IT201800009974A1 - Trattamento combinato farmacologico per cancro - Google Patents

Trattamento combinato farmacologico per cancro

Info

Publication number
IT201800009974A1
IT201800009974A1 IT102018000009974A IT201800009974A IT201800009974A1 IT 201800009974 A1 IT201800009974 A1 IT 201800009974A1 IT 102018000009974 A IT102018000009974 A IT 102018000009974A IT 201800009974 A IT201800009974 A IT 201800009974A IT 201800009974 A1 IT201800009974 A1 IT 201800009974A1
Authority
IT
Italy
Prior art keywords
cancer
pharmacological treatment
combined pharmacological
combined
treatment
Prior art date
Application number
IT102018000009974A
Other languages
English (en)
Inventor
Lilia Alberghina
Rosa Maria Moresco
Silvia Valtorta
Daniela Gaglio
Original Assignee
Universita' Degli Studi Di Milano - Bicocca
Consiglio Nazionale Ricerche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universita' Degli Studi Di Milano - Bicocca, Consiglio Nazionale Ricerche filed Critical Universita' Degli Studi Di Milano - Bicocca
Priority to IT102018000009974A priority Critical patent/IT201800009974A1/it
Priority to PCT/EP2019/079843 priority patent/WO2020089398A1/en
Publication of IT201800009974A1 publication Critical patent/IT201800009974A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
IT102018000009974A 2018-10-31 2018-10-31 Trattamento combinato farmacologico per cancro IT201800009974A1 (it)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102018000009974A IT201800009974A1 (it) 2018-10-31 2018-10-31 Trattamento combinato farmacologico per cancro
PCT/EP2019/079843 WO2020089398A1 (en) 2018-10-31 2019-10-31 Combinatorial drug treatment for cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102018000009974A IT201800009974A1 (it) 2018-10-31 2018-10-31 Trattamento combinato farmacologico per cancro

Publications (1)

Publication Number Publication Date
IT201800009974A1 true IT201800009974A1 (it) 2020-05-01

Family

ID=65199530

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102018000009974A IT201800009974A1 (it) 2018-10-31 2018-10-31 Trattamento combinato farmacologico per cancro

Country Status (2)

Country Link
IT (1) IT201800009974A1 (it)
WO (1) WO2020089398A1 (it)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016014890A1 (en) * 2014-07-24 2016-01-28 Calithera Biosciences, Inc. Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase
US20170049790A1 (en) * 2014-05-02 2017-02-23 The Wistar Institute Of Anatomy And Biology Combination therapies targeting mitochondria for cancer therapy
US20170333430A1 (en) * 2014-06-13 2017-11-23 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170049790A1 (en) * 2014-05-02 2017-02-23 The Wistar Institute Of Anatomy And Biology Combination therapies targeting mitochondria for cancer therapy
US20170333430A1 (en) * 2014-06-13 2017-11-23 Calithera Biosciences, Inc. Combination therapy with glutaminase inhibitors
WO2016014890A1 (en) * 2014-07-24 2016-01-28 Calithera Biosciences, Inc. Treatment of multiple myeloma with heterocyclic inhibitors of glutaminase

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
"Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling", MOLECULAR CELL, vol. 59, pages 345 - 358
ALAGESAN, B. ET AL.: "Combined MEK and PI3K inhibition in a mouse model of pancreatic cancer", CLIN CANCER RES, vol. 21, 2015, pages 396 - 404
ALIKHANI, N. ET AL.: "Mammary tumor growth and pulmonary metastasis are enhanced in a hyperlipidemic mouse model", ONCOGENE, vol. 32, 2013, pages 961 - 967
ELVIRE PONS-TOSTIVINT, B.T.; JULIE GUILLERMET-GUIBER: "Targeting PI3K Signaling in Combination Cancer Therapy", TRENDS IN CANCER, vol. 3, 2017, pages 454 - 469, XP009505180, DOI: doi:10.1016/j.trecan.2017.04.002
GAGLIO, D. ET AL.: "Divergent in vitro/in vivo responses to drug treatments of highly aggressive NIH-Ras cancer cells: a PET imaging and metabolomics-mass-spectrometry study", ONCOTARGET, vol. 7, 2016, pages 52017 - 52031
GUO LILI ET AL: "Blockage of glutaminolysis enhances the sensitivity of ovarian cancer cells to PI3K/mTOR inhibition involvement of STAT3 signaling", TUMOR BIOLOGY, KARGER, BASEL, CH, vol. 37, no. 8, 19 February 2016 (2016-02-19), pages 11007 - 11015, XP036219275, ISSN: 1010-4283, [retrieved on 20160219], DOI: 10.1007/S13277-016-4984-3 *
HEUDEL, P.E. ET AL.: "Phase II study of the PI3K inhibitor BKM120 in patients with advanced or recurrent endometrial carcinoma: a stratified type I-type II study from the GINECO group", BRITISH JOURNAL OF CANCER, vol. 116, 2017, pages 303 - 309
HU, H. ET AL.: "Phosphoinositide 3-Kinase Regulates Glycolysis through Mobilization of Aldolase from the Actin Cytoskeleton", CELL, vol. 164, 2016, pages 433 - 446
HUANG, S. ET AL.: "Novel personalized pathway-based metabolomics models reveal key metabolic pathways for breast cancer diagnosis", GENOME MEDICINE, vol. 8, 2016, pages 34
KILGOZ, H.O. ET AL.: "KRAS and the Reality of Personalized Medicine in Non-small Cell Lung Cancer", MOLECULAR MEDICINE, 2016
METALLO, C.M. ET AL.: "Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia", NATURE, vol. 481, 2011, pages 380 - 384

Also Published As

Publication number Publication date
WO2020089398A1 (en) 2020-05-07

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