IT201900008841A1 - METHOD FOR DETERMINING THE CONCENTRATION OF 7-ETHYL-10- [4- (PIPERIDINO) -1-PIPERIDINO] -CARBONYLOXYCAMPTOTECIN (IRINOTECAN) IN PLASMA SAMPLES - Google Patents

METHOD FOR DETERMINING THE CONCENTRATION OF 7-ETHYL-10- [4- (PIPERIDINO) -1-PIPERIDINO] -CARBONYLOXYCAMPTOTECIN (IRINOTECAN) IN PLASMA SAMPLES

Info

Publication number
IT201900008841A1
IT201900008841A1 IT102019000008841A IT201900008841A IT201900008841A1 IT 201900008841 A1 IT201900008841 A1 IT 201900008841A1 IT 102019000008841 A IT102019000008841 A IT 102019000008841A IT 201900008841 A IT201900008841 A IT 201900008841A IT 201900008841 A1 IT201900008841 A1 IT 201900008841A1
Authority
IT
Italy
Prior art keywords
piperidino
carbonyloxycamptotecin
irinotecan
ethyl
concentration
Prior art date
Application number
IT102019000008841A
Other languages
Italian (it)
Inventor
Gregorio Bonazza
Salvatore Daniele
Federico Polo
Giuseppe Toffoli
Stefano Tartaggia
Original Assignee
Univ Ca Foscari
Centro Di Riferimento Oncologico
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Ca Foscari, Centro Di Riferimento Oncologico filed Critical Univ Ca Foscari
Priority to IT102019000008841A priority Critical patent/IT201900008841A1/en
Priority to PCT/IB2020/055546 priority patent/WO2020250201A1/en
Publication of IT201900008841A1 publication Critical patent/IT201900008841A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/48—Systems using polarography, i.e. measuring changes in current under a slowly-varying voltage
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/06—Preparation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48714—Physical analysis of biological material of liquid biological material by electrical means for determining substances foreign to the organism, e.g. drugs or heavy metals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/884—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample organic compounds
IT102019000008841A 2019-06-13 2019-06-13 METHOD FOR DETERMINING THE CONCENTRATION OF 7-ETHYL-10- [4- (PIPERIDINO) -1-PIPERIDINO] -CARBONYLOXYCAMPTOTECIN (IRINOTECAN) IN PLASMA SAMPLES IT201900008841A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102019000008841A IT201900008841A1 (en) 2019-06-13 2019-06-13 METHOD FOR DETERMINING THE CONCENTRATION OF 7-ETHYL-10- [4- (PIPERIDINO) -1-PIPERIDINO] -CARBONYLOXYCAMPTOTECIN (IRINOTECAN) IN PLASMA SAMPLES
PCT/IB2020/055546 WO2020250201A1 (en) 2019-06-13 2020-06-12 Metod for determining the concentration of 7-ethyl-10-[4-(piperidino)-1-piperidino]-carbonyloxycamptothecin (irinotecan) in plasma samples and instrument for realisation of the method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000008841A IT201900008841A1 (en) 2019-06-13 2019-06-13 METHOD FOR DETERMINING THE CONCENTRATION OF 7-ETHYL-10- [4- (PIPERIDINO) -1-PIPERIDINO] -CARBONYLOXYCAMPTOTECIN (IRINOTECAN) IN PLASMA SAMPLES

Publications (1)

Publication Number Publication Date
IT201900008841A1 true IT201900008841A1 (en) 2020-12-13

Family

ID=68234146

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000008841A IT201900008841A1 (en) 2019-06-13 2019-06-13 METHOD FOR DETERMINING THE CONCENTRATION OF 7-ETHYL-10- [4- (PIPERIDINO) -1-PIPERIDINO] -CARBONYLOXYCAMPTOTECIN (IRINOTECAN) IN PLASMA SAMPLES

Country Status (2)

Country Link
IT (1) IT201900008841A1 (en)
WO (1) WO2020250201A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2543994A1 (en) 2010-03-03 2013-01-09 Hitachi High-Technologies Corporation Analysis device
CN107677734A (en) 2016-08-02 2018-02-09 上海朴颐化学科技有限公司 A kind of UPLC analysis methods of SN-38

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000067011A1 (en) * 1999-04-30 2000-11-09 Hw Electrochem Technology Pte Ltd. Apparatus for voltammetric analysis
EP3289346B1 (en) * 2015-04-29 2022-01-12 AMS Trace Metals, Inc. Renewable mercury meniscus electrode with mercury circulation system and contaminant removal

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2543994A1 (en) 2010-03-03 2013-01-09 Hitachi High-Technologies Corporation Analysis device
CN107677734A (en) 2016-08-02 2018-02-09 上海朴颐化学科技有限公司 A kind of UPLC analysis methods of SN-38

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BONAZZA GREGORIO ET AL: "Voltammetric behaviour of the anticancer drug irinotecan and its metabolites in acetonitrile. Implications for electrochemical therapeutic drug monitoring", ELECTROCHIMICA ACTA, ELSEVIER, AMSTERDAM, NL, vol. 289, 15 September 2018 (2018-09-15), pages 483 - 493, XP085495723, ISSN: 0013-4686, DOI: 10.1016/J.ELECTACTA.2018.09.094 *
LAURENT P RIVORY ET AL: "Identification and Properties of a Major Plasma Metabolite of Irinotecan (CPT-11) Isolated from the Plasma of Patients1", WOOLLOONGABBA. QUEENSLAND BORDEAUX CANCER CHEMOTHER. PHARMACOL, 15 August 1995 (1995-08-15), pages 1689 - 3694, XP055662589, Retrieved from the Internet <URL:https://cancerres.aacrjournals.org/content/canres/56/16/3689.full.pdf> [retrieved on 20200127] *
SHOUHONG GAO ET AL: "One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS", JOURNAL OF ANALYTICAL METHODS IN CHEMISTRY, vol. 2018, 24 June 2018 (2018-06-24), pages 1 - 12, XP055661928, ISSN: 2090-8865, DOI: 10.1155/2018/7967694 *
ZELJKO M. PRIJOVICH ET AL: "Versatile online SPE-HPLC method for the analysis of Irinotecan and its clinically relevant metabolites in biomaterials : Liquid Chromatography", JOURNAL OF SEPARATION SCIENCE., vol. 37, no. 4, 1 February 2014 (2014-02-01), DE, pages 360 - 367, XP055662586, ISSN: 1615-9306, DOI: 10.1002/jssc.201301191 *

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Publication number Publication date
WO2020250201A1 (en) 2020-12-17

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