IT1319666B1 - ANTIBIOTICS ADDUCTS WITH NATURAL POLYESACCHARIDE POLYMERS IN FORMATS AQUEOUS SOLUTIONS. - Google Patents

ANTIBIOTICS ADDUCTS WITH NATURAL POLYESACCHARIDE POLYMERS IN FORMATS AQUEOUS SOLUTIONS.

Info

Publication number
IT1319666B1
IT1319666B1 IT2000MI002478A ITMI20002478A IT1319666B1 IT 1319666 B1 IT1319666 B1 IT 1319666B1 IT 2000MI002478 A IT2000MI002478 A IT 2000MI002478A IT MI20002478 A ITMI20002478 A IT MI20002478A IT 1319666 B1 IT1319666 B1 IT 1319666B1
Authority
IT
Italy
Prior art keywords
polyesaccharide
adducts
antibiotics
formats
polymers
Prior art date
Application number
IT2000MI002478A
Other languages
Italian (it)
Inventor
Piergiorgio Anzaghi
Rosanna Stefli
Original Assignee
Pharma Biotech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Biotech Ltd filed Critical Pharma Biotech Ltd
Priority to IT2000MI002478A priority Critical patent/IT1319666B1/en
Priority to PCT/IB2001/002172 priority patent/WO2002040057A1/en
Priority to EP01980848A priority patent/EP1335748A1/en
Priority to AU2002212632A priority patent/AU2002212632A1/en
Publication of ITMI20002478A1 publication Critical patent/ITMI20002478A1/en
Application granted granted Critical
Publication of IT1319666B1 publication Critical patent/IT1319666B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
IT2000MI002478A 2000-11-17 2000-11-17 ANTIBIOTICS ADDUCTS WITH NATURAL POLYESACCHARIDE POLYMERS IN FORMATS AQUEOUS SOLUTIONS. IT1319666B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT2000MI002478A IT1319666B1 (en) 2000-11-17 2000-11-17 ANTIBIOTICS ADDUCTS WITH NATURAL POLYESACCHARIDE POLYMERS IN FORMATS AQUEOUS SOLUTIONS.
PCT/IB2001/002172 WO2002040057A1 (en) 2000-11-17 2001-11-16 Antibiotics adducts with natural polysaccharide polymers in the form of aqueous solutions
EP01980848A EP1335748A1 (en) 2000-11-17 2001-11-16 Antibiotic adducts with natural polysaccharide polymers in the form of aqueous solutions
AU2002212632A AU2002212632A1 (en) 2000-11-17 2001-11-16 Antibiotics adducts with natural polysaccharide polymers in the form of aqueous solutions

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT2000MI002478A IT1319666B1 (en) 2000-11-17 2000-11-17 ANTIBIOTICS ADDUCTS WITH NATURAL POLYESACCHARIDE POLYMERS IN FORMATS AQUEOUS SOLUTIONS.

Publications (2)

Publication Number Publication Date
ITMI20002478A1 ITMI20002478A1 (en) 2002-05-17
IT1319666B1 true IT1319666B1 (en) 2003-10-23

Family

ID=11446119

Family Applications (1)

Application Number Title Priority Date Filing Date
IT2000MI002478A IT1319666B1 (en) 2000-11-17 2000-11-17 ANTIBIOTICS ADDUCTS WITH NATURAL POLYESACCHARIDE POLYMERS IN FORMATS AQUEOUS SOLUTIONS.

Country Status (4)

Country Link
EP (1) EP1335748A1 (en)
AU (1) AU2002212632A1 (en)
IT (1) IT1319666B1 (en)
WO (1) WO2002040057A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10209821A1 (en) 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of proteins to a modified polysaccharide
DE10209822A1 (en) * 2002-03-06 2003-09-25 Biotechnologie Ges Mittelhesse Coupling of low molecular weight substances to a modified polysaccharide
WO2005014655A2 (en) 2003-08-08 2005-02-17 Fresenius Kabi Deutschland Gmbh Conjugates of hydroxyalkyl starch and a protein

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2925009A1 (en) * 1979-06-21 1981-01-08 Basf Ag PREPARATION FOR SUBSTANCES, METHOD FOR THE PRODUCTION AND USE THEREOF
US4663316A (en) * 1985-06-28 1987-05-05 Warner-Lambert Company Antibiotic clathrates and pharmaceutical compositions thereof
IT1312110B1 (en) * 1999-05-18 2002-04-04 Istituto Biochimico Pavese Pha NATURAL ANTIBIOTIC-POLYESACCHARIDIC POLYMER ADDUCTS
JP2001058994A (en) * 1999-08-19 2001-03-06 Eisai Co Ltd Stabilized amoxicillin inclusion complex

Also Published As

Publication number Publication date
ITMI20002478A1 (en) 2002-05-17
WO2002040057A1 (en) 2002-05-23
EP1335748A1 (en) 2003-08-20
AU2002212632A1 (en) 2002-05-27

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