IT201800009959A1 - Nanoparticelle di ferritina comprendenti un agente chemioterapico - Google Patents

Nanoparticelle di ferritina comprendenti un agente chemioterapico

Info

Publication number
IT201800009959A1
IT201800009959A1 IT102018000009959A IT201800009959A IT201800009959A1 IT 201800009959 A1 IT201800009959 A1 IT 201800009959A1 IT 102018000009959 A IT102018000009959 A IT 102018000009959A IT 201800009959 A IT201800009959 A IT 201800009959A IT 201800009959 A1 IT201800009959 A1 IT 201800009959A1
Authority
IT
Italy
Prior art keywords
chemotherapy agent
nanoparticles including
ferritin nanoparticles
ferritin
chemotherapy
Prior art date
Application number
IT102018000009959A
Other languages
English (en)
Inventor
Serena Mazzucchelli
Fabio Corsi
Marta Truffi
Davide Prosperi
Miriam Colombo
Michela Bellini
Original Assignee
Inthena Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inthena Srl filed Critical Inthena Srl
Priority to IT102018000009959A priority Critical patent/IT201800009959A1/it
Priority to EP19808536.7A priority patent/EP3873535B1/en
Priority to PCT/EP2019/079832 priority patent/WO2020089394A1/en
Priority to US17/289,807 priority patent/US20210393539A1/en
Priority to EP23184063.8A priority patent/EP4268899A3/en
Priority to AU2019372164A priority patent/AU2019372164A1/en
Publication of IT201800009959A1 publication Critical patent/IT201800009959A1/it
Priority to IL282792A priority patent/IL282792A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5169—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT102018000009959A 2018-10-31 2018-10-31 Nanoparticelle di ferritina comprendenti un agente chemioterapico IT201800009959A1 (it)

Priority Applications (7)

Application Number Priority Date Filing Date Title
IT102018000009959A IT201800009959A1 (it) 2018-10-31 2018-10-31 Nanoparticelle di ferritina comprendenti un agente chemioterapico
EP19808536.7A EP3873535B1 (en) 2018-10-31 2019-10-31 Ferritin nanoparticles comprising a chemotherapeutic agent
PCT/EP2019/079832 WO2020089394A1 (en) 2018-10-31 2019-10-31 Ferritin nanoparticles comprising a chemotherapeutic agent
US17/289,807 US20210393539A1 (en) 2018-10-31 2019-10-31 Ferritin nanoparticles comprising a chemotherapeutic agent
EP23184063.8A EP4268899A3 (en) 2018-10-31 2019-10-31 Ferritin nanoparticles comprising a chemotherapeutic agent
AU2019372164A AU2019372164A1 (en) 2018-10-31 2019-10-31 Ferritin nanoparticles comprising a chemotherapeutic agent
IL282792A IL282792A (en) 2018-10-31 2021-04-29 Ferritin nanoparticles containing a chemotherapeutic agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102018000009959A IT201800009959A1 (it) 2018-10-31 2018-10-31 Nanoparticelle di ferritina comprendenti un agente chemioterapico

Publications (1)

Publication Number Publication Date
IT201800009959A1 true IT201800009959A1 (it) 2020-05-01

Family

ID=65244522

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102018000009959A IT201800009959A1 (it) 2018-10-31 2018-10-31 Nanoparticelle di ferritina comprendenti un agente chemioterapico

Country Status (6)

Country Link
US (1) US20210393539A1 (it)
EP (2) EP4268899A3 (it)
AU (1) AU2019372164A1 (it)
IL (1) IL282792A (it)
IT (1) IT201800009959A1 (it)
WO (1) WO2020089394A1 (it)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115920083A (zh) * 2023-01-06 2023-04-07 浙江树人学院 一种载姜黄素的去铁铁蛋白纳米笼与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015135597A1 (en) * 2014-03-12 2015-09-17 Cic Nanogune - Asociación Centro De Investigación Cooperativa En Nanociencias Uses and methods for delivery to the nucleus

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BELLINI M. ET AL: "Protein nanocages for self-triggered nuclear delivery of DNA-targeted chemotherapeutics in Cancer Cells", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 196, 13 October 2014 (2014-10-13), pages 184 - 196, XP029112401 *
BELLINI M; MAZZUCCHELLI S; GALBIATI E; SOMMARUGA S; FIANDRA L; TRUFFI M; RIZZUTO MA; COLOMBO M; TORTORA P; CORSI F, J CONTROL RELEASE., vol. 196, 28 December 2014 (2014-12-28), pages 184 - 96
BRACCI, L. ET AL.: "Immune-based mechanisms of cytotoxic chemotherapy: implications for the design of novel and rationale-based combined treatments against cancer", CELL DEATH DIFFER, vol. 21, no. 1, 2014, pages 15 - 25
LEE B.-R. ET AL: "Engineered Human Ferritin Nanoparticles for Direct Delivery of Tumor Antigens to Lymph Node and Cancer Immunotherapy", SCIENTIFIC REPORTS, vol. 6, 35182, 11 October 2016 (2016-10-11), XP002792566 *
MA, Y. ET AL.: "Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells", IMMUNITY, vol. 38, no. 4, 2013, pages 729 - 41
MATTAROLLO, S.R. ET AL.: "Pivotal role of innate and adaptive immunity in anthracycline chemotherapy of established tumors", CANCER RES, vol. 71, no. 14, 2011, pages 4809 - 20
MAZZUCCHELLI S. ET AL.: "Nanometronomic tratment of 4T1 breast cancer with nanocaged doxorubicin prevents drug resistance and circumvents cardiotoxicity", ONCOTARGET, vol. 8, no. 5, 25 December 2016 (2016-12-25), pages 8383 - 8396, XP002792565 *
MAZZUCCHELLI S; BELLINI M; FIANDRA L; TRUFFI M; RIZZUTO MA; SORRENTINO L; LONGHI E; NEBULONI M; PROSPERI D; CORSI F, ONCOTARGET, vol. 8, no. 5, 31 January 2017 (2017-01-31), pages 8383 - 8396
REUSCHENBACH, M.; M. VON KNEBEL DOEBERITZ; N. WENTZENSEN: "A systematic review of humoral immune responses against tumor antigens", CANCER IMMUNOL IMMUNOTHER, vol. 58, no. 10, 2009, pages 1535 - 44, XP019738069, DOI: doi:10.1007/s00262-009-0733-4
TRUFFI MARTA ET AL: "Ferritin nanocages: A biological platform for drug delivery, imaging and theranostics in cancer", PHARMACOLOGICAL RESEARCH, ACADEMIC PRESS, LONDON, GB, vol. 107, 9 March 2016 (2016-03-09), pages 57 - 65, XP029533463, ISSN: 1043-6618, DOI: 10.1016/J.PHRS.2016.03.002 *
TSUNG, K.; J.A. NORTON: "In situ vaccine, immunological memory and cancer cure", VACCIN IMMUNOTHER, vol. 12, no. 1, 2016, pages 117 - 9
VERMA, R. ET AL.: "Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer", BREAST CANCER RES, vol. 18, no. 1, 2016, pages 10

Also Published As

Publication number Publication date
WO2020089394A1 (en) 2020-05-07
EP3873535A1 (en) 2021-09-08
EP4268899A3 (en) 2023-12-06
IL282792A (en) 2021-06-30
AU2019372164A1 (en) 2021-06-17
EP4268899A2 (en) 2023-11-01
US20210393539A1 (en) 2021-12-23
EP3873535C0 (en) 2023-10-11
EP3873535B1 (en) 2023-10-11

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