IT201800001663A1 - “uso di un peptide derivato dalla proteina umana ntimp3 nella terapia della nefropatia diabetica” - Google Patents

“uso di un peptide derivato dalla proteina umana ntimp3 nella terapia della nefropatia diabetica”

Info

Publication number
IT201800001663A1
IT201800001663A1 IT201800001663A IT201800001663A IT201800001663A1 IT 201800001663 A1 IT201800001663 A1 IT 201800001663A1 IT 201800001663 A IT201800001663 A IT 201800001663A IT 201800001663 A IT201800001663 A IT 201800001663A IT 201800001663 A1 IT201800001663 A1 IT 201800001663A1
Authority
IT
Italy
Prior art keywords
ntimp3
therapy
human protein
diabetic nephropathy
peptide derived
Prior art date
Application number
IT201800001663A
Other languages
English (en)
Inventor
Massimo Federici
Rossella Menghini
Viviana Casagrande
Stefano Menini
Original Assignee
Univ Degli Studi Di Roma Tor Vergata
Univ Degli Studi Roma La Sapienza
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Di Roma Tor Vergata, Univ Degli Studi Roma La Sapienza filed Critical Univ Degli Studi Di Roma Tor Vergata
Priority to IT201800001663A priority Critical patent/IT201800001663A1/it
Priority to US16/964,071 priority patent/US20210115111A1/en
Priority to PCT/IB2019/050482 priority patent/WO2019145840A1/en
Priority to EP19704680.8A priority patent/EP3743439A1/en
Publication of IT201800001663A1 publication Critical patent/IT201800001663A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IT201800001663A 2018-01-23 2018-01-23 “uso di un peptide derivato dalla proteina umana ntimp3 nella terapia della nefropatia diabetica” IT201800001663A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT201800001663A IT201800001663A1 (it) 2018-01-23 2018-01-23 “uso di un peptide derivato dalla proteina umana ntimp3 nella terapia della nefropatia diabetica”
US16/964,071 US20210115111A1 (en) 2018-01-23 2019-01-21 Use of a peptide derived from the human protein ntimp3 in the treatment of diabetic nephropathy
PCT/IB2019/050482 WO2019145840A1 (en) 2018-01-23 2019-01-21 Use of a peptide derived from the human protein ntimp3 in the treatment of diabetic nephropathy
EP19704680.8A EP3743439A1 (en) 2018-01-23 2019-01-21 Use of a peptide derived from the human protein ntimp3 in the treatment of diabetic nephropathy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT201800001663A IT201800001663A1 (it) 2018-01-23 2018-01-23 “uso di un peptide derivato dalla proteina umana ntimp3 nella terapia della nefropatia diabetica”

Publications (1)

Publication Number Publication Date
IT201800001663A1 true IT201800001663A1 (it) 2019-07-23

Family

ID=62218051

Family Applications (1)

Application Number Title Priority Date Filing Date
IT201800001663A IT201800001663A1 (it) 2018-01-23 2018-01-23 “uso di un peptide derivato dalla proteina umana ntimp3 nella terapia della nefropatia diabetica”

Country Status (4)

Country Link
US (1) US20210115111A1 (it)
EP (1) EP3743439A1 (it)
IT (1) IT201800001663A1 (it)
WO (1) WO2019145840A1 (it)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007016482A2 (en) * 2005-07-29 2007-02-08 Imperial Innovations Limited Mutant timp-3

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060088882A1 (en) * 2002-06-27 2006-04-27 Jain Rakesh K Methods for the treatment or prevention of obesity

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007016482A2 (en) * 2005-07-29 2007-02-08 Imperial Innovations Limited Mutant timp-3

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JONATHAN WANG ET AL: "Peptide and antibody ligands for renal targeting: nanomedicine strategies for kidney disease", BIOMATERIALS SCIENCE, vol. 5, no. 8, 1 January 2017 (2017-01-01), GB, pages 1450 - 1459, XP055507100, ISSN: 2047-4830, DOI: 10.1039/C7BM00271H *
LOREDANA FIORENTINO ET AL: "Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay : TIMP3 regulates FoxO1 in diabetic kidney disease", EMBO MOLECULAR MEDICINE, vol. 5, no. 3, 1 March 2013 (2013-03-01), Weinheim, pages 441 - 455, XP055507096, ISSN: 1757-4676, DOI: 10.1002/emmm.201201475 *
MENG-HUEE LEE ET AL: "Full-Length and N-TIMP-3 Display Equal Inhibitory Activities toward TNF-[alpha] Convertase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 280, no. 3, 1 January 2001 (2001-01-01), AMSTERDAM, NL, pages 945 - 950, XP055507098, ISSN: 0006-291X, DOI: 10.1006/bbrc.2000.4192 *

Also Published As

Publication number Publication date
US20210115111A1 (en) 2021-04-22
EP3743439A1 (en) 2020-12-02
WO2019145840A1 (en) 2019-08-01

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