, aerosols, in particular compression ones, have the drawback of providing bulky devices, and in any case requiring relatively long treatment times, that is, of the order of 15 minutes at a minimum. Therefore, these devices cannot be used extemporaneously and frequently during a vocal performance to the public, for example during a singing performance, an acting performance, a school or university lesson, an arbitration activity in a sports competition, a radio and television news. an activity with a high density of events, a speech to the general public, other representation activities and in specific social contexts. In such circumstances, prolonged breaks such as those necessary for an aerosol session are not allowed. Furthermore, the use of specific equipment has a significant visual impact and is somewhat uncomfortable.
[0005] Esistono altresì dei nebulizzatori spray, che sono concepiti per somministrare taluni principi attivi depositandoli nel solo cavo oro-faringeo, quindi non più in profondità nelle vie respiratorie. Essi non impiegano vapore quale veicolo per i principi attivi, ma producono gocce microscopiche di una soluzione contenente i principi attivi, normalmente una soluzione di un estratto di particolari erbe. [0005] There are also spray nebulizers, which are designed to administer certain active ingredients by depositing them only in the oropharyngeal cavity, therefore no more deeply in the respiratory tract. They do not use steam as a vehicle for the active ingredients, but produce microscopic drops of a solution containing the active ingredients, usually a solution of an extract of particular herbs.
[0006] Anche questi dispositivi, seppure di uso più comodo rispetto agli aerosol, presentano degli inconvenienti. Infatti, per favorire la suddetta nebulizzazione essi utilizzano solventi come alcool in quantità tali da non poter essere inalati in modo sistematico o frequente, come è richiesto per far giungere i principi attivi fino alle corde vocali. Infatti, tali quantità dei suddetti solventi non sono tollerati dal tessuto bronchiale e polmonare. [0006] Even these devices, although more convenient to use than aerosols, have drawbacks. In fact, to favor the aforementioned nebulization, they use solvents such as alcohol in such quantities that they cannot be inhaled in a systematic or frequent way, as is required for the active ingredients to reach the vocal cords. In fact, such quantities of the aforesaid solvents are not tolerated by the bronchial and lung tissue.
Sintesi dell’invenzione Summary of the invention
[0007] È quindi scopo della presente invenzione fornire una composizione per trattare condizioni dell’apparato fonatorio di un soggetto, più specificatamente una composizione che permetta di idratare e/o sfiammare le corde vocali e la laringe in un tempo di applicazione molto inferiore a dispositivi di tecnica nota quali aerosol, in modo da poter essere utilizzato durante attività professionali e/o artistiche quali lezioni, conferenze, esecuzioni canore e recitative, senza alterare e ritardare il ritmo di dette attività. [0007] It is therefore an object of the present invention to provide a composition for treating conditions of the speech apparatus of a subject, more specifically a composition that allows to hydrate and / or defuse the vocal cords and the larynx in a much shorter application time than devices of known technique such as aerosols, so that it can be used during professional and / or artistic activities such as lessons, conferences, singing and recitative performances, without altering and delaying the rhythm of these activities.
[0008] È inoltre scopo dell’invenzione fornire una siffatta composizione che possa essere utilizzata con un dispositivo di dimensioni più contenute e di più semplice utilizzo rispetto ai dispositivi di tecnica anteriore. [0008] It is also an object of the invention to provide such a composition that can be used with a device of smaller dimensions and easier to use than prior art devices.
[0009] È anche scopo dell’invenzione fornire una siffatta composizione che abbia un effetto idratante prolungato nel tempo, proteggendo le corde vocali in caso di prosecuzione anche intensiva delle suddette attività dopo l’applicazione. [0009] It is also the purpose of the invention to provide such a composition that has a prolonged moisturizing effect over time, protecting the vocal cords in the event of continuing, even intensive, the aforementioned activities after application.
[0010] È altresì scopo dell’invenzione fornire una siffatta composizione che il soggetto possa inalare senza sostanziali conseguenze per il proprio tessuto bronchiale e polmonare. [0010] It is also an aim of the invention to provide such a composition that the subject can inhale without substantial consequences for his own bronchial and lung tissue.
