IT1393700B1 - SYNTHESIS OF 3 - {[(2R) -1-METHYLPYROLIDIN-2-IL] METHYL} -5- [2- (PHENILSULFONYL) ETYL] -1H-INDOL - Google Patents

SYNTHESIS OF 3 - {[(2R) -1-METHYLPYROLIDIN-2-IL] METHYL} -5- [2- (PHENILSULFONYL) ETYL] -1H-INDOL

Info

Publication number
IT1393700B1
IT1393700B1 ITMI2009A000678A ITMI20090678A IT1393700B1 IT 1393700 B1 IT1393700 B1 IT 1393700B1 IT MI2009A000678 A ITMI2009A000678 A IT MI2009A000678A IT MI20090678 A ITMI20090678 A IT MI20090678A IT 1393700 B1 IT1393700 B1 IT 1393700B1
Authority
IT
Italy
Prior art keywords
phenilsulfonyl
methylpyrolidin
etyl
indol
synthesis
Prior art date
Application number
ITMI2009A000678A
Other languages
Italian (it)
Inventor
Siro Serafini
Santo Claudio Dal
Original Assignee
F S I Fabbrica Italiana Sint
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F S I Fabbrica Italiana Sint filed Critical F S I Fabbrica Italiana Sint
Priority to ITMI2009A000678A priority Critical patent/IT1393700B1/en
Priority to PCT/EP2009/064850 priority patent/WO2010121673A1/en
Priority to JP2012506351A priority patent/JP5663559B2/en
Priority to EP09751896.3A priority patent/EP2421853B1/en
Priority to CN200980158923.7A priority patent/CN102414198B/en
Priority to US12/995,390 priority patent/US8426612B2/en
Priority to CA2756234A priority patent/CA2756234C/en
Priority to ES09751896T priority patent/ES2432066T3/en
Publication of ITMI20090678A1 publication Critical patent/ITMI20090678A1/en
Application granted granted Critical
Publication of IT1393700B1 publication Critical patent/IT1393700B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
ITMI2009A000678A 2009-04-22 2009-04-22 SYNTHESIS OF 3 - {[(2R) -1-METHYLPYROLIDIN-2-IL] METHYL} -5- [2- (PHENILSULFONYL) ETYL] -1H-INDOL IT1393700B1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
ITMI2009A000678A IT1393700B1 (en) 2009-04-22 2009-04-22 SYNTHESIS OF 3 - {[(2R) -1-METHYLPYROLIDIN-2-IL] METHYL} -5- [2- (PHENILSULFONYL) ETYL] -1H-INDOL
PCT/EP2009/064850 WO2010121673A1 (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole
JP2012506351A JP5663559B2 (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2R) -1-methylpyrrolidin-2-yl] methyl} -5- [2- (phenylsulfonyl) ethyl] 1H-indole
EP09751896.3A EP2421853B1 (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole
CN200980158923.7A CN102414198B (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole
US12/995,390 US8426612B2 (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole
CA2756234A CA2756234C (en) 2009-04-22 2009-11-09 Synthesis of 3-{[(2r)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1h-indole
ES09751896T ES2432066T3 (en) 2009-04-22 2009-11-09 Synthesis of 3 - {[(2R) -1-methylpyrrolidin-2-yl] methyl} -5- [2- (phenylsulfonyl) ethyl] -1H-indole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI2009A000678A IT1393700B1 (en) 2009-04-22 2009-04-22 SYNTHESIS OF 3 - {[(2R) -1-METHYLPYROLIDIN-2-IL] METHYL} -5- [2- (PHENILSULFONYL) ETYL] -1H-INDOL

Publications (2)

Publication Number Publication Date
ITMI20090678A1 ITMI20090678A1 (en) 2010-10-23
IT1393700B1 true IT1393700B1 (en) 2012-05-08

Family

ID=41314669

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI2009A000678A IT1393700B1 (en) 2009-04-22 2009-04-22 SYNTHESIS OF 3 - {[(2R) -1-METHYLPYROLIDIN-2-IL] METHYL} -5- [2- (PHENILSULFONYL) ETYL] -1H-INDOL

Country Status (8)

Country Link
US (1) US8426612B2 (en)
EP (1) EP2421853B1 (en)
JP (1) JP5663559B2 (en)
CN (1) CN102414198B (en)
CA (1) CA2756234C (en)
ES (1) ES2432066T3 (en)
IT (1) IT1393700B1 (en)
WO (1) WO2010121673A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102786514B (en) * 2012-07-26 2014-01-29 武汉人福医药集团股份有限公司 Novel preparation method of eletriptan
CN104341397A (en) * 2013-07-31 2015-02-11 上海威智医药科技有限公司 Eletriptan free base with crystal forms, preparing method thereof and applications of the eletriptan free base
CN105175397B (en) * 2015-09-15 2017-10-10 上海现代哈森（商丘）药业有限公司 A kind of hydrobromic acid eletriptan synthetic method
JP2019502761A (en) * 2016-01-21 2019-01-31 ラボラトリオス レヴィ エセエレ Method of making ((R) -3-[(-1-methylpyrrolidin-2-yl) methyl] -5- (2-phenylsulfonylethyl) -1H-indole

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2091562C (en) 1990-10-15 2001-03-27 John Eugene Macor Indole derivatives useful in psychotherapeutics
US5545644A (en) 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
US20030166704A1 (en) * 2000-12-20 2003-09-04 Pfizer Inc. New process
GB0031094D0 (en) * 2000-12-20 2001-01-31 Pfizer Ltd New Process
MXPA05010070A (en) 2003-04-11 2005-11-23 Pfizer Pharmaceutical combination comprising eletriptan and sodium bicarbonate.
GB0317229D0 (en) * 2003-07-23 2003-08-27 Pfizer Ltd Improved process
US6927296B2 (en) * 2003-07-23 2005-08-09 Pfizer Inc. Process
EP2093224A1 (en) 2007-05-01 2009-08-26 Plus Chemicals B.V. Process for preparing eletriptan hydrobromide form beta
US20080319205A1 (en) * 2007-05-29 2008-12-25 Roman Bednar Process for preparing 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole
US20100285075A1 (en) 2007-12-17 2010-11-11 Actavis Group Ptc Ehf Novel Hemioxalate Salt of Eletriptan
US20090299077A1 (en) * 2008-05-22 2009-12-03 Vinod Kumar Kansal Salts of (R)-5-(2phenylsulphonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole, 5-bromo-3-[(R)-1-methyl-pyrrolidin-2-ylmethyl]-1H-indole and of eletriptan

Also Published As

Publication number Publication date
WO2010121673A1 (en) 2010-10-28
JP5663559B2 (en) 2015-02-04
ES2432066T3 (en) 2013-11-29
CA2756234A1 (en) 2010-10-28
US8426612B2 (en) 2013-04-23
CN102414198A (en) 2012-04-11
ITMI20090678A1 (en) 2010-10-23
US20110166364A1 (en) 2011-07-07
EP2421853B1 (en) 2013-07-24
CA2756234C (en) 2017-01-03
EP2421853A1 (en) 2012-02-29
CN102414198B (en) 2014-11-12
JP2012524736A (en) 2012-10-18

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