IT201700081419A1 - Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici - Google Patents

Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici

Info

Publication number
IT201700081419A1
IT201700081419A1 IT102017000081419A IT201700081419A IT201700081419A1 IT 201700081419 A1 IT201700081419 A1 IT 201700081419A1 IT 102017000081419 A IT102017000081419 A IT 102017000081419A IT 201700081419 A IT201700081419 A IT 201700081419A IT 201700081419 A1 IT201700081419 A1 IT 201700081419A1
Authority
IT
Italy
Prior art keywords
isossazolic
inductors
beta
derivatives
fetal hemoglobin
Prior art date
Application number
IT102017000081419A
Other languages
English (en)
Inventor
Ilaria Lampronti
Roberto Gambari
Daniele Simoni
Original Assignee
Rare Partners Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rare Partners Srl filed Critical Rare Partners Srl
Priority to IT102017000081419A priority Critical patent/IT201700081419A1/it
Priority to PCT/EP2018/069158 priority patent/WO2019016103A1/en
Priority to US16/631,295 priority patent/US11077116B2/en
Priority to EP18743729.8A priority patent/EP3654974A1/en
Publication of IT201700081419A1 publication Critical patent/IT201700081419A1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
IT102017000081419A 2017-07-18 2017-07-18 Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici IT201700081419A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT102017000081419A IT201700081419A1 (it) 2017-07-18 2017-07-18 Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici
PCT/EP2018/069158 WO2019016103A1 (en) 2017-07-18 2018-07-13 ISOXAZOLE DERIVATIVES AS FETAL HEMOGLOBIN INDUCERS IN ERYTHROID PRECURSOR CELLS FROM BETA-THALASSEMIC PATIENTS
US16/631,295 US11077116B2 (en) 2017-07-18 2018-07-13 Isoxazole derivatives as inducers of fetal hemoglobin in erythroid precursor cells from beta-thalassemic patients
EP18743729.8A EP3654974A1 (en) 2017-07-18 2018-07-13 Isoxazole derivatives as inducers of fetal hemoglobin in erythroid precursor cells from beta-thalassemic patients

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102017000081419A IT201700081419A1 (it) 2017-07-18 2017-07-18 Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici

Publications (1)

Publication Number Publication Date
IT201700081419A1 true IT201700081419A1 (it) 2019-01-18

Family

ID=60990909

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102017000081419A IT201700081419A1 (it) 2017-07-18 2017-07-18 Derivati isossazolici come induttori di emoglobina fetale in precursori eritroidi derivati da pazienti beta-talassemici

Country Status (4)

Country Link
US (1) US11077116B2 (it)
EP (1) EP3654974A1 (it)
IT (1) IT201700081419A1 (it)
WO (1) WO2019016103A1 (it)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010000748A1 (en) * 2008-07-04 2010-01-07 Sigma-Tau Research Switzerland S.A. 5-phenyl-isoxazole-3-carboxamides modulating hsp90 with antitumoral activities
US20160113936A1 (en) * 2014-10-27 2016-04-28 Georgia Regents Research Institute, Inc. Methods for modulating monocyte function

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010000748A1 (en) * 2008-07-04 2010-01-07 Sigma-Tau Research Switzerland S.A. 5-phenyl-isoxazole-3-carboxamides modulating hsp90 with antitumoral activities
US20160113936A1 (en) * 2014-10-27 2016-04-28 Georgia Regents Research Institute, Inc. Methods for modulating monocyte function

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CIPRIAN ANEA ET AL: "Cytoprotective Chaperone Proteins Are Novel Anti-Inflammatory Targets in Sickle Cell Disease | The FASEB Journal", 1 April 2017 (2017-04-01), XP055471273, Retrieved from the Internet <URL:https://www.fasebj.org/doi/abs/10.1096/fasebj.31.1_supplement.981.3> [retrieved on 20180427] *
KAVITA NATARAJAN ET AL: "Heat Shock Protein Inhibition in Sickle Cell Disease: A Novel Approach to Attenuating the Inflammatory Response?.", BLOOD, vol. 110, no. 11, 16 November 2007 (2007-11-16), pages 2263, XP055471278 *
LOREDANA VESCI ET AL: "Preclinical antitumor activity of SST0116CL1: A novel heat shock protein 90 inhibitor", INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 45, no. 4, 1 August 2014 (2014-08-01), GR, pages 1421 - 1429, XP055470578, ISSN: 1019-6439, DOI: 10.3892/ijo.2014.2575 *

Also Published As

Publication number Publication date
WO2019016103A1 (en) 2019-01-24
US11077116B2 (en) 2021-08-03
US20200206234A1 (en) 2020-07-02
EP3654974A1 (en) 2020-05-27

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