[0011] Tali scopi vengono raggiunti, secondo l’invenzione, da una composizione definita dalla rivendicazione indipendente n. 1 allegata, nonché da un ricambio per sigarette elettroniche come definito dalla rivendicazione indipendente n.9, mentre le rivendicazioni dipendenti definiscono forme realizzative particolari dell’invenzione. [0011] These purposes are achieved, according to the invention, by a composition defined by independent claim no. 1 attached, as well as a spare part for electronic cigarettes as defined by independent claim 9, while the dependent claims define particular embodiments of the invention.
[0012] Secondo un aspetto dell’invenzione, una composizione inalabile per trattare gli organi di fonazione di un soggetto, in particolare per idratare e sfiammare le corde vocali, comprende: [0012] According to an aspect of the invention, an inhalable composition for treating the speech organs of a subject, in particular to hydrate and inflame the vocal cords, comprises:
− un estratto di Aloe vera, per una proporzione in peso compresa tra il 3% e il 40% sul peso totale di detta composizione; - an extract of Aloe vera, for a proportion by weight between 3% and 40% of the total weight of said composition;
− un solvente comprendente un liquido a base di acqua e/o una miscela di un glicole biologicamente accettabile e glicerina. - a solvent comprising a water-based liquid and / or a mixture of a biologically acceptable glycol and glycerin.
[0013] Siffatte composizioni, grazie alla presenza della miscela del glicole e della glicerina, ed in particolare quando tale miscela prevale sulla parte acquosa, può essere usata in un dispositivo di inalazione di tipo noto quale una comune sigaretta elettronica, in cui una resistenza disposta immersa in un liquido come la composizione dell’invenzione, all'interno di una porzione atomizzatrice, viene alimentata da una batteria surriscaldandosi, in modo da far evaporare il liquido, che viene così reso disponibile per l’inalazione. [0013] Such compositions, thanks to the presence of the mixture of glycol and glycerin, and in particular when this mixture prevails over the aqueous part, can be used in an inhalation device of a known type such as a common electronic cigarette, in which a resistance arranged immersed in a liquid such as the composition of the invention, inside an atomising portion, it is powered by a battery, overheating, so as to evaporate the liquid, which is thus made available for inhalation.
[0014] Tale modalità di somministrazione, consentita dalla presenza della miscela glicole/glicerina quale solvente, è esente dai problemi, sopra descritti, che si presenterebbero se si tentasse di somministrare i principi attivi ottenuti dall’Aloe vera mediante un dispositivo aerosol a compressione o a ultrasuoni. La sigaretta elettronica ha dimensioni molto inferiori a tali dispositivi, è molto più semplice da usare e permette di ottenere un effetto idratante e/o antinfiammatorio in tempi molto inferiori. [0014] This method of administration, allowed by the presence of the glycol / glycerin mixture as a solvent, is free from the problems described above, which would arise if an attempt were made to administer the active ingredients obtained from Aloe vera by means of an aerosol device by compression or by ultrasound. The electronic cigarette has much smaller dimensions than these devices, it is much easier to use and allows to obtain a moisturizing and / or anti-inflammatory effect in a much shorter time.
[0015] Pertanto, con la composizione secondo l’invenzione, attraverso l’uso di una sigaretta elettronica, è possibile effettuare una somministrazione di principi attivi dell’Aloe anche in situazioni in cui l’impiego dei dispositivi per aerosol sarebbe alquanto scomodo se non impossibile, quali concerti per voce ed esecuzioni canore prolungate in genere, conferenze, dibattiti, lezioni scolastiche e universitarie, competizioni sportive e attività di rendicontazione in diretta di attività a forte densità di eventi. [0015] Therefore, with the composition according to the invention, through the use of an electronic cigarette, it is possible to carry out an administration of active ingredients of Aloe even in situations in which the use of aerosol devices would be somewhat inconvenient if not impossible, such as concerts for voice and prolonged singing performances in general, conferences, debates, school and university lessons, sports competitions and live reporting of activities with a high density of events.
[0016] La sigaretta elettronica permette inoltre di associare a tale effetto terapeutico aspetti di tipo ludico che sono propri di un siffatto dispositivo, scegliendo il rapporto tra glicole e glicerina a piacere, o prevedendo nella composizione aromi di vario tipo, in base ai gusti dell’inalatore, tra cui la stessa nicotina. [0016] The electronic cigarette also makes it possible to associate playful aspects to this therapeutic effect that are typical of such a device, by choosing the ratio between glycol and glycerin as desired, or by providing various types of aromas in the composition, based on the tastes of the 'inhaler, including the nicotine itself.
