IT1395351B1 - ORAL FORMULATIONS WITH HIGH BIOAVAILABILITY ORAL AVAILABLE MIXED BY LIPOFILE AND HYDROPHILE FRACTIONS OBTAINED FROM THE PROPOLIS - Google Patents

ORAL FORMULATIONS WITH HIGH BIOAVAILABILITY ORAL AVAILABLE MIXED BY LIPOFILE AND HYDROPHILE FRACTIONS OBTAINED FROM THE PROPOLIS

Info

Publication number
IT1395351B1
IT1395351B1 ITMI2009A001219A ITMI20091219A IT1395351B1 IT 1395351 B1 IT1395351 B1 IT 1395351B1 IT MI2009A001219 A ITMI2009A001219 A IT MI2009A001219A IT MI20091219 A ITMI20091219 A IT MI20091219A IT 1395351 B1 IT1395351 B1 IT 1395351B1
Authority
IT
Italy
Prior art keywords
oral
lipofile
hydrophile
propolis
fractions obtained
Prior art date
Application number
ITMI2009A001219A
Other languages
Italian (it)
Inventor
Favela Mariana Gabriela Alvarez
Original Assignee
Axioma Srl
Nuovo Titolare Flash Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axioma Srl, Nuovo Titolare Flash Spa filed Critical Axioma Srl
Priority to ITMI2009A001219A priority Critical patent/IT1395351B1/en
Priority to PCT/EP2010/003843 priority patent/WO2011057686A1/en
Publication of ITMI20091219A1 publication Critical patent/ITMI20091219A1/en
Application granted granted Critical
Publication of IT1395351B1 publication Critical patent/IT1395351B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Animal Husbandry (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ITMI2009A001219A 2009-07-09 2009-07-09 ORAL FORMULATIONS WITH HIGH BIOAVAILABILITY ORAL AVAILABLE MIXED BY LIPOFILE AND HYDROPHILE FRACTIONS OBTAINED FROM THE PROPOLIS IT1395351B1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ITMI2009A001219A IT1395351B1 (en) 2009-07-09 2009-07-09 ORAL FORMULATIONS WITH HIGH BIOAVAILABILITY ORAL AVAILABLE MIXED BY LIPOFILE AND HYDROPHILE FRACTIONS OBTAINED FROM THE PROPOLIS
PCT/EP2010/003843 WO2011057686A1 (en) 2009-07-09 2010-06-28 Oral formulations with high oral bioavailability consisting of mixtures of lipophilic and hydrophilic fractions obtained from propolis

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2009A001219A IT1395351B1 (en) 2009-07-09 2009-07-09 ORAL FORMULATIONS WITH HIGH BIOAVAILABILITY ORAL AVAILABLE MIXED BY LIPOFILE AND HYDROPHILE FRACTIONS OBTAINED FROM THE PROPOLIS

Publications (2)

Publication Number Publication Date
ITMI20091219A1 ITMI20091219A1 (en) 2011-01-10
IT1395351B1 true IT1395351B1 (en) 2012-09-14

Family

ID=41467288

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2009A001219A IT1395351B1 (en) 2009-07-09 2009-07-09 ORAL FORMULATIONS WITH HIGH BIOAVAILABILITY ORAL AVAILABLE MIXED BY LIPOFILE AND HYDROPHILE FRACTIONS OBTAINED FROM THE PROPOLIS

Country Status (2)

Country Link
IT (1) IT1395351B1 (en)
WO (1) WO2011057686A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201609113A (en) * 2014-07-18 2016-03-16 歐文 約翰 蓋奇波 Therapeutic compositions and uses thereof
CN113559060B (en) * 2021-08-12 2023-05-02 广东药科大学 Submicron emulsion of propolis phospholipid complex and preparation method thereof
FR3127696A1 (en) * 2021-10-04 2023-04-07 Larena Process for the manufacture of a powder comprising a biological support on which is deposited a biological extract

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US504323A (en) 1893-09-05 btje kle
IT1215291B (en) 1985-07-17 1990-01-31 Inverni Della Beffa Spa FLAVANOLIGNANI COMPLEXES WITH PHOSPHOLIPIDS, THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS.
IT1201149B (en) 1987-01-14 1989-01-27 Indena Spa BIOFLAVONOID COMPLEXES WITH PHOSPHOLIPIDS, THEIR PREPARATION, USE AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS
US6241975B1 (en) * 1999-07-24 2001-06-05 Pacific Corporation Method for preparation of plant extract powder
ITMI20022549A1 (en) 2002-12-02 2004-06-03 Actimex S R L QUATERNARY COMPOSITION INCLUDING PROPOLIS AS AN ACTIVE SUBSTANCE.
AT502628A1 (en) * 2005-11-09 2007-05-15 Imhof Martin Dr USE OF PROPOLIS FOR THE MANUFACTURE OF A MEDICAMENT
EP1837030A1 (en) 2006-03-09 2007-09-26 INDENA S.p.A. Phospholipid complexes of curcumin having improved bioavailability

Also Published As

Publication number Publication date
ITMI20091219A1 (en) 2011-01-10
WO2011057686A1 (en) 2011-05-19

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