IT201800002269A1 - METHOD FOR DETECTING THE DECREASE OF STAMINALITY IN HEPATOCELLULAR CARCINOMA CELLS BY MEANS OF A SPECIFIC INDICATOR OF STAMINALITY AND USE OF THIS INDICATOR FOR THE TREATMENT OF THE PERSISTENCE OF STEM CELLS IN HEPATOCELLULAR CARCINOMA - Google Patents

METHOD FOR DETECTING THE DECREASE OF STAMINALITY IN HEPATOCELLULAR CARCINOMA CELLS BY MEANS OF A SPECIFIC INDICATOR OF STAMINALITY AND USE OF THIS INDICATOR FOR THE TREATMENT OF THE PERSISTENCE OF STEM CELLS IN HEPATOCELLULAR CARCINOMA

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Publication number
IT201800002269A1
IT201800002269A1 IT201800002269A IT201800002269A IT201800002269A1 IT 201800002269 A1 IT201800002269 A1 IT 201800002269A1 IT 201800002269 A IT201800002269 A IT 201800002269A IT 201800002269 A IT201800002269 A IT 201800002269A IT 201800002269 A1 IT201800002269 A1 IT 201800002269A1
Authority
IT
Italy
Prior art keywords
staminality
hepatocellular carcinoma
indicator
cells
persistence
Prior art date
Application number
IT201800002269A
Other languages
Italian (it)
Inventor
Gianluigi Giannelli
Original Assignee
I R C C S Saverio De Bellis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by I R C C S Saverio De Bellis filed Critical I R C C S Saverio De Bellis
Priority to IT201800002269A priority Critical patent/IT201800002269A1/en
Publication of IT201800002269A1 publication Critical patent/IT201800002269A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
IT201800002269A 2018-01-31 2018-01-31 METHOD FOR DETECTING THE DECREASE OF STAMINALITY IN HEPATOCELLULAR CARCINOMA CELLS BY MEANS OF A SPECIFIC INDICATOR OF STAMINALITY AND USE OF THIS INDICATOR FOR THE TREATMENT OF THE PERSISTENCE OF STEM CELLS IN HEPATOCELLULAR CARCINOMA IT201800002269A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
IT201800002269A IT201800002269A1 (en) 2018-01-31 2018-01-31 METHOD FOR DETECTING THE DECREASE OF STAMINALITY IN HEPATOCELLULAR CARCINOMA CELLS BY MEANS OF A SPECIFIC INDICATOR OF STAMINALITY AND USE OF THIS INDICATOR FOR THE TREATMENT OF THE PERSISTENCE OF STEM CELLS IN HEPATOCELLULAR CARCINOMA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT201800002269A IT201800002269A1 (en) 2018-01-31 2018-01-31 METHOD FOR DETECTING THE DECREASE OF STAMINALITY IN HEPATOCELLULAR CARCINOMA CELLS BY MEANS OF A SPECIFIC INDICATOR OF STAMINALITY AND USE OF THIS INDICATOR FOR THE TREATMENT OF THE PERSISTENCE OF STEM CELLS IN HEPATOCELLULAR CARCINOMA

Publications (1)

Publication Number Publication Date
IT201800002269A1 true IT201800002269A1 (en) 2019-07-31

Family

ID=62143445

Family Applications (1)

Application Number Title Priority Date Filing Date
IT201800002269A IT201800002269A1 (en) 2018-01-31 2018-01-31 METHOD FOR DETECTING THE DECREASE OF STAMINALITY IN HEPATOCELLULAR CARCINOMA CELLS BY MEANS OF A SPECIFIC INDICATOR OF STAMINALITY AND USE OF THIS INDICATOR FOR THE TREATMENT OF THE PERSISTENCE OF STEM CELLS IN HEPATOCELLULAR CARCINOMA

Country Status (1)

Country Link
IT (1) IT201800002269A1 (en)

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JOAN FERNANDO ET AL: "A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells : CD44 and mesenchymal traits in liver cancer cell response to sorafenib", INTERNATIONAL JOURNAL OF CANCER, vol. 136, no. 4, 4 August 2014 (2014-08-04), US, pages E161 - E172, XP055506680, ISSN: 0020-7136, DOI: 10.1002/ijc.29097 *
NA RI PARK ET AL: "Synergistic effects of CD44 and TGF-[beta]1 through AKT/GSK-3[beta]/[beta]-catenin signaling during epithelial-mesenchymal transition in liver cancer cells", ELSEVIER BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 477, no. 4, 16 June 2016 (2016-06-16), pages 568 - 574, XP055506349, DOI: https://doi.org/10.1016/j.bbrc.2016.06.077 *
RANI B ET AL: "P0320 : Targeting TGF-beta I with the transforming growth factor receptor type I kinase inhibitor, LY2157299, modulates stemness-related biomarkers in hepatocellular carcinoma", JOURNAL OF HEPATOLOGY, vol. 62, April 2015 (2015-04-01), XP029161555, ISSN: 0168-8278, DOI: 10.1016/S0168-8278(15)30535-3 *
TERESITA NJ FLORES-TÉLLEZ ET AL: "Road to stemness in hepatocellular carcinoma", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 23, no. 37, 7 October 2017 (2017-10-07), CN, pages 6750 - 6776, XP055506634, ISSN: 1007-9327, DOI: 10.3748/wjg.v23.i37.6750 *
YUAN GAO ET AL: "Knockdown of CD44 inhibits the invasion and metastasis of hepatocellular carcinoma both in vitro and in vivo by reversing epithelial-mesenchymal transition", ONCOTARGET, vol. 6, no. 10, 8 March 2015 (2015-03-08), pages 7828 - 7837, XP055506317, DOI: https://doi.org/10.18632/oncotarget.3488 *

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