[0017] Come tale, la composizione sopra definita può essere utilizzata per rimediare efficacemente a condizioni che necessitano la repentina idratazione dell’organo vocale, per esempio: [0017] As such, the composition defined above can be used to effectively remedy conditions that require sudden hydration of the vocal organ, for example:
− a stress vocale nel caso di eloquio prolungato per ragioni professionali da parte di insegnanti, consulenti, rappresentanti, avvocati, radio- e telecronisti, ecc. - vocal stress in the case of prolonged speech for professional reasons by teachers, consultants, representatives, lawyers, radio and commentators, etc.
− utilizzo atletico dell’organo vocale da parte di cantanti e attori; - athletic use of the vocal organ by singers and actors;
− secchezza dovuta a reazioni emotive per un’imminente performance vocale, - dryness due to emotional reactions to an upcoming vocal performance,
ma anche: but also:
− disturbi cronici che comportano l’inefficienza dell’organo vocale, raucedine, bruciore e secchezza delle mucose come il reflusso gastro esofageo e il morbo di Sjögren; - chronic disorders that involve the inefficiency of the vocal organ, hoarseness, burning and dryness of the mucous membranes such as gastroesophageal reflux and Sjögren's disease;
− secchezza delle mucose dovuta a trattamenti farmacologici. - dryness of the mucous membranes due to pharmacological treatments.
[0018] Anche questa composizione può essere inalata utilizzando una sigaretta elettronica o un vaporizzatore, e presenta il vantaggio di non utilizzare solventi che potrebbero non essere tollerati da taluni soggetti. [0018] This composition can also be inhaled using an electronic cigarette or a vaporizer, and has the advantage of not using solvents that may not be tolerated by some subjects.
[0019] Preferibilmente, la composizione comprende inoltre un estratto, preferibilmente una tintura madre, di Malva sylvestris, in una percentuale in peso compresa tra il 5% e il 20%. La Malva sylvestris comporta un effetto idratante e antinfiammatorio più intenso e duraturo rispetto a una composizione base. Si ritiene che ciò sia dovuto a un film protettivo e sigillante la cui formazione sulle corde vocali viene esaltata quando taluni principi attivi presenti nell’estratto di Malva sylvestris entrano in contatto con le mucose. [0019] Preferably, the composition further comprises an extract, preferably a mother tincture, of Malva sylvestris, in a weight percentage comprised between 5% and 20%. Malva sylvestris has a more intense and lasting moisturizing and anti-inflammatory effect than a basic composition. It is believed that this is due to a protective and sealing film whose formation on the vocal cords is enhanced when certain active ingredients present in the Malva sylvestris extract come into contact with the mucous membranes.
[0020] Preferibilmente, l’estratto di Aloe vera è una tintura madre. Con il termine “tintura madre” si intende un liquido ottenuto mediante macerazione o percolazione di un dato materiale vegetale, in questo caso l’Aloe vera, in un solvente costituito da una soluzione idroalcolica, secondo un rapporto in peso compreso in un intervallo predeterminato. In questo caso, si considera che il rapporto in peso materiale vegetale/solvente sia compreso tra 1/20 e 1/5. [0020] Preferably, the Aloe vera extract is a mother tincture. The term "mother tincture" means a liquid obtained by maceration or percolation of a given plant material, in this case Aloe vera, in a solvent consisting of a hydroalcoholic solution, according to a weight ratio within a predetermined range. In this case, the weight ratio of plant material / solvent is considered to be between 1/20 and 1/5.
[0021] Preferibilmente, tale glicole biologicamente accettabile è glicole propilenico, e la miscela può avere un rapporto in peso glicerina/glicole propilenico compreso tra 90/10 e 50/50. [0021] Preferably, such biologically acceptable glycol is propylene glycol, and the mixture can have a glycerin / propylene glycol weight ratio of between 90/10 and 50/50.
[0022] Preferibilmente, la concentrazione dell’Aloe vera è compresa tra il 3% e il 20% in peso, in particolare tra il 3% e il 10% in peso sul peso totale di detta composizione. Un elevato contenuto di Aloe vera potrebbe avere, in alcuni soggetti sensibili, effetti lassativi. [0022] Preferably, the concentration of Aloe vera is between 3% and 20% by weight, in particular between 3% and 10% by weight on the total weight of said composition. A high content of Aloe vera could have laxative effects in some sensitive subjects.
