IT201700085789A1 - METHOD FOR THE PREPARATION OF RUCAPARIB WITH HIGH PURITY - Google Patents

METHOD FOR THE PREPARATION OF RUCAPARIB WITH HIGH PURITY

Info

Publication number
IT201700085789A1
IT201700085789A1 IT102017000085789A IT201700085789A IT201700085789A1 IT 201700085789 A1 IT201700085789 A1 IT 201700085789A1 IT 102017000085789 A IT102017000085789 A IT 102017000085789A IT 201700085789 A IT201700085789 A IT 201700085789A IT 201700085789 A1 IT201700085789 A1 IT 201700085789A1
Authority
IT
Italy
Prior art keywords
rucaparib
preparation
high purity
purity
Prior art date
Application number
IT102017000085789A
Other languages
Italian (it)
Original Assignee
Olon Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olon Spa filed Critical Olon Spa
Priority to IT102017000085789A priority Critical patent/IT201700085789A1/en
Priority to PCT/EP2018/069740 priority patent/WO2019020508A1/en
Publication of IT201700085789A1 publication Critical patent/IT201700085789A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT102017000085789A 2017-07-26 2017-07-26 METHOD FOR THE PREPARATION OF RUCAPARIB WITH HIGH PURITY IT201700085789A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IT102017000085789A IT201700085789A1 (en) 2017-07-26 2017-07-26 METHOD FOR THE PREPARATION OF RUCAPARIB WITH HIGH PURITY
PCT/EP2018/069740 WO2019020508A1 (en) 2017-07-26 2018-07-20 Method for the preparation of high-purity rucaparib

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000085789A IT201700085789A1 (en) 2017-07-26 2017-07-26 METHOD FOR THE PREPARATION OF RUCAPARIB WITH HIGH PURITY

Publications (1)

Publication Number Publication Date
IT201700085789A1 true IT201700085789A1 (en) 2019-01-26

Family

ID=60990986

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000085789A IT201700085789A1 (en) 2017-07-26 2017-07-26 METHOD FOR THE PREPARATION OF RUCAPARIB WITH HIGH PURITY

Country Status (2)

Country Link
IT (1) IT201700085789A1 (en)
WO (1) WO2019020508A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109824677B (en) * 2019-04-03 2021-09-03 江苏开元药业有限公司 Preparation method of medicine Ruipafeb for treating ovarian cancer
CN111004244A (en) * 2019-12-27 2020-04-14 重庆市碚圣医药科技股份有限公司 Synthetic method of Ruipafebu camphorsulfonate
KR102589441B1 (en) * 2021-08-03 2023-10-16 고려대학교 산학협력단 A new synthetic method of rucaparib as a PARP inhibitor and intermediates thereof
CN114133396B (en) * 2022-01-04 2023-07-21 浙江乐普药业股份有限公司 Synthesis method of 8-fluoro-1, 3,4, 5-tetrahydro-azepino [5,4,3-cd ] indol-6-one

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7323562B2 (en) * 2004-09-22 2008-01-29 Agouron Pharmaceuticals, Inc. Method of preparing poly(ADP-ribose) polymerases inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU229875B1 (en) 1999-01-11 2014-11-28 Agouron Pharmaceuticals Inc La Jolla Tricyclic inhibitors of poly(adp-ribose) polymerases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7323562B2 (en) * 2004-09-22 2008-01-29 Agouron Pharmaceuticals, Inc. Method of preparing poly(ADP-ribose) polymerases inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ADAM T. GILLMORE ET AL: "Multkilogram Scale-Up of a Reductive Alkylation Route to a Novel PARP Inhibitor", ORGANIC PROCESS RESEARCH AND DEVELOPMENT, vol. 16, no. 12, 21 December 2012 (2012-12-21), US, pages 1897 - 1904, XP055250298, ISSN: 1083-6160, DOI: 10.1021/op200238p *

Also Published As

Publication number Publication date
WO2019020508A1 (en) 2019-01-31

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