[0023] Preferibilmente, detta glicerina è glicerina vegetale, in modo da evitare la presenza nella soluzione di possibili contaminati chimici provenienti da un processo industriale di produzione della glicerina. [0023] Preferably, said glycerin is vegetable glycerin, so as to avoid the presence in the solution of possible chemical contaminants coming from an industrial process for the production of glycerin.
[0024] Il liquido a base di acqua può essere acqua distillata, oppure, preferibilmente in assenza della miscela di glicerina e glicole, una soluzione salina isotonica (fisiologica) o ipotonica, cioè una soluzione acquosa di cloruro di sodio in acqua trattata almeno purificata, a una concentrazione di NaCl prossima a o inferiore allo 0,9% peso/volume. In quest’ultimo caso, la composizione secondo l’invenzione può essere utilizzata anche in un dispositivo per aerosol, per un trattamento al di fuori dalle attività professionali e/o artistiche sopra ricordate. The water-based liquid can be distilled water, or, preferably in the absence of the glycerin and glycol mixture, an isotonic (physiological) or hypotonic saline solution, i.e. an aqueous solution of sodium chloride in at least purified treated water, at a NaCl concentration close to or less than 0.9% weight / volume. In the latter case, the composition according to the invention can also be used in an aerosol device, for a treatment outside the professional and / or artistic activities mentioned above.
[0025] Vantaggiosamente, la composizione comprende inoltre una tintura madre di semi di pompelmo e/o di semi di rosa canina, in una percentuale in peso compresa tra il 3% e il 15% sul peso totale di detta composizione. Tali componenti aumentano l’effetto antiinfiammatorio della composizione, oltre ad avere proprietà antibatteriche. [0025] Advantageously, the composition further comprises a mother tincture of grapefruit seeds and / or rosehip seeds, in a percentage by weight of between 3% and 15% of the total weight of said composition. These components increase the anti-inflammatory effect of the composition, as well as having antibacterial properties.
[0026] Una siffatta composizione è idonea altresì per essere utilizzata, più in generale, con un vaporizzatore, che può presentare la maggior parte dei vantaggi offerti dalle sigarette elettroniche. [0026] Such a composition is also suitable for use, more generally, with a vaporizer, which can have most of the advantages offered by electronic cigarettes.
[0027] Secondo un altro aspetto dell’invenzione, viene fornita una cartuccia per sigarette elettroniche comprendente un serbatoio configurato per essere installato in una sigaretta elettronica e contenente una composizione come sopra descritta. [0027] According to another aspect of the invention, a cartridge for electronic cigarettes is provided comprising a tank configured to be installed in an electronic cigarette and containing a composition as described above.
Esempi Examples
[0028] L’invenzione verrà di seguito illustrata con alcuni esempi di composizione I-XIX, fatti a titolo esemplificativo e non limitativo. [0028] The invention will be illustrated below with some examples of composition I-XIX, given by way of non-limiting example.
[0029] [0029]
Tabella 1 - Composizioni con solvente glicerina/glicol o combinazioni di solvente glicerina/glicol e un liquido a base di acqua Table 1 - Compositions with glycerin / glycol solvent or combinations of glycerin / glycol solvent and a water-based liquid
(*) Estratti ottenuti mediante macerazione dei rispettivi materiali vegetali in soluzione (tinture madri). (*) Extracts obtained by maceration of the respective plant materials in solution (mother tinctures).
[0030] [0030]
Tabella 2 - Composizioni con solvente a base di acqua (acqua distillata) Table 2 - Water-based solvent compositions (distilled water)
[0031] [0031]
Tabella 3 - Composizioni con solvente a base di acqua (soluzione fisiologica) Table 3 - Compositions with water-based solvent (physiological solution)
[0032] Composizioni degli esempi I-VII sono state sottoposte a una giuria di 50 soggetti mediante inalazione per circa 10 minuti attraverso sigaretta elettronica. La giuria era così composta: [0032] Compositions of Examples I-VII were submitted to a jury of 50 subjects by inhalation for about 10 minutes through electronic cigarette. The jury was composed as follows:
1) Sesso: maschi 68%, femmine 32%; 1) Gender: males 68%, females 32%;
2) Fasce di età: 18-30 anni, 45%; 31-50 anni, 46%; 51-65 anni, 8%; 2) Age ranges: 18-30 years, 45%; 31-50 years, 46%; 51-65 years, 8%;
3) Fumatori: 48%; 3) Smoking: 48%;
4) Utilizzatori di sigarette elettroniche: 40%; 4) Users of electronic cigarettes: 40%;
5) Utilizzatori professionali della propria voce: 44%, di cui cantanti, 38% e insegnanti, 14%; 5) Professional users of their own voice: 44%, of which singers, 38% and teachers, 14%;
6) Utilizzatori amatoriali della propria voce: 66%, di cui cantanti, 46% e attori, 2%; 6) Amateur users of their own voice: 66%, of which singers, 46% and actors, 2%;
7) Motivazione al possibile uso di dispostivi per salvaguardare la voce: uso atletico della voce, 70%; eloquio abitualmente prolungato, 34%; raucedine cronica, 16%; reflusso gastro-esofageo: 32%. Di tale giuria, in merito alla condizione della propria voce dopo l’inalazione delle varie composizioni, in media: 7) Motivation for the possible use of devices to safeguard the voice: athletic use of the voice, 70%; usually prolonged speech, 34%; chronic hoarseness, 16%; gastroesophageal reflux: 32%. Of this jury, regarding the condition of their voice after inhaling the various compositions, on average:
- ha rilevato un peggioramento: lo 0% - found a worsening: 0%
- non ha rilevato alcun cambiamento: il 4% - did not detect any change: 4%
- ha rilevato un lieve miglioramento: il 46% - found a slight improvement: 46%
- ha rilevato un importante miglioramento: 40% - found an important improvement: 40%
[0033] Un esame laringoscopico eseguito su un campione dei componenti la giuria prima e dopo il trattamento ha evidenziato la formazione di un film viscoso in corrispondenza delle corde vocali, tale da favorire l’accostamento delle stesse richiesto durante l’attività fonatoria. La formazione di tale film era particolarmente accentuata nel caso delle composizioni III, VI e VII, contenenti tintura madre di Malva sylvestris. [0033] A laryngoscopic examination performed on a sample of the members of the jury before and after the treatment showed the formation of a viscous film in correspondence of the vocal cords, such as to favor the approach of the same required during the speech activity. The formation of this film was particularly accentuated in the case of compositions III, VI and VII, containing mother tincture of Malva sylvestris.
[0034] La descrizione di cui sopra di forme realizzative dell’invenzione è in grado di mostrare l’invenzione dal punto di vista concettuale in modo che altri, utilizzando la tecnica nota, potranno modificare e/o adattare in varie applicazioni tali forme realizzative specifiche senza ulteriori ricerche e senza allontanarsi dal concetto inventivo e, quindi, si intende che tali adattamenti e modifiche saranno considerabili come equivalenti delle forme realizzative specifiche. I mezzi e i materiali per realizzare le varie funzioni descritte potranno essere di varia natura senza per questo uscire dall’ambito dell’invenzione. S’intende che le espressioni o la terminologia utilizzate hanno scopo puramente descrittivo e, per questo, non limitativo. [0034] The above description of embodiments of the invention is able to show the invention from the conceptual point of view so that others, using the known art, will be able to modify and / or adapt these specific embodiments in various applications without further research and without departing from the inventive concept and, therefore, it is understood that such adaptations and modifications will be considered as equivalent to the specific embodiments. The means and materials for carrying out the various functions described may be of various nature without thereby departing from the scope of the invention. It is understood that the expressions or terminology used have a purely descriptive purpose and, therefore, are not limiting.
Claims (10)
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| US9364512B1 (en) * | 2015-02-08 | 2016-06-14 | Halister Joseph Drummond, III | Aloe vera based vaping compositions |
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| US5288492A (en) * | 1992-11-13 | 1994-02-22 | Morris Michael A | Decongestant composition containing aloe vera |
| US20140190496A1 (en) * | 2012-11-28 | 2014-07-10 | E-Nicotine Technology, Inc. | Methods and devices for compound delivery |
| US9364512B1 (en) * | 2015-02-08 | 2016-06-14 | Halister Joseph Drummond, III | Aloe vera based vaping compositions